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3 results on '"gated hybrid materials"'

1. Fluorogenic Detection of Human Serum Albumin Using Curcumin-Capped Mesoporous Silica Nanoparticles

Author

Ismael Otri, Serena Medaglia, Elena Aznar, Félix Sancenón, and Ramón Martínez-Máñez

Subjects
mesoporous silica, gated hybrid materials, sensors, HSA detection, Organic chemistry, QD241-441
Abstract

Mesoporous silica nanoparticles loaded with rhodamine B and capped with curcumin are used for the selective and sensitive fluorogenic detection of human serum albumin (HSA). The sensing mesoporous silica nanoparticles are loaded with rhodamine B, decorated with aminopropyl moieties and capped with curcumin. The nanoparticles selectively release the rhodamine B cargo in the presence of HSA. A limit of detection for HSA of 0.1 mg/mL in PBS (pH 7.4)-acetonitrile 95:5 v/v was found, and the sensing nanoparticles were used to detect HSA in spiked synthetic urine samples.

Published
2022
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2. Fluorogenic Detection of Human Serum Albumin Using Curcumin-Capped Mesoporous Silica Nanoparticles

Author

Otri, Ismael, Medaglia, Serena, Aznar, Elena, Sancenón Galarza, Félix, and Martínez-Máñez, Ramón

Subjects
mesoporous silica, gated hybrid materials, sensors, HSA detection, Curcumin, Pharmaceutical Science, Serum Albumin, Human, Analytical Chemistry, QD241-441, QUIMICA ORGANICA, Drug Discovery, Humans, Physical and Theoretical Chemistry, Fluorescent Dyes, Gated hybrid materials, Sensors, Rhodamines, QUIMICA INORGANICA, Organic Chemistry, Silicon Dioxide, body regions, Spectrometry, Fluorescence, Chemistry (miscellaneous), embryonic structures, Molecular Medicine, Nanoparticles, Mesoporous silica
Abstract

[EN] Mesoporous silica nanoparticles loaded with rhodamine B and capped with curcumin are used for the selective and sensitive fluorogenic detection of human serum albumin (HSA). The sensing mesoporous silica nanoparticles are loaded with rhodamine B, decorated with aminopropyl moieties and capped with curcumin. The nanoparticles selectively release the rhodamine B cargo in the presence of HSA. A limit of detection for HSA of 0.1 mg/mL in PBS (pH 7.4)-acetonitrile 95:5 v/v was found, and the sensing nanoparticles were used to detect HSA in spiked synthetic urine samples., This research was funded by the Spanish Government (RTI2018-100910-B-C41 (MCUI/FEDER, EU)) and the Generalitat Valenciana (PROMETEO 2018/024). I.O. was funded by Erasmus Mundus Programme, Action 2, Lot 1, Syria (predoctoral fellowship). S.M. was funded by Generalitat Valenciana (Santiago Grisolia fellowship).

Published
2021

3. Fluorogenic Detection of Human Serum Albumin Using Curcumin-Capped Mesoporous Silica Nanoparticles.

Author

Otri, Ismael, Medaglia, Serena, Aznar, Elena, Sancenón, Félix, and Martínez-Máñez, Ramón

Subjects
*SILICA nanoparticles, *MESOPOROUS silica, *SERUM albumin, *DETECTION limit, *CURCUMIN
Abstract

Mesoporous silica nanoparticles loaded with rhodamine B and capped with curcumin are used for the selective and sensitive fluorogenic detection of human serum albumin (HSA). The sensing mesoporous silica nanoparticles are loaded with rhodamine B, decorated with aminopropyl moieties and capped with curcumin. The nanoparticles selectively release the rhodamine B cargo in the presence of HSA. A limit of detection for HSA of 0.1 mg/mL in PBS (pH 7.4)-acetonitrile 95:5 v/v was found, and the sensing nanoparticles were used to detect HSA in spiked synthetic urine samples. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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