Search

Your search keyword '"genotypes 1b and 3a"' showing total 4 results
Start Over Descriptor "genotypes 1b and 3a"
4 results on '"genotypes 1b and 3a"'

1. Sequence variability at the internal ribosome entry site of the HCV genome in relation to therapy outcome

Author

Jovanović-Ćupić Snežana, Simonović-Babić Jasmina, Blagojević Jelena, Božić Milena, Ješić Rada, Nožić D., and Stamenković Gorana

Subjects
hepatitis C virus, interferon, internal ribosome entry site, genotypes 1b and 3a, Biology (General), QH301-705.5
Abstract

Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p < 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p < 0.05).

Published
2009
Full Text
View/download PDF

2. Varijabilnost nukleotidne sekvence 'unutrašnjeg ribozomalnog ulaznog mesta' u genomu virusa hepatitisa tipa C u odnosu na uspešnost terapije

Author

Jovanović-Ćupić, Snežana, Simonović-Babić, Jasmina, Blagojević, Jelena, Božić, Milena, Ješić, Rada, Nožić, D., and Stamenković, Gorana

Subjects
hepatitis C virus, internal ribosome entry site, genotypes 1b and 3a, interferon
Abstract

Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p < 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p < 0.05). Interferonska terapija se danas najčešće koristi u lečenju infekcije virusom hepatitisa tipa C (HCV). In vitro rezultati su pokazali da interferoninhibira translaciju kod ovog virusa preko interakcije sa delom genoma koji učestvuje u inicijaciji translacije tzv. 'unutrašnje ribozomalno ulazno mesto' (IRES). U ovom radu smo ispitivali nukleotidne izmene u IRES-u kod izolata HCV-a dobijenih iz seruma osoba koje su primale kombinovanu terapiju interferon/ribavirin. U analiziranoj grupi od 56 HCV izolata, nukleotidne izmene su utvrđene u: IIIb petlji, regiji između 243 nt i 248 nt i polipirimidin-II regiji. Utvrđena varijabilnost IRES-a kod izolata genotipa 3a značajno je veća u poređenju sa izolatima genotipa 1b (p < 0.05). Prosečan broj nukleotidnih izmena kod izolata genotipa 3a je u korelaciji sa odgovorom na primenjenu terapiju (p < 0.05). Projekat ministarstva br. 143010 i 143011

Published
2009

3. Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome

Author

Rada Jesic, Jasmina Simonovic-Babic, Gorana Stamenković, Jelena Blagojević, Milena Bozic, Darko Nozic, and Snezana Jovanovic-Cupic

Subjects
hepatitis C virus, Combination therapy, internal ribosome entry site, Hepatitis C virus, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Interferon, Genotype, medicine, lcsh:QH301-705.5, 030304 developmental biology, 0303 health sciences, Ribavirin, Nucleic acid sequence, Translation (biology), interferon, Virology, 3. Good health, Internal ribosome entry site, lcsh:Biology (General), chemistry, genotypes 1b and 3a, 030211 gastroenterology & hepatology, General Agricultural and Biological Sciences, medicine.drug
Abstract

Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p < 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p < 0.05).

Published
2009

4. Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome

Author

Jovanović-Ćupić, Snežana P., Simonovic-Babic, Jasmina, Blagojevic, Jelena, Božić, Milena, Ješić, Rada, Nozic, D., Stamenković, Gorana, Jovanović-Ćupić, Snežana P., Simonovic-Babic, Jasmina, Blagojevic, Jelena, Božić, Milena, Ješić, Rada, Nozic, D., and Stamenković, Gorana

Abstract

Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p LT 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p LT 0.05).

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results