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2 results on '"gradient echo T2*-weighted imaging"'

1. The value of T(2) (*)-weighted gradient echo imaging for detection of familial cerebral cavernous malformation: A study of two families

Author

Shu-hua Wang, Zhaofu Chi, Xue-wu Liu, Xiuhe Zhao, Shengjun Wang, and Li-Jun Su

Subjects
Cancer Research, Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, diagnosis, Magnetic resonance imaging, General Medicine, Inversion recovery, Articles, Fluid-attenuated inversion recovery, medicine.disease, Gradient echo imaging, gradient echo T2*-weighted imaging, Immunology and Microbiology (miscellaneous), Hemosiderin, medicine, familial cerebral cavernous malformation, magnetic resonance imaging, Nuclear medicine, business, T2 weighted, Familial cerebral cavernous malformation, Calcification
Abstract

The aim of this study was to investigate the value of T(2) (*)-weighted gradient echo imaging (GRE T(2) (*)-WI) for the detection of familial cerebral cavernous malformation (FCCM). Twenty-six members of 2 families with FCCM were examined using computed tomography (CT), conventional magnetic resonance imaging (MRI) and GRE T(2) (*)-WI sequences. We identified 12 cases of FCCM using GRE T(2) (*)-WI sequences. These 12 patients had multiple lesions (mean 23). The lesions were most commonly located in the ganglia. Other areas included the cortex-subcortex, thalamus, cerebellum and brainstem. These lesions appeared as a reticulated core of mixed signal intensity with a surrounding rim of decreased signal intensity representing hemosiderin from previous hemorrhages. The mean numbers of lesions and cases of FCCM identified by various conventional MRI sequences were 5-17 and 3-9, respectively. Conventional MRI examination involved T(1)-weighted imaging (T(1)WI), T(2)-weighted imaging (T(2)WI), T(2)-fluid-attenuated inversion recovery (T(2)Flair), diffusion-weighted imaging (DWI) and spin-echo imaging (SE) sequences, in that order. The numbers of lesions identified by MRI were fewer than those identified by GRE T(2) (*)-WI. CT only identified 3 cases with large lesions combined with hemorrhage and calcification. These findings suggest that GRE T(2) (*)-WI is the first choice when diagnosing FCCM compared with CT and conventional MRI.

Published
2012

2. Gradient Echo T2∗-weighted Magnetic Resonance Imaging Revealing Cerebral Microbleeds in A Patient with Microscopic Polyangiitis Complicated by Cerebrovascular Disease.

Author

Yamashiro, Kazuo, Mori, Akio, Shimada, Yoshiaki, Furuya, Tsuyoshi, Noda, Kazuyuki, Urabe, Takao, Hattori, Nobutaka, and Okuma, Yasuyuki

Abstract

A 67-year-old woman developed alveolar hemorrhage and was positive for the myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA). She was diagnosed as having probable microscopic polyangiitis (MPA) in accordance with the Japanese criteria. Brain computed tomographic and magnetic resonance imaging (MRI) scans revealed asymptomatic chronic cerebral hemorrhage and white matter lesions. She also later developed thalamic infarction. Gradient echo T2-weighted MRI showed cerebral microbleeds. Cerebral microbleeds in our patient represent bleeding-prone necrotizing vasculitis, which is a characteristic pathologic feature of MPA. Although cerebrovascular disease is not major complication of MPA, cerebral hemorrhage occurs more frequently than ischemic infarction, and it can be critical and fatal. Brain MRIs, including gradient echo T2-weighted imaging, should be performed on patients diagnosed as or suspected of having MPA to assess the risk of cerebral hemorrhage. [Copyright &y& Elsevier]

Published
2012
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