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2 results on '"ha-cat cells"'

1. Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

Author

Juškaitė Vaida, Ramanauskienė Kristina, and Briedis Vitalis

Subjects
microemulsion, resveratrol, photostability, ha-cat cells, uvb, oxidative stress, Pharmaceutical industry, HD9665-9675
Abstract

Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed. Results of biopharmaceutical evaluation in vitro demonstrated that up to 60 % of resveratrol was released from microemulsions within 6 hours under a constant release rate profile. In vivo biological testing confirmed the ability of resveratrol to protect cells from oxidative stress and to increase cell viability. It was concluded that microemulsions might be considered in the development of UV light sensitive compounds.

Published
2017
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2. Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

Author

Kristina Ramanauskienė, Vaida Juškaitė, and Vitalis Briedis

Subjects
Keratinocytes, Antioxidant, endocrine system diseases, Ultraviolet Rays, medicine.medical_treatment, Pharmaceutical Science, 02 engineering and technology, Resveratrol, photostability, medicine.disease_cause, 030226 pharmacology & pharmacy, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Delivery Systems, Drug Stability, In vivo, Stilbenes, medicine, Humans, Microemulsion, Viability assay, ha-cat cells, skin and connective tissue diseases, uvb, Pharmaceutical industry, Pharmacology, Chemistry, organic chemicals, food and beverages, General Medicine, microemulsion, 021001 nanoscience & nanotechnology, resveratrol, HaCaT cells, UVB, oxidative stress, HaCaT, Oxidative Stress, Drug delivery, Biophysics, Emulsions, HD9665-9675, 0210 nano-technology, hormones, hormone substitutes, and hormone antagonists, Oxidative stress
Abstract

Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed. Results of biopharmaceutical evaluation in vitro demonstrated that up to 60 % of resveratrol was released from microemulsions within 6 hours under a constant release rate profile. In vivo biological testing confirmed the ability of resveratrol to protect cells from oxidative stress and to increase cell viability. It was concluded that microemulsions might be considered in the development of UV light sensitive compounds.

Published
2017

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