1. Ototoxicity associated with hematopoietic stem cell transplantation; what are the risk factors?
- Author
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Uzunoğlu, Eray, Akalın, Muhittin, Özkurt, Zübeyde Nur, Yegin, Zeynep Arzu, and Karamert, Recep
- Subjects
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HEARING disorder diagnosis , *HEMATOPOIETIC stem cell transplantation , *RISK assessment , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *OTOTOXICITY , *DISEASE risk factors , *ADULTS - Abstract
Background: Hematopoietic stem cell transplantation (HSCT) is a critical treatment for various hematologic malignancies but can lead to complications, including ototoxicity. Aim/objectives: This study aims to explore the relationship between patient-specific factors and ototoxicity in adult HSCT patients. Material and Methods: We conducted a retrospective analysis of 129 adult patients who underwent HSCT between 2003 and 2020. Age, gender, transplant indications, conditioning regimens, and pre- and post-transplant audiometry thresholds data were collected from patient files. A hearing loss of 10 decibels or more at two consecutive frequencies or a hearing loss of 20 decibels or more at a single frequency was considered as significant hearing loss (SHL). Statistical analyses were performed to describe factors associated with SHL. Results: SHL occurred in 16.3% of patients. Older age was significantly associated with an increased risk of SHL (p =.035). Poorer pretransplant hearing thresholds at 4000 Hz and 6000 Hz were also significant predictors of SHL (p =.039 and p =.014, respectively). There was no significant relationship between the donor type of HSCT (autologous vs. allogeneic) and ototoxicity (p =.45), and between conditioning regimens and ototoxicity (p =.860). Conclusions: Age and pre-existing hearing levels are significant predictors of ototoxicity post-HSCT. Careful management and monitoring are essential to prevent and address hearing loss in HSCT patients to improve hearing-related quality of life. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
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