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First-ever measurements of particulate matter (PM2.5, PM10, and TSP) along with gaseous pollutants (CO, NO2, and SO2) were performed from June 2019 to April 2020 in Faisalabad, Metropolitan, Pakistan, to assess their seasonal variations; Summer 2019, Autumn 2019, Winter 2019-2020, and Spring 2020. Pollutant measurements were carried out at 30 locations with a 3-km grid distance from the Sitara Chemical Industry in District Faisalabad to Bhianwala, Sargodha Road, Tehsil Lalian, District Chiniot. ArcGIS 10.8 was used to interpolate pollutant concentrations using the inverse distance weightage method. PM2.5, PM10, and TSP concentrations were highest in summer, and lowest in autumn or winter. CO, NO2, and SO2 concentrations were highest in summer or spring and lowest in winter. Seasonal average NO2 and SO2 concentrations exceeded WHO annual air quality guide values. For all 4 seasons, some sites had better air quality than others. Even in these cleaner sites air quality index (AQI) was unhealthy for sensitive groups and the less good sites showed Very critical AQI (> 500). Dust-bound carbon and sulfur contents were higher in spring (64 mg g-1) and summer (1.17 mg g-1) and lower in autumn (55 mg g-1) and winter (1.08 mg g-1). Venous blood analysis of 20 individuals showed cadmium and lead concentrations higher than WHO permissible limits. Those individuals exposed to direct roadside pollution for longer periods because of their occupation tended to show higher Pb and Cd blood concentrations. It is concluded that air quality along the roadside is extremely poor and potentially damaging to the health of exposed workers.

Heat stress exposure in intermittent heat waves and subsequent exposure during war theaters pose a clinical challenge that can lead to multi-organ dysfunction and long-term complications in the elderly. Using an aged mouse model and high-throughput sequencing, this study investigated the molecular dynamics of the liver-brain connection during heat stress exposure. Distinctive gene expression patterns induced by periodic heat stress emerged in both brain and liver tissues. An altered transcriptome profile showed heat stress-induced altered acute phase response pathways, causing neural, hepatic, and systemic inflammation and impaired synaptic plasticity. Results also demonstrated that proinflammatory molecules such as S100B, IL-17, IL-33, and neurological disease signaling pathways were upregulated, while protective pathways like aryl hydrocarbon receptor signaling were downregulated. In parallel, Rantes, IRF7, NOD1/2, TREM1, and hepatic injury signaling pathways were upregulated. Furthermore, current research identified Orosomucoid 2 (ORM2) in the liver as one of the mediators of the liver-brain axis due to heat exposure. In conclusion, the transcriptome profiling in elderly heat-stressed mice revealed a coordinated network of liver-brain axis pathways with increased hepatic ORM2 secretion, possibly due to gut inflammation and dysbiosis. The above secretion of ORM2 may impact the brain through a leaky blood-brain barrier, thus emphasizing intricate multi-organ crosstalk.

Electrifying freight trucks will be key to alleviating air pollution burdens on disadvantaged communities and mitigating climate change. The United States plans to pursue this aim by adding vehicle charging infrastructure along specific freight corridors. This study explores the coevolution of the electricity grid and freight trucking landscape using an integrated assessment framework to identify when each interstate and drayage corridor becomes advantageous to electrify from a climate and human health standpoint. Nearly all corridors achieve greenhouse gas emission reductions if electrified now. Most can reduce health impacts from air pollution if electrified by 2040 although some corridors in the Midwest, South, and Mid-Atlantic regions remain unfavorable to electrify from a human health standpoint, absent policy support. Recent policy, namely, the Inflation Reduction Act, accelerates this timeline to 2030 for most corridors and results in net human health benefits on all corridors by 2050, suggesting that near-term investments in truck electrification, particularly drayage corridors, can meaningfully reduce climate and health burdens.

1. This study assessed the addition of dried stinging nettle (SN) leaves at 0%, 2.5% and 5.0% in feed on egg production, egg quality, chemical composition and antioxidant content in eggs from laying hens.2. Seventy-two Hy-Line Brown laying hens, housed in 36 enriched layer cages, were used in the study from 43 to 47 weeks of age. Feeding dry SN leaves did not affect (p > 0.05) egg production variables.3. Dietary SN inclusion linearly increased (p < 0.001) carotenoid content more than six-fold, in addition to yellowness and redness of the yolks at the maximum inclusion. Providing eggs from hens fed carotenoid enriched diets, e.g. SN, may be used to increase carotenoids in human diets. [ABSTRACT FROM AUTHOR]

In recent years, overexplorations of ore and the growth of industries are the prime factors in the release of heavy metals in environments. As a result, the food crops and water bodies are contaminated with metals which may have several adverse effects on the health of humans and other living species. These metals and metalloids, such as Zn, Cu, Mn, Ni, Cr, Pb, Cd, and As, upset the biochemical pathways of metabolite synthesis in living organisms and contribute to the etiology of different diseases. Microorganisms include bacteria, archaea, viruses, and many unicellular eukaryotes, which can span three domains of life--Archaea, Bacteria, and Eukarya--and some microorganisms, such as cyanobacteria, have shown high efficiency in the biosorption rate of heavy metals. Cyanobacteria are suitable for bioremediation as they can grow in adverse environments, have a less negative impact on the surrounding environment, and are relatively cheaper to manage. The structure of cyanobacteria has shown no extensive internal-bound membranes, so it can directly employ the physiological mechanisms to uptake heavy metals from contamination sites. Such biochemical makeups are suitable for managing and bioremediating heavy metal concentrations in polluted environments. This review aims to explore the potential of cyanobacteria in the bioremediation of heavy metals and metalloids in water bodies. Additionally, we have identified the prospects for enhancing bioremediation effectiveness. [ABSTRACT FROM AUTHOR]

Background: Plastics are the most flexible products developed with a wide range of applications. They have been incorporated into almost every aspect of daily life due to their strength and low weight. However, widespread use and inadequate waste management have resulted in the accumulation of tiny plastic particles throughout the environment. Main text: Microplastics are found in oceans, rivers, sediments, sewers, soil, and agricultural products, even in table salts. Human beings are affected by microplastics through food ingestion and inhalation. Incorporated microplastics may accrue within the body and affect gastrointestinal, immune, endocrine, brain, and respiratory systems. It also interferes with the functions of major organs and causes chromosomal abnormalities. Conclusion: Addressing the issue of micro and nanoplastics requires interdisciplinary research, sustainable solutions, and improved waste management systems. The main focus of this review is to cover the harmful effects and impact of microplastics on human health and stress the need for combating strategies. [ABSTRACT FROM AUTHOR]

AbstractBisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in the candidate list of substances of very high concern (SVHC). On this basis, its use has been banned or restricted in some products. As a consequence, industries turned to bisphenol alternatives, such as bisphenol S (BPS) and bisphenol F (BPF), which are now found in various consumer products, as well as in human matrices at a global scale. However, due to their toxicity, these two bisphenols are in the process of being regulated. Other BPA alternatives, whose potential toxicity remains largely unknown due to a knowledge gap, have also started to be used in manufacturing processes. The gradual restriction of the use of BPA underscores the importance of understanding the potential risks associated with its alternatives to avoid regrettable substitutions. This review aims to summarize the current knowledge on the potential hazards related to BPA alternatives prioritized by European Regulatory Agencies based on their regulatory relevance and selected to be studied under the European Partnership for the Assessment of Risks from Chemicals (PARC): BPE, BPAP, BPP, BPZ, BPS-MAE, and TCBPA. The focus is on data related to toxicokinetic, endocrine disruption, immunotoxicity, developmental neurotoxicity, and genotoxicity/carcinogenicity, which were considered the most relevant endpoints to assess the hazard related to those substances. The goal here is to identify the data gaps in BPA alternatives toxicology and hence formulate the future directions that will be taken in the frame of the PARC project, which seeks also to enhance chemical risk assessment methodologies using new approach methodologies (NAMs). [ABSTRACT FROM AUTHOR]

AbstractAstaxanthin (AXT), a natural carotenoid, has strong antioxidant and anti-ageing effects and can reduce ultraviolet light-induced damage to cells and DNA, stimulate the immune system, and improve cardiovascular disease prognosis. Despite its wide applications in the: nutraceutical, cosmetic, aquaculture, and pharmaceutical industries, AXT industrial production and application are hindered by natural source scarcity, low production efficiency, and high requirements. This review compares the qualitative differences of AXT derived from different natural sources, evaluates the upstream procedures for AXT expression in different chassis organisms, and investigates synthetic biology- and cell factory-based strategies for the industrial production of natural AXT. Synthetic biology is a promising novel strategy for reprogramming plants or microorganisms to produce AXT. Additionally, genetic engineering using cell factories extends beyond terrestrial applications, as it may contribute to the long-term sustainability of human health during space exploration and migration endeavors. This review provides a theoretical basis for the efficient and accurate genetic engineering of AXT from the microalga Haematococcuspluvialis, providing a valuable reference for future research on the biomanufacturing of AXT and other biological metabolites. [ABSTRACT FROM AUTHOR]

The quality of the internal microclimate is a very important issue nowadays, considering that people in developed societies spend a good part of their day inside buildings and means of transport. But the poor quality of indoor air has a double effect; on the one hand, it can harm human health, and on the other hand, it can cause the degradation of materials. Thus, the current study considers the potential influence of a number of 20 pollutants on the exhibits, visitors, and employees of a synagogue that is over 140 years old in the Municipality of Oradea (Romania), which today is included in the list of historical monuments and is open to be visited. The monitoring period consisted of 9 months, during which parameters such as temperature, relative humidity, CO concentration, light intensity, concentration of particulate matter, and other pollutants were monitored. All the obtained values were then reported to the international standards in force for each indicator, both regarding the potential for human health and the integrity of the exhibits. The results indicate that the values of most pollutants respect the allowed thresholds, with more or less permitted exceptions. The most problematic are the values of temperature, relative humidity, HCHO, and VOC, which substantially exceed the allowed limits and vary a considerable difference. This can induce additional stress on the exhibits, leading over time to damage and premature aging; in terms of human health, the indoor microclimate can, in rare cases, cause discomfort associated with headaches, dizziness, and irritation, but the potential to cause persistent ailments is quite low. To maintain a clean internal microclimate, preventive conservation through the continuous monitoring of internal parameters as well as the establishment of long‐term strategies to stabilize the values of pollutants are necessary actions. [ABSTRACT FROM AUTHOR]

Life cycle assessment (LCA) along with a survey on epidemiologic and oxidative potential studies was used for analysing the current evidence of the impact of airborne emissions from municipal solid waste incineration (MSWI) on human health. The correspondence among investigated health outcomes and pollutants was discussed based on the Chemical Abstract Service (CAS) and the International Agency for Research on Cancer (IARC). LCA indicated the ability of MSWI in avoiding human health impact, about − 2 × 10−4 DALY/tonne together with avoided emissions of particulate matter (PM) and resource depletion, about − 2.5 × 10−3 kg Sbeq/tonne and about − 0.11 kg PM2.5 eq/tonne, respectively. Positive emissions were detected for greenhouses (about 900 kg CO2eq/tonne) and ecotoxicity (about 15,000 CTUe/tonne). Epidemiologic studies performed on population exposed to MSWI reported quite contrasting results. In some of these, hazard ratio (HR) ranging from about 0.7 to 2.2 was reported concerning the incidence of stomach, liver, breast and bladder cancer. Larger agreement was detected concerning the incidence of larynx and lung cancer with HR ranging from about 1 to about 2.6. Direct causal nexuses were not definitively identified. Oxidative potential of PM was characterized by a high Pearson correlation > 0.8 to the presence of CrVI, Cu and Zn. These heavy metals were also identified by both CAS and IARC as toxic (i.e. Cu and Zn) and cancerous (i.e. CrVI) substances affecting the organs of both respiratory and digestive apparatus. In general, even if more research is necessary, LCA, oxidative potential and the epidemiologic survey results showed a high level of accordance. This suggests their integrated exploitation for supporting the investigation of both direct and indirect consequences on environment and health related to waste incineration for both retrospective and predictive studies. [ABSTRACT FROM AUTHOR]

AbstractFunctional fermented foods are increasingly recognized for their positive impact on human health, and this study aims to identify the factors that influence these products’ consumption in Iran. The study uses structural equation modeling (SEM) to test the conceptual model incorporating the theory of planned behavior (TPB), protection motivation theory (PMT), and flow theory (FT). Data from 319 individuals having prior experience with such foods were analyzed to test the hypothesized relationships. Based on the results, the integrated model components demonstrated a strong predictive power, explaining 70.6% of the variance in functional fermented food consumption. The study found that perceived vulnerability, perceived severity, and response cost from the PMT were the main drivers of functional fermented food consumption among Iranians. The study also offers practical insights, including highlighting health benefits, promoting pleasurable aspects, and mitigating accessibility challenges to these foods for Iranian consumers. [ABSTRACT FROM AUTHOR]

Artificial light at night (ALAN) is a growing environmental issue associated with adverse health consequences, but the association with low birth weight remains unknown. We aim to explore associations between outdoor ALAN and low birth weight across 7,808 census tracts in California. We use data from the California Communities Environmental Health Screening Tool (CalEnviroScreen) at the census tract level. VIIRS Nighttime Day/Night Band Composites Version 1 dataset within the Google Earth Engine platform was used to assess outdoor ALAN. Multivariable linear regression was used to analyze the data. Our findings showed that an interquartile range increase in outdoor ALAN resulted in an increase of 0.42% (95% CI: 0.37, 0.46) in low birth weight rate on average, after adjusting for all potential covariates. The results demonstrate a significant association between outdoor ALAN and low birth weight. These associations remained consistent in sensitivity analyses. [ABSTRACT FROM AUTHOR]

Flowering plants are essentially sessile organisms that disperse their genes through pollination, expanding their areas of occurrence through seed dispersal. In orchids, seed dispersal is commonly mediated by air currents. Conversely, members of several genera have evolved seeds adapted to endozoochory. This is the case for Vanilla, the most economically important genus in the orchid family. The role of indehiscent fruits in the attraction and rewarding of Vanilla seed dispersers was investigated based on field observations, analysis of fragrances, reward substances, and investigation of seed viability through the digestive tract. Indehiscent Vanilla fruits are consumed exclusively by herbivores, i.e. agoutis. Besides providing nutritional rewards, the fruits are rich in polyphenols that are unpalatable to omnivores. The most dominant compound in fruits is attractive only to agoutis. This is the first study showing synzoochory in Orchidaceae and specificity of seed dispersal in orchids. Indehiscent fruits may have evolved early in Neotropical Vanilla in response to selection pressures mediated by large herbivores as the genus emerged ca. 34 Mya in South America, concomitantly with megafauna diversification in the Oligocene. Extinction of the megafauna during the Pleistocene has left agoutis as inheritors of seed dispersal in species with large fleshy fruits. Apart from the effects on omnivores, this study shows that indehiscent fruits of V. chamissonis are consumed exclusively by agoutis, providing the first evidence of target mutualism in orchid seed dispersal. [ABSTRACT FROM AUTHOR]

Many people have associated e-cigarettes with adjectives such as trendy and cool, and regarded vaping as "a safer alternative to cigarette smoking". Compared with the conventional cigarettes, the public is less familiar with the dangers of e-cigarettes. E-cigarettes produce an aerosol by heating the e-liquid (usually comprising nicotine, flavorings, propylene glycol, vegetable glycerin, and other additives). Harmful substances are generated during the vaporization, such as formaldehyde. Cellular damages and DNA hypermethylation are also found to be associated with vaping. We reviewed the clinical neoplastic cases of patients with vaping history (three oral squamous cell carcinomas, one conjunctival squamous intraepithelial neoplasia, and one thoracic NUT-midline carcinoma). These patients tend to be younger than the average cancer patients. Although the exact relations between the cellular damages or DNA hypermethylation and vaping still need further investigations, we should be very careful about the dangers of using e-cigarettes as aids for cigarette smoking cessation. [ABSTRACT FROM AUTHOR]

Phytochemists are aware of the contribution of plant biodiversity in providing chemical entities to the therapeutic arsenal, but the links between biodiversity and the emergence of pandemics are less described. "Healthy" biodiverse ecosystems protect us humans against emergence of infectious diseases and transmission as exemplified by the "dilution effect" developed upon the eco-epidemiological tick-borne Lyme disease. The emergence and spread of viral pandemics is not only due to the degradation of biodiversity but also compounded by anthropogenic factors such as the intensification and acceleration of trade and intercontinental transport, unprecedented urban human concentrations, climate change, industrialisation, massification and genetic uniformity in industrial breeding, consumption of bushmeat and promiscuity in certain markets with living animals. "One-Health" holistic approach to sustainable development is an excellent option to reduce the emergence of future pandemics. It tackles global environmental, human and animal health issues while respecting climate and ecological climate objectives. Surprisingly, this type of strategy implies accepting parasites and viruses and not seeing them as enemies to be eliminated. It also calls for recognition of the role of the local and indigenous communities in taking care traditionally and sustainably of more than a quarter of the world's land area. Only by thinking globally and acting locally this way, we will be able to reduce the risk of (re)-emergences of zoonoses and parasitic diseases. [Display omitted] • Links between biodiversity and emergence of pandemics need to be more considered. • Biodiverse ecosystems protect us against emergence of infectious diseases as exemplified by the "dilution effect". • Other factors are important as intercontinental transport, human and animal concentrations and consumption of bushmeat. • "One-Health" holistic approach is an excellent option to reduce the emergence of future pandemics. [ABSTRACT FROM AUTHOR]

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Plastic has been known as an artificial polymer whereas environmental microplastics become a global concern. Microplastics are reported to cause immunotoxicity in humans through gut deposition and entering the bloodstream. This study is a comprehensive indication of the recent research on microplastic toxicity in the gastrointestinal system. We performed bibliographic analysis using VOS viewer software and analyzed the data received on microplastics and their impact on gut health which has grown exponentially since 2016. Recent findings also support microplastic toxicity in combination with heavy metals. The smaller particle size and other factors enhanced the adsorption ability of environmental contamination such as heavy metals on microplastic which increased their bioaccumulation. Such toxic complexes of heavy metals and microplastics are a concern to natural ecosystems and environmental biologists. Few reports also demonstrated the biofilm formation on microplastic surfaces which might cause greater environmental as well as human health risks. Notably, terms of determining the microplastics in human tissues through several analytical techniques are still limited to some extent. Future research should be focused on the quantification of microplastics in human tissues, the combined effect of microplastics with other contaminants, and their effects on pre-existing diseases. This study boosts understanding of the potential impacts of microplastic and nanoplastic toxicity in the human gastrointestinal system. [ABSTRACT FROM AUTHOR]

Airborne fungi and bacteria have been extensively studied by researchers due to their significant effects on human health. We provided an overview of the distribution and sources of airborne pathogenic microbes, and a detailed description of the detrimental effects that these microorganisms cause to human health in both outdoor and indoor environments. By analyzing the large body of literature published in this field, we offered valuable insights into how airborne microbes influence our well-being. The findings highlight the harmful consequences associated with the exposure to airborne fungi and bacteria in a variety of natural and human-mediated environments. Certain demographic groups, including children and the elderly, immunocompromised individuals, and various categories of workers are particularly exposed and vulnerable to the detrimental effect on health of air microbial pollution. A number of studies performed up to date consistently identified Alternaria, Cladosporium, Penicillium, Aspergillus, and Fusarium as the predominant fungal genera in various indoor and outdoor environments. Among bacteria, Bacillus, Streptococcus, Micrococcus, Enterococcus, and Pseudomonas emerged as the dominant genera in air samples collected from numerous environments. All these findings contributed to expanding our knowledge on airborne microbe distribution, emphasizing the crucial need for further research and increased public awareness. Collectively, these efforts may play a vital role in safeguarding human health in the face of risks posed by airborne microbial contaminants. [ABSTRACT FROM AUTHOR]

Telomere length is a putative biomarker of aging and is associated with multiple age-related diseases. There are limited data on the landscape of rare genetic variations in telomere length. Here, we systematically characterize the rare variant associations with leukocyte telomere length (LTL) through exome-wide association study (ExWAS) among 390,231 individuals in the UK Biobank. We identified 18 robust rare-variant genes for LTL, most of which estimated effects on LTL were significant (> 0.2 standard deviation per allele). The biological functions of the rare-variant genes were associated with telomere maintenance and capping and several genes were specifically expressed in the testis. Three novel genes (ASXL1, CFAP58, and TET2) associated with LTL were identified. Phenotypic association analyses indicated significant associations of ASXL1 and TET2 with cancers, age-related diseases, blood assays, and cardiovascular traits. Survival analyses suggested that carriers of ASXL1 or TET2 variants were at increased risk for cancers; diseases of the circulatory, respiratory, and genitourinary systems; and all-cause and cause-specific deaths. The CFAP58 carriers were at elevated risk of deaths due to cancers. Collectively, the present whole exome sequencing study provides novel insights into the genetic landscape of LTL, identifying novel genes associated with LTL and their implications on human health and facilitating a better understanding of aging, thus pinpointing the genetic relevance of LTL with clonal hematopoiesis, biomedical traits, and health-related outcomes. [ABSTRACT FROM AUTHOR]

Heavy metals contamination of poultry products is a major concern for public health. This study aimed to determine the concentration of mercury (Hg), lead (Pb), and iron (Fe) in the edible parts of broilers, as well as in feed, drinking water, and litter as sources of contamination and to assess their possible human health risk in the province of Jijel (Northeast Algeria). The range of Hg, Pb, and Fe in edible parts were 0.004–0.007, 0.185–0.480, and 28.536–88.306 mg/kg, respectively, and the difference in content was only significant (p < 0.05) for lead. Breast and thigh samples had Pb concentrations above the maximum limit. Spearman coefficient analysis revealed that most correlations were positive between metals detected in feed, water, and litter and those in the edible parts of broilers. But most of them were insignificant (p > 0.05). The estimated daily intake (EDI) values of examined metal exceeded the tolerable daily intake (PTDI). The target hazard quotients (THQ) and hazard index (HI) of all metals were lower than 1, suggesting no significant carcinogenic risks. The calculated incremental lifetime cancer risk (ILCR) of Pb was higher than 10−4 for men, women, and children, indicating the presence of carcinogenic risk. Considering the wide consumption of broiler meat, regular national monitoring of heavy metals in the broiler production chain is recommended to protect population health. [ABSTRACT FROM AUTHOR]

6-methoxybenzoxazolinone (6-MBOA) is a secondary plant metabolite predominantly found in monocotyledonous plants, especially Gramineae. In damaged tissue, 2-β-D-glucopyranosyloxy-4-hydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA-Glc) is hydrolyzed to DIMBOA, which spontaneously decomposes into 6-MBOA. It is commonly detected in plants consumed by voles and livestock and can also be present in cereal-based products. Discovered in 1955, this compound is renowned for its ability to trigger animal reproduction. However, there is a lack of research on its functional and mechanistic properties, leaving much of their potential unexplored. This review aimed to comprehensively summarize the effects of 6-MBOA on animal reproduction and human health, as well as its defensive role against herbivores. Studies have shown that 6-MBOA effectively inhibits the digestion, development, growth, and reproduction of insects. 6-MBOA may act as a partial agonist of melatonin and exert a regulatory role in mammalian reproduction, resulting in either promoting or inhibiting effects. 6-MBOA has been theorized to possess anti-tumor, anti-AIDS, anti-anxiety, and weight-loss effects in humans. However, insufficient attention has been paid to its defense properties against mammalian herbivores, and the mechanisms underlying its effects on mammalian reproduction remain unclear. In addition, research on its impact on human health is still in its preliminary stages. The review emphasizes the need for further systematic and comprehensive research on 6-MBOA to fully understand its diverse functions. Elucidating the effects of 6-MBOA on animal reproduction, adaptation, and human health would advance our understanding of plant–herbivore coevolution and the influence of environmental factors on animal population dynamics. Furthermore, this knowledge could potentially promote its application in human health and animal husbandry. [ABSTRACT FROM AUTHOR]

Background: The Mediterranean diet (MD), globally recognized for its sustainability and health benefits, traditionally emphasizes the consumption of plant-based foods in raw or minimally processed forms. However, shifting lifestyles, even in Mediterranean regions, have led to an increasing consumption of ultra-processed foods (UPF). Epidemiological evidence suggests that UPF consumption may be detrimental to human health, but there is only one clinical trial on this topic which is largely debated in the scientific community. This study aims to investigate the impact of the inclusion of UPF within a Mediterranean-based dietary pattern on cardiometabolic markers, gut microbiota, and other markers of human and planet health. Methods: Fifty clinically healthy individuals showing overweight and presenting a low-to-moderate cardiovascular risk profile will be recruited for a 7-month randomized, open, cross-over dietary trial. Eligible participants will be randomly assigned to a 3-month high-UPF MD (intervention group) or a low-UPF MD (control group), with a 1-month wash-out period. Both intervention diets will have identical food group compositions, with the intervention group consuming 5 servings/day of selected UPF items, and the control group consuming raw/minimally processed items from the same food group. Blood, urine, and fecal samples, alongside food/lifestyle diaries, will be collected from each participant before and after the dietary interventions. The primary endpoint will be the change in plasma LDL-cholesterol levels from baseline. Additional markers include blood pressure, anthropometric parameters, chemical parameters, glucose and lipid-related metabolic markers, incretins, inflammatory and oxidative stress markers, fecal microbiota composition, and short-chain fatty acids. Finally, food waste production will be evaluated through specific validated food diaries. The study has been approved by the Ethical Committee of the University of Milan and the Tuscany Regional Ethics Committee of the Azienda Ospedaliera Universitaria (AOU) - Careggi, Florence. Discussion: Results from the PROMENADE study will improve knowledge about the impact of UPF consumption on human and planet health and will contribute to the scientific debate on this topic. Trial registration: ClinicalTrials.gov NCT06314932. Registered on March 13, 2024. [ABSTRACT FROM AUTHOR]

The use of carbon nanotubes (CNTs) in the nanotechnology sector is rapidly increasing due to their distinct characteristics and vast application potential. Large-scale preparation of these nanostructures is either prohibitive or, in some cases, environmentally unfavorable. Numerous studies have been conducted in this field to develop novel approaches for producing CNTs that are savious and cost-effective. This review briefly describes the synthesis, characterization methods, and uses of CNTs from scrap materials. The utilization of waste materials not only addresses environmental concerns but also contributes to the circular economy by repurposing otherwise discarded resources. This eco-friendly approach has several benefits for human health and the environment. [ABSTRACT FROM AUTHOR]

Background: Gallstone disease poses a global threat to human health and is strongly linked to environmental factors. However, there is currently no data on the presence of rare earth elements (REEs) in human gallstones. This paper investigates the concentration and distribution of REEs in gallstones for the first time, aiming to explore the environmental implications on human health. Methods: A total of 25 gallstone samples were collected in Shanghai and the content of REEs was measured by Inductively coupled plasma-Mass Spectrometry (ICP-MS) to explore the distribution of REEs in gallstones. Results: The concentration of REEs in gallstones ranged from 4.89 to 190.8 ng/g (mean 39.21). In most of the gallstone analyses, REEs have been detected and generally attributed to environmental exposure or food contamination. The Y/Ho ratio of gallstones was lower than that of continental rocks, similar to that in the blood, indicating limited fractionation during fluid transport processes in the gallbladder. Conclusions: The upper continental crust (UCC)-normalized REEs pattern in gallstones showed depletion of light REEs, while most showed enrichment of heavy REEs. Positive Gd anomalies were found in most samples, while few samples suggested anthropogenic influence. Whether exogenous inputs or in vivo biofractionation lead to changes in REEs fractionated patterns require further analyses. [ABSTRACT FROM AUTHOR]

Background: Rheumatoid arthritis (RA) is a debilitating inflammatory disorder characterized by an overactive immune system targeting joints, leading to inflammation and intense pain. While current RA therapies effectively alleviate symptoms, they are often associated with significant side effects. This study aimed to assess the anti-inflammatory and anti-arthritic properties of an Ethanolic Extract of Myxopyrum serratulum A.W. Hill (EEMS) using animal models. Results: The acute toxicity study with EEMS (2000 mg/kg, p.o.) on rats showed no toxicity or mortality up to the highest dose. Inflammation was induced using carrageenan, and rats were treated with varying doses of EEMS (100, 200, and 400 mg/kg, p.o.) and diclofenac to assess anti-inflammatory effects. Anti-arthritic efficacy was evaluated using Complete Freund's adjuvant (CFA)-induced inflammation, comparing EEMS to methotrexate. The results revealed dose-dependent anti-inflammatory effects of EEMS and a reversal of arthritic-induced weight loss in treated groups. Paw volume reduction was significant in both EEMS and methotrexate groups. Biochemical analyses showed elevated markers in the arthritic control group, which were normalized by EEMS and methotrexate. Notably, EEMS (400 mg/kg) significantly reduced cathepsin-D levels compared to the positive control. EEMS administration also lowered hepatic lipid peroxidation and increased endogenous antioxidants (SOD, GSH, and GPX). The 200 and 400 mg/kg doses reduced the iNOS/GADPH ratio, while the 400 mg/kg dose restored cellular and joint structure and significantly decreased IL1 levels. Conclusions: In conclusion, EEMS demonstrated substantial protective effects, mitigating health risks associated with chronic inflammation such as arthritis. These findings underscore the ethnomedical potential of Myxopyrum serratulum as a promising anti-inflammatory and anti-arthritis agent. The study suggests that EEMS could be a viable alternative or complementary therapy for RA, offering therapeutic benefits with potentially fewer side effects than current treatments. [ABSTRACT FROM AUTHOR]

Carbon dots (CDs) are novel carbon‐based luminescent materials with wide‐ranging applications in biosensing, bioimaging, drug transportation, optical devices, and beyond. Their advantageous attributes, including biocompatibility, biodegradability, antioxidant activity, photostability, small particle size (<10 nm), and strong light absorption and excitation across a broad range of wavelengths, making them promising candidates in the field of photodynamic therapy (PDT) as photosensitizers (PSs). Further enhancements in functionality are imperative to enhance the effectiveness of CDs in PDT applications, notwithstanding their inherent benefits. Recently, doping agents and solvents have been demonstrated to improve CDs' optical properties, solubility, cytotoxicity, and organelle targeting efficiency. These improvements result from modifications to the CDs' carbon skeleton matrices, functional groups on the surface state, and chemical structures. This review discusses the modification of CDs with heteroatom dopants, dye dopants, and solvents to improve their physicochemical and optical properties for PDT applications. The correlations between the surface chemistry, functional groups, the structure of the CDs, and their optical characteristics toward quantum yield, redshift feature, and reactive oxygen species (ROS) generation, have also been discussed. Finally, the progressive trends for the use of CDs in PDT applications are also addressed in this review. [ABSTRACT FROM AUTHOR]

Calcium (Ca) is a vital nutrient essential for structural development and signal transmission in both plants and animals. In humans, inadequate calcium intake has been correlated with various diseases, including osteoporosis, cardiovascular and cerebrovascular diseases, and cancer. In areas where plants serve as a main dietary source, calcium intake is significantly lower than the recommended adequate intake, notably in low‐ and middle‐income countries (LMICs). Exploring the connections between calcium consumption and cardiovascular disease (CVD) and cancer has significant implications for public health, given that these two conditions are the primary contributors to global mortality. This study conducted a systematic review of existing literature to assess the evidence regarding calcium intake and its effect on blood pressure control, stroke prevention, and the controversial association with myocardial infarction. Furthermore, the preventive effect of calcium intake on tumor development, particularly in cancer prevention, was discussed. The study explores the potential of agronomic biofortification as a key strategy to enhance plant‐based dietary calcium density and improve human health. By advocating for the incorporation of calcium‐rich plants and plant‐derived products, alongside appropriate calcium supplementation, the study emphasizes the economic and practical benefits of plants as a calcium source. This approach is aligned with global dietary patterns and socioeconomic disparities. The review also highlights the need for further research to better understand the mechanisms through which agronomic biofortification can increase dietary calcium intake and reduce the risks of CVD and cancer associated with calcium deficiency. Ultimately, this study aims to deepen our understanding of the complex relationship between calcium intake and health. [ABSTRACT FROM AUTHOR]

Understanding radon‐prone areas is vital to prevent radon‐related health problems, enhance public safety, and ensure adherence to regulations aimed at minimizing radon exposure. We conducted a comprehensive review of cross‐sectional studies reporting on residential radon exposure in Iran. Our review encompassed studies published until February 13, 2022. Out of the 966 articles initially identified, 37 studies were included in our analysis, which measured indoor radon levels in a total of 3480 residential buildings in Iran. Notably, the highest residential radon levels (Bq.m−3) were found in Mazandaran province, with the most hazardous recorded levels in Talesh Mahalleh (3235), followed by Ramsar (1299). Conversely, Tehran, the capital city of Iran, had the lowest recorded levels of residential radon, at 11.0 Bq.m−3. Remarkably, indoor radon concentration exceeded both the reference levels recommended by the World Health Organization (WHO) and the standard levels set by the U.S. Environmental Protection Agency (US.EPA), with approximately 51% and 26%, respectively. The mean effective doses received by Iranian residents were 5.0 mSv.y−1 (0.3–81.7). Moreover, the mean excess lifetime cancer risk (ELCR) associated with indoor radon exposure was determined to be two per 1000 people. The annual incidence of lung cancer cases (LCCs) per million people attributed to indoor radon exposure in Iranian residential buildings ranged from 5.00E − 06 to 1.47E − 03. The included studies addressed a wide range of variables affecting radon levels, but they did not cover all factors comprehensively. These factors encompass the meteorological parameters, geological characteristics, building construction materials, building type, window type, occupancy information, and ventilation rates in enclosed spaces. The potential health risks associated with indoor radon exposure necessitate the implementation of effective control measures. These should include raising public awareness, revising construction regulations, enhancing ventilation systems, identifying high‐risk areas, and conducting more comprehensive studies to better understand the factors that influence radon concentration. [ABSTRACT FROM AUTHOR]

AbstractIn indoor air the reaction of ozone (O3) with terpenes may lead to the formation of irritating gas-phase products which may induce acute airway effects (i.e. sudden, short-term changes or symptoms related to the respiratory system). We aimed to perform an in vitro study on possible health effects of products from the O3-initiated reaction of limonene with printer exhaust, representing real-life mixtures in offices. Human bronchial epithelial cells were exposed for 1 hour (h) to limonene and O3, combined with printer exhaust. The resulting concentrations represented 34% and 6% of the generated initial concentrations of limonene (400 µg/m³) and O3 (417 µg/cm³), respectively, which were in range of high end realistic indoor concentrations. We observed that the reaction of limonene with O3 generated an increase of ultrafine particles within 1 h, with a significant increase of secondary reaction products 4-oxopentanal and 3-isopropenyl-6-oxo-heptanal at high end indoor air levels. Simultaneous printing activity caused the additional release of micron-sized particles and a further increase in reaction products. Relevant cellular endpoints to evaluate the possible induction of acute airway effects were measured. However, none of the test atmospheres representing office air was observed to induce these effects. [ABSTRACT FROM AUTHOR]

Bioaerosols, including airborne bacteria, are significant pollutants affecting both indoor and outdoor air quality, with implications for human health. Despite extensive research on indoor air quality, there is a notable lack of comprehensive data on ambient bacterial concentrations and their interactions with pollutants and meteorological factors. This review focuses on bacterial aerosols in the atmosphere, measured using the culture-based method, considered the "gold standard" for microorganism detection and identification. Studies reveal significant variability in bacterial concentrations across different environments and seasons, influenced by factors such as temperature, humidity, wind speed, solar radiation, and precipitation, underscoring the need for further research and monitoring to enhance health risk assessments and mitigation strategies. The presence of air pollutants such as particulate matter (PM) and ozone (O3) further complicates these dynamics. The authors emphasize the need for more extensive research on outdoor bacterial aerosols and recommend that future studies prioritize detailed bioaerosol characterization to establish comprehensive exposure standards in ambient air, thereby improving public health protection and environmental management practices. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has provided an opportunity to examine the impact of reduced human activity on air quality. This study assesses the levels of particulate matter (PM10) in three cities—Bucharest, Brașov, and Iași—during the pandemic restrictions in 2020, comparing them with data from the pre-pandemic period (2017–2019) and post-lockdown period (2021–2022). The results show a significant decrease in PM10 levels during the lockdown, which is closely associated with reduced traffic and mobility. Notably, while PM10 concentrations initially spiked at the beginning of 2020, they markedly declined following the enforcement of lockdown measures, during which mobility to workplaces in these cities decreased by about 60% in Bucharest, 50% in Brașov, and 45% in Iași. Health risks related to PM10 exposure were evaluated using the hazard quotient method, following EU and WHO guidelines. Despite the reduction in pollution levels in 2020, the findings suggest long-term human health risks for residents of these cities. This research highlights the critical need for sustainable strategies to address air quality issues in urban areas and protect public health. [ABSTRACT FROM AUTHOR]

Fish farming is increasingly important globally and nationally, playing a crucial role in fish production for human consumption. Monitoring microbiological and chemical contaminants from water discharge is essential to mitigate the risk of contaminating water and fish for human consumption. This study analyzes the physicochemical and E. coli parameters of water and tambacu fish muscles (Colossoma macropomum × Piaractus mesopotamicus) in Western Maranhão, Brazil. It also includes a qualitative characterization of zooplankton in the ponds. Samples were collected from tambacu ponds in a dam system fed by natural watercourses from the Tocantins River tributaries, located at the connection of the Brazilian savanna and Amazon biomes. The physicochemical and E. coli parameters of water did not meet national standards. The zooplankton community included Rotifera, Cladocera, Copepoda, and Protozoa representatives, with no prior studies on zooplankton in the region, making these findings unprecedented. The biological quality of freshwater is crucial in fish farming, as poor quality can lead to decreased productivity and fish mortality, raising significant food safety concerns. The water quality studied is related to the potential influence of untreated wastewater as a source of contamination, leaving the studied region still far from safe water reuse practices. The findings on chemical and E. coli contamination of fish farming waters concern human health and emphasize the need for appropriate regulations. [ABSTRACT FROM AUTHOR]

As a result of some chemical element (heavy metals) pollution of dust, environmental pollution of dust has become an increasing concern, necessitating an assessment of risks to both ecology and human health, particularly in urban areas. Most of these pollutants settle on the outdoors and eventually become part of the outdoor dust. These will have negative long-term repercussions on ecosystems and human health. In this research, energy dispersive X-ray fluorescence (EDXRF) spectrometry analytical method was used to assess the pollution characteristics of the eight heavy metals (HMs): Mn, Cu, As, Hg, Ni, Cr, Zn, and Pb in the East Mediterranean Sea area. The concentration of As, Mn, Cr, Cu, Hg, Ni, Pb, and Zn analyzed in outdoor dust samples varied from 0.94 to 19.52 mg kg−1, 190.08 to 1019.7 mg kg−1, 20.46 to 45.9 mg kg−1, 19.5 to 62.56 mg kg−1, 0.01 to 0.93 mg kg−1, 10.48 to 40.64 mg kg−1, 12. 6 to 36.1 mg kg−1, and 48.96 to 112.41mg kg−1, respectively. HMs have been detected in the outdoor dust samples analyzed in the study, and, as a result, mean concentrations followed the order Mn > Zn > Cu > Cr > Ni > Pb > As > Hg, respectively. The ecological risk was observed at various contamination levels, with As and Hg pollution being the most severe. The highest hazard quotient (HQ) for adults and children was determined as a result of As and Cr, respectively. According to the US-EPA health risk threshold, the cancer risk in the study area is negligible. [ABSTRACT FROM AUTHOR]

The presence of pesticides in milk is a serious concern at the global level, which can threaten human health. Detection of pesticides in milk is a challenge due to their small concentration and large amounts of other interfering substances that can be co-extracted along with the pesticides. In this study, we have compared two variants (original and acetate) of quick, cheap, effective and safe (QuEChERS) method to evaluate the efficiency and suitability of these methods for the extraction of organochlorine and organophosphorous residues from milk using GC-MS/MS. The acetate method was found to be more efficient in terms of recovery of all the studied pesticides, except monocrotophos. It resulted in good linearity (R² > 0.9928% in matrix and >0.9940% in solvent), recovery (71.69%-99.38%) over the range 10-250 ng/ml and precision of RSD% < 20%. This method can be easily applied for the extraction of pesticide residues in milk and its products, and further quantification using GC-MS/MS in the dairy sector. [ABSTRACT FROM AUTHOR]

AbstractMosquito-borne diseases continue to pose significant threats to human populations, especially in developing and underdeveloped regions, where access to effective preventive measures remains limited. Mosquito repellents represent a cornerstone in the arsenal against these diseases, providing a barrier against mosquito bites. Mosquito repellents come in various formulations, including topical ointments and commercial vaporizers, with varying compositions. Common constituents include deodorized kerosene (DOK) as a solvent, pyrethroids, amides, essential oils for fragrance, and synergists. Despite their widespread use, the toxicological profiles of these repellents remain inadequately understood, raising questions about their safety in prolonged or excessive exposure scenarios. However, while their efficacy in preventing mosquito-borne illnesses is well-established, concerns persist regarding their potential toxicity to humans and the environment. This review critically examines the existing literature on the toxicity of mosquito repellents, focusing on their adverse effects on human health and environmental sustainability. Through an extensive analysis of available research, this review aims to shed light on the potential health risks associated with mosquito repellents, such as dermatological irritation, respiratory complications, and allergic reactions in humans. [ABSTRACT FROM AUTHOR]

In human body, free radicals cause oxidative stress which is reported to be the main reason of many life style human diseases. This stress induced by the imbalance of antioxidants and oxidants. Many deadly diseases induced by oxidative stress as it forms the root cause of several degenerative changes in the cells and tissues. Nucleic acids, lipids and proteins in our body are demaged by this stress, made changes to cellular functions and lead to apoptosis or necrosis. Antioxidants have an important role in protection human body from oxidative damages and prevention of many chronic diseases, for example, diabetes, cardiovascular disease, aging, even diseases related to the nervous system. Currently, the exploration of natural antioxidants is trends in the pharmaceutical industries because synthetic antioxidants are reported to cause major side effects. Antioxidants of natural origin are considered safe and highly effective. These substances are abundant in many medicinal herbs including algae, fungi, plants and animals. Among them, seaweed is believed to be a potential source of medicinal herbs capable of synthesizing compounds with good biological activity. Off these, macroalgae, including red, brown, and green macroalgae, are considered a natural source of antioxidant components that can provide a valuable contribution to the innovation of pharmaceutical and industrial fields. Since algal products' antioxidant properties and nutritional benefits have been increasingly recognized, their properties as antioxidants require further investigative studies. This review provides information on various aspects of antioxidants, including algal sources containing antioxidants, the chemical composition of macroalgae, and antioxidant components, as well as their benefits to human health. [ABSTRACT FROM AUTHOR]

It is imperative to say that we are immersed in a sea of microorganisms due to their ubiquitous presence on the planet, from soil to water and air. Human bodies harbor a vast array of microorganisms from both the inside and out called the human microbiome. It is composed of single-celled organisms, including archaea, fungi, viruses, and bacteria, including bacteriophages, where bacteria are the biggest players, and this is collectively referred to as the human microbiome. These organisms have a symbiotic relationship with humans and impact human physiology where they colonize various sites on and in the human body, adapting to specific features of each niche. However, dysbiosis, or the deviation from normal microbial composition, is associated with adverse health effects, disrupted ecosystems, and eco-imbalance in nature. In this review, we delve into the comprehensive oversight of bacteria, their cosmopolitan presence, and their additional applications affecting human lives. [ABSTRACT FROM AUTHOR]

In this paper, a highly sensitive fiber-optic sensor was proposed for the detection of Cu2+ traces in aqueous solution which has a nonnegligible impact on human health. Based on the principle of SPR, a uniform chitosan (CS) material was coated on a multimode fiber-single mode fiber-multimode fiber (MSM) structure with silver layer by glutaraldehyde (GLA) and graphene oxide modification. The amino and hydroxyl groups in the material have a recognition function for Cu2+, which can chelate with Cu2+ and change the ambient layer refractive index of the sensor leading to a shift in the SPR spectrum. Trace Cu2+ can be detected by monitoring the shift in the resonance wavelength of the SPR spectrum. The results illustrate that within the range of 0.1 ~ 1 mg/L Cu2+ concentration, as the Cu2+ concentration increasing, the SPR spectrum undergoes a red shift and the maximum detection sensitivity of Cu2+ ions achieves 49.466 nm/(mg/L), with a good linearity of 0.996. The temperature experimental results indicate that the sensor has good stability at room temperature (25 ~ 35 °C). The stability and repeatability characteristics of the system are also investigated. The good performance provides a new method in trace Cu2+ in-situ detection. [ABSTRACT FROM AUTHOR]

Natural carotenoids (CARs) such as β-carotene, astaxanthin, lutein, norbixin, bixin, capsanthin, lycopene, β-Apo-8-carotenal, canthaxanthin, β-apo-8-carotenal-ester, and zeaxanthin are being explored for possible applications in feed, food, cosmeceuticals, and nutraceuticals. Three primary areas of carotenoid research are emerging: (1) encapsulations for improved chemical and physical properties; (2) natural source carotenoid manufacturing; and (3) preclinical, epidemiological, and clinical studies of carotenoids' potential health benefits. The recent advancements in research on the chemistry and antioxidant activity, marketing strategies, dietary sources, bioavailability, and bioaccessibility, extraction, dietary consumption, encapsulating techniques, and health advantages of carotenoids are all extensively discussed in this review. Carotenoids are pigments found naturally in most fruits and vegetables, algae, plants, and photosynthetic bacteria. Carotenoids cannot be synthesized by humans and must be consumed in the form of food or supplements. There are several roles for carotenoids in human health. Although individual carotenoids may function in different ways, their main action is to act as antioxidants. There are validated techniques for separating and purifying carotenoids, yet, industrial production requires the development of economically viable techniques for larger-scale implementation. Carotenoids have been shown to boost cognitive performance and cardiovascular health, as well as help prevent some types of cancer. Despite evidence for carotenoids' health benefits, major population-based supplementation trials have yielded conflicting outcomes for several carotenoids. This review includes recent developments in carotenoid metabolism and nutritional and health advantages. It also offers an outlook on future directions in these areas. [ABSTRACT FROM AUTHOR]

With the widespread use of plastic products globally, plastic pollution is becoming more and more serious. Plastic particles formed by the breakdown of plastics have received significant attention in recent years. There are various sources of plastic particles. Plastic particles can enter the human body through respiratory tract inhalation, digestive tract intake, direct skin contact and other ways, and then affect multiple systems of the human body through oxidative stress, inflammatory response and other mechanisms. In addition, plastic particles can also be co-exposed with additives, heavy metals, bacteria, viruses and other toxic pollutants, which have an impact on the human body. This review summarizes the definition and sources of plastic particles, their entry into the human body, detection methods and their effects on various human systems. It serves as a theoretical basis for subsequent efforts in preventing and mitigating plastic pollution and reducing the harmful impact of plastic particles on human health. [ABSTRACT FROM AUTHOR]

Cancer is characterized by uncontrolled cell proliferation and the dysregulation of numerous biological functions, including metabolism. Because of the potential implications of targeted therapies, the metabolic alterations seen in cancer cells, such as the Warburg effect and disruptions in lipid and amino acid metabolism, have gained attention in cancer research. In this review, we delve into recent research examining the influence of natural products on altered cancer metabolism. Natural products were selected based on their ability to target cancer's altered metabolism. We identified the targets and explored the mechanisms of action of these natural products in influencing cellular energetics. Studies discussed in this review provide a solid ground for researchers to consider natural products in cancer treatment alone and in combination with conventional anticancer therapies. [ABSTRACT FROM AUTHOR]

Calcium is a fundamental and integrative element and helps to ensure optimal health by regulating various physiological and pathological processes. While there is substantiated evidence confirming the beneficial effects of calcium in the treatment, management, and prevention of various health conditions, including cancer, conflicting studies are imperative to acknowledge the potential negative role of calcium supplementation. The studies on calcium supplementation showed that a specific dose can help in the maintenance of good human health, and in the control of different types of diseases, including cancer. Calcium alone and when combined with vitamin D, emerges as a promising therapeutic option for efficiently managing cancer growth, when used with chemotherapy. Combination therapy is considered a more effective approach for treating advanced types of colorectal cancer. Nevertheless, several challenges drastically influence the treatment of cancer, such as individual discrepancy, drug resistance, and stage of cancer, among others. Henceforth, novel preventive, reliable therapeutic modalities are essential to control and reduce the incidence and mortality of colorectal cancer (CRC). The calcium-sensing receptor (CaSR) plays a pivotal role in calcium homeostasis, metabolism, and regulation of oncogenesis. Numerous studies have underscored the potential of CaSR, a G protein-coupled receptor, as a potential biomarker and target for colorectal cancer prevention and treatment. The multifaceted involvement of CaSR in anti-inflammatory and anti-carcinogenic processes paves the way for its utilization in the diagnosis and management of colorectal cancer. The current review highlights the important role of supplemental calcium in overall health and disease, along with the exploration of intricate mechanisms of CaSR pathways in the management and prevention of colorectal cancer. [ABSTRACT FROM AUTHOR]

Currently, information on the toxicity profile of the majority of the identified e‐waste chemicals, while extensive and growing, is admittedly fragmentary, particularly at the cellular and molecular levels. Furthermore, the toxicity of the chemical mixtures likely to be encountered by humans during and after informal e‐waste recycling, as well as their underlying mechanisms of action, is largely unknown. This review paper summarizes state‐of‐the‐art knowledge of the potential underlying toxicity mechanisms associated with e‐waste exposures, with a focus on toxic responses connected to specific organs, organ systems, and overall effects on the organism. To overcome the complexities associated with assessing the possible adverse outcomes from exposure to chemicals, a growing number of new approach methodologies have emerged in recent years, with the long‐term objective of providing a human‐based and animal‐free system that is scientifically superior to animal testing, more effective, and acceptable. This encompasses a variety of techniques, typically regarded as alternative approaches for determining chemical‐induced toxicities and holds greater promise for a better understanding of key events in the metabolic pathways that mediate known adverse health outcomes in e‐waste exposure scenarios. This is crucial to establishing accurate scientific knowledge on mixed e‐waste chemical exposures in shorter time frames and with greater efficacy, as well as supporting the need for safe management of hazardous chemicals. The present review paper discusses important gaps in knowledge and shows promising directions for mechanistically anchored effect‐based monitoring strategies that will contribute to the advancement of the methods currently used in characterizing and monitoring e‐waste‐impacted ecosystems. [ABSTRACT FROM AUTHOR]

The food security of Lima—Peru's capital city, which shelters over 30% of the total country's population—depends on the food production of its nearest agricultural areas, the Chancay-Huaral and Chillón valleys, wherein agrochemicals are widely used. This study primarily aimed to determine the characteristics of pesticide use in these two valleys, located 83 and 30 km north of Lima City, respectively. A second aim was to assess whether proximity to Lima provides access to technical assistance regarding agricultural activities. A questionnaire-based survey assessing socioeconomic aspects, occupational exposure, and agrochemical-related knowledge was conducted on a sample of 102 participants (farmers and fieldworkers). The results revealed that the average age for starting to handle pesticides was 15 years, while life-long occupational-exposure averaged 30 years. Most pesticides used were organophosphates and carbamates. Personal protective equipment was not used and, therefore, dermal exposure and inhalation were major routes of intoxication. Despite their proximity to Lima, both valleys lack an official agronomic advisory agency, and this void has been occupied by agrochemical manufacturing companies and trading houses focused on increasing their sales. Based on the results, it is urgent to implement an official technical advisory service and a capacity-building program on pesticide use in Peru, as well as the implementation of measures for improved control, trade, and storage of pesticides. Simultaneously, a permanent epidemiological surveillance at the country level is needed to improve public health and to contribute to achieving the Sustainable Development Goals of the United Nations' 2030 Agenda in Peru. [ABSTRACT FROM AUTHOR]

Plastics are a major source of marine pollution. One form of plastic pollution is microfibers, which are synthetic fibers five micrometers or smaller that are shed by artificial clothing. The size of microfibers enables them to easily be ingested by a number of marine organisms, including oysters. Oysters are filter feeders and a major aquaculture asset, which presents a concern for the effects of microfiber ingestion on human health. Very few studies have been conducted quantifying microfibers using Pacific oysters (Crassostrea gigas) sourced from California. This study quantifies microfiber content in the Pacific oyster farmed for human consumption in Morro Bay, California. Microfibers were quantified after being isolated from oyster samples. An average of 9.12 microfibers were recovered per oyster sample. Although some of the smaller oysters contained more microfibers compared to larger oysters, this difference was not significant. There also was no significant difference between the quantities of black and blue microfibers. However, there was a significant increase in quantities of black microfibers compared to green or red microfibers. The results of this study indicate that a large amount of microfibers are present in commercial oysters, but more research needs to be conducted to determine how this will impact human health. [ABSTRACT FROM AUTHOR]