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Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the chemical transformation which typically eliminates the requirements for any conventional work-up or purification of the reaction stream.

Abstract: A novel heterogeneous silica supported palladium ethylthioglycolate catalyst which is active and recyclable for Suzuki and Heck reactions is reported. [Copyright &y& Elsevier]

Abstract: A range of sulfides can be selectively oxidised to the corresponding sulfoxides in good yields using catalytic quantities of immobilised cerium alkyl phosphonate and either sodium bromate or tert-butyl hydroperoxide as oxidants. [Copyright &y& Elsevier]

A range of allylic alcohols can be selectively oxidised to either the corresponding epoxide or the enone in good yields using catalytic quantities of vanadyl or cobalt(II) alkyl phosphonate modified silicas, CoEPS3 and VOEPS3 and tert-butyl hydroperoxide. [Copyright &y& Elsevier]

The allylic and benzylic oxidation of a range of substrates proceeds in good yield using catalytic quantities of cobalt(II) alkyl phosphonate modified silica and tert-butyl hydroperoxide. [Copyright &y& Elsevier]

Abstract: A range of sulfides can be selectively oxidised to the corresponding sulfoxides in good yields using catalytic quantities of immobilised vanadyl, cobalt or nickel alkyl phosphonates and the reoxidant sodium bromate or vanadyl alkyl phosphonate with tert-butyl hydroperoxide or aqueous hydrogen peroxide as oxidants. [Copyright &y& Elsevier]

The oxidation of a range of alcohols to ketones or carboxylic acids proceeds in good yield using catalytic quantities of cerium(IV) phosphonate modified silica and sodium bromate as the re-oxidant. [Copyright &y& Elsevier]

Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the chemical transformation which typically eliminates the requirements for any conventional work-up or purification of the reaction stream.