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This article is a commentary to the 2021 article “Generating theory by abduction” by Sætre and Van de Ven about abductive thinking in management theory. Here the authors elaborate on the third stage, idea generation, of Sætre and Van de Ven’s abductive thinking method by expanding upon hunches, serendipitous insights, and disciplined imagination.

Large volumes of liquid water transiently existed on the surface of Mars more than 3 billion years ago. Much of this water is hypothesized to have been sequestered in the subsurface or lost to space. We use rock physics models and Bayesian inversion to identify combinations of lithology, liquid water saturation, porosity, and pore shape consistent with the constrained mid-crust (∼11.5 to 20 km depths) seismic velocities and gravity near the InSight lander. A mid-crust composed of fractured igneous rocks saturated with liquid water best explains the existing data. Our results have implications for understanding Mars' water cycle, determining the fates of past surface water, searching for past or extant life, and assessing in situ resource utilization for future missions.

We report the case of DT, a man in his fifties who suffered a large right fronto-parietal hemorrhage, resulting in a dense left weakness and a persistent anosognosia for the resultant hemiplegia. DT engaged in several video-feedback sessions. Video feedback therapy has been successful in previously reported cases of anosognosia, resulting in immediate and lasting resolution. In the current case, similarly dramatic effects were observed, but with a subsequent recurrence of the anosognosic ideation. The present case sheds light on the interplay of neurologic and psychological mechanisms involved in anosognosia and on some of the pragmatic emotional considerations of engaging in this form of rehabilitative therapy. [ABSTRACT FROM AUTHOR]

Bipolar disorder is thought to determine the insights and coping attitudes that affect a patient's compliance with treatment, which can positively affect the prognosis of the disease. This study aimed to investigate the relationship between insight and coping attitudes in bipolar disorder patients. This descriptive study was carried out with 127 volunteer patients who were diagnosed with bipolar disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and who were in a euthymic state. The Personal Information Form, Beck Cognitive Insight Scale (BCIS) and Scale of Coping Attitudes (COPE) were used as data collection tools. We found positive correlations between the total COPE score, the total BCIS score and the self-reflectivity subscale score of the BCIS. A positive and significant correlation was also determined between the BCIS subscales and total scores and coping attitudes toward adaptation with the COPE subscales (p < 0.05). A positive and significant relationship was found between the insight scores and total coping scores of the patients and their coping attitudes toward adaptation. We found that when patients' levels of insight increased, their coping attitudes toward adaptation were used more frequently. This study revealed that individuals with high self-reflectivity can cope more effectively with the situations they face. [ABSTRACT FROM AUTHOR]

Reward cues have long been considered to enhance creative performance; however, little is known about whether rewards can affect creative problem solving by manipulating states of flexibility and persistence. This study sought to elucidate the differential impacts of real versus hypothetical rewards on the creative process utilizing the Chinese compound remote association task. Behavioral analysis revealed a significantly enhanced solution rate and response times in scenarios involving real rewards, in contrast to those observed with hypothetical rewards. Electrophysiological findings indicated that hypothetical rewards led to more positive P200-600 amplitudes, in stark contrast to the amplitudes observed in the context of real rewards. These findings indicate a positive impact of real rewards on creative remote associations and contribute new insights into the relationship between rewards and creative problem solving, highlighting the crucial role of persistence/flexibility in the formation of creativity. [ABSTRACT FROM AUTHOR]

Objectives. Earlier work found gaps with respect to legislative compliance and disparities in perceptions, attitudes and beliefs towards occupational health and safety in the Ontario manufacturing sector. The current follow-up study was undertaken to gain a more thorough understanding of the cause of these gaps and differences in perspectives. Methods. Focus group discussions were held with workers and managers separately. Key questions related to health and safety in general, health and safety training, and health and safety communication were asked of each focus group. The discussions were qualitatively analysed. Results. Overall, 12 worker focus groups (n = 76) and seven manager focus groups (n = 38) were conducted. Individuals who felt safe in their workplace indicated that it was a supportive environment, and that health and safety was a priority. Health and safety training was considered important but improvements in engagement and frequency were suggested. Conclusions. Health and safety communication might be hindered by technical terms and language barriers. Delivering this communication in multiple ways as well as the tone of communication should be taken into consideration. Overall, safety culture was lacking and manufacturing workplaces should be mindful of the gaps identified to improve health and safety performance. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine the explanatory power of a predictive model of psychological well-being, consisting of mindfulness, private self-consciousness with its two dimensions, self-reflection and insight, emotional regulation, psychological inflexibility and external shame. Also, it was the author's intention to explore the mediating effect of insight on the relationship between emotional regulation and psychological well-being. The current research involved a nonexperimental, cross-sectional design exploring the presence of psychological well-being at clinical personality patterns. The quantitative methodology was used to collect and analyse the data obtained from all the respondents. Researchers adapted and pretested the questionnaire set (PWB, MAAS, AAQ-II, OAS-II, ERQ, SRIS) to the Romanian context before distributing it to 268 participants. SPSS (V. 20) and Hayes's PROCESS tool were used to investigate the data. The research findings illustrated that the effectiveness of predictors varies depending on clinical personality patterns. Among participants without clinical personality pattern scores, psychological inflexibility, emotional regulation, and self-reflection emerged as significant psychological factors predicting psychological well-being. For those identified with a histrionic clinical personality pattern, emotional regulation and psychological inflexibility constituted the most robust explanatory model for psychological well-being. Similarly, for individuals exhibiting depressive clinical personality patterns, only emotional regulation and psychological inflexibility played pivotal roles in predicting psychological well-being. Furthermore, the study highlighted a significant indirect effect of emotional regulation on psychological well-being through insight. Elevated emotional regulation levels indirectly contribute to higher psychological well-being by enhancing insight, thus promoting overall psychological well-being. [ABSTRACT FROM AUTHOR]

The discussion about the thought and views of Ayn-al-Qużāt Hamadānī, the famous mystic of the 6th century, has always been attractive due to his special mystical-philosophical system of thought, as well as his openness and exemplary carelessness in expressing his inner thoughts. Along with the rational view of a religious philosopher, he has presented a different view from the point of view of a mystic. One of the important things in the intellectual system of Ayn-al-Qużāt Hamadānī is his definition and analysis of the category of" wisdom". He has specified a way for wisdom, and where the wisdom cannot reach, he calls it beyond wisdom, and to achieve this, the eyes of human insight must be opened. Moreover, the judge calls wisdom a "special measure" and believes it does not have the ability to reach the realm of the kingdom. Therefore, beyond wisdom, it is pure knowledge and insight that can guide the seeker to the truth of existence. By researching and pondering the works of Ayn-al-Qużāt Hamadānī, this article analyzes his philosophical-mystical points of views on the status and dignity of wisdom and also introduces the definition and characteristics of wisdom from his mystical point of view. [ABSTRACT FROM AUTHOR]

Genetic investigations do not form part of the routine assessment of patients with psychosis in secure settings. The case of a man admitted to a low secure unit after initial civil detention is presented. He was arrested after violence at home and there followed persistent violence in adult general wards. Many risk factors for violence were present and would usually be considered sufficient explanations for the totality of his presentation and risk. The novel aspect was the results of genetic testing. This revealed associations with his physical appearance, development and neurodevelopment, early onset violence and aggression, psychosis, and possibly the excellent response to clozapine. Array Comparative Genomic Hybridisation (aCGH) revealed a 15q13.2-13.3 microduplication, with the genetic report suggesting that many of the clinical aspects were, at least in part, attributable to this finding. This provided a complimentary narrative explanation for a presentation which had been difficult to treat and understand by both the patient and treating team. This is the only case report to describe this specific diagnosis from the patient's perspective and the helpful impact of the genetic diagnosis, particularly for the patient himself. A brief overview of genetic findings relevant to forensic practice is described. [ABSTRACT FROM AUTHOR]

The AHA experience, a moment of deep understanding during insightful problem-solving involving feelings of certainty, pleasure, and surprise, has captivated psychologists for more than a century. Recently, a new theoretical framework has proposed a link between the AHA experience and prediction error (PE), a popular concept in decision-making and reinforcement learning. This framework suggests that participants maintain a meta-cognitive prediction about the time it takes to solve a problem and the AHA experience arises when the problem is solved earlier than expected, resulting in a meta-cognitive PE. In our preregistered online study, we delved deeper into this idea, investigating whether prediction errors also pertain to participants' predictions regarding the solvability of the problem itself, and which dimension of the AHA experience aligns with the meta-cognitive PE. Utilizing verbal insight problems, we found a positive association between the AHA experience and the meta-cognitive PE, specifically in regards to problem solvability. Specifically, the element of surprise, a critical AHA dimension, emerged as a key indicator of the meta-cognitive PE, while other dimensions—such as pleasure, certainty, and suddenness—showed no signs for similar relationships, with suddenness exhibiting a negative correlation with meta-cognitive PE. This new finding provides further evidence that aspects of the AHA experience, surprise in particular, correspond to a meta-cognitive PE. The finding also underscores the multifaceted nature of this phenomenon, linking insights with learning theories and enhancing our understanding of this intriguing phenomenon. [ABSTRACT FROM AUTHOR]

Eugen Bleuler introduced the concept of double bookkeeping in schizophrenia to describe the tendency for people who experience delusions to simultaneously be convinced of the delusional content and yet to act as if the delusion(s) was untrue/irrelevant or be unbothered by discrepancies. We open the question of whether there exists a double reality in individuals with addiction and whether double bookkeeping can be applied to addiction. While double bookkeeping has primarily been explored in schizophrenia, this concept may hold promise in elucidating insight deficits in individuals with substance use disorders. We propose two forms of addiction double bookkeeping: 1) Partial compartmentalization: individuals demonstrate some awareness of the deleterious consequences of drug use, but continue to engage in addictive behaviors; and 2) Total compartmentalization: individuals who act as if the negative consequences of addiction do not exist, reflecting a more generalized and deeper lack of awareness into their own actions. We propose that a basic alteration in the individual's sense of self occurs in addiction double bookkeeping as it does in schizophrenic double bookkeeping. We describe the proposed double reality in addiction from first-person and third-person perspectives, accounting for their differences. Three clinical exemplar cases are presented, and conceptual implications are explored. [ABSTRACT FROM AUTHOR]

Background: Impaired self-awareness (ISA) is common in individuals with an acquired brain injury (ABI) and can lead to reduced awareness of one's difficulties. Previous reviews have found that ISA impacts on functional outcomes in rehabilitation. However, to date there has not been a systematic literature review which examines how ISA impacts on the process of rehabilitation in ABI populations. Method: A literature search was conducted using several databases in May 2024, including Academic Search Premier, CINAHL, MEDLINE, APA PsycARTICLES and APA PsycINFO. Seventeen articles were selected for the review and were analyzed using Narrative Synthesis. Results: Four themes arose from the findings, including goal setting, treatment adherence, engagement and willingness to change and time spent in hospital. ISA was found to impact on the value adult ABI participants placed in rehabilitation, which decreased treatment compliance, motivation, and engagement. ISA also impacted on goal setting and behavior and resulted in a longer length of time spent in hospital. Conclusion: This review emphasizes the impact of ISA on various aspects/processes of rehabilitation in ABI and provides considerations of how clinicians might adapt interventions to manage these difficulties. [ABSTRACT FROM AUTHOR]

In this study, we examined the mediating role of self-compassion in the relationship between insight and altruism and flourishing among mental health professional candidates. We adopted a cross-sectional atemporal design to examine how mental health professional candidates' insight and altruism affect their flourishing via self-compassion. The model was tested using structural equation modeling (SEM). Four hundred one participants (Male = 76, Female = 324; Mage = 20.5, SD = 1.8) took part in the study via a web-based survey and completed the Psychological Well-Being Scale, Altruism Scale, Self-compassion Scale, and Insight Scale. The study results showed that insight, altruism, and self-compassion were meaningful psychological dynamics supporting flourishing. The results revealed that self-compassion played a mediating role in the effect of insight on flourishing. On the other hand, the results showed that self-compassion did not mediate the effect of altruism on flourishing. [ABSTRACT FROM AUTHOR]

The present study was conducted to investigate the relationship between emotional intelligence and organizational climate of secondary school teachers. A sample of 1403 teachers (939 male and 464 female), (1089 govt. and 314), (297 Urban and1106 Rural) were chosen from secondary schools of Doda, Kishtwar and Ramban district of union territory of Jammu and Kashmir. Organizational climate scale for teachers developed by Venita Singh and emotional intelligence scale developed by Nahid and Jamal Sajjid. The data were analysed using descriptive analyses (mean, standard deviation, t-test, and coefficient of correlation 'r'). Result of the study exhibit that there is significant interaction between emotional intelligence and organizational climate of secondary school teachers. Thus, the null hypothesis, "that there is no significant correlation between organizational climate and emotional intelligence" is rejected. Further, the effect size (commonness) between organizational climate and emotional intelligence is 19%. It means two variables share 19% variance between them. The implication of this paper is to provide an insight and efficient information related to organizational climate and emotional intelligence which is prerequisite in improving teacher's performance in schools. This study has suggested a feasible research strategy that would be helpful to gain a good organizational climate as well as maximize the emotional intelligence of teachers. [ABSTRACT FROM AUTHOR]

Impact cratering is one of the fundamental processes throughout the history of the Solar System. The formation of new impact craters on planetary bodies has been observed with repeat images from orbiting satellites. However, the time gap between images is often large enough to preclude detailed analysis of smaller‐scale features such as secondary impact craters, which are often removed or buried over a short time period. Here we use a seismic event detected on Mars by the NASA InSight mission to investigate secondary cratering at a new impact crater. We strengthen the case that the seismic event that occurred on Sol 1034 (S1034a) is the result of a new impact cratering event. Using the exact timing of this event from InSight, we investigated the resulting new impact crater in orbital image data. The S1034a impact crater is approximately 9 m in diameter but is responsible for over 900 secondary impact events in the form of low albedo spots that are located at distances of up to almost 7 km from the primary crater. We suggest that the low albedo spots formed from relatively low energy ejecta, with individual ejecta block velocities less than 200 m s−1. We estimate that the low albedo spots, the main evidence of secondary impact processes at this new impact event, fade within 200–300 days after formation. Plain Language Summary: On 23 October 2021, the seismometer instrument on the NASA InSight lander detected a seismic event on Mars. The nature of the seismic signal shared characteristics with other events attributed to meteorites impacting the surface of Mars. Reanalysis of images taken by cameras on orbiting spacecraft identified a new impact crater whose location and time of formation matched with the seismic analysis. Our study shows that this 9 m diameter crater has produced over 900 additional, or secondary, impact features up to 7 km away. These secondary features are characterized as being dark spots, often with a tail that points away from the direction of impact, which fade over time. The relatively high number of secondary features from this small impact event is likely due to the low porosity of the rock that was impacted at the surface. We estimate that the dark spots disappear in 200–300 days, thus removing a key set of features used in identifying new impact events on Mars. This timescale places useful limits for future image searches attempting to identify small new impact craters on Mars, and suggests that other such small impact events have been captured in existing data sets and not yet recognized. Key Points: A new 9‐m‐diameter impact crater on Mars identified with in situ seismic and orbital image dataOver 900 low albedo spots identified as a result of secondary ejecta processesSmall impact events have likely been captured in existing data sets and not yet recognized [ABSTRACT FROM AUTHOR]

The belief that people suffering from psychiatric disorders are more violent, in particular psychotic patients that do not have insight into their illness, is very common in the general population. Therefore, this review aimed to present a more accurate depiction of the link between lack of insight and violent behavior, by evaluating the existing scientific literature on the topic. For this purpose, a literature search on PubMed, Embase, and Google Scholar was conducted, selecting the relevant papers published during a 20-year period (2004–2024). The paper defined insight as a multi-dimensional concept and discussed its classification, explanatory models, and clinical implications, followed by a presentation of several insight-measuring scales. The meaning of violent behavior, its prevalence, underlying mechanisms, and different measuring scales were discussed, followed by the confounding factors that influence the relationship between insight and violent behavior, treatment options for violence in forensic psychiatry settings, and methods to improve medication adherence. Contrasting results were observed regarding the impact of each factor on leading to violent acts, which suggested that the relationship between insight and violence is more complex than previously thought. In conclusion, increased attention must be paid to the investigated dimensions of both the concepts and the confounding factors, with further research required on this topic.

Amaç: Bu araştırmada, şizofrenili bireylerde Bireyselleştirilmiş İçgörü Eğitimi’nin (BİE), bireylerin içgörü düzeyi, aktivite performansı ve aktivitelerden duydukları memnuniyet düzeyine etkisinin incelenmesi amaçlandı.Yöntemler: Çalışma, psikiyatri hekimi tarafından şizofreni tanısı almış 6 birey ile gerçekleştirildi. Tüm bireylere Bireyselleştirilmiş İçgörü Eğitimi (BİE) haftada 1 kez toplamda 16 seans boyunca uygulandı. Bireylere (3’ü kadın 3’ü erkek) eğitim öncesi ve sonrasında Sosyodemografik Bilgi Formu, Kanada Aktivite Performans Ölçeği (KAPÖ) ve İçgörünün Üç Bileşenini Değerlendirme Ölçeği (İÜBDÖ) uygulandı. Veriler gruplar arası değerlendirme yöntemlerinden Wilcoxon testi ile analiz edildi.Bulgular: BİE sonucunda şizofrenili bireylerin içgörü düzeyinde (p=,027), aktivitelerdeki performans düzeyinde (p=,026; p=,027; p=,039) ve aktivitelerden duyulan memnuniyet düzeyinde (p=,026; p=,027; p=,042) istatistiksel olarak anlamlı bir değişikliğin olduğu görüldü. Ayrıca, BİE ile içgörü düzeyleri, aktivite performansları ve aktivitelerden duydukları memnuniyet düzeyleri önemli derecede iyileşti.Sonuç: Bu araştırma, şizofrenili bireylerde içgörü gelişiminin, bireylerin günlük yaşam aktivitelerindeki performans ve bu performanstan duyulan memnuniyet seviyesinde artış oluşturabileceğine dair ön kanıtlar sunmaktadır. Ayrıca BİE’nin, klinik uygulamalarda profesyoneller için, uygulanabilir yöntemlerden biri olabileceğini düşünmekteyiz.

People with schizophrenia-spectrum and bipolar disorders have difficulty accurately estimating their abilities and skills (impaired introspective accuracy [IA]) and tend to over- or underestimate their performance. This discrepancy between self-reported and objective task performance has been identified as a significant predictor of functional impairment. Yet, the factors driving this discrepancy are currently unclear. To date, the relationships between sleep quality and IA have not been examined. The current study aimed to explore the relationships between sleep quality and IA in participants diagnosed with schizophrenia (SCZ; n = 36), schizoaffective disorder (SCZ-A; n = 55), and bipolar disorder with psychotic features (BP; n = 87). Participants completed tasks of emotion recognition, estimated their performance on the tasks (used to calculate IA), and provided confidence ratings for their accuracy judgments. Participants also self-reported their sleep quality. These results suggest significantly greater discrepancies between self-reported and actual task scores for those with SCZ and SCZ-A compared to participants with BP. For those with SCZ, lower confidence on the tasks and underestimation of abilities were associated with lower sleep quality, while for those with SCZ-A, lower sleep quality was associated with higher confidence and overestimation of performance. Results suggest differential relationships between diagnostic groups. Future research is needed to further explore the factors driving these differing relationships, particularly the contrasting relationships between SCZ and SCZ-A.

People with dementia vary in awareness of difficulties. Evaluating awareness could facilitate personalized care. However, current research measures are unsuitable for practical clinical application. We aimed to develop a brief multidimensional awareness interview for clinical use. Informed by available evidence about awareness of dementia, items suitable for both in-person and remote administration were modified from validated measures or developed for clinical application. The interview was administered via telephone or videoconference to 31 community-dwelling people with mild-to-moderate dementia. An informant completed a corresponding questionnaire. A multidimensional profile of awareness was created using self-report of symptoms, and discrepancies between self-rating and either informant rating or objective memory task performance. Feedback from participants and informants and discussions with clinical advisory and patient and public involvement groups helped finalize the interview. Remote administration was straightforward taking on average under 11 min. Awareness profiles showed a spectrum of awareness across domains. Feedback indicated that the items were acceptable and understandable. Certain aspects could be mildly upsetting where current difficulties were highlighted. Subject to further validation, the Healthcare Awareness Profile Interview (HAPI) shows potential as an evidence-based brief clinical tool for assessing awareness in people with mild-to-moderate dementia. [ABSTRACT FROM AUTHOR]

Abstract Background Recovery from severe mental illness, including psychosis has been described as a personal and unique process, but it rarely is a journey undertaken without profound influences of significant others (family, mental health professionals). Diverging perspectives between persons with severe mental illness, family and professionals are frequent during the recovery process, notably in psychotic disorders. We aimed to explore processes of collaboration during recovery, to inform recovery supporting practices. Methods Current qualitative study had a participatory design and was set within long-term mental healthcare for severe mental illness. We conducted semi-structured interviews and focus groups with persons with severe mental illness (most had a history of psychosis), family and professionals on their mutual contact during recovery. Using reflexive thematic analysis, we developed themes representing processes of collaboration during recovery. Results We described roles persons with severe mental illness, family and professionals attribute to each other in mutually influential terms of unconditional and meaningful contact (which takes time to establish) and problem-oriented aspects. Secondly, experienced differences over problem definition, “needing help” and consequently over the role parties attribute to one another, may result in negative interactions, in the area of having expectations; (not) informing; (not) having agency to change; experiencing (dis)agreement or struggle. Conclusions unconditional, meaningful contact and knowing each other’s perspective are important to fruitful interaction in a triad when perspectives on mental health problems diverge. Relationally centered and process oriented care with continuity of family and professionals involved are needed to advance recovery in severe mental illness, especially psychosis.

Pathogenic constitutional APC variants underlie familial adenomatous polyposis, the most common hereditary gastrointestinal polyposis syndrome. To improve variant classification and resolve the interpretative challenges of variants of uncertain significance (VUSs), APC-specific variant classification criteria were developed by the ClinGen-InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP) based on the criteria of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP). A streamlined algorithm using the APC -specific criteria was developed and applied to assess all APC variants in ClinVar and the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) international reference APC Leiden Open Variation Database (LOVD) variant database, which included a total of 10,228 unique APC variants. Among the ClinVar and LOVD variants with an initial classification of (likely) benign or (likely) pathogenic, 94% and 96% remained in their original categories, respectively. In contrast, 41% ClinVar and 61% LOVD VUSs were reclassified into clinically meaningful classes, the vast majority as (likely) benign. The total number of VUSs was reduced by 37%. In 24 out of 37 (65%) promising APC variants that remained VUS despite evidence for pathogenicity, a data-mining-driven work-up allowed their reclassification as (likely) pathogenic. These results demonstrated that the application of APC -specific criteria substantially reduced the number of VUSs in ClinVar and LOVD. The study also demonstrated the feasibility of a systematic approach to variant classification in large datasets, which might serve as a generalizable model for other gene- or disease-specific variant interpretation initiatives. It also allowed for the prioritization of VUSs that will benefit from in-depth evidence collection. This subset of APC variants was approved by the VCEP and made publicly available through ClinVar and LOVD for widespread clinical use. [Display omitted] Application of the gene-specific ACMG/AMP variant classification criteria to >10,000 publicly available germline APC variants through a streamlined algorithm reduced the fraction of VUSs by 37%, demonstrating the feasibility of a systematic classification approach in large datasets. This study might serve as a model for other variant interpretation initiatives. [ABSTRACT FROM AUTHOR]

Background: Schizophrenia, a severe mental disorder, is often complicated by Type 2 Diabetes Mellitus (T2DM), which can further impact patients' psychological health. This study investigated the differences in eating attitudes, depression, and insight between schizophrenic patients with and without comorbid T2DM and explored the correlations among these factors to provide empirical support for clinical interventions. Methods: This case-control study was conducted in Guangdong Province, China. From December 2022 to May 2023, a total of 300 hospitalized patients with schizophrenia (92 with comorbid T2DM and 208 without T2DM) were recruited. Data were collected using the Personal Information Form, Eating Attitudes Test (EAT-26), Hamilton Depression Scale (HAMD), and Insight and Treatment Attitudes Questionnaire (ITAQ). Statistical analyses, including t-tests, ANOVA, and multiple linear regression, were performed to examine differences and predictive factors of eating attitudes among patients. This study was approved by the Ethics Committee of the Affiliated Brain Hospital of Guangzhou Medical University (approval number: 2020028), and written informed consent was obtained from all participants. Results: Patients with schizophrenia and comorbid T2DM exhibited significantly higher risks of eating disorders (EAT-26: 12.54 ± 9.77 vs. 9.07 ± 7.90, P =0.003), more severe depression (HAMD: 14.71 ± 7.36 vs. 11.80 ± 6.04, P =0.001), and poorer insight (ITAQ: 10.46 ± 6.01 vs. 12.16 ± 6.09, P =0.025) compared to those without T2DM. Regression analysis revealed that gender, weekly exercise frequency, depression, and insight were significant predictors of eating attitudes among patients with T2DM. For patients without T2DM, weekly exercise frequency, smoking status, and insight were significant predictors. Conclusion: Schizophrenic patients with comorbid T2DM are facing increasing risks related to eating attitudes, depression, and insight which highlight the need for targeted interventions. Regular psychological assessment and tailored support strategies might improve their mental health and quality of life. Future research should focus on longitudinal studies to clarify causal relationships and develop more effective interventions. [ABSTRACT FROM AUTHOR]

Introduction: Postoperative depression is a condition of depressive effects in patients without symptoms of depressive mood that occurs a few weeks after surgery and persists for at least 2 weeks. It generally possesses the same symptoms as major depressive disorder. Review: Their difference is that surgery is the trigger of depression in postoperative depression cases. Postoperative depression is associated with increased patients’ morbidity and mortality, increased the risk of disease complications, reduced postoperative healing process, prolonged the duration of treatment, and reduced patients’ quality of life. Therefore, mental health conditions should always be assessed on patients after undergoing surgery. Postoperative depression therapy needs to consider the benefits of antidepressants and adequate pain management. Antidepressant considerations also need to consider interactions with other drugs. Psychotherapy and cognitive behavioral therapy are also useful in postoperative depression management. Conclusion: This review is aimed to give insight about postoperative depression, its importance, and how to treat it. [ABSTRACT FROM AUTHOR]

One of Gottlob Frege's most original contributions to logic and philosophy was his logical notation, his 'Begriffsschrift'. While long criticized, dismissed, or simply ignored, the recent secondary literature contains some helpful re-evaluations and partial defenses of it. These rely largely on technical, pragmatic, or cognitive-psychological considerations. In this paper, we reconsider Frege's own reasons for valuing his notation highly. We argue that there is a further semiotic dimension, one that matters epistemologically. This dimension becomes evident once one takes seriously, partly also literally, some striking visual metaphors Frege uses. The result is an interpretation highlighting a side of Frege's position that is not widely known. It involves his views about the indispensable role that language, or sign systems more generally, play for human thought, and especially, for logic and mathematics. More particularly and as we read Frege, a good logical notation allows for expressing conceptual/inferential relations in a 'visually inscribed', thus 'perspicuous' way, and this leads to a special kind of 'insight' in mathematics. Or as we elaborate this point further, it involves a kind of articulation and understanding hardly possible without it. Frege designed his Begriffsschrift with that specific goal in mind. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the demand for digital skills in the workplaces of agricultural graduates to shed light on the specific requirements of digital skills in their jobs. The study employed a qualitative approach and conducted a total of eight semi-structured interviews with graduates from two departments of an agricultural university in Vietnam. The obtained data, processed through thematic coding techniques, successfully revealed insights into digital skills' demand in the jobs of selected participants. Firstly, digital skills were found to be compulsory requirements for jobs for agricultural graduates, although the specific requirements for digital skills varied from job to job. Secondly, the findings revealed that different jobs require different types and levels of digital skills. Thirdly, the performance of digital skills depends on the availability and management of workplaces' digital technology. The study also found that graduates may have the opportunity to obtain jobs that are not directly related to their learning programmes but require digital skills associated with their speciality. The study recommends applying the findings to multiple stakeholders, including government policymakers, higher education policymakers, employers, and higher education students, to bridge the gap between the higher education supply and the market demand for digital skills. [ABSTRACT FROM AUTHOR]

Somatic KIT activating mutations drive most gastrointestinal stromal tumors (GISTs). Disease progression eventually develops with first-line imatinib, commonly due to KIT secondary mutations, and different kinase inhibitors have various levels of treatment efficacy dependent on specific acquired resistance mutations. Ripretinib is a broad-spectrum switch-control KIT/PDGFRA tyrosine kinase inhibitor for patients with advanced GIST who received prior treatment with three or more kinase inhibitors, including imatinib. Exploratory baseline circulating tumor DNA analysis from the second-line INTRIGUE trial determined that patients with advanced GIST previously treated with imatinib harboring primary KIT exon 11 mutations and secondary resistance mutations restricted to KIT exons 17/18 had greater clinical benefit with ripretinib versus sunitinib. We describe the rationale and design of INSIGHT (NCT05734105), an ongoing Phase III open-label study of ripretinib versus sunitinib in patients with advanced GIST previously treated with imatinib exclusively harboring KIT exon 11 + 17/18 mutations detected by circulating tumor DNA. Clinical Trial Registration:NCT05734105 (ClinicalTrials.gov) Plain Language Summary Gastrointestinal stromal tumor (GIST) is rare, but it is the most common mesenchymal tumor (a type of tumor that develops from cells which give rise to soft tissues) of the gastrointestinal tract. The primary treatment for advanced GIST is medication that targets the abnormal mechanisms in cancer cells in order to block tumor growth and spread. Ripretinib is an inhibitor of a protein known as KIT, which is a member of the tyrosine kinase protein family and is involved in the growth of GIST. In a Phase III clinical trial called INTRIGUE, the effects of ripretinib and another receptor tyrosine kinase inhibitor, sunitinib, were compared in patients with advanced GIST previously treated with the drug imatinib. An exploratory analysis from the INTRIGUE trial that characterized baseline circulating tumor DNA in the blood showed a greater clinical benefit with ripretinib versus sunitinib in patients with gene mutations solely occurring in KIT exon 11 + 17 and/or 18 (exon 11 + 17/18). This article describes the rationale and design for a Phase III clinical trial called INSIGHT that will evaluate the benefit of ripretinib compared with sunitinib in patients with advanced GIST whose tumors have mutations in KIT exon 11 and KIT exon 17 and/or 18. Patients will receive ripretinib or sunitinib in 6-week cycles, and investigators will assess survival without cancer progression as the primary outcome, and overall survival, and response of the tumor to these two drugs as secondary outcomes. Tweetable Abstract This article describes the rationale and design for the INSIGHT Phase III trial evaluating patients with second-line advanced GIST who harbor primary KIT exon 11 mutations and secondary resistance mutations restricted to the activation loop (KIT exons 17/18). Executive summary Disease overview & management Gastrointestinal stromal tumor (GIST) is the most common gastrointestinal sarcoma, with approximately 80% of cases driven by activating mutations in KIT. Sunitinib is a multitargeted tyrosine kinase inhibitor (TKI) approved as a second-line therapy for advanced GIST after disease progression on or intolerance to imatinib. Ripretinib is a broad-spectrum switch-control KIT/PDGFRA TKI approved as a fourth-line therapy for advanced GIST. Differential activity of ripretinib & sunitinib against secondary KIT mutations Exploratory baseline circulating tumor DNA (ctDNA) analysis from INTRIGUE determined that patients with KIT exon 11 + 13/14 mutations had improved progression-free survival (PFS) and objective response rate (ORR) with sunitinib versus ripretinib, while those with KIT exon 11 + 17/18 mutations had improved PFS, ORR and overall survival (OS) and a better safety profile with ripretinib versus sunitinib. Design INSIGHT is an international, Phase III, randomized, multicenter, open-label study evaluating the efficacy of ripretinib versus sunitinib in patients with advanced GIST previously treated with imatinib and who have KIT exon 11 mutations and co-occurring mutations exclusively in KIT exons 17/18, as identified by ctDNA. Approximately 54 patients will be randomized 2:1 to receive ripretinib 150 mg once daily (QD; continuous) or sunitinib 50 mg QD (4 weeks on/2 weeks off) in 6-week cycles. Eligible patients must have a histologic diagnosis of advanced GIST and co-occurring KIT exon 11 + 17/18 mutations confirmed by central laboratory ctDNA analysis, as well as radiologic progression on imatinib. The primary outcome measure is PFS based on blinded independent radiologic review (IRR) using modified Response Evaluation Criteria in Solid Tumors version 1.1 (mRECIST v1.1), while key secondary outcome measures are ORR based on blinded IRR using mRECIST v1.1 and OS. Infographic [ABSTRACT FROM AUTHOR]

Background: Schizophrenia, a severe mental disorder, is often complicated by Type 2 Diabetes Mellitus (T2DM), which can further impact patients' psychological health. This study investigated the differences in eating attitudes, depression, and insight between schizophrenic patients with and without comorbid T2DM and explored the correlations among these factors to provide empirical support for clinical interventions. Methods: This case-control study was conducted in Guangdong Province, China. From December 2022 to May 2023, a total of 300 hospitalized patients with schizophrenia (92 with comorbid T2DM and 208 without T2DM) were recruited. Data were collected using the Personal Information Form, Eating Attitudes Test (EAT-26), Hamilton Depression Scale (HAMD), and Insight and Treatment Attitudes Questionnaire (ITAQ). Statistical analyses, including t-tests, ANOVA, and multiple linear regression, were performed to examine differences and predictive factors of eating attitudes among patients. This study was approved by the Ethics Committee of the Affiliated Brain Hospital of Guangzhou Medical University (approval number: 2020028), and written informed consent was obtained from all participants. Results: Patients with schizophrenia and comorbid T2DM exhibited significantly higher risks of eating disorders (EAT-26: 12.54 ± 9.77 vs. 9.07 ± 7.90, P=0.003), more severe depression (HAMD: 14.71 ± 7.36 vs. 11.80 ± 6.04, P=0.001), and poorer insight (ITAQ: 10.46 ± 6.01 vs. 12.16 ± 6.09, P=0.025) compared to those without T2DM. Regression analysis revealed that gender, weekly exercise frequency, depression, and insight were significant predictors of eating attitudes among patients with T2DM. For patients without T2DM, weekly exercise frequency, smoking status, and insight were significant predictors. Conclusion: Schizophrenic patients with comorbid T2DM are facing increasing risks related to eating attitudes, depression, and insight which highlight the need for targeted interventions. Regular psychological assessment and tailored support strategies might improve their mental health and quality of life. Future research should focus on longitudinal studies to clarify causal relationships and develop more effective interventions. [ABSTRACT FROM AUTHOR]

The assessment of creativity as an individual difference has historically focused on divergent thinking, which is increasingly viewed as involving the associative processes that are also understood to be a key component of creative potential. Research on associative processes has proliferated in many sub-fields, often using Compound Remote Associates (CRA) tasks with an open response format and relatively small participant samples. In the present work, we introduce a new format that is more amenable to large-scale data collection in survey designs, and present evidence for the reliability and validity of CRA measures in general using multiple large samples. Study 1 uses a large, representative dataset (N = 1,323,480) to demonstrate strong unidimensionality and internal consistency (α =.97; ωt =.87), as well as links to individual differences in temperament, cognitive ability, occupation, and job characteristics. Study 2 uses an undergraduate sample (N = 685) to validate the use of a multiple-choice format relative to the traditional approach. Study 3 uses a crowdsourced sample (N = 357) to demonstrate high test–retest reliability of the items (r =.74). Finally, Study 4 uses a sample that overlaps with Study 1 (N = 1,502,922) to provide item response theory (IRT) parameters for a large set of high-quality CRA items that use a multiple-choice response mode, thus facilitating their use in future research on creativity, insight, and related topics. [ABSTRACT FROM AUTHOR]

Within the domain of face processing, researchers have been interested in quantifying the relationship between objective (i.e., performance on laboratory tests of recognition and matching) and subjective measures of ability (typically, self-report questionnaires). Put simply, do people show high levels of metacognitive insight into their own abilities with faces? Although several studies have suggested that the association between these two types of measures may only be moderate, there remain several important issues that require consideration before this question can be sensibly investigated. First, specificity is needed regarding both objective and subjective measurements because both tend to span a wide range of potentially separable abilities. Second, experimental tasks appear to focus on different contexts to those tapped in self-report questionnaire items. Third, recent issues with statistical approaches and visualisation can result in numerical artefacts and misinterpretations. Finally, the sizes of population-level insights suggested by recent work provide only limited information regarding individuals within these populations, and so researchers aiming to identify people at the extremes of ability must be careful when drawing conclusions. Taken together, we argue that more attention to these issues is needed when attempting to investigate metacognitive insight within this domain. [ABSTRACT FROM AUTHOR]

Background: In recent years, both meditation and psychedelics have attracted rapidly increasing scientific interest. While the current state of evidence suggests the promising potential of psychedelics, such as psilocybin, to enhance meditative training, it remains equivocal whether these effects are specifically bound to psilocybin or if other classical psychedelics might show synergistic effects with meditation practice. One particularly promising candidate is N,N -dimethyltryptamine (DMT), an active ingredient of ayahuasca. Aim: This study aims to investigate the effect of the psychedelic substance DMT, combined with the monoamine oxidase inhibitor harmine (DMT-harmine), on meditative states, compared to meditation with a placebo. Method: Forty experienced meditators (18 females and 22 males) participated in a double-blind, placebo-controlled study over a 3-day meditation retreat, receiving either placebo or DMT-harmine. Participants' levels of mindfulness, compassion, insight, and transcendence were assessed before, during, and after the meditation group retreat, using psychometric questionnaires. Results: Compared to meditation with a placebo, meditators who received DMT and harmine self-attributed greater levels of mystical-type experiences, non-dual awareness, and emotional breakthrough during the acute substance effects and, when corrected for baseline differences, greater psychological insight 1 day later. Mindfulness and compassion were not significantly different in the DMT-harmine group compared to placebo. At 1-month follow-up, the meditators who received DMT and harmine rated their experience as significantly more personally meaningful, spiritually significant, and well-being-enhancing than the meditators who received placebo. Conclusion: Investigating the impact of DMT-harmine on meditators in a naturalistic mindfulness group retreat, this placebo-controlled study highlights the specific effects of psychedelics during meditation. Trial registration: ClinicalTrials.gov identifier NCT05780216. [ABSTRACT FROM AUTHOR]

Quality of life has emerged as a powerful indicator of therapeutic success. However, little research has been conducted to study potential factors that influence quality of life in persons with schizophrenia, particularly in low-income developing nations. This study aimed to investigate how insight and empathy impacted the quality of life and severity of symptoms in patients. A descriptive cross-sectional research design was conducted on 168 patients with schizophrenia using the PANSS Scale, Schizophrenia Quality of Life Scale R4, the Interpersonal Reactivity Index, and the Birchwood Insight Scale. Our findings show that the mean score for quality of life was (70.9 ± 9.2), whereas the mean scores for empathy and insight were (60.8 ± 15.8) and (5.8 ± 1.9), respectively. Insight and empathy have predicted effects on QoL (adjusted r square = 0.035, sig = 0.009) and (adjusted r square = 0.012, sig = 0.027), respectively. On the other hand, the regression model also showed a substantial inverse relationship between the severity of the illness and both empathy and insight. Conclusion: The majority of the clients had poor quality of life, low insight, and low empathy. Insight and empathy play a role in anticipating the patient's perceptions of quality of life. They might affect how severe their illness is. Our findings highlight the importance of developing empathy and insight, and therapies that do so may aid patients with low quality of life. [ABSTRACT FROM AUTHOR]

Summary: Insight in psychosis is associated with reduced psychotic symptom severity, less coercive treatment and better functioning. Controversially, it has been suggested that insight may lead to depression, higher suicide risk and worse self-perceived quality of life. Future clinical trials are warranted to address this 'insight paradox', particularly the direction of causality. [ABSTRACT FROM AUTHOR]

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Copyright of REMark: Revista Brasileira de Marketing is the property of Revista Brasileira de Marketing (UNINOVE) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: This article presents a methodology for detecting Insights, which are defined as meaningful perceptions that reveal a deep understanding of consumer needs and desires. Methodology: This model was developed based on an extensive literature review and tested through research projects and real data analytics conducted for companies across various industries to verify its effectiveness. Results: The methodology combines qualitative and quantitative approaches, integrating traditional and novel techniques to identify the underlying factors influencing purchasing behavior. The proposed method is developed through four stages: data, information, knowledge, and Insight, providing a practical tool for strategic decision-making across various industries. Conclusions: Practical applications in different contexts let us understand how this methodology has enabled the identification of revealing Insights and improved the understanding of consumer motivations. The originality and contributions of this methodology lie in its ability to integrate multiple approaches and uncover critical underlying patterns for business success. [ABSTRACT FROM AUTHOR]

One pathologist reflects upon her own medical journey and shares how that perspective is carried forward in her practice and her life. [ABSTRACT FROM AUTHOR]

The Cognitive Assessment Interview (CAI) is an interview-based scale measuring cognitive impairment and its impact on functioning in subjects with schizophrenia (SCZ). The present study aimed at assessing, in a large sample of SCZ (n = 601), the agreement between patients and their informants on CAI ratings, to explore patients' insight in their cognitive deficits and its relationships with clinical and functional indices. Agreement between patient- and informant-based ratings was assessed by the Gwet's agreement coefficient. Predictors of insight in cognitive deficits were explored by stepwise multiple regression analyses. Patients reported lower severity of cognitive impairment vs. informants. A substantial to almost perfect agreement was observed between patients' and informants' ratings. Lower insight in cognitive deficits was associated to greater severity of neurocognitive impairment and positive symptoms, lower severity of depressive symptoms, and older age. Worse real-life functioning was associated to lower insight in cognitive deficit, worse neurocognitive performance, and worse functional capacity. Our findings indicate that the CAI is a valid co-primary measure with the interview to patients providing a reliable assessment of their cognitive deficits. In the absence of informants with good knowledge of the subject, the interview to the patient may represent a valid alternative. [ABSTRACT FROM AUTHOR]

Double bookkeeping is a term introduced by Eugen Bleuler to describe a fundamental feature of schizophrenia where psychotic reality can exist side by side with shared reality even when these realities seem mutually exclusive. Despite increasing theoretical interest in this phenomenon over the recent years, there are no empirical studies addressing this issue. We have, therefore, conducted a phenomenologically descriptive qualitative study of 25 patients with schizophrenia in which we addressed the following issues: (1) Experience of double reality; (2) Emergence and development of two realities; (3) Truth quality of psychotic or private reality; (4) Insight into illness; (5) Communication of psychotic experiences. The most important result was that most patients felt to be in contact with another dimension of reality. Hallucinatory and delusional experience pertained to this different reality, which patients most frequently kept separated from the shared reality. This other dimension was considered by the patients as being more profound and real. The pre-psychotic and psychotic experiences were difficult to verbalize and typically described as totally different than ordinary experience. Double reality was persistent across remissions. None of the patients considered their condition as an illness analogous to a somatic disorder. Most patients described a vague sense of duality preceding the crystallization of double bookkeeping. This emergence of doubleness was associated with a fundamental alienation from oneself, the world, and others stretching back to childhood or early adolescence. We discuss the results with a special emphasis on the concept of psychosis, clinical interview, treatment, and pathogenetic research. [ABSTRACT FROM AUTHOR]

Background: The exploration of metacognition in relation to anxiety has received considerable attention in recent decades. Research indicates that it plays a role in the development and maintenance of anxiety disorders while also providing benefits, including the ability to assess situations, modify behaviors, and make informed decisions. Summary: We propose that having an awareness of a disorder, also known as insight, is related to metacognition in anxiety. This relationship stems from the ability it provides individuals to recognize their mental state through reflection on personal experiences. We discuss the impact of insight and metacognition on decision-making, treatment-seeking behaviors, and coping strategy selection. Key Messages: Understanding the concept of insight in anxiety disorders, as compared to other mental disorders like psychosis, requires exploring its complexities while carefully considering the balance of harms and benefits. While the medicalization of symptoms in psychosis is widely regarded as clearly beneficial, evaluating the role of insight in anxiety disorders demands a more nuanced understanding. Gaining a fuller perspective on patients' beliefs can impact their behaviors and decision-making. Clinicians can achieve this by encouraging active self-reflection to increase awareness, which includes evaluating both severity and impact on daily functioning. This also involves expressing experiences and exploring attributions of anxiety. This practical approach enables clinicians to understand engagement and treatment-seeking behaviors, allowing them to tailor treatment plans and develop effective coping and management strategies. Ultimately, this knowledge promotes a deeper comprehension of insight into anxiety disorders. [ABSTRACT FROM AUTHOR]

Simple Summary: Detour behavior refers to the ability to reach a goal object that is not directly accessible due to an obstacle (opaque or transparent) by circumventing it. It varies among species, suggesting that environmental adaptation may drive insight behavior. Some species of marine and freshwater fish were placed in a corridor with social stimuli at the end, not directly accessible due to an opaque barrier. Two symmetrical apertures positioned midline in the corridor allowed the fish to temporarily abandon the view of the goal and attempt to circumvent the barrier. All fish showed the ability to move around an interposed obstacle. This is the first evidence of detour behavior in marine fishes within the "four-compartment box task", while results in freshwater fishes confirmed previous evidence. The comparable performance of marine and freshwater fishes suggests similar selective ecological pressure even in different aquatic habitats (e.g., sea and freshwater basins). Moreover, different exploratory behaviors emerged between correct and incorrect compartments (particularly in Danio rerio), providing evidence for a possible mental representation or "permanence in existence" of the goal while performing the obstacle circumvention, as opposed to a more parsimonious idea suggesting that the detour ability emerges only from primitive forms of exploratory behavior such as taxis. Evidence of detour ability to reach a salient goal in marine fishes (Chromis viridis, Chrysiptera parasema, Dascyllus aruanus) and freshwater fishes (Xenotoca eiseni, Danio rerio) has been observed using a "four-compartment box task" with an opaque barrier. The first experiment investigated this ability in marine fishes (Chromis viridis, Chrysiptera parasema, Dascyllus aruanus). Fish were placed in a four-compartment box, with social stimuli not accessible due to an opaque barrier. Two symmetrical apertures midline in the corridor allowed the fish to temporarily abandon the goal's view and attempt to circumvent the barrier. Marine fish showed searching behavior in the two compartments near the social stimuli. In the second experiment, the detour abilities of a marine fish (Dascyllus aruanus) and two freshwater fishes (Xenotoca eiseni, Danio rerio) were compared using a modified version of the apparatus, with elongated compartments continuing further from the obstacle barrier and social stimuli. This enabled the evaluation of the dependence on effective distance to achieve the social goal. Both marine and freshwater fish exhibited detour skills. Additionally, Danio rerio's differential spatial explorations inside compartments supported an active interest in searching for conspecifics, suggesting possible social object permanence retention. Overall, these results highlight the ecological salience of detour skills in fishes, irrespective of species-specific adaptations. [ABSTRACT FROM AUTHOR]