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Dąbrowska Justyna, Wójcik Magdalena, Boreński Grzegorz, Bator Damian, Milanowska Joanna. Influence of diet on the gut microbiota. Journal of Education, Health and Sport. 2020;10(5):33-41. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.05.003 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.05.003 https://zenodo.org/record/3802145 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.04.2020. Revised: 20.04.2020. Accepted: 06.05.2020. ‘ Influence of diet on the gut microbiota Justyna Dąbrowska1*, Magdalena Wójcik1, Grzegorz Boreński1, Damian Bator1, Joanna Milanowska2 (1) Student Science Club at the Department of Applied Psychology, Medical University of Lublin (2) Department of Applied Psychology, Medical University of Lublin * E-mail address: grzegorz.borenski@gmail.com ORCID ID: Justyna Dąbrowska https://orcid.org/0000-0002-1356-6965 Grzegorz Boreński https://orcid.org/0000-0002-5359-7555 Magdalena Wójcik https://orcid.org/0000-0002-0999-6284 Damian Bator https://orcid.org/0000-0002-8464-932X Joanna Milanowska https://orcid.org/0000-0002-8464-932X Abstract Introduction: Gut microbiota is still a new direction in medicine. The intestinal microbiota contains up to 100 trillion bacteria and around 1000 species. The composition of the intestinal microflora may be affected by external factors, among which eating habits can be considered as one of the most important. There are evidences how gut microbiota may affect the course of diseases, such as autism spectrum disorders, mood disorders, celiac disease, irritable bowel syndrome, diabetes and colorectal cancer The aim of the study: The purpose of this systemic review was to collect and analyse current and new information on the effect of diet on intestinal microbiota. Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed database was carried out using the following keywords: microbiota, gut, diet, gluten-free-diet, ketogenic-diet. Description of the state of knowledge: There are many studies that show the effect of diet on the intestinal microflora. Changing the amount of plant fiber consumed, ketogenic diet, gluten-free diet can affect the composition of the intestinal microflora in various ways, as shown by the evidence presented by us. For instance ketogenic diet in patients with refractory epilepsy may reduce the symptoms of the disease, which is associated with changes in the composition of gut microbiota. Summary: Diet is a promising direction of development, due to being a factor which may improve the course of many diseases. However, despite the fact that many new studies have appeared in this field in the last decade, time is still needed to draw specific conclusions. Keywords: microbiota, gut, diet, gluten-free-diet, ketogenic-diet

Contains fulltext : 88466.pdf (Publisher’s version ) (Closed access) Glucose transporter-1 deficiency syndrome is caused by mutations in the SLC2A1 gene in the majority of patients and results in impaired glucose transport into the brain. From 2004-2008, 132 requests for mutational analysis of the SLC2A1 gene were studied by automated Sanger sequencing and multiplex ligation-dependent probe amplification. Mutations in the SLC2A1 gene were detected in 54 patients (41%) and subsequently in three clinically affected family members. In these 57 patients we identified 49 different mutations, including six multiple exon deletions, six known mutations and 37 novel mutations (13 missense, five nonsense, 13 frame shift, four splice site and two translation initiation mutations). Clinical data were retrospectively collected from referring physicians by means of a questionnaire. Three different phenotypes were recognized: (i) the classical phenotype (84%), subdivided into early-onset (