1. Treatment of Pediatric non-Hodgkin lymphomas in a country with limited resources: Results of the first national protocol in Nicaragua
- Author
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Gloria Tridello, Angelo Rosolen, R. Palacios, Fulgencio Baez, G. Mendez, Cavalli Franco, Valentino Conter, Roberta Ortiz, Giuseppe Masera, Mg. Valsecchi, Elena C. Ocampo, L. Manfredini, T. Gutierrez, F. Fossati Bellani, Marta Pillon, Baez, F, Pillon, M, Manfredini, L, Ocampo, E, Mendez, G, Ortiz, R, Palacios, R, Gutierrez, T, Tridello, G, Conter, V, Valsecchi, M, Fossati Bellani, F, Cavalli, F, Masera, G, and Rosolen, A
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,limted resources ,Adolescent ,Drug availability ,Developing country ,Nicaragua ,Context (language use) ,Developing Countrie ,linfoma non-Hodgkin ,child ,immune system diseases ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,Overall survival ,Humans ,Medicine ,Developing Countries ,Protocol (science) ,Antineoplastic Combined Chemotherapy Protocol ,business.industry ,Lymphoma, Non-Hodgkin ,Infant ,Hematology ,Oncology ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business ,Limited resources - Abstract
We report the results of a protocol for the diagnosis and treatment of pediatric non-Hodgkin lymphomas (NHL) conducted in Nicaragua in the context of an international collaborative program. Fifty-three children with NHL treated between 1996 and 2003 were retrospectively evaluated. Therapy was designed based on local drug availability and affordability with dose and schedule adaptations for Burkitt and lymphoblastic lymphomas. With a median follow-up of 3 years, the projected 9-year overall survival was 63% and event-free survival 53%. The treatment was efficacious, feasible, and well tolerated in spite of the local socio-economical conditions.
- Published
- 2008