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Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPA) is an extremely rare neoplasm that generally originates from the nasopharynx surface epithelium. The case presented herein is of a 70-year-old male patient referred from another centre, who was observed to have this tumour together with squamous cell carcinoma. The clinicopathological findings of this combination are presented, which has very rarely been mentioned in the literature. Although the prognosis of TL-LGNPA is generally excellent, it may sometimes be combined with other tumours, and therefore it must be kept in mind that it could have a clinically more aggressive course.

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPA) is an extremely rare neoplasm that generally originates from the nasopharynx surface epithelium. The case presented herein is of a 70-year-old male patient referred from another centre, who was observed to have this tumour together with squamous cell carcinoma. The clinicopathological findings of this combination are presented, which has very rarely been mentioned in the literature. Although the prognosis of TL-LGNPA is generally excellent, it may sometimes be combined with other tumours, and therefore it must be kept in mind that it could have a clinically more aggressive course. [ABSTRACT FROM AUTHOR]

Low-grade nasopharyngeal papillary adenocarcinoma (NPAC) is a rare nasopharyngeal malignancy that runs an indolent course. It presents with a variety of symptoms including but not limited to nasal obstruction, runny nose, postnasal drip, and nasal bleeding. The main stay of treatment is surgery, but other adjuvant treatments including radiotherapy and photodynamic therapy have been used with varying degrees of successes. Due to its low grade nature and absence of distant metastases, its prognosis is excellent. Here, we report the case of a 22-year-old young woman with low-grade NPAC who was treated in our hospital by simple surgical excision., Competing Interests: There are no conflicts of interest., (Copyright: © 2022 Journal of the West African College of Surgeons.)