1. Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience
- Author
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Dragana Stanic, Ivana Miskovic, Rosanda Ilić, Danica Grujicic, Dragana Janic, Marija Popovic-Vukovic, Marina Nikitovic, Lejla Paripovic, Savo Raičević, Jelena Bokun, Borko Nidžović, Milan Saric, Vesna Ilić, Tatjana Pekmezovic, and Marija Pudrlja Slović
- Subjects
Ependymoma ,Male ,Cancer Treatment ,Disease ,Pediatrics ,Neurosurgical Procedures ,0302 clinical medicine ,Brainstem glioma ,Medicine and Health Sciences ,Disseminated disease ,Child ,Neurological Tumors ,Univariate analysis ,Multidisciplinary ,Brain Neoplasms ,Glioma ,Tumor Resection ,Prognosis ,3. Good health ,Survival Rate ,Surgical Oncology ,Treatment Outcome ,Oncology ,Neurology ,030220 oncology & carcinogenesis ,Child, Preschool ,Medicine ,Female ,Serbia ,Research Article ,Clinical Oncology ,medicine.medical_specialty ,Adolescent ,Science ,Surgical and Invasive Medical Procedures ,Antineoplastic Agents ,03 medical and health sciences ,Malignant Tumors ,Diagnostic Medicine ,Internal medicine ,medicine ,Cancer Detection and Diagnosis ,Humans ,Risk factor ,Surgical Resection ,Radiotherapy ,business.industry ,cancer and neoplasms ,Infant, Newborn ,Cancers and Neoplasms ,Infant ,medicine.disease ,malignant tumore ,Histopathology ,Clinical Medicine ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveThis study aimed to evaluate the characteristics of children with primary brain tumors, the effectiveness of treatment modalities, and to detect factors related to the outcome.MethodsA detailed analysis was performed on a series of 173 pediatric patients treated in a Serbian referral oncology institution between 2007 and 2016, based on their clinical, histological, treatment, and follow-up data.ResultsMean survival time of all children was 94.5months. 2-, 5- and 10-year overall survival probabilities were 68.8%, 59.4%, and 52.8%, respectively. Patients with supratentorial tumors had longer survival than patients with infratentorial tumors and patients with tumors in both compartments (p = 0.011). Children with the unknown histopathology (brainstem glioma) and high-grade glioma had a shorter life than embryonal tumors, ependymoma, and low-grade glioma (pConclusionsWith an organized and dedicated multidisciplinary team, the adequate outcomes can be achieved in a middle-income country setting. The presence of local residual disease after surgery and disseminated disease has a strong negative effect on survival.
- Published
- 2021