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The aim of this work was to evaluate the efficacy of adding Dexamethazone (DEX)) to Clomiphene citrate (CC) in polycystic ovary syndrome (PCOS) with normal dehydroepiandrosterone sulphate (DHEAS) in induction of ovulation. Materials and Methods: 120 infertile women with PCOS were randomly assigned into two groups. Group I: Clomiphene citrate 100 mg/day was given from day 3 to day 7 of the cycle and DEX 1 mg/day from day 3 to day 12 of the cycle. Group II: Same protocol of CC combined with placebo (Folic acid tablets) was given from day 3 to day 12 of the cycle. The main outcome was ovulation. Secondary measures included number of follicles >18 mm, pregnancy rate and ovarian follicular response were monitored by ultrasound. Results: There were no statistically significant differences between groups as regards age, duration of infertility, BMI, menstrual pattern, serum DHEAS. The mean number of follicles >18 mm were significantly higher in the DEX group than in the placebo group (p=0.059). Similarly, there were significantly higher rates of ovulation and pregnancy in the DEX group. Dexamethazone was very well tolerated as no patients complained of any side effect. Conclusion: Induction of ovulation by adding DEX to CC in PCOS with normal DHEAS is associated with higher ovulation and pregnancy rates and seems to be an effective, cheap and simple method.

Lorzadeh N1, Ghafarzadeh M1, Vahabi S2, Lashgar-ara GhR3 1. Assistant professor, Department of gynecology, Faculty of medicine, Lorestan University of medical sciences 2. Assistant profwssor, Department of anesthesiology, Faculty of medicine, Lorestan University of medical sciences 3. General practitioner, Information and drugs center of Lorestan health department Abstract Background: In this study we evaluate the outcome of pregnancy in the patient that received M. MR vaccine during M.MR vaccination program on Lorestan of fall 2003. Materials and methods: This is a descriptive epidemiologic study, we evaluated all of women that vaccinated with M.MR vaccine during pre and post conception. We collected and analyzed all of information like prognosis of pregnancy, congenital rubella syndrome, gestational age weigh of newborn. Results: In 92 pregnancy women infected with MMR vaccine, the prognosis of pregnancy clearly seen 88 pregnant women (96%) 73 (83%) had normal and healthy newborn infant and 5 (6%) had spontaneot abortion and 10 pregnant women (11%) had legal abortion. Mean gestational age at birth was 39.5 ± 2.1 and weigh of newborn was 3257 ± 535 grams. None of the live born infants had not congenital rubella syndrome. Conclusion: In this study we showed M.MR vaccination during pregnancy had not any complication pregnancy. But pregnancy yet is an contraindication for M.MR vaccibnation, vecause this patient theories have risk of congenital rubella syndrome.

Background: Pre-eclampsia along with bleeding and infection constitute a triad that is a major cause of maternal mortality. Many factors have been recognized which can help us to determine the severity of the disease and early diagnosis of it. Since throphoblastic disorder is one of the etiological causes of pre-eclampsia, we decided to measure the level of β-hCG as a marker of detecting the activity of throphoblasts in normotensive, mild and sever pre-eclamptic pregnant women. Materials and Methods: This research was a cross - sectional study which carried out on 75 pregnant women admitted to Asali hospital. All patients matched for age and gravidity. Patients were divided into 3 groups: 25 cases of mild pre-eclampsia, 25 cases of severe pre-eclampsia and 25 cases of normotensive pregnant women. The level of β-hCG in each group was measured by ELISA assay. Findings: The level of β-hCG was 18572  2123 IU/L in normotensive group 23962  6558 IU/L in mild pre-eclamptic group and 59220  4634 IU/L in sever pre-eclamptic group. Statistical analysis by Kruskal-Wallis test showed that the level of β-hCG in severe pre-eclamptic group was significantly higher than the other two groups (p< 0/001). The level of the hormone was not significantly different in mild pre-eclamptic and normotensive. Conclusion: The level of in pregnant women with severe pre-eclampsia was more than the other two groups (Normotensive and mild pre-eclamptic). Therefore, higher levels of β-hCG can determine the severity of pre-eclampsia but is not valid marker for early detection of the disease.

Introduction: Cardiovascular diseases (CVD) are among the major problems in post- menopausal women. One of the important reasons for CVD is atherosclerosis and it is supposed that estrogen prevent women from atherosclerosis. Soya contains, isoflavones suh as Genistein and Daidzen, that subelassed phytoestrogens. The present study was carried out to determine the effects of soya on hypercholesterlemic postmenopausal women’s lipid and lipoproteins levels in serum. Materials and Methods: This study is a clinical trial on 100 hypercholesterolemic postmenopausal women, undergoing to check in Khorramabab Assali hospital in 2002. We divided the patients into two groups randomly. The first group received capsule containing 500 mg soya, at the does, 2 gr/day, SID, and second group received placebo capsule, for 12 weeks. The research was a triple blind study. We took blood sample for laboratory measurement prior and, as well as 12 weeks after the treatment. Differences between two groups were analyzed using SPSS software. Findings: Results of the study showed that the mean of serum cholesterol, TG, HDL and LDL were not significant different between soya and placebo groups, before treatment and 12 weeks after the treatment (PV>0.05). These findings showed that soya has no significant effect on CHOL, TG, HDL and LDL levels in hyper cholesterolemic postmenopausal women. Conclusion: Regarding the above mentioned results soya can not be a good substitution for estrogen.