1. Travelers Can Import Colistin-Resistant Enterobacteriaceae, Including Those Possessing the Plasmid-Mediated mcr-1 Gene
- Author
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Vincent Perreten, Andrea Endimiani, Christoph Hatz, João Pires, Odette J Bernasconi, Regula Tinguely, Alessandra Carattoli, Esther Kuenzli, University of Zurich, and Endimiani, Andrea
- Subjects
antibiotic resistance ,vancomycin ,Cephalosporin ,Drug Resistance ,bacterial protein ,quinolone derivative ,plate count ,0302 clinical medicine ,Plasmid ,middle aged ,2736 Pharmacology (medical) ,genetics ,Pharmacology (medical) ,colistin ,610 Medicine & health ,travel ,beta lactam antibiotic ,Agar ,aminoglycoside antibiotic agent ,beta lactamase CTX M ,carbapenem ,cefotaxime ,cephalosporin ,chloramphenicol derivative ,cotrimoxazole ,extended spectrum beta lactamase ,macrolide ,mcr 1 protein ,polymyxin ,rifampicin ,sulfonamide ,tetracycline derivative ,unclassified drug ,antiinfective agent ,beta lactamase ,cephalosporin derivative ,colistin, adult ,agar medium ,antibiotic sensitivity ,Article ,bacterial colonization ,bacterial gene ,bacterial strain ,broth dilution ,carbapenem resistant Enterobacteriaceae ,clinical article ,controlled study ,Enterobacteriaceae ,epsilometer test ,Escherichia coli ,feces ,female ,human ,India ,male ,minimum inhibitory concentration ,multilocus sequence typing ,plasmid ,priority journal ,Switzerland ,traveller diarrhea ,young adult ,drug effects ,Enterobacteriaceae infection ,metabolism ,microbiology ,pathogenicity ,plasmid, Anti-Bacterial Agents ,beta-Lactamases ,Cephalosporins ,Colistin ,Drug Resistance, Bacterial ,Enterobacteriaceae Infections ,Humans ,Plasmids ,630 Agriculture ,adult ,Bacterial ,030106 microbiology ,Microbiology ,03 medical and health sciences ,Pharmacology ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,570 Life sciences ,biology ,MCR-1 ,0301 basic medicine ,Drug resistance ,medicine.disease_cause ,polycyclic compounds ,030212 general & internal medicine ,Anti-Bacterial Agents ,3004 Pharmacology ,Infectious Diseases ,medicine.drug ,medicine.drug_class ,Biology ,Epidemiology and Surveillance ,Bacterial genetics ,medicine ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,2725 Infectious Diseases ,biology.organism_classification - Abstract
Stool samples from 38 travelers returning from India were screened for extended-spectrum cephalosporin- and carbapenem-resistant Enterobacteriaceae implementing standard selective plates. Twenty-six (76.3%) people were colonized with CTX-M or DHA producers, but none of the strains was colistin resistant and/or mcr-1 positive. Nevertheless, using overnight enrichment and CHROMagar Orientation plates supplemented with colistin, four people (10.5%) were found to be colonized with colistin-resistant Escherichia coli . One cephalosporin-susceptible sequence type 10 (ST10) strain carried a 4,211-bp IS Apl1-mcr-1 -IS Apl1 element in an IncHI2 plasmid backbone.
- Published
- 2016
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