1. In vitro neuronal network activity as a new functional diagnostic system to detect effects of Cerebrospinal fluid from autoimmune encephalitis patients
- Author
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Stephan Theiss, Holger Lerche, Christian G. Bien, Christian E. Elger, Angela Vincent, Klaus-Peter Wandinger, Cristina Elena Niturad, Marcel Dihné, Michael P. Malter, Peter Körtvelyessy, and Henner Koch
- Subjects
0301 basic medicine ,Male ,lcsh:Medicine ,metabolism [Nervous System] ,Nervous System ,Mice ,0302 clinical medicine ,Cerebrospinal fluid ,Pregnancy ,Medicine ,pathology [Neurons] ,lcsh:Science ,pathology [Encephalitis] ,antagonists & inhibitors [Receptors, N-Methyl-D-Aspartate] ,Cerebrospinal Fluid ,Anti-N-Methyl-D-Aspartate Receptor Encephalitis ,Neurons ,Multidisciplinary ,metabolism [Hashimoto Disease] ,diagnosis [Hashimoto Disease] ,Middle Aged ,diagnosis [Encephalitis] ,drug therapy [Encephalitis] ,metabolism [Neurons] ,physiology [Cerebrospinal Fluid] ,NMDA receptor ,Encephalitis ,Female ,drug therapy [Anti-N-Methyl-D-Aspartate Receptor Encephalitis] ,medicine.medical_specialty ,Hashimoto Disease ,Diagnostic system ,pharmacology [2-Amino-5-phosphonovalerate] ,Receptors, N-Methyl-D-Aspartate ,Article ,03 medical and health sciences ,pathology [Hashimoto Disease] ,Internal medicine ,Biological neural network ,Animals ,Humans ,drug effects [Neurons] ,drug therapy [Hashimoto Disease] ,Pathological ,Autoimmune encephalitis ,business.industry ,lcsh:R ,drug effects [Nervous System] ,pathology [Nervous System] ,diagnosis [Anti-N-Methyl-D-Aspartate Receptor Encephalitis] ,In vitro ,Electrophysiology ,030104 developmental biology ,Endocrinology ,2-Amino-5-phosphonovalerate ,metabolism [Encephalitis] ,lcsh:Q ,drug effects [Cerebrospinal Fluid] ,business ,ddc:600 ,030217 neurology & neurosurgery - Abstract
The intent of this study was to investigate if cerebrospinal fluid (CSF) from autoimmune encephalitis (AE) patients regulates in vitro neuronal network activity differentially to healthy human control CSF (hCSF). To this end, electrophysiological effects of CSF from AE patients or hCSF were measured by in vitro neuronal network activity (ivNNA) recorded with microelectrode arrays (MEA). CSF from patients with either N-methyl-D-aspartate-receptor-antibody (pCSFNMDAR, n = 7) or Leucine-rich-glioma-inactivated-1-Ab (pCSFLGI1, n = 6) associated AE suppressed global spiking activity of neuronal networks by a factor of 2.17 (p p p p p
- Published
- 2019
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