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4 results on '"myocardial fluorodeoxyglucose uptake"'

1. Improvement of diagnostic accuracy of 18fluorine-fluorodeoxyglucose PET/computed tomography in detection of infective endocarditis using a 72-h low carbs protocol

Author

Domenico Albano, Elisabetta Cerudelli, Maria Gazzilli, Claudio Mesquita Tinoco, Rexhep Durmo, Raffaele Giubbini, and Francesco Bertagna

Subjects
Male, diet preparation, infective endocarditis, myocardial fluorodeoxyglucose uptake, PET/computed tomography, Diet, High-Fat, Endocarditis, Female, Humans, Middle Aged, ROC Curve, Retrospective Studies, Diet, High-Protein Low-Carbohydrate, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Computed tomography, Diagnostic accuracy, Visual scale, 030218 nuclear medicine & medical imaging, Lesion, Fluorodeoxyglucose PET, 03 medical and health sciences, 0302 clinical medicine, Region of interest, medicine, Radiology, Nuclear Medicine and imaging, Pathological, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, Infective endocarditis, medicine.symptom, business, Nuclear medicine
Abstract

BACKGROUND The major challenge in diagnosing infective endocarditis using fluorine-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is the high physiological myocardial F-FDG uptake, which may interfere with the detection of pathological uptake. Our aim was to retrospectively analyse the impact of a low-carbohydrate, high-protein, high-fat (LCHPHF) diet starting 72 h before the examination with classic overnight fasting. METHODS We included 92 patients (51 with LCHPHF diet 72 h before the examination and 41 with overnight fast only). Left ventricular (LV) myocardial F-FDG uptake was visually evaluated, to estimate the effect of LCHPHF on myocardial F-FDG uptake, we used a three-point visual scale: 0, negligible uptake and evaluable examination; 1, mild uptake and doubtful examination and 2, intense uptake and not evaluable examination. SUVmax and SUVmean were calculated putting a region of interest on LV myocardium at the level of the largest cardiac footprint and on the site of suspected lesion. Thus, a ratio between SUV of the suspect lesion and SUV of LV was calculated as SUV ratio. RESULTS By visual assessment, in LCHPHF diet group 46 patients (96.1%) had score 0, 3 patients (5.9%) had score 1 and nobody had score 2. In control group, 23 patients (56.1%) had a score 2, 12 (29.3%) patients obtained a score 1 with a doubtful examination and 6 patients (14.6%) were classified with a score 0 with reportable examination. CONCLUSION We demonstrated that an LCHPHF diet can adequately suppress the physiological myocardial uptake leading to a significant improvement in the interpretability and diagnostic accuracy of F-FDG PET/CT in infective endocarditis.

Published
2020

2. Quantitative analysis of myocardial 18F-fluorodeoxyglucose uptake by PET/CT for detection of cardiac sarcoidosis.

Author

Rami Yokoyama, Masao Miyagawa, Hideki Okayama, Takeshi Inoue, Hitoshi Miki, Akiyoshi Ogimoto, Jitsuo Higaki, and Teruhito Mochizuki

Subjects
*POSITRON emission tomography, *CARDIOGRAPHIC tomography, *FLUORODEOXYGLUCOSE F18, *SARCOIDOSIS diagnosis, *CARDIAC imaging, *CARDIAC patients, *HEART disease diagnosis
Abstract

Background Imaging with fluorodeoxyglucose (FDG) PET/CT is used to diagnose patients with cardiac sarcoidosis (CS). However, its specificity is relatively low. We aimed to demonstrate that higher diagnostic specificity for CS can be obtained using quantitative methodology to analyze PET/CT. Methods A total of 125 consecutive patients with suspected CS were enrolled in the study. After clinical assessment and cardiac imaging studies, the patients underwent FDG PET/CT imaging after eating a low-carbohydrate diet followed by an overnight fast lasting ≥ 18 h. For visual analysis, fusion and maximum intensity projection images were reviewed. For quantitative analysis, the maximum standardized uptake value (SUVmax) within the myocardium was obtained. Results Of the 92 patients who met study inclusion criteria, 37 were diagnosed with CS. Myocardial SUVmax was significantly higher in patients with CS compared with non-CS patients (9.5 ± 4.8 vs. 3.0 ± 1.7, p < 0.0001). The area under the curve by receiver operating characteristic analysis was 0.960 for SUVmax. Using a cut-off value of 4.0, the sensitivity was 97.3% and specificity was 83.6% for diagnosing CS, which is more accurate than visual analysis. Moreover, SUVmax was the only significant predictor of CS among 10 clinical and imaging variables. In 18 patients who received steroid therapy with a mean follow-up duration of 6.4 ± 5.2 months, SUVmax significantly decreased from 9.8 ± 4.2 to 5.5 ± 3.5 (p = 0.003). Conclusion When evaluated by quantification of myocardial SUVmax, FDG PET/CT imaging provides high sensitivity and specificity for diagnosing CS. [ABSTRACT FROM AUTHOR]

Published
2015
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4. Quantitative analysis of myocardial 18F-fluorodeoxyglucose uptake by PET/CT for detection of cardiac sarcoidosis.

Author

Yokoyama R, Miyagawa M, Okayama H, Inoue T, Miki H, Ogimoto A, Higaki J, and Mochizuki T

Subjects
Aged, Dimensional Measurement Accuracy, Female, Humans, Male, Middle Aged, Multimodal Imaging methods, Positron-Emission Tomography methods, ROC Curve, Radiopharmaceuticals pharmacology, Sensitivity and Specificity, Tomography, X-Ray Computed methods, Cardiomyopathies diagnosis, Fluorodeoxyglucose F18 pharmacology, Myocardium pathology, Sarcoidosis diagnosis
Abstract

Background: Imaging with fluorodeoxyglucose (FDG) PET/CT is used to diagnose patients with cardiac sarcoidosis (CS). However, its specificity is relatively low. We aimed to demonstrate that higher diagnostic specificity for CS can be obtained using quantitative methodology to analyze PET/CT., Methods: A total of 125 consecutive patients with suspected CS were enrolled in the study. After clinical assessment and cardiac imaging studies, the patients underwent FDG PET/CT imaging after eating a low-carbohydrate diet followed by an overnight fast lasting ≥ 18 h. For visual analysis, fusion and maximum intensity projection images were reviewed. For quantitative analysis, the maximum standardized uptake value (SUV max) within the myocardium was obtained., Results: Of the 92 patients who met study inclusion criteria, 37 were diagnosed with CS. Myocardial SUV max was significantly higher in patients with CS compared with non-CS patients (9.5 ± 4.8 vs. 3.0 ± 1.7, p < 0.0001). The area under the curve by receiver operating characteristic analysis was 0.960 for SUV max. Using a cut-off value of 4.0, the sensitivity was 97.3% and specificity was 83.6% for diagnosing CS, which is more accurate than visual analysis. Moreover, SUV max was the only significant predictor of CS among 10 clinical and imaging variables. In 18 patients who received steroid therapy with a mean follow-up duration of 6.4 ± 5.2 months, SUV max significantly decreased from 9.8 ± 4.2 to 5.5 ± 3.5 (p = 0.003)., Conclusion: When evaluated by quantification of myocardial SUV max, FDG PET/CT imaging provides high sensitivity and specificity for diagnosing CS., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)

Published
2015
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