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Copyright of Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas is the property of Universidad de Santiago de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: With a high mortality rate, diabetes mellitus (DM) is the result of insulin deficiency during its secretion or action, more common in patients over 40 years old, being responsible for 95% of morbidity cases in Brazil. Well-planned physical therapy, with efficient interventions and exercises, aims to improve mobility and balance in individuals with peripheral diabetic neuropathy (PDN). Objective: The objective of this article is to describe the physical therapy interventions in patients with diabetic neuropathy. Methodology: The present work is a literature review, with data collection between August 2021 and May 2022, through a search in PubMed, SciELO and PEDro databases. Results and discussion: Considering the clinical repercussions of patients, professionals use treatment techniques with the objective of preventing the progression of symptoms and degeneration of neural function. Final Considerations: An isolated treatment considered the gold standard to be applied in patients with PDN was not found in the literature, transcutaneous electrical stimulation does not present among scholars a concession of applicability. [ABSTRACT FROM AUTHOR]

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Fisioterapia Brasil is the property of Atlantica Editora and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introducción: La Neuroartropatía de Charcot puede ser mal diagnosticada. Objetivo: Describir los elementos básicos para el diagnóstico de la Neuroartropatía de Charcot en personas con Diabetes mellitus. Material y Métodos: Se realizó una revisión bibliográfica descriptiva. Se utilizó como motor de búsqueda a Google Académico. Se empleo información de diferentes bases de datos. Las palabras clave utilizadas fueron: Diabetes mellitus; neuropatía diabética; neuroartropatía de Charcot; artropatía neuropática; pie de Charcot; pie diabético (en inglés y español). Se evaluaron artículos, que en general tenían menos de 10 años de publicados, en los idiomas referidos y que por el título trataban el tema de estudio. Fueron excluidos los que no abordaran la relación entre Diabetes mellitus y la neuroartropatía de Charcot. Se referenciaron 50 artículos. Desarrollo: La hiperglucemia persistente es causa de alteraciones neurotróficas, vasculares, inflamatorias e inmunológicas, que contribuyen a la aparición de la Neuroartropatía de Charcot, la cual se debe sospechar en personas con factores de riesgo que condicionan su aparición. Su diagnóstico es eminentemente clínico y puede evolucionar desde un estadio agudo (activo) a su etapa crónica (menos activa o inactiva). Las imágenes de Rx convencional y resonancia magnética de la zona afectada, pueden ayudar al diagnóstico positivo y diferencial. Conclusiones: El diagnóstico de la Neuroartropatía de Charcot, se realiza a través de la verificación de la existencia de factores de riesgo que condicionan su aparición en una persona con Diabetes mellitus. Su diagnóstico es predominantemente clínico y la imagenología, pueden ayudar al diagnóstico positivo y diferencial.

Introduction: Cardiac autonomic neuropathy is a little known and underdiagnosed entity in diabetic patients, characterized by damage to autonomic nerve fibers causing symptoms such as exercise intolerance and postural hypotension; the prevalence and risk factors in the Colombian diabetic population are unclear and understudied. Objective: To determine the prevalence of cardiac autonomic neuropathy and associated factors in diabetic patients in a Colombian population. Materials and method: Analytical cross-sectional study, in a population of 107 patients with a diagnosis of diabetes mellitus type I and type II, who consulted a second level of care hospital in Colombia, between April and September 2022. Diagnosis was performed using the Ewing test of cardiovascular autonomic reflex. Statistical analyses were performed at descriptive and association level by logistic regression calculating odds ratio and 95% confidence intervals. Results: The study population had a mean age of 62 years, 56.1% of whom were women. 94.4% (CI 95%: 89.9-98.6) of the participants presented a positive evaluation for cardiac autonomic neuropathy; incipient status was 6.5%, 26.2% confirmed involvement and 61.7% severe involvement; age is associated with cardiac autonomic neuropathy presentation, ORa: 1.07 (CI 95%: 1.03-1.11). Conclusions: The current study found high prevalence of cardiac autonomic neuropathy (94.4%) when using the gold standard of diagnosis. The age of patients has association with the presence and severity of this disease. [ABSTRACT FROM AUTHOR]

La diabetes mellitus desencadena entre otras complicaciones la neuropatía periférica diabética, que tiene compromiso nervioso periférico, entre sus consecuencias principales es la disminución de la sensibilidad, la fuerza y la funcionalidad. El Objetivo de este estudio fue establecer un programa de ejercicios terapéuticos para restablecer la funcionalidad y sensibilidad de tobillo y pie en personas con neuropatía periférica diabética. De un total 34 pacientes, se realizaron las evaluaciones antes y posterior a la intervención fisioterapéutica que fueron ejercicios de equilibrio y fuerza, se evaluaron con el Test de Michigan Neuropathy Screening Instrument (MNSI) que es para valorar los síntomas y una exploración física, la prueba de lo Monofilamentos de Sammes-Weinstein (10g-MF) que sirve para evaluar la sensibilidad y para la valorar la fuerza con la Dinamometría Manual (HHD). Solo 17 pacientes culminaron este estudio, donde mostraron el test de Michigan no se encontró resultados estadísticamente significativos, pero si clínicamente, en cambio para la valoración con la prueba 10G-MF y HHD si se encontró cambios significativos. Los resultados obtenidos fueron insertados en una base de datos con el objetivo de crear un repositorio para futuros estudios en el Ecuador. Para insertar la información se desarrolló un sistema de gestión que permite registrar los datos sociodemográficos de los pacientes, registrar las patologías, la intervención fisioterapéutica implementada, y los resultados alcanzados para cada caso, en determinados periodos de tiempos que también son registrados. Este estudio mostró que los ejercicios implantados en tobillo y pie son beneficiosos para mejorar la sensibilidad y fuerza de los pacientes con DPN.

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Copyright of Revista Habanera de Ciencias Médicas is the property of Universidad de Ciencias Medicas de La Habana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diabetes mellitus, a chronic and progressive condition, was the third most common cause of death in Mexico between January and June 2021. Its most frequent chronic complication is diabetic neuropathy, which has a major impact on the nervous system. A multidisciplinary group of experts met in Mexico City to establish a treatment algorithm considering the symptomatic and etiopathogenic aspects of diabetic neuropathy. A real-time Delphi method with two rounds of interative questions was used. The implementation of the proposed algorithm will allow a comprehensive approach to the diabetic patient with painful and non-painful neuropathy, both in terms of symptoms and etiopathogenesis. This approach provides the opportunity to improve quality of life and achieve reintegration into family and work life. The expert panel recommends thioctic acid as the first line etiopathogenic treatment for diabetic neuropathy. [ABSTRACT FROM AUTHOR]

Introduction: diabetes mellitus leads to many associated complications, including diabetic neuropathy and diabetic angiopathy, both with a high incidence in the onset diabetic foot and including also the diabetic retinopathy disease cause of blindness. Objective: determine if there is any correlation between the onset diabetes foot and whether or not diabetic retinopathy present in patients treated at the Hospital Provincial, María Eugenia Neto, Zaire, Republic of Angola, from September 2020 to September 2020. Method: a descriptive study was carried out in 181 patients treated in the diabetic foot department of the aforementioned hospital; variables described were as follow: age, sex, associated chronic diseases, presence or absence of diabetic retinopathy, lower limb ulcers, limb amputation and years with diabetes. Bivariate correlation tests were performed, and the Pearson´s correlation coefficient was analyzed. Results: the average age was 59.3 years, the age group over 70 years (28.2%) and the female sex (57.5%) predominated. The 41.8% of patients presented previous amputations and 40.1% had ulcers. The 65.19% of patients had irregular treatment patterns, statistically strong and significant correlation between diabetic foot and diabetic retinopathy. Conclusions: there is evidence of a strong and significant relationship between patients with diabetic foot, who may suffer from a certain degree of diabetic retinopathy, more frequent in females after their sixth decade of life that cause a longer evolution of his disease.

Copyright of Revista de la ALAD is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: foot examination is essential in patients with diabetes mellitus (DM). The correct evaluation of the foot in the patient who attends diabetes control is key to establish risk factors for the development of ulcers, detect injuries, take preventive measures, make an early referral and educate in foot care. Objectives: in this study, the feet of people with DM were examined during the Diabetic Foot Awareness and Prevention Campaign on November 1, 2019 in order to assess the presence of symptoms and signs related to neuropathy, peripheral vascular disease, prevalence of the same and know the risk. Materials and methods: 165 patients were analyzed in four centers: Sanatorio Güemes (Diabetes and Endocrinology Service), PREDIGMA (Preventive Medicine Center, Posadas, Misiones), Central Hospital of San Isidro, Nexo Medical Center (Junín City) and Hospital Municipal of General Viamonte (Province of Buenos Aires).

La neuropatía diabética (nd) es una complicación frecuente de la diabetes y es una de las principales causas de discapacidad asociada a la diabetes tipo 2 ya que produce alteraciones en las fibras nerviosas. A la fecha se desconoce su etiología, aunque se han propuesto diversas teorías para explicarla. Los objetivos de esta revisión son describir la fisiopatología, etiología de la nd y valorar las herramientas para su diagnóstico. Se efec-tuó una búsqueda en español e inglés de artículos originales, revisiones sistemáticas y meta-análisis en las bases de datos PubMed, Google Scholar, Scielo y Science Direct con las siguientes palabras clave: Neuropatía diabética, marcadores electrofisiológicos, exploración física y pie diabético. Se eligieron 64 publicaciones entre 1981 y 2019. Se encontró una mayor posibilidad de tamizaje mediante el uso de pruebas electrofisiológicas en combinación con pruebas de evaluación mixta, ya que permiten un abordaje objetivo, mínimamente invasivo y reproducible

BACKGROUND: Diabetic hand syndrome is a frequent complication and is little valued by health personnel. Classically it is described as osteoarticular abnormalities related to long-standing diabetes, poor metabolic control, and microvascular complications. However, other disorders, such as skin involvement, infection of the hand and entrapment of peripheral nerves are part of this illness. CLINICAL CASE: A 66-year-old man, with a history of long-standing type 2 diabetes mellitus, undergoing intensive insulin therapy, consulted for presenting non-painful blisters on the fingers and palms of both hands, associated with weakness, changes in sensitivity and rigidity of the same. He had microvascular complications due to nephropathy, retinopathy and diabetic neuropathy, his glycated hemoglobin was 10.9%. Physical examination documented semiological findings compatible with diabetic bullosis and diabetic cheiroarthropathy. CONCLUSIONS: Osteoarticular, dermatological and neuropathic involvement of the hand should be recognized by health personnel as a specific complication of long-standing diabetes. Its early detection is of great value to prevent its progression and guide the search for microvascular complications. The diagnosis of this entity is clinical; therefore, it is advisable to carry out a routine evaluation of the hands of the diabetic patient, in order to install multidisciplinary management that will improve the outcomes. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the proportion of evidence of neuropathy and peripheral arterial disease, and to identify its relationship with sociodemographic variables, lifestyle and clinical factors with the classification of risk related to the foot of people with Diabetes Mellitus. Methods: Cross-sectional, descriptive, quantitative study. Sample for convenience 60 people in three Basic Health Units. It was used a sociodemographic form, clinical form for the assessment and screening of neuropathic pain, loss of protective sensitivity and peripheral arterial disease in primary care, a questionnaire for evidence of diabetic neuropathy. Pearson's test was applied in the relationship study. Results: Female predominance, mean age 58.1 (± 12.6) years, diagnosis time 12 years (± 9.6) and casual blood glucose 211.3mg/dl (± 91.7). Five participants presented evidence for neuropathy and none presented evidence for peripheral arterial disease. Significant correlation between risk classification, scores for neuropathic impairment (p <0.05) and monofilament (p <0.002). Conclusion: There was a low proportion of neuropathy and peripheral arterial disease, neuropathic impairment score and sensitivity to monofilament, were associated with risk classification. These relationships represent the need for intervention through the practice of screening for complications, which may contribute to the prevention of diabetic foot with amputation. [ABSTRACT FROM AUTHOR]

Copyright of Gaceta Médica de Caracas is the property of Academia Nacional de Medicina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article describes the construction of classification models by applying machine learning algorithms, in the kinesiological domain of neuropathy diagnosis, in patients with diabetes. The process is developed using the Cross Industry Standard Process for Data Mining guide (CRISP-DM), according to the general process of Knowledge Discovery in Databases (KDD). The main objective of the research is to build a model for classifying the condition of diabetic neuropathy in patients, using the data recorded by the expert and, mainly, by using a Wii Balance Board to capture the postural variations of a subject undergoing a series of clinical evaluations. In this research, the results obtained in each phase of the process are analyzed and the degree of achievement of objectives and performance metrics in the evaluation of machine learning models are measured. The results obtained will be expanded with the analysis of time series and the extraction of features, under the hypothesis that the center of pressure (COP) is a sufficient and reliable predictor to discriminate against the existence of a neuropathy. [ABSTRACT FROM AUTHOR]

Copyright of Revista de la ALAD is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Universitas Médica is the property of Pontificia Universidad Javeriana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Cardiovascular autonomic neuropathy (CAN) is a common complication of diabetes and is associated with cardiovascular morbidity and mortality. Despite its prevalence, it is usually underdiagnosed. Objective to assess frequency of CAN in type 2 diabetes, treated at the Diabetology Service at Cordoba Hospital, Argentina.Methods: Cross-sectional study was conducted from May 2015 to May 2016. Cardiovascular Autonomic Tests (Ewing´s battery) were performed: response to Valsalva maneuver, expiration-to-inspiration ratio (E/I ratio), standing to lying flat and postural hypotension.Results: 100 type 2 diabetes patients, 53% females. The mean age and diabetes duration 52 years old and 8.4 years, respectively. Hemoglobin A1c level of 8.7% and 47% were insulin-requiring type 2 diabetes patients. 29% had early CAN, 54% confirmed CAN (10% severe CAN) and 17% normal cardiovascular tests. Confirmed CAN was higher in those with longer duration of diabetes; longer duration of insulin therapy, older patients and severe hypoglycemia events was higher in those with confirmed CAN versus without CAN or early CAN (p 0.003). The risk factors associated were hypertension OR 2.55 (p 0.02), peripheral neuropathy OR 11.7 (p 7% OR 2.57 (p 0, 03).Conclusions: frequency of CAN was high, was associated with hypertension, microvascular complications, older age, poor metabolic control, longer duration of disease and insulin therapy. Patients with a higher risk of developing CAN should be identified, in order to reduce the impact of this complication.

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: strategic interventions intended to reduce the amputation rates and enhance the survival among patients with diabetes mellitus starts from the prevention based on educating the patients, identifies risk factors and multidisciplinary treatment of the wounds. Objective: To describe the effective interventions to prevent the amputation in patients with diabetic foot. Methodology: It is a comprehensive review of literature, including articles in Spanish, English and Portuguese coming from any country and conducted under any design that were published between 2015 and 2020 in the data bases: Clinicalkey, BVS biblioteca virtual en salud, Scopus, EBSCOHost, Pubmed y Cuiden. Selection was filtered based on abstract, title and full text. Articles were sorted according to evidence level and recommendation. Finally, a critical reading was carried out after the scales of Amstar, Consort, Strobe, CASPe y Trend. Results: At the end 29 article were selected and strategies were organized in to 3 topics according to the prevention level: Level one: promotion, prevention and mitigation of damage. Level two: identification, diagnosis and treatment, and level three: rehabilitation. Conclusions: Regular evaluation of diabetic foot is crucial and must be done by an interdisciplinary team. [ABSTRACT FROM AUTHOR]

The diabetic neuropathy is a severe complication resulting from Diabetes Mellitus (DM), which can cause ulcerations in the feet and lead to amputations in the lower limbs (LL). The aim of the present study is to evaluate the feet, self-care and the neuropathy impairment of LL in individuals with Type 2 DM (DM2), as well as to correlate impairment with age, diagnosis time and glycemic control. Socio-demographic and anthropometric data were collected, and fasting blood glucose and glycated hemoglobin (HbA1C) tests were conducted, as well as clinic examination was applied to the feet. Plantar protective sensitivity was assessed, as well as the Neuropathy Impairment Score (NIS), the Neuropathy Symptom Score (NSS) and the Diabetes Self-Management Questionnaire (DSMQ). Results were descriptively shown and the Spearman correlation test was adopted to correlate DM2 diagnosis time with NIS, NSS, age and HbA1C (p<0.05). Sixty-six individuals, at the age group 62 years (56-65) were evaluated. The physical examination showed signs of neuropathic foot and arterial insufficiency. There was change in the plantar protective sensitivity (48.5%), in the neuropathy impairment (48.5%) and in the neuropathy symptoms (59%). The combination between NIS and NSS diagnosed 33% of patients with peripheral diabetic neuropathy. There were weak positive correlation between age and DM2 diagnosis time, age and NIS, HbA1c and NSS, and among DM2 diagnosis time, NIS and NSS. The self-management items concerning the feet presented good adhesion. Conclusion: We found signs of neuropathic foot and insufficient arterial, these predictive factors of future foot ulcerations, weak positive correlation between age and time of diagnosis with neuropathic changes and good adherence to self-care with feet. [ABSTRACT FROM AUTHOR]

Neuropathic pain (NP) ¡s the most frequent reason for consultation in patients with peripheral neuropathy, an especially frequent condition in patients with diabetes mellitus. Distal symmetric polyneuropathy is the most prevalent presentation of diabetic neuropathy (DNP), which tends to feature NP in up to a third of the patients, representing a significant detriment in their quality of life. Several drugs and strategies have been designed to correctly approach patients with NP. Among conventional treatments, anticonvulsants such as pregabalin and gabapentin are central alternatives, followed by serotonin and noradrenalin reuptake inhibitors such as duloxetine and venlafaxine, as well as tricyclic antidepressants. Opioids are more controversial and have not been universally recommended. Various novel molecules are currently under study, focused on various therapeutic targets at different points in neuronal function. The objective of this review is to describe the management of NP in patients with DNP, and examine new recently proposed treatment strategies. [ABSTRACT FROM AUTHOR]

Listado: • Adulto mayor con diabetes y caídas a repetición: factores asociados, análisis secundario del estudio SABE Colombia. Morros E, Venegas LC, Vargas MP, Chacón E, Chavarro D, Cano CA. • Análisis comparativo entre pruebas clínicas y pruebas electrofisiológicas para la detección de neuropatía diabética en pacientes del servicio electrodiagnóstico de la Clínica Somefyr en 2018. Pineda LO, Peña AA, Monroy MA. • Conocimiento, tratamiento y control de la diabetes mellitus tipo 2 en colombianos de 35-70 años: estudio PURE. García LM1 , Alvernia MJ1 , Camacho PA1 , Uribe S2 , Pérez M2 , López P1 • Consumo de hipoglucemiantes en pacientes con diabetes mellitus tipo 2 en la costa atlántica colombiana. Fernández JC, Orjuela LT, Ospina JD, Amézquita MA • Determinantes de la prevalencia de prediabetes y diabetes mellitus tipo 2 en Colombia: estudio PURE. Alvernia MJ1 , García M1 , Camacho PA1 , Uribe S2 , Pérez M2 , López P1. • Dulaglutide Has Higher Adherence and Persistence Than Liraglutide and Exenatide OnceWeekly: 1-Year Follow-Up from United States Real-World Data. Landó LF1 , Mody R1 , Huang Q2 , Yu M3 , Zhao R2 , Patel H1 , et al. • Efecto hipoglucemiante de Anacardium occidentale L como posible tratamiento en pacientes con diabetes mellitus. Parga CH, Tapia AD, Botero AC, Brito JE, De las Salas M, Fruto AC, et al. • Efecto de una intervención educativa en el conocimiento de la enfermedad del paciente con diabetes mellitus hospitalizado. Rojas N, Saldarriaga M, Builes CE, Arango CM, Prieto C, Jaramillo C. • Gestión individualizada del riesgo en población diabética de Javesalud: experiencia de atención centrada en la persona en cuidado ambulatorio. Gordon SG, Páez PL, Castro DF, Robayo CX. • Hiperglucemia severa de difícil manejo: síndrome de resistencia a los análogos de insulina. Pino JJ, Monsalve C, Aristizábal N • Lesser Estimated Glomerular Filtration Rate Decline with Dulaglutide Regardless of Weight Changes in People with Type 2 Diabetes and Moderate to Severe Chronic Kidney Disease. Tuttle KR1 , Lakshmanan MC2 , Rayner B3, Busch RS4 , Zimmermann AG2 , Woodward BD2 , et al. • Modelo matemático de la homeostasis de la glucosa: una mirada al comportamiento de pacientes con diabetes tipo 1. Ruiz N1 , Colorado V1 , Lema L1 , Builes CE2 • Modelo semifísico de base fenomenológica del rol del páncreas en la homeostasis de la glucosa en humanos. Dávila MA1 , Tutalcha HA1 , Lema L1 , Builes CE2 • Nivel de adherencia a los tratamientos no farmacológicos de pacientes con diabetes mellitus, Barranquilla, 2017. Amador E, Montealegre L, Arteta M, De Oro C, Navarro G. • Niveles de vitamina B12 en pacientes con diabetes mellitus en tratamiento con metformina. Gómez JM, Laverde LA, González S, Penagos K, Rincón P, Tafurt Y. • Prediabetes, una condición frecuente en el ámbito hospitalario. Mejía HJ, Figueroa CL, Rodríguez RM, Romero DG, Gualdrón V, Sánchez D, et al. • Registro colombiano de pacientes con diabetes tipo 2. Reynales H, Castaño DM • Relación entre la severidad del síndrome de apnea-hipopnea del sueño (SAHOS) y la diabetes mellitus tipo 2 (DM2). Mendoza T1,2, Parra LA2, 3, 4. • Resultados en hospitalización y mortalidad por causa médica de la adherencia al tratamiento farmacológico en pacientes con diabetes mellitus tipo 2. Guzmán G1 , Iriarte MB2 , Ortega S2 , Ortiz D2 , Pardo N2 , Plaza E2 , et al. • Trasplante único de páncreas para paciente diabética tipo 1: reporte de un caso. Guzmán GE1, 2, Martínez V1, 2, Durán CE 2,3 Manzi E 4 , Mesa L3 , Schweineberg J3 , et al. • Uso de agonistas del receptor de GLP1 para el tratamiento de la diabetes mellitus: experiencia de la vida real. Builes CE, Rojas N, Prieto C, Arango CM, Gutiérrez J, Saldarriaga M, et al.

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dilemas Contemporáneos: Educación, Política y Valores is the property of Dilemas Contemporaneos: Educacion, Politica y Valores and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de la ALAD is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diabetes is a chronic and progressive disease associated with potentially disabling complications. Among them, diabetic neuropathy is probably the most frequent symptomatic manifestation, having an important social and economic impact. Painful somatic neuropathy and autonomic neuropathy treatment have been a challenge for years. New medical approaches that relief pain are now available and give hope to diabetic patients.

Symposium 15: Other conditions and diabetes Is neuropathy in patients with diabetes always caused by diabetes? There are diverse types of diabetic neuropathy, being the distal polyneuropathy the most frequent complication in diabetes. A 10% of the patients with diabetes exhibit neuropathy at the moment they were diagnoses with diabetes, while that percentage elevates to 40%-60%, depending on the use of electrophysiology or clinical criteria.

ABSTRACT The objective of this study was to investigate the effects of 2% L-glutamine supplementation on myenteric innervation in the ileum of diabetic rats, grouped as follows: normoglycemic (N); normoglycemic supplemented with L-glutamine (NG); diabetic (D); and diabetic supplemented with L-glutamine (DG). The ileums were subjected to immunohistochemical techniques to localize neurons immunoreactive to HuC/D protein (HuC/D-IR) and neuronal nitric oxide synthase enzyme (nNOS-IR) and to analyze varicosities immunoreactive to vasoactive intestinal polypeptide (VIP-IR) and calcitonin gene-related peptide (CGRP-IR). L-Glutamine in the DG group (i) prevented the increase in the cell body area of nNOS-IR neurons, (ii) prevented the increase in the area of VIP-IR varicosities, (iii) did not prevent the loss of HuC/D-IR and nNOS-IR neurons per ganglion, and (iv) reduced the size of CGRP-IR varicosities. L-Glutamine in the NG group reduced (i) the number of HuC/D-IR and nNOS-IR neurons per ganglion, (ii) the cell body area of nNOS-IR neurons, and (iii) the size of VIP-IR and CGRP-IR varicosities. 2% L-glutamine supplementation exerted differential neuroprotective effects in experimental diabetes neuropathy that depended on the type of neurotransmitter analyzed. However, the effects of this dose of L-glutamine on normoglycemic animals suggests there are additional actions of this beyond its antioxidant capacity.

Diabetic neuropathy (DN) is the most common and early microvascular alteration associated to diabetes mellitus (DM); however, this event is most missed and less diagnosed. At the same time, it is widely known that metabolic syndrome (MS) is highly prevalent and the relationship between this status and macrovascular commitment is documented. The Diabetic Neuropathy Committee is focused in analyzing the neuropathic effect within the framework of MS and in one of its components such as non-diabetic disglycemia. The under diagnosis and increase of morbidity and mortality risk of these patients alert the medical community of the existence of this microvascular alteration exceeding the DM framework and is also present in MS and disglycemia either at fasting and postprandial.

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Introduction. Up to 76% of patients who present for consultation for diabetes mellitus (DM) have reported having one or more gastrointestinal symptoms, while 50-55% of patients report having upper gastrointestinal symptoms. The autonomic neuropathy explains to a large extent the disorders of digestive motility in these subjects, however, it is possible that other factors are involved. Our objective was to determine the prevalence and relationship between gastrointestinal symptoms in patients with diabetes mellitus and its associated factors. Material and Methods. a prospective, cross-sectional and comparative study, in which the PAGI SYM questionnaires (validated in Spanish) were applied to subjects with type 2 diabetes mellitus that presented to two reference centers in 2013. Descriptive statistics and SPSS V. 22 were used. Results. 157 subjects were included (69.4% women), with an average age of 55.8 years. The average time of evolution of the DM was 10.9 ± 9.1 years and the average glycosylated hemoglobin (HbA1c) was 13.5 ± 31.5. The most common complication was diabetic neuropathy with 27.40%. 83.4% of the patients had at least one upper GI symptom. The presence of the most common GI symptoms according to the PAGI SYM were: heartburn in 38.9%, postprandial fullness with 38.2% and 31.8% nocturnal heartburn. The overall presence of symptoms compatible with gastroparesis was 71%. Discussion. More than 80% of patients with type 2 DM have at least one GI symptom, the most frequent being symptoms associated with gastroparesis. The factors associated with the presence of GI symptoms were glycemic control and the presence of neuropathy and retinopathy. [ABSTRACT FROM AUTHOR]

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Fragmento La Diabetes Mellitus es una enfermedad muy común; así por ejemplo se considera que en los Estados Unidos existen 3 millones de personas que la sufren. Es conocida desde tiempos muy remotos ya que los Papiros de Ebers la mencionan 3.500 años antes de Cristo.

Introducción: el pie diabético constituye un problema de salud en los pacientes portadores de diabetes mellitus y se registra como la primera causa de amputación no traumática de los miembros. El conocimiento de sus particularidades clínico-epidemiológicas resulta de sumo interés. Objetivo: caracterizar clínica y epidemiológicamente a los pacientes con pie diabético neuroinfeccioso en el Hospital "Dr. Joaquín Castillo Duany" de Santiago de Cuba. Método: se realizó un estudio descriptivo retrospectivo. El universo estuvo constituido por 96 pacientes diagnosticados con pie diabético durante el periodo comprendido entre el 2011 y el 2015. Se emplearon variables demográficas y relacionadas con factores de riesgo generales y específicos del pie diabético. Resultados: el pie diabético predominó entre la cuarta y sexta décadas de vida (24,7 %) y en pacientes del sexo femenino (59,7 %). La diabetes mellitus tipo 2 estuvo representada en el 52,5 %. Mientras el factor de riesgo general de pie diabético más frecuente fue la obesidad (56,7 %), la neuropatía diabética, como factor de riesgo específico se presentó en el 98,9 % de los enfermos estudiados. Conclusiones: el pie diabético predominó en la cuarta y sexta décadas de la vida y en el sexo femenino. El mayor porcentaje de los pacientes era portador de diabetes mellitus tipo 2. La obesidad, la neuropatía diabética periférica, el sobrepeso, y la hiperglucemia constituyeron los factores de riesgo prevalecientes.

Objetivo: Determinar mediante un estudio de costo efectividad cual de tres intervenciones en Xoxocotla, Morelos es la màs costo efectiva para disminuir la prevalencia de neuropatìa diabètica secundaria a Diabetes Mellitus.Material y Mètodos: En una muestra de 556 personas se realizó el cálculo del coeficiente costoefectividad y se aplicó la regla de decision. Resultados: Se obtuvo que la intervención A, llamada “Equilibra tu vida”, basada en actividad física, consulta nutricional y taller a familiar fue la más costo efectiva, obteniendo un costo total $311,841.00 con un porcentaje de efectividad del 30%, y un coeficiente de efectividad de 10.39 Conclusiones: No necesariamente una intervención màs costosa, es la intervención màs efectiva, y asì dar respuesta congruentes y concretas a la necesidades de salud.

OBJETIVO: Construir o perfil epidemiológico dos idosos com DMT2 cadastrados na Estratégia de Saúde da Família a partir das características de saúde, descrição do autocuidado e correlação entre alterações sensitivas e equilíbrio funcional. METODOLOGIA: Após aprovação do Comitê de Ética e Pesquisa da Universidade Estadual do Piauí (nº 462.651), a população do estudo compôs-se de 32 idosos com DMT2, idade média de 70,16(±6,74), atendidos pela Unidade Básica de Saúde do Bairro Poty Velho em Teresina, Piauí. RESULTADOS/CONCLUSÃO: Observou-se que 81,10% da amostra pertencem ao gênero feminino, 12,50% já apresentaram úlcera plantar, 84,40% com diagnóstico de polineuropatia e 59,40% enquadrados no estágio 3 de comprometimento sensitivo. Ao correlacionar-se o gradiente de alterações sensitivas com a classificação do Timed Up and Go Test e com a presença de neuropatia diabética, percebeu-se correlação significativa apenas no segundo caso. A adesão ao autocuidado foi maior quanto à terapia medicamentosa e mínima à monitorização da glicemia e prática de atividade física. Verificou-se que o autocuidado pode ser moldado através da reflexão sobre como realizavam os cuidados.

La diabetes representa un síndrome de enfermedades metabólicas complejas caracterizada por la presencia de la hiperglicemia, que muestra diversos orígenes (deficiencia y/o resistencia de insulina y consecuencias sistémicas del embarazo). Se sabe que la morbilidad y mortalidad de la diabetes es debida al desarrollo de las complicaciones macrovasculares y microvasculares. Sin embargo, la neuropatía diabética genera más hospitalizaciones que las otras complicaciones y es la causa más frecuente de amputaciones y falla autonómica. En ese sentido, la neuropatía diabética es heterogénea por sus síntomas, comprende patrones neurológicos, tiempo, riesgo y alteraciones patológicas que llevan a mecanismos que conducen al daño del nervio.

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La diabetes es una enfermedad crónica que se desencadena cuando el páncreas no produce sufi ciente insulina o cuando el organismo no la puede utilizar con efi cacia, derivando en serias complicaciones e incrementando el riesgo de muerte. Según el último informe de la OMS se aprecia un marcado aumento de la carga global de diabetes pasando de 180 millones de personas con esta enfermedad en 1980 a 422 millones en 2014, por lo cual esta organización recomienda mejorar la vigilancia, prevención y control de la diabetes y sus complicaciones. De acuerdo con la metodología, se realizó una búsqueda sistemática en Medline. Las palabras clave empleadas fueron: “Neuropatía diabética”, “nefropatía diabética”, “diabetes mellitus”, “enfermedad cardiovascular” y “pie diabético” En la búsqueda inicial fueron seleccionados 218 artículos originales y de revisión publicados en los últimos cinco años de los cuales 83 cumplían los criterios establecidos, su análisis permitió el desarrollo de un artículo de fácil comprensión enfocado en la fi siopatología y diagnóstico clínico de las complicación anteriormente mencionadas que responde a la problemática mundial en la cual la demanda de pacientes diabéticos supera la oferta de especialistas y en donde el médico de atención primeria juega un papel fundamental en el manejo de estos pacientes.