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OBJECTIVE: One large focus of personality psychology is to understand the biopsychosocial factors responsible for adult personality development and well-being change. However, little is known about how macro-level contextual factors, such as rurality-urbanicity, are related to personality development and well-being change. METHOD: The present study uses data from two large longitudinal studies of U.S. Americans (MIDUS, HRS) to examine whether there are rural-urban differences in levels and changes in the Big Five personality traits and well-being (i.e., psychological well-being, and life satisfaction) in adulthood. RESULTS: Multilevel models showed that Americans who lived in more rural areas tended to have lower levels of openness, conscientiousness, and psychological well-being, and higher levels of neuroticism. With the exception of psychological well-being (which replicated across MIDUS and HRS), rural-urban differences in personality traits were only evident in the HRS sample. The effect of neuroticism was fully robust to the inclusion of socio-demographic and social network covariates, but other effects were partially robust (i.e., conscientiousness and openness) or were not robust at all (i.e., psychological well-being). In both samples, there were no rural-urban differences in Big Five or well-being change. CONCLUSIONS: We discuss the implications of these findings for personality and rural health research.

BACKGROUND: Psilocybin Therapy (PT) is being increasingly studied as a psychiatric intervention. Personality relates to mental health and can be used to probe the nature of PTs therapeutic action. METHODS: In a phase 2, double-blind, randomized, active comparator controlled trial involving patients with moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, over a core 6-week trial period. Five-Factor model personality domains, Big Five Aspect Scale Openness aspects, Absorption, and Impulsivity were measured at Baseline, Week 6, and Month 6 follow-up. RESULTS: PT was associated with decreases in neuroticism (B = -0.63), introversion (B = -0.38), disagreeableness (B = -0.47), impulsivity (B = -0.40), and increases in absorption (B = 0.32), conscientiousness (B = 0.30), and openness (B = 0.23) at week 6, with neuroticism (B = -0.47) and disagreeableness (B = -0.41) remaining decreased at month 6. Escitalopram Treatment (ET) was associated with decreases in neuroticism (B = -0.38), disagreeableness (B = -0.26), impulsivity (B = -0.35), and increases in openness (B = 0.28) at week 6, with neuroticism (B = -0.46) remaining decreased at month 6. No significant between-condition differences were observed. CONCLUSIONS: Personality changes across both conditions were in a direction consistent with improved mental health. With the possible exception of trait absorption, there were no compelling between-condition differences warranting conclusions regarding a selective action of PT (v. ET) on personality; however, post-ET changes in personality were significantly moderated by pre-trial positive expectancy for escitalopram, whereas expectancy did not moderate response to PT.

Personality psychology subdivides the narcissism of healthy persons into the grandiose and the vulnerable types (2 factor model), which can be further described in a more differentiated way with the three personality factors extroversion, intolerance/antagonism and neuroticism (3 factor model). The grandiose and the vulnerable types of narcissism can also be found in narcissistically disturbed patients. The narcissistic personality disorder (NPD), which in DSM‑5 is exclusively characterized by the grandiose features also shows vulnerable features; however, these are hidden behind the grandiose features. Grandiose narcissism is relatively rare in the clinical routine. So far vulnerable narcissism could not be diagnosed in DSM‑5 or ICD-10; however, in the future this will be demonstrable in ICD-11 by the dimensional concept of personality disorder even if it does not exist as an official diagnosis in ICD-11. [ABSTRACT FROM AUTHOR]

Objective: Analyzing the relationship between negative life events and depressive symptoms in university freshmen, and the mediating effects of neuroticism and the moderating role of exercise frequency. Methods: A sampling of 8 079 university freshmen, and the Patient Health Questionnaire was used to assess depressive symptoms, the Eysenck Personality Inventory-Neuroticism subscale to assess neuroticism, the self-administered questionnaire to assess the number of negative life events that the participants had experienced and the exercise frequency. Model 4 in the Process plug-in was used to test the mediating effect of neuroticism, and Model 7 to test the moderating role of exercise frequency. Results: The numbers of negative life events were positively correlated with the depressive symptoms scores ( r = 0.16 P < 0.01), and were positively correlated with the neuroticism scores (r =0. 26, P < 0.01) . The neuroticism scores were positively correlated with the depressive symptoms scores (r = 0.52, P < 0.01) . Neuroticism score partially mediated between negative life events and depressive symptoms score, with a mediating effect of 78.4%, and exercise frequency score moderated between negative life events and neuroticism scores ( beta = 0.05 P = 0.032) . Conclusion: Negative life events are associated with depressive symptoms, neuroticism plays a mediating role, and exercise frequency could moderate negative life events and neuroticism. [ABSTRACT FROM AUTHOR]

Deviant peer affiliation (DPA) and moral disengagement (MD) play a vital role in adolescents' cyberbullying perpetration (CP). However, moderating mechanisms underlying this association remain largely unknown. Based on the Social-ecological conceptual framework of cyberbullying (SECF-C), we tested a moderated mediating model to examine whether MD mediated the relationships between DPA and CP and whether these mediating processes were moderated by neuroticism and gender. A sample of 777 adolescents (aged from 11 to 16 years) participated in our survey. The results revealed that MD partially mediated the connections between DPA and CP. Also, neuroticism moderated the relationship between DPA and CP in adolescent boys. Finally, neuroticism and gender moderated the relationship between MD and CP, revealing the conditional indirect effects of DPA on CP via MD. The indirect impact was more pronounced for boys and high neuroticism. These mechanisms have potential implications for developing tailored interventions and preventive strategies. [ABSTRACT FROM AUTHOR]

• Neuroticism contributes to the development and maintenance of emotional disorders. • The UP targets shared mechanisms of neuroticism and related emotion dysregulation. • The UP is an effective treatment for emotional disorders and neuroticism. • The UP can address a variety of problems across different cultures and identities. Before the development of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP), evidence-based treatment options for commonly co-occurring anxiety, mood, and related disorders consisted of numerous single-disorder protocols that shared many similarities, reflecting the overlap among these disorders themselves. The UP distilled common elements of cognitive behavioral protocols into a unified intervention directly targeting core temperamental features underlying these disorders of emotion, namely neuroticism and associated emotion dysregulation. The UP has since become a leading "transdiagnostic" treatment for emotional disorders, which is now available in several formats (e.g., individual, group, digital) and has accumulated a strong evidence base, leading to international implementation. There is now also research evidence that the UP can be flexibly applied to a range of clinical presentations, including borderline personality disorder, trauma- and stressor-related disorders, eating disorders, alcohol use disorder, and comorbid chronic physical health conditions. Yet additional research is needed to evaluate the UP in routine clinical settings, with more heterogeneous patient populations, and under circumstances that mirror actual clinical practice. Thus, we must also continue to explore the benefits of large-scale UP training initiatives and implementation in major healthcare systems. [ABSTRACT FROM AUTHOR]

• The first use of MR to evaluate the association between neuroticism and IAs. • Using large GWAS data, with a large sample size, results are more reliable. • Further validate the reliability of the results using multiple databases. The aim of this study was to assess the potential causal relationship between neuroticism and 12 neuroticism items with intracranial aneurysms (IAs) and aneurysmal subarachnoid hemorrhage (aSAH) using a two-sample Mendelian randomization (MR) approach. Study data were obtained from the Genome-Wide Association Study (GWAS) pooled dataset, and we extracted summary statistics for neuroticism, 12 neuroticism items, and IAs, which were categorized into ruptured and unruptured aneurysms (IA), aSAH, and unruptured IAs (uIA). Single nucleotide polymorphisms (SNPs) were used as instrumental variables (IVs) to explore the causal relationship between exposure and outcome using five Mendelian randomization methods, with Inverse variance weighted (IVW) as the primary study method. Horizontal multiple validity tests, sensitivity analyses, and inverse MR ensured the stability of the results. The two-sample MR showed a genetically predictive association between neuroticism and IA [odds ratio (OR) = 1.16; 95 % confidence interval (95 % CI): 1.04–1.30; p = 0.009], aSAH (OR = 1.17; 95 % CI: 1.03–1.33; p = 0.013) and uIA (OR = 1.30; 95 % CI: 1.07–1.59; p = 0.009) were all genetically predictive of association. Ivw showed a positive association between 5 neuroticism items and IA risk, 5 neuroticism items and aSAH risk as well as no genetically predictive association between neuroticism items and uIA. Sensitivity analysis and inverse MR confirmed the robustness of the results. Our Mendelian randomization analysis demonstrated genetic causality between neuroticism and neuroticism items with intracranial aneurysms, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysms, and further studies are needed to confirm these results and explore potential mechanisms of action. [ABSTRACT FROM AUTHOR]

Math anxiety and personality influence numeracy, although the nature of their contribution has been overlooked. In the present study, we investigated whether their association with numeracy depended on field of study and gender in higher education. Participants were Italian undergraduates in either the humanities (N = 201) or Science, Technology, Engineering and Math (STEM; N = 209) fields of study. These participants remotely completed standardized tests assessing numeracy, math anxiety, personality, intelligence, and basic numerical skills. We tested whether math anxiety and personality interacted with field of study and gender in predicting numeracy. Results showed that math anxiety was negatively associated with numeracy independently of field of study and gender, while the effect of personality, especially neuroticism, on numeracy interacted with field of study over and above intelligence and basic numerical skills. Specifically, humanities undergraduates with higher neuroticism levels scored lower in numeracy than STEM undergraduates. These findings underscore the importance of emotional experience for a good performance in mathematics, beyond math anxiety and the other personality traits, in the students that are less familiar with mathematics. Finally, no robust gender moderation emerged, suggesting that its role may be overridden by differences associated with career choice. [ABSTRACT FROM AUTHOR]

Media celebrities can exert significant influence on societal change, and adolescents are the most vulnerable population to such influence given that this is a period when personal identity-seeking starts to become increasingly important. However, there is a lack of research examining the factors that contribute to adolescents' vulnerability to celebrity worship. The present study investigated the relationship between neuroticism, avoidant identity style, and celebrity worship among adolescents with a particular focus on mediating the role of the need to belong among a convenience sample of Iranian adolescents (N = 396; girls = 68%; age = 15.76 ± 1.99). Structural equation modeling showed that the association between avoidant identity style and celebrity worship was partially mediated by the need to belong, while the latter fully mediated the relationship between neuroticism and celebrity worship. The findings draw attention to the need to belong as an important factor underlying celebrity worship. Limitations and future directions are discussed. [ABSTRACT FROM AUTHOR]

Research on the nature and prevalence of phenomena like climate anxiety (or eco-anxiety) is increasing rapidly but there is little understanding of the conditions under which climate change worry becomes more or less likely to significantly impact mental wellbeing. Here, we considered two plausible moderators of the relationship between climate change worry and mental wellbeing: neuroticism and efficacy beliefs. Analysis was conducted with survey data gathered in six European countries in autumn 2019. Participants were recruited from universities in the participating countries using opportunity sampling. We found that climate change worry is negatively related to mental wellbeing at any level of perceived efficacy. In contrast, climate change worry is only significantly related to mental wellbeing at low and average levels of neuroticism. High neuroticism appears to have a masking, rather than amplifying, role in the relationship between climate change worry and mental wellbeing. The cross-sectional design of the study precludes verification of causal relationships among variables. The brief measure of neuroticism employed also did not allow for nuanced analysis of how different facets of neuroticism contribute to the observed interaction with climate change worry. Findings cannot be indiscriminately generalised to less privileged groups facing the worst impacts of the climate crisis. Our findings lend to a view that harmful impacts of climate change worry on mental wellbeing cannot simply be ascribed to dispositional traits like neuroticism. We advocate for interventions that tackle negative climate-related emotions as unique psychological stressors. • We examined whether neuroticism and efficacy beliefs interact with climate worry. • Efficacy beliefs did not moderate climate worry – mental wellbeing relationship. • Climate worry and mental wellbeing only significantly linked at low neuroticism. • High neuroticism has a masking role in climate worry – mental wellbeing link. [ABSTRACT FROM AUTHOR]

This study aimed to determine the relationship between nurses' personality profiles, perception of conscience, and their tendency to medical error. This cross-sectional study was conducted with 241 nurses between 05.03.2023 and 10.04.2023 in two private hospitals in Türkiye. There was a negative correlation between neuroticism and tendency to medical error (r = −0.348; p < 0.05) and a positive correlation between agreeableness, extroversion, conscientiousness, and openness and tendency to medical error (r = 0.157; r = 0.248; r = 0.276; r = 0.241; p < 0.05, respectively). A positive correlation (r = 0.172; p < 0.05) was revealed between the authority subscale of the Perception of Conscience Questionnaire and hospital infection subdimension. According to the regression analysis conducted to determine the predictive levels of conscience and personality traits, it was found that conscientiousness, neuroticism, and authority explained 17.4% of the tendency to medical error. Accordingly, it was revealed that the neuroticism personality trait (β = −0.260, p < 0.05) increased the tendency to medical error, whereas the conscientiousness personality trait (β = 0.165, p < 0.05) and the authority subscale (β = 0.164, p < 0.05) decreased the tendency to medical error. In this regard, managers should determine the work and responsibility areas of nurses by making personality and perception of conscience evaluations to reduce the tendency to medical error. [ABSTRACT FROM AUTHOR]

Background Methods Results Conclusions Stressors induce depression together with parenting experienced in childhood, personality traits, and sleep. In this study, we investigated factors associated with the development of depression in a long‐term stressful environment, namely, the Antarctic Research Expedition wintering party, by comparing 2 groups, the depression and nondepression groups.A self‐administered questionnaire was used to survey 91 members of the Japanese Antarctic Research Expedition who spent winters in the Antarctic base. Psychological evaluations of depression, anxiety, and sleep were performed using a questionnaire every 3 months during the participants’ stay in Antarctica. The primary endpoint was the occurrence of minor or major depression, as evaluated by the PHQ‐9 score.Participants with a PHQ‐9 score of 5 or more during their stay in Antarctica were defined as the depression group (25 subjects), and participants with a PHQ score of 4 or less were defined as the nondepression group (43 subjects). Compared with the nondepression group, the depression group had significantly higher scores for predeparture PHQ‐9, state and trait anxiety, sleep disturbance, and neuroticism. Multivariable logistic regression analyses showed that higher predeparture scores of subthreshold depressive symptoms and neuroticism were found to be significant predictors of the occurrence of depression during their stay in Antarctica.This study prospectively showed that subthreshold depressive symptoms and neuroticism, which were suggested as risk factors in previous studies, were confirmed to be risk factors for depression. The results of our study are expected to contribute to the understanding of depression in harsh environments. [ABSTRACT FROM AUTHOR]

AbstractObjectivesMethodsResultsConclusionsPredicting therapy responders can significantly improve clinical outcomes. This study aims to identify predictors of response to short-term dynamic therapy.Data from 95 patients who underwent 16-session therapy were analyzed using machine learning. Weekly progress was monitored with the Outcome Questionnaire (OQ45) and Target Complaints (TC). A machine learning model identified change trajectories for responders and non-responders, with a random forest algorithm and elastic net modeling predicting trajectory group membership using pre-treatment data.A weak positive relationship was found between the trajectories of the two outcome variables. The results of the different analysis methods were compared and discussed. Important predictors of OQ45 trajectories, based on random forest modeling, included initial symptom severity, difficulties in emotion regulation, coldness, avoidant attachment, conscientiousness, interpersonal problems, non-acceptance of negative emotion, neuroticism, emotional clarity, impulsivity, and emotion awareness (72.8% accuracy). Initial problem severity, self-scarifying extraversion, and non-assertiveness were the most dominant predictors for TC trajectories (62.8% accuracy).These findings offer data-driven insights for selecting short-term dynamic therapy. Predicting response for the OQ45, a nomothetic measure, does not extend to the TC, an idiographic measure, and vice versa, highlighting the importance of multidimensional outcome evaluations for personalized treatment. [ABSTRACT FROM AUTHOR]

Background: In recent years, fighting arts (e.g., Karate, Judo, Jujitsu, Boxe) have gained broader attention due to their multiple benefits, involving both physical and psychological enhancements for practitioners. Despite that, studies revolving around specific psychological characteristics such as personality traits are scarce. This study explored potential connections between the personality traits of practitioners and the specific fighting art they engage in, and investigated levels of anxiety and depression in fighting artists. Methods: A web-based cross-sectional survey instrument was developed and disseminated across the entire Italian territory. Participants were eligible if adults (> 18 years old) engaged in any fighting arts for a minimum of one year, with no additional restrictions. The survey employed the Big Five Inventory (BFI) with 44 questions to explore personality traits using the OCEAN model, and the Hospital Anxiety and Depression Scale (HADS) to explore anxiety and depression levels. Results: A total of 770 questionnaires were collected from July to September 2023. Participants were mainly men (M = 571, 74.5%; F = 199, 25.8%; mean age 45.2 ± 14.8), and most of the participants practised in the North of Italy (N = 493, 64.0%). The mean age of practice was 28.5 ± 14.9 years and the most practised fighting arts were Judo (N = 349, 45.3%), Karate (N = 272, 35.3%) and Jujitsu (N = 42, 5.5%). Personality traits were identified as openness, conscientiousness, extroversion, agreeableness, neuroticism and the results were as follows: O) 40.1 ± 6.30; C) 37.1 ± 5.78; E) 28.2 ± 5.64; A) 35.1 ± 5.08; N) 19,8 ± 5,51. Anxiety and depression scored respectively 5.93 ± 3.14 and 3.67 ± 2.74. Conclusions: Fighting artists exhibit elevated levels of positive personality traits, such as openness, conscientiousness, extraversion, and agreeableness. Conversely, neuroticism tends to be lower among them. Moreover, anxiety and depression levels among fighting artists are lower than the Italian normative values. Fighting arts, particularly Karate and Judo, emerge as promising avenues for adults seeking innovative or complementary strategies to foster positive personality traits (e.g., openness, conscientiousness) while mitigating anxiety and depression. Future studies could explore other personality traits, including Machiavellianism, and explore additional psychological characteristics such as aggressiveness to provide a more comprehensive understanding. [ABSTRACT FROM AUTHOR]

Objective: Despite advancements in understanding panic disorder (PD), its etiology and pathogenesis remain elusive, particularly concerning the influence of psychosocial factors. This study aims to explore the mediating roles of neuroticism and anxiety sensitivity (AS) in the relationship between childhood trauma and PD severity. Methods: We conducted a cross-sectional analysis involving 84 individuals diagnosed with PD and 112 age- and gender-matched healthy controls (HC). Childhood trauma was assessed using the validated Childhood Trauma Questionnaire (CTQ), while anxiety sensitivity levels were measured using the Anxiety Sensitivity Index-3 (ASI-3). Neuroticism was evaluated using the Chinese Big Five Personality Inventory (CBF-PI-B). The severity of PD was determined using the Panic Disorder Severity Scale (PDSS). Statistical analysis encompassed both correlation and mediation techniques to thoroughly examine the relationships among childhood trauma, neuroticism, AS, and PD severity. Results: Individuals with PD exhibited significantly higher CTQ, ASI-3, and neuroticism scores compared to HC (all P<0.05). Within the PD group, strong positive correlations were found between CTQ scores, ASI-3 scores, neuroticism levels, and PDSS scores, with correlation coefficients ranging from 0.336 to 0.504 (all P<0.001). Additionally, our results indicated that neuroticism and AS acted as mediating factors in the relationship between childhood trauma and the severity of PD, with the 95% confidence interval for the indirect effects ranging from 0.028 to 0.116. Conclusion: This study highlights that PD patients exhibit significantly higher levels of childhood trauma, neuroticism, and AS compared to HC. Furthermore, childhood trauma indirectly influences PD severity through a chain mediation involving neuroticism and AS. These findings suggest the importance of psychological factors in moderating the impact of early adverse experiences on the development and progression of PD. [ABSTRACT FROM AUTHOR]

Introduction: In this study, we mainly evaluated the associations of borderline personality disorder (BPD), neuroticism, and childhood trauma with the selfrated and clinician-rated overall functional impairment levels of adult euthymic patients with bipolar disorder-1 (BD-1). In addition, we compared patient and healthy control groups regarding the levels of of childhood trauma, neuroticism, BPD and functional impairment. Methods: In total, 90 euthymic BD-1 patients and 90 healthy controls were enrolled. The Childhood Trauma Questionnaire-Short Form, the neuroticism subscale of the Eysenck Personality Questionnaire Revised-Abbreviated Form, the Borderline Personality Questionnaire, the Functioning Assessment Short Test, and the Sheehan Disability Scale were administered to the participants. Results: The study revealed that the levels of BPD, neuroticism, emotional abuse, physical abuse, global childhood trauma, self-rated overall functional impairment, all the subdomains of self-rated functional impairment, clinician-rated overall functional impairment, and all the subdomains of clinician-rated functional impairment (except leisure time) were significantly higher in the patients than those in the healthy controls (p < 0.05). Clinician-rated functional impairment levels were significantly correlated with levels of BPD (r = 0.555, p<0.001), neuroticism (r = 0.429, p < 0.001), global childhood trauma (r = 0.391, p <0.001), and all subtypes of childhood trauma except sexual abuse. Self-rated functional impairment levels were significantly correlated with levels of neuroticism (r= 0.289, p = 0.006), physical neglect (r = 0.213, p = 0.044), and BPD (r = 0.557, p < 0.001). In the regression analyses, the self-rated overall functional impairment levels were only significantly associated with the BPD feature levels (b = 0.319, p < 0.001) and the clinician-rated overall functional impairment levels were only significantly associated with the BPD feature levels (b = 0.518, p < 0.001). Conclusion: The present study's findings suggest that BPD features should be addressed in psychosocial interventions aimed at ameliorating functional impairment in patients with BD-1. Only BPD features were associated with selfrated and clinician-rated overall functional impairment levels in the regression analyses in the BD-1 patients. Performing self-rated and clinician-rated functional impairment assessments in the same clinical trial may give rise to relevant findings in the future. [ABSTRACT FROM AUTHOR]

AbstractThe pathways between personality traits and older adults’ quality of life (QOL) have been well studied. However, perceived social support and positive coping styles should not be ignored by older adults’ QOL. Hence, this study examines the chain mediating role of perceived social support and positive coping styles between personality traits and older adults’ QOL. In total, 230 older individuals (Meanage = 69.43, SDage = 7.23, age range from 60 to 93) participated in this study. All older people provided a rating of QOL and perceived social support, the Chinese Big Five personality, and positive coping styles. (1a) the five personality traits of older adults were significantly associated with QOL; (2b) perceived social support mediated the relationship between three personality traits (neuroticism, extraversion, and agreeableness) and QOL; (3c) positive coping styles played a mediator role in the personality traits (neuroticism, extraversion, and agreeableness) and QOL; (4d) perceived social support and positive coping styles had a significant chain mediating effect on the three dimensions of personality traits (neuroticism, extraversion, and agreeableness) and QOL. As mediating influences, social support and positive coping styles can be applied to efforts to promote QOL for older adults who share the personality traits of neuroticism, extraversion, and agreeableness. [ABSTRACT FROM AUTHOR]

Background: Previous research has indicated that personality traits, loneliness, and problematic internet use (PIU) significantly contribute to the prevalence of adolescent depression. However, the specific interrelationships among these variables in explaining the occurrence of depression remain unclear. Drawing upon susceptibility theory and cognitive-behavioral theory, this study explored whether personality traits influences adolescent depression through loneliness and PIU. Methods: A total of 2476 adolescents (aged 12–18) from all over the country completed a psycho-social test, including the 10-Item Big Five Personality Inventory (BFI-10), three-Item Loneliness Scale (T-ILS), Problematic Internet Use Questionnaire-Short Form (PIUQ-SF-6) and the Patient Health Questionnaire-9 (PHQ-9). The mediation model was built and bootstrap method was used to test the mediating effect. Results: Results showed that neuroticism, conscientiousness, openness, and agreeableness have a direct role on depression. Loneliness and PIU partially mediated the relationship between neuroticism, conscientiousness, agreeableness and depression, and completely mediated the relationship between extroversion and depression. Conclusions: The results suggest that loneliness and PIU play important mediating roles in the relationship between personality traits and depression. This remind us that alleviating sense of loneliness and reducing overuse of the internet are a strategy for improve depression among adolescents. [ABSTRACT FROM AUTHOR]

The objective of this study was to analyze the causal relationship between Neuroticism and aortic aneurysm using Mendelian randomization (MR). The study aimed to establish a foundation for the development of effective prevention and treatment strategies. Genetic association data for Neuroticism were obtained from the UK Biobank, which included 393,411 individuals and 11,968,760 single nucleotide polymorphisms (SNPs). Genetic association data for aortic aneurysm were obtained from a genome-wide association study (GWAS), which included 479,194 individuals and 24,191,825 SNPs. Heterogeneity was assessed using the Cochran's Q statistic test. The study also utilized the MR Pleiotropy RESidual Sum and Outlier (Mr-PRESSO) test, as well as the MR-Egger regression method, to examine horizontal pleiotropy and determine the reliability of the findings through the leave-one-out method. Forward MR analysis showed that the risk of aortic aneurysm was elevated in individuals with genetically predicted Neuroticism compared to those without Neuroticism (OR = 1.1315, 95 % CI: 1.0269–1.2468; P = 0.0126). The Cochran's Q test showed no heterogeneity (P > 0.05), and the MR-PRESSO test did not identify instrumental variables of horizontal pleiotropy (P > 0.05). The MR analysis remained robust after removing SNPs one by one. Inverse MR analysis did not observe an association between aortic aneurysm and having Neuroticism OR = 1.030, 95 % CI: 0.9459–1.118, P = 0.488). Our study has established a clear causal relationship between genetically determined Neuroticism and the development of aortic aneurysms. It is therefore important to intensify screening and prevention efforts for aortic aneurysms in neurotic patients. It also opens new avenues for exploring the disease's pathogenesis. • Existing Evidence Gap: Psych trait-cardiovascular studies common, but few MR analyses explore neuroticism-aortic aneurysm link. • Novel Contribution: Forward MR shows higher neuroticism genetically linked to increased aortic aneurysm risk. • Clinical Significance: Findings suggest intensified screening & prevention for aortic aneurysms in neurotic individuals. • Future Directions: Study prompts deeper investigation into aortic aneurysm mechanisms & discovery of new genetic pathways. [ABSTRACT FROM AUTHOR]

Introduction: Graduate students face unprecedented levels of neuroticism and pressure compared to their peers. Despite existing research examining the connection between neuroticism and depressive symptoms, a gap in the current understanding of the mediating mechanisms that act on this relationship, especially among this specific student population. Methods: This study investigated the potential chain-mediating roles of social support and positive coping in the relationship between neuroticism and depressive symptoms among graduate students. The participants were 1845 graduate students who provided demographic information and complete assessments including the Eysenck Personality Questionnaire (EPQ), Depression Rating Scale (BDI-II), Social Support Rating Scale (SSRS), and Coping Style Questionnaire (SCSQ). The analysis involved correlational analysis and a chain mediation model was used to investigate the associations among neuroticism, social support, positive coping mechanisms, and depressive symptoms. Results: The results show significant correlations among neuroticism, depressive symptoms, social support, and positive coping. Moreover, our findings verify that neuroticism affects depressive symptoms in graduate students through three pathways: the mediating effect of social support, the mediating effect of positive coping, and the chain-mediating effect of social support and positive coping. Discussion: Overall, the hypothesized chain model conclusively fits the data: Neuroticism directly affects depressive symptoms among graduate students and influences depressive symptoms through the mediating effects of social support and positive coping, as well as the chain mediating effects of these two variables. [ABSTRACT FROM AUTHOR]

We examined the mediating effect of self-efficacy on the relationship between personality traits and foreign language anxiety among university students of English as a foreign language. Using a cross-sectional study design, 524 Chinese undergraduate students completed the Foreign Language Classroom Anxiety Scale (FLCAS), the Big Five Inventory (BFI), and the General Self-Efficacy Scale (GSE). The PROCESS mediation analysis findings indicated that personality traits predicted foreign language learning anxiety. Self-efficacy significantly mediated the relationship between personality traits and foreign language anxiety, associated with lower foreign language anxiety. Openness and extroversion were associated with higher self-efficacy and lower foreign language anxiety. Neuroticism was associated with lower self-efficacy and higher foreign language anxiety. Educational programs, therapeutic interventions, and policy measures should be designed to enhance self-efficacy as an asset in foreign language learning experiences. [ABSTRACT FROM AUTHOR]

Cognitive and non-cognitive traits are frequently analyzed in isolation. However, there is an increasing acknowledgment that their interplay should be considered for enhancing our understanding of human psychological differences. Testing both traits in the same sample of individuals is desirable when addressing their relationships. Here, for that purpose, 299 university students from Spain (mean age = 18.5 years., 83% female) completed a cognitive ability battery comprised by nine tests, the NEO-FFI for assessing the big five personality traits, and the SCL-90-R for evaluating a range of subjective psychopathological symptoms. This resulted in 23 cognitive and non-cognitive variables that were submitted to a data reduction providing four factors: (1) neuroticism/p, (2) cognitive ability/g, (3) agreeableness/A, and (4) introversion/I. Summary factor scores revealed a positive correlation between p and I (0.47), along with negative correlations of A with p (−0.26) and with g (−0.24), and a negative correlation between A and I (−0.16). These factors were related to some degree even when the assessment of the cognitive and non-cognitive variables cannot be considered straightforwardly comparable because the former was performance based, whereas the later was based on self-reports. Conceptual and methodological implications are discussed regarding the three-way relationship among cognitive ability, personality, and subjective psychopathological symptoms. [ABSTRACT FROM AUTHOR]

Objective: Epidemiological studies revealed an unestablished association between neuroticism and posttraumatic stress disorder (PTSD) and we conducted mendelian randomization (MR) analyses to examine whether neuroticism clusters of worry, depressed affect, and sensitivity to environmental stress and adversity (SESA) were involved in the development of PTSD. Method: We obtained data on three neuroticism clusters, PTSD, and nine other psychiatric disorders from genome‐wide association studies summary statistics and employed univariable, multivariable, and mediation MR analyses to explore causal associations among them. Results: Neuroticism clusters were linked with PTSD (depressed affect (odds ratio [OR]: 2.94 [95% confidence interval: 2.21–3.92]); SESA (2.69 [1.95–3.71]; worry (1.81 [1.37–2.99])). Neuroticism clusters were also associated with psychiatric disorders, with the depressed effect on panic disorder (PD) (2.60 [1.14–5.91]), SESA on anorexia nervosa (AN) (2.77 [1.95–3.94]) and schizophrenia (2.55 [1.99–3.25]), worry on major depressive disorder (MDD) (2.58 [2.19–3.05]). In multivariable MR, only the SESA‐PTSD association remained (2.60 [2.096, 3.107]) while worry‐PTSD and depressed affect‐PTSD associations attenuated to nonsignificance. Mediation MR analyses suggested that PD mediated 3.76% of the effect of depressed effect on PTSD and AN mediated 10.33% of the effect of SESA on PTSD. Conclusion: Delving deeper into neuroticism clusters, we comprehensively understand the role of neuroticism in PTSD. [ABSTRACT FROM AUTHOR]

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that influences an individual's cognitive functions and social interaction. While most studies have focused on children and adolescents diagnosed with ASD, elevated levels of autistic traits in subclinical populations may also influence individuals' daily functioning. Autistic traits are also linked to the Big Five personality. In particular, neuroticism (emotion instability) has been shown to be positively associated with autistic traits, which may contribute to behavioral symptoms of autistic traits. The present study aimed to investigate the association between autistic symptoms and sensorimotor processing among a subclinical population. One hundred young adults (Mage = 20.32 years; SD = 3.69 years; 69 female) completed a choice reaction time (RT) task, and their behavioral performance was analyzed using the ex-Gaussian modeling. The Autism Quotient (AQ) and the Ten-Item Personality Inventory (TIPI) were used to assess autistic traits and neuroticism, respectively. The mediation analysis was conducted to examine the behavioral mechanism through which autistic traits influence sensorimotor processing. The results showed that the AQ score was negatively correlated with RT and positively correlated with neuroticism score. Importantly, the mediation analysis indicated an indirect effect, suggesting that neuroticism mediates the association between the AQ score and RT. The findings indicated a possible mechanism of the association between autistic traits and sensorimotor responses and suggested that neuroticism should be included as an intervention target for ASD. The present study contributes to the research on autistic traits and has practical implications for future intervention programs to improve daily functioning among individuals with ASD. [ABSTRACT FROM AUTHOR]

Cognitive decline is a public health concern affecting about 50 million individuals worldwide. Neuroticism, defined as the trait disposition to experience intense and frequent negative emotions, has been associated with an increased risk of late-life cognitive decline. However, the underlying biological mechanisms of this association remain unknown. This study investigated the relationship between genetic predisposition to neuroticism, computed by polygenic risk score (PRS), and performance in cognitive domains of reasoning, processing speed, visual attention, and memory in individuals over age 60. The sample consisted of UK Biobank participants with genetic and cognitive data available (N = 10,737, 4686 females; mean age = 63.4 ± 2.71). The cognitive domains were assessed at baseline for all participants and seven years later for a subset (N = 645, 262 females; mean age = 62.9 ± 2.44). Neuroticism PRS was not associated cross-sectionally with cognitive measures (p > 0.05). However, the trajectory of change for processing speed (β = 0.020; 95% CI = [0.006, 0.035], adjusted p = 0.0148), visual attention (β = −0.077; 95% CI = [−0.0985, −0.0553], adjusted p = 1.412 × 10−11), and memory (β = −0.033; 95% CI = [−0.0535, −0.0131], adjusted p = 0.005) was significantly associated with neuroticism PRS. Specifically, a higher genetic predisposition to neuroticism was associated with less decline in these cognitive domains. This trend persisted after sensitivity analysis using complete cases, although it only remained nominally significant for visual attention. [ABSTRACT FROM AUTHOR]

Our current understanding of the relationship between personality traits and subjective well-being, or happiness, is limited to the conceptualization of subjective well-being as being life satisfaction and a positive affective experience (i.e., the presence of positive emotions and the absence of negative ones), thus lacking the sense of acceptance, balance, adaptation, and self-transcendent unity (i.e., harmony in life) that is appreciated as part of the good life in many ancient and modern cultures. Moreover, most studies use the Big Five Model to understand which personality traits predict subjective well-being. Here, I examine the predictive power of personality on harmony in life using the Big Five Model, the Dark Triad, and Cloninger's Biopsychosocial Model. The present study utilized past published data from three cross-sectional studies. In each separate sample, participants self-reported personality by answering the Big Five Inventory (N1 = 297), the Short Dark Triad (N2 = 1876), or the Temperament and Character Inventory (N3 = 436). All participants (NTotal = 3698) answered to the Harmony in Life Scale. The traits in the Biopsychosocial Model explained the highest variance in harmony in life (R2 = 0.435, F(7, 428) = 47.136, p < 0.001), followed by the Big Five (R2 = 0.341, F(5, 291) = 30.110, p < 0.001) and the Dark Triad (R2 = 0.096, F(3, 1872) = 66.055, p < 0.001). The key significant predictors were Self-Directedness, Self-Transcendence, and Harm Avoidance from the Biopsychosocial Model and Agreeableness, Conscientiousness, and Neuroticism from the Big Five. Narcissism was the only predictor from the Dark Triad, although this relationship was very small. The findings underscore the importance of a multidimensional approach for understanding subjective well-being and the inclusion of harmony in life as its third component. The Biopsychosocial Model's inclusion of both temperament and character dimensions provided the most comprehensive understanding of harmony in life. While positive traits like Agreeableness, Self-Directedness, and Self-Transcendence enhance harmony, negative traits like Neuroticism and Harm Avoidance diminish it. Moreover, research only including "dark traits" might give the impression that an inflated sense of self-importance, a deep need for admiration, and a lack of empathy for others (i.e., Narcissism) is predictive of balance in life. However, this association was not only extremely low but can be interpreted as misguided since the results using the other models showed that helpful, empathetic, kind, and self-transcendent behavior predicted harmony. These results suggest that interventions aimed at enhancing well-being should consider a broad range of personality traits, especially those that are not present in the Big Five Model, thus advocating for a biopsychosocial approach to well-being interventions. [ABSTRACT FROM AUTHOR]

The qualifications of faculty members play a crucial role in the success of educational systems. Academics with a high level of organizational citizenship behaviour (OCB) are mostly valued due to the excellent services they offer to their students. This study aims to investigate the impact of faculty members' personality traits on their OCB. Additionally, it examines the moderating role of the perceived university brand in the relation between the two variables. This study is quantitative in nature and the sample includes professors working at seven prestigious Iranian universities. Overall, 422 questionnaires were gathered. By the use of Smart‐PLS, the results indicate that academic members with conscientious, agreeable and openness personality traits tend to show higher levels of OCB. On the flip side, neuroticism negatively predicts academics' OCB. Moreover, this research indicates that perceived university brand significantly moderates only the effect of openness trait on faculty members' OCB, meaning that professors with openness to experience traits who are working at such universities, are more likely to engage in OCB. [ABSTRACT FROM AUTHOR]

This study addresses a gap in the literature by exploring the longitudinal effects of hassles in mediating the relationship between neuroticism and the tripartite model of depression and anxiety. The research investigates these associations in a large sample of university students, utilising baseline and 6‐month follow‐up data. Initial assessments involved participants completing measures for neuroticism, depression and anxiety symptoms, and the occurrence of stress, followed by monthly assessments of stress, anxiety symptom and mood symptoms over a 6‐month period. Our results illuminate the mediating role of daily hassles in the relationship between neuroticism and various dimensions of anxiety and depression, including general distress, specific depression, and anxiety symptoms. These findings underscore the significant impact of neuroticism and hassles on a broad spectrum of mood symptoms, offering valuable insights for both research and clinical practice. Discussions around the implications of these findings are provided in the our paper, where we also outline potential directions for future research and clinical applications. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to assess the trajectory of women's depressive symptoms during the first six months postpartum, identify risk factors (sociodemographic, obstetric and personality) associated with classes, and examine associations between classes and postpartum PTSD at two months and bonding at six months. Methods: The final sample included 212 women who gave birth in the maternity wards of a large tertiary health center that were approached at 1–3 days, two months, and six months postpartum and completed a demographic questionnaire and measures of neuroticism (BFI) and postpartum depression (EPDS), postpartum PTSD (City Birth Trauma Scale) and bonding (PBQ). Obstetric data were taken from the medical files. Results: Cluster analysis revealed three distinctive clusters: "stable-low" (64.2%), "transient-decreasing" (25.9%), and "stable-high" (9.9%). Neuroticism, general-related PTSD symptoms, and bonding were associated with differences between all trajectories. Birth-related PTSD symptoms were associated with differences between both stable-high and transient-decreasing trajectories and the stable-low trajectory. No obstetric or demographic variables were associated with differences between trajectories. Conclusion: We suggest that screening women for vulnerabilities such as high levels of neuroticism and offering treatment can alleviate the possible deleterious effects of high-symptom depression trajectories that may be associated with their vulnerability. [ABSTRACT FROM AUTHOR]

Aim: This study aimed to explore the relationships between serum cortisol levels, personality traits, and the development of Post‐Traumatic Stress Disorder (PTSD) over 2 years among individuals with physical injuries. Methods: Participants were consecutively recruited from a trauma center and followed prospectively for 2 years. At baseline, serum cortisol levels were measured, and personality traits were categorized into five dimensions (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness), using the Big Five Inventory‐10. The diagnosis of PTSD during follow‐up (at 3, 6, 12, and 24 months post‐injury) was determined using the Clinician‐Administered PTSD Scale for DSM‐5. Binary and multinomial logistic regression analyses were conducted to examine the interactions between cortisol levels, personality traits, and PTSD development. Results: Among 923 patients analyzed, 112 (12.1%) were diagnosed with PTSD at some point during the study period, with prevalence rates decreasing from 8.8% at 3 months to 3.7% at 24 months post‐injury. Direct associations between cortisol levels or personality traits and PTSD were not observed. However, a significant interaction between lower cortisol levels and higher Neuroticism in relation to PTSD risk was identified, especially during the early follow‐up periods (3 to 6 months), but this association waned from the 12‐month follow‐up onward. Conclusion: Our findings reveal Neuroticism‐dependent associations between serum cortisol levels and PTSD development, exhibiting temporal variations. These results suggest that PTSD development may be influenced by a complex, time‐sensitive interplay of biological and psychosocial factors, underscoring the importance of considering individual differences in stress reactivity and personality in PTSD research and treatment. [ABSTRACT FROM AUTHOR]

Whether attending college, entering the workforce, or finding a romantic partner, single emerging adults navigate a pivotal stage of their lives. The present cross-sectional study sought to examine the heterogeneity in happiness of single emerging adults (N = 1,073) with a person-centered, group-differential approach. Using five predictors of life satisfaction (friendship satisfaction, family satisfaction, self-esteem, neuroticism, and extraversion) as indicators in latent profile analysis (LPA), we identified five distinct profiles (or groups) of young singles. The profiles, ordered from favorable to unfavorable indicator patterns, presented diverse shape and level differences that corresponded to varying happiness levels. Singles in Profile 1 with the most favorable indicator patterns (e.g., high friendship satisfaction, low neuroticism) were the happiest, while those in Profile 5 with the least favorable indicator patterns (e.g., low friendship satisfaction, high neuroticism) were the unhappiest. In the middle profiles, singles often offset disadvantages in one area (e.g., high neuroticism) with advantages in others (e.g., high friendship satisfaction) to achieve average to somewhat high levels of happiness. Importantly, friendship satisfaction emerged as a vital indicator, often distinguishing which singles were happy or not. Covariate analyses further validated the profiles and revealed additional profile differences (e.g., gender, anxiety, depression). Overall, our findings underscore the essential role of satisfying friendships in promoting the well-being of single emerging adults. [ABSTRACT FROM AUTHOR]

The present longitudinal study investigates the development of both positive and negative personal traits (i.e., self-esteem and neuroticism, respectively) among newlywed couples. The aim is to identify distinct joint trajectories of self-esteem and neuroticism and then compare marital quality across different trajectory classes. A sample of 268 Chinese newlyweds completed self-esteem, neuroticism, and marital quality questionnaires at three time points. Dyadic Latent Class Growth Analyses were used to examine the joint trajectory of self-esteem and neuroticism. The study identified three trajectory groups: the adaptive couples group (c1), the stable couples and husbands more adaptive than wives group (c2), and the stable husbands and wives more adaptive than husbands group (c3). The adaptive couples group had the highest level of initial marital quality. The two other groups, characterized by initial differences between partners in self-esteem and neuroticism, had relatively lower baseline marital quality. In comparison, wives in the c3 group initially displayed higher levels of marital quality than those in the c2 group. This research improves our understanding of personal development in couples and sheds light on the complex associations between personal and relational development in the context of marriage. [ABSTRACT FROM AUTHOR]

Purpose: Existing measures of rumination assess ruminative thought without reference to the content of ruminations. The present studies describe the construction and validation of the Rumination Domains Questionnaire, a new measure of rumination which considers the domain specificity of ruminative thought. Methods: A theoretical definition of rumination and domains of life were formulated through a literature review. Items were based on these domains, clinical/counselling case studies, and expert feedback. In Study 1, 106 preliminary items were reduced to 60 items through empirical analyses. In Study 2, the content and structural validity were assessed. Results: Items were retained based on empirical criteria and the final scale demonstrated acceptable fit for both a 10-factor model and a hierarchical model. Content validity and criterion validity were supported, and both 10-factor and hierarchical models demonstrated acceptable fit. Conclusions: Overall, we present strong evidence supporting the validity of the RDQ. [ABSTRACT FROM AUTHOR]

Purpose: Postpartum depression (PPD) brings adverse and serious consequences to both new parents and newborns. Neuroticism affects PPD, which remains controversial for confounding factors and reverse causality in cross-sectional research. Therefore, mendelian randomization (MR) study has been adopted to investigate their causal relationship. Methods: This study utilized large-scale genome-wide association study genetic pooled data from three major databases: the United Kingdom Biobank, the European Bioinformatics Institute, and the FinnGen databases. The causal analysis methods used inverse variance weighting (IVW). The weighted median, MR-Egger method, MR-PRESSO test, and the leave-one-out sensitivity test have been used to examine the results' robustness, heterogeneity, and horizontal pleiotropy. The fixed effect model yielded the results of meta-analysis. Results: In the IVW model, a meta-analysis of the MR study showed that neuroticism increased the risk of PPD (OR, 1.17; 95% CI, 1.11–1.25, p < 0.01). Reverse analysis showed that PPD could not genetically predict neuroticism. There was no significant heterogeneity or horizontal pleiotropy bias in this result. Conclusion: Our study suggests neuroticism is the risk factor for PPD from a gene perspective and PPD is not the risk factor for neuroticism. This finding may provide new insights into prevention and intervention strategies for PPD according to early detection of neuroticism. [ABSTRACT FROM AUTHOR]

Objective: The aim was to investigate psychological risk profiles of cardiovascular disease (CVD). Depression and anxiety have been linked to CVD, but research has not incorporated personality and sex-specific analyses are warranted. In this study, we examine the role of sex, neuroticism, extraversion, anxiety and depression on the risk of CVD. Method: Using data from the HUNT-study and the mortality register, 32,383 (57.10% men) participants were followed for an average of 10.48 years. During this time, 142 died of myocardial infarction (MI) and 111 of stroke. Results: Cox regression showed that depression (HR = 1.07, 95% CI = [1.00, 1.14]) and neuroticism (1.23 [1.08, 1.40]) were significantly related to an increased risk of MI. One standard unit increase in depression and neuroticism was associated with 1.22 [CI 1.01, 1.47] increase and 1.43 [CI 1.14, 0.78] increase in the risk of MI respectively. For stroke, there was no significant effect of anxiety, depression or personality. However, we found a significant interaction effect between sex and extraversion where higher extraversion was associated with greater risk of stroke for women only. Conclusions: Both neuroticism and depression were related to MI. We observed an interaction between extraversion and sex with stroke, but the effect size was small. The role of extroversion as a risk factor for CVD remains inconclusive. [ABSTRACT FROM AUTHOR]

The personality traits of top judo referees are crucial for fair decision-making in elite competitions, shaping the experience for athletes, coaches, and spectators. This study examines potential differences in personality traits among 63 referees from the World Judo Tour between 1 January 2018 and 31 December 2022. Factors analyzed include completing the IJF Academy course Level 1, elite athlete status, number of officiated events, performance ratings, and participation in the Olympic or Paralympic Games. Our research shows that older referees tend to exhibit greater extraversion, whereas less experienced officials show lower levels of this trait. Referees with limited experience generally demonstrate higher agreeableness than their more experienced counterparts. Female referees and those with top performance ratings display greater conscientiousness than male referees. Completing the IJF Academy course is associated with lower neuroticism, while lower performance ratings are linked to higher neuroticism. Openness tends to decrease with increased officiating experience, with less experienced referees showing higher levels of this trait. In conclusion, competitive experience, training completion, and officiating tenure are associated with specific personality traits among judo referees, highlighting the importance of continuous training for effective officiating. The analysis of personality traits revealed no statistically significant differences between male and female referees in the dimensions measured by the BFI (Big Five Inventory). This indicates that the levels of extraversion, agreeableness, conscientiousness, neuroticism, and openness were similar for both genders, with no significant variation in how these traits were expressed. [ABSTRACT FROM AUTHOR]

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This study aims to investigate the factors that contribute to internship stress among Vietnamese students by analyzing the associations between personality traits, internship stress, stress mindset, and demographics. A cross-sectional study design was utilized, comprising 149 Vietnamese students who were engaged in internship programs. The data gathering process encompassed the assessment of personality traits, internship stress levels, stress mindset, and participant demographics, which encompassed gender, age, GPA, and internship hours. We conducted path analyses to examine the relationships between these variables, and conducted moderation analyses to explore the interaction between age and the impact of extraversion on internship stress. Increased degrees of neuroticism were associated with a negative stress mindset, and this association was largely mediated by the stress experienced during an internship. Age moderated the negative association between the trait of extraversion and internship stress. More precisely, the association between extraversion and stress was significantly greater among younger students than it was among older students. Female students reported a lower stress mindset compared to male students, and higher GPAs were associated with both reduced internship stress and a more optimistic stress mindset. The results indicate that specific personality traits, such as neuroticism and extraversion, as well as internship stress, have a notable impact on the stress mindset of Vietnamese students. Gaining insight into these aspects can guide the development of internship programs that provide greater support and equip students with specific coping methods to enhance their well-being and manage internship difficulties more efficiently. [ABSTRACT FROM AUTHOR]

In observational studies, a significant association between neurotic personality and bipolar disorder (BD) has been observed, but it remains unclear. Additionally, current genetic studies have primarily utilized a sum score of psychological traits, only focusing on variants that affect the majority of aggregated items. Here, we aim to leverage recent large-scale genome-wide association studies (GWAS) to investigate the causal connection between neuroticism items and BD. This study employs Mendelian randomization to investigate the bidirectional association between specific items used to measure the neuroticism and BD. Neuroticism items' genome-wide association study (GWAS) data were obtained from the EBI database, while BD GWAS data were sourced from the Psychiatric Genomics Consortium (PGC). The main analytical method in this study was inverse variance weighted (IVW) method. Our findings indicating that specific neuroticism items (feeling tense, feeling hurt, and feeling lonely) have a potential association with BD. Additionally, individuals often exhibit changes in personality after developing the disease, becoming more prone to feeling tense, hurt, and experiencing emotional fluctuations. Overall, our research provides evidence of a bidirectional relationship between neuroticism items and BD. These findings highlight the genetic complexity of BD, which may be influenced by the genetic structure of individual neuroticism subscale items. It also uncovering the biological basis behind complex psychological and behavioral traits, and providing new perspectives and methods for clinical interventions and treatments. [ABSTRACT FROM AUTHOR]

Objective: The present study aimed to model the structural relationships between personality traits (neuroticism and openness) and mental health with the mediating role of social support among students. Methods and Materials: The research method was fundamental in terms of purpose and correlational in terms of method, specifically using structural equation modeling. The statistical population included all students of Islamic Azad University, Sari branch, in the 2023-2024 academic year, totaling 5,400 individuals. Using Kline's method and a non-random (available) sampling method, 269 individuals were selected as the sample. After explaining the research by the investigator and obtaining the respondents' willingness to participate, the NEO Five-Factor Inventory (NEO-FFI) (McCrae & Costa, 1992), the 28-item General Health Questionnaire (GHQ-28) (Goldberg, 1972), and the Perceived Social Support Questionnaire (Zimet, 1988) were administered. For data analysis, both descriptive (dispersion index, central tendency index, mean, and standard deviation, data normalization) and inferential (structural equations) statistical methods were used. Findings: The results showed that the two personality traits of neuroticism and openness have a direct effect on mental health. Additionally, the personality traits of openness and neuroticism have an indirect effect on mental health through the mediation of social support. Furthermore, the findings indicated that 59% of mental health can be explained by personality traits and social support in direct and indirect pathways (R² = 0.59). Specifically, the personality trait of neuroticism has a 31% direct effect on mental health, and neuroticism with the mediation of social support has a 37% indirect effect on mental health among students. The findings also showed that 12% of mental health can be explained by the variables of neuroticism and social support in direct and indirect pathways (R² = 0.12). Additionally, the results indicated that the personality trait of openness has a 15% direct effect on mental health, and openness with the mediation of social support has a 26% indirect effect on mental health among students. The findings further suggested that 3% of mental health can be explained by the variables of extraversion and social support in direct and indirect pathways (R² = 0.03). Conclusion: The results indicated that the personality traits of neuroticism and openness have a significant direct effect on mental health; and that these traits, through the mediating role of social support, have an indirect effect on mental health. [ABSTRACT FROM AUTHOR]

PCSK9-inhibitors (PCSK9i) are new drugs recently approved to lower LDL-cholesterol levels. However, due to the lack of long-term clinical data, the potential adverse effects of long-term use are still unknown. The PCSK9 genetic locus has been recently implicated in mood disorders and hence we wanted to assess if the effect of PCSK9i that block the PCSK9 protein can lead to an increase in the incidence of mood disorders. We used genetically-reduced PCSK9 protein levels (pQTLs) in plasma, serum, cerebrospinal fluid as a proxy for the effect of PCSK9i. We performed Mendelian randomization analyses using PCSK9 levels as exposure and mood disorder traits major depressive disorder, mood instability, and neuroticism score as outcomes. We find no association of PCSK9 levels with mood disorder traits in serum, plasma, and cerebrospinal fluid. We can conclude that genetically proxied on-target effect of pharmacological PCSK9 inhibition is unlikely to contribute to mood disorders. [ABSTRACT FROM AUTHOR]

AbstractPurposeMethodsResultsConclusionWhile some studies have started to focus on the link between psychological well-being and age-related macular degeneration (AMD), the relationship remains uncertain. Our research aims to provide new insights into this association, laying a foundation for future interventions and addressing existing knowledge gaps.We utilized the “TwoSampleMR” package in R for a bidirectional Mendelian randomization analysis of psychological well-being (subjective well-being, depression, neuroticism, and Sensitivity to Environmental Stress and Adversity) and early-stage AMD. Causal effects were estimated using the inverse-variance weighted method, and additional methods included weighted median and MR-Egger regression. Sensitivity analyses included Cochran’s Q test, MR-Egger intercept analysis, MR-PRESSO, and leave-one-out analysis.The study found that the population with genetic predisposition to neuroticism had a 39.7% lower risk of early-stage AMD (OR = 0.603, 95% CI = 0.385–0.945, p = 0.027). Conversely, the population with genetic predisposition to subjective well-being had a 3.2% increased risk of early-stage AMD (OR = 1.032, 95% CI = 1.003–1.063, p = 0.029). No significant causal relationships were found from depression or Sensitivity to Environmental Stress and Adversity to early-stage AMD, nor from early-stage AMD to psychological well-being.This study provides preliminary evidence that the relationship between psychological well-being and early-stage AMD may be complex and multifaceted. It suggests that moderate neuroticism levels might reduce early-stage AMD risk through health behaviors, pathophysiological mechanisms, and other factors, while high subjective well-being levels might increase this risk similarly. However, these findings are insufficient for preventive strategies due to a lack of substantial evidence and still require extensive experimental research for further validation. [ABSTRACT FROM AUTHOR]

Striving towards perfection is an important concept of study, given its heterogenous associations with both positive and negative outcomes. To address this matter, recent work has emphasized the need to differentiate between striving towards perfection (perfectionism) and excellence (excellencism). However, the applicability of this differentiation in adolescence remains largely unexplored, despite this life phase being particularly sensitive for the development of perfectionism. To better understand striving towards perfection in adolescence, we examined the psychometric properties of the German Scale of Perfectionism and Excellencism (SCOPE) and evaluated the nomological net with the Big Five and self‐esteem in 788 German adolescents (Mage = 15.49 years; 50% female). The results underscored the distinctiveness of the different strivings in adolescents but pointed to mixed evidence regarding convergent and discriminant validities. Notably, striving towards perfection was related to lower levels of openness and self‐esteem but higher levels of neuroticism, whereas striving towards excellence was related to higher levels of every trait except neuroticism. Finally, most results remained consistent across genders and school types. We discuss how the differentiation between perfectionism and excellencism deepens our understanding of adolescents' perfectionistic strivings and how it might inform future research across different psychological fields. [ABSTRACT FROM AUTHOR]

Purpose: Social media (SM) has become a common activity for today's young people. It is sometimes overused and potentially results in SM addiction. This study aims to assess SM addiction and its associated factors in medical students and to examine its relationship with dimensions of personality global selfesteem, and social self-esteem. Materials and methods: We carried out a cross-sectional study among a sample of medical students in the region of Sfax in Tunisia. Social Media Addiction Scale-Student Form (SMAS-SF), Big Five Inventory, Rosenberg Self-Esteem Scale, and Social Self-Esteem Inventory were used to collect data. Results: Overall, 116 medical students were included in the survey. The median age of the participants was 26 years, and 91 students (78.4%) were female. Almost half of them (55.20%) were enrolled in the third cycle. The most widely used SM was Facebook (98.3%). Students with the highest SMAS-SF scores had a significantly younger age of first use (p=0.011, r=-0.235), spent more time on their favorite SM (p=0.005, r=0.260), and performed more activities on SM, namely: making comments (p=0.005), browsing SM profiles (p=0.018), and posting videos (p=0.007) or pictures (p=0.002). The need to establish an identity was significantly associated with higher SMAS-SF scores (p=0.011). We also found that neuroticism and a low level of conscientiousness were linked to high SMAS-SF scores (p=0.006, r=0.252 and p=0.050, r=-0.183, respectively). Moreover, high SMAS-SF scores were significantly related to lower global and social self-esteem scores (p=0.015, r=-0.226 and p=0.032, r=-0.199, respectively). Conclusion: Our results highlight the critical need to take into consideration the evaluation and intervention of self-esteem and personality dimensional issues to target interventions for SM addiction among medical students. [ABSTRACT FROM AUTHOR]

Values and personality are interrelated, multifactorial constructs that represent different aspects of the Self. The intricate relationships between personality and value have seldom been explored using appropriate person-centered approaches. In this study, latent profile analyses were performed to examine the personality-value relationships of 2886 Chinese adolescents as measured by established inventories. The LPA results for the five-factor personality traits of neuroticism, openness, extraversion, agreeableness, and conscientiousness yielded four distinct profiles: "Reserved and Undependable" (4.26%), "Sunny but Self-centered" (5.02%), "Emotional but Cooperative" (18.57%), and "Average" (72.14%). The LPA results for the eight-factor values of egalitarianism, collectivism, compliance, family, friendship, self-transcendence, fashion, and hedonism yielded three distinct profiles: "Rebels" (32.92%), "Moderates" (42.86%), and "Role Models" (24.22%). Subsequent analyses revealed significant associations between the personality profiles and the value profiles. Specifically, the "Reserved and Undependable" tended to associate with the "Rebels," whereas the "Emotional but Cooperative" tended to associate with the "Role Models." Besides, the findings also uncovered the rebellious and apathetic tendencies among Chinese adolescents. Research implications and future directions were discussed. [ABSTRACT FROM AUTHOR]

AbstractThe aim of the study was to understand the role of transdiagnostic vulnerabilities, namely intolerance of uncertainty (IU) and neuroticism, in initiating safety-seeking preparatory behaviors under the threat of an imminent war. A sample of N = 1460 adults were recruited via convenience sampling in March 2022, after the outbreak of the Russia-Ukraine war from nearing countries. Due to the lack of suitable measures in the literature to cover the phenomenon, first a short inventory for measuring these safety actions, the War-Related Preparatory Safety-Seeking Inventory (W-PRESS) was elaborated and validated via Item Response Theory. Next, a transdiagnostic cognitive behavioral framework was proposed for the determinants of W-PRESS: IU (IUS-12), fear of war (FoW), neuroticism (Big-Five), and anxiety (DASS). The SEM results confirmed the proposed model. A strong positive relationship was found of both IU and neuroticism with anxiety, FoW, and W-PRESS. Higher neuroticism was associated with higher W-PRESS, fully mediated by IU. IU also partially mediated the relationship of neuroticism with anxiety and FoW, respectively. In contextual uncertainty evoked by the outbreak of the nearby war, dispositional vulnerabilities, like IU and neuroticism may enhance the individual level of crisis management in the sense of preparing for and dealing with emerging risks. [ABSTRACT FROM AUTHOR]

Data on the relationship between personality traits and athletes' level of sportsmanship are not sufficiently documented. Therefore, it is reasonable to look for differences in personality traits between athletes from different levels: amateur, competitive and professional, as these groups of athletes function differently on a daily basis. Therefore, the aim of this article was to gain knowledge about the relationship between personality traits and the sporting level of athletes. The experiment examined male and female athletes (N = 119) aged 19-34, including 100 Polish professional athletes: 30 basketball players, 40 football players, 30 kyokushin style karate competitors; and 19 professional athletes (among them were the elite: 3 Olympic medallists): 4-person Polish Biathlon Team, 7-person Polish Luge Team, 8-person Swiss Mountain Bike (MTB) Team. The NEO-FFI Personality Questionnaire was used. Analyses were performed with the IBM SPSS Statistics 29.0 package at a statistical significance of a = 0.05. Significant differences were found in comparisons between groups of athletes: football players and karate competitors (in severity of neuroticism, extraversion, agreeableness, conscientiousness), football players and basketball players (in severity of neuroticism, extraversion, openness to experience, conscientiousness), football players and lugers (in severity of agreeableness), football players and mountain bikers (in severity of neuroticism). One significant difference was noted in the comparisons between athletes from different levels: competitive athletes had higher neuroticism severity than elite athletes. A weak and negative correlation between neuroticism and sporting levels was verified. But no correlation was shown between personality traits and the likelihood of becoming a professional. It was concluded that the observed differences between the studied groups of athletes could be derived from the specifics of the different sports. The elite are characterised by a lower intensity of neuroticism in relation to the competitive athletes, which can be seen in the relationship: the lower the neuroticism, the higher the sporting level. [ABSTRACT FROM AUTHOR]

Depression and anxiety are highly prevalent around the world. Previous research mainly adopted variable-centered analyses, which overlooked different latent patterns. Moreover, few studies focused on the comorbidity patterns and risk factors of depression and anxiety within the Chinese context. This study aims to explore the comorbidity patterns of depression and anxiety among psychiatric patients in China and examine the potential predictors of their severity categorization. We recruited 282 patients diagnosed with depression and/or anxiety in China and used questionnaires to collect data. Latent Profile Analysis (LPA) was employed to identify subgroups within the sample. Subsequently, we used multinomial logistic regression to explore the factors predicting those subgroups. The LPA results revealed three subgroups: Mild Symptoms Group, Moderate Symptoms Group, and Severe Symptoms Group. The regression results indicated that poor family function, high neuroticism, and rumination were significant predictors of classification into more severe symptom groups. The findings suggest that clinicians should assess patients more accurately and implement tailored interventions based on the severity levels of the patients. [ABSTRACT FROM AUTHOR]

AbstractBased on Aron’s (2020) DOES model, we developed the DOES Scale to measure Sensory Processing Sensitivity (SPS) with four dimensions: Depth of Processing, Overstimulation, Emotional Reactivity, and Sensing the Subtle. Using interview data from the study by Roth et al. (2023), we created a 20-item questionnaire (5 items per dimension) in German and English. In three studies with 1,365 subjects from Switzerland, Germany, Austria, and the UK, we evaluated the psychometric properties of the scale using confirmatory factor analysis and examined construct validity with the established Highly Sensitive Person Scale (HSPS) and different personality measures. The results confirmed each subscale’s unidimensionality and good psychometric properties. Considering the four subscales together indicated that they could be best described as correlated factors rather than in terms of a second-order factor. Convergent validity was confirmed, especially for Overstimulation in its association with the HSPS total score and its subscales EOE and LST. Regarding discriminant validity, the Sensing the Subtle dimension exhibited clear distinctiveness, while the other three subscales overlapped with neuroticism, extraversion, empathy, and rumination, aligning with theoretical expectations. The DOES Scale emerges as a reliable, valid tool for assessing SPS, recommending its four dimensions be interpreted as a trait constellation. [ABSTRACT FROM AUTHOR]