1. Nonwoven Carboxylated Agarose-Based Fiber Meshes with Antimicrobial Properties
- Author
-
Aurelien Forget, Rotsiniaina Randriantsilefisoa, Daniel Jonas, Florian Miessmer, V. Prasad Shastri, Marion Buck, Vincent Ahmadi, Anton Blencowe, Neha Arya, Forget, Aurelien, Arya, Neha, Randriantsilefisoa, Rotsiniaina, Miessmer, Florian, Buck, Marion, Ahmadi, Vincent, Jonas, Daniel, Blencowe, Anton, and Shastri, V Prasad
- Subjects
Staphylococcus aureus ,antimicrobial properties ,Polymers and Plastics ,polysaccharides ,Carboxylic Acids ,Nanofibers ,Bioengineering ,Microbial Sensitivity Tests ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Hydrogel, Polyethylene Glycol Dimethacrylate ,Biomaterials ,chemistry.chemical_compound ,Adsorption ,Polymer chemistry ,Materials Chemistry ,medicine ,Solubility ,Elastic modulus ,nonwoven carboxylated agarose-based fiber meshes ,integumentary system ,Sepharose ,021001 nanoscience & nanotechnology ,Electrospinning ,Anti-Bacterial Agents ,0104 chemical sciences ,chemistry ,Chemical engineering ,Pseudomonas aeruginosa ,Drug delivery ,Ionic liquid ,Agarose ,Swelling ,medicine.symptom ,0210 nano-technology - Abstract
Hydrogel forming polysaccharides, such as the seaweed derived agarose, are well suited for wound dressing applications as they have excellent cell and soft tissue compatibility. For wound dressings, fibrous structure is desirable as the high surface area can favor adsorption of wound exudate and promote drug delivery. Although electrospinning offers a straightforward means to produce nonwoven fibrous polymeric structures, processing agarose and its derivatives into fibers through electrospinning is challenging as it has limited solubility in solvents other than water. In this study we describe the processing of carboxylated agarose (CA) fibers with antibacterial properties by electrospinning from a solution of the ionic liquid (IL) 1-butyl-3-methylimidazolium chloride ([Bmim]+Cl-) possessing antimicrobial properties. The extent of carboxylation was found to impact fiber diameter, mesh elastic modulus, fiber swelling, and the loading and release of IL. IL-bearing CA fibers inhibited the growth of Staphylococcus aureus and Pseudomonas aeruginosa, bacteria commonly found in wound exudate. In sum, nonwoven CA fibers processed from IL are promising as biomaterials for wound dressing applications. Refereed/Peer-reviewed
- Published
- 2016
- Full Text
- View/download PDF