Search

The intention of my diploma thesis was estimate the effective doses from different examinations in the area of the nuclear medicine and radiodiagnosis and find out what numbers are of the examinations in the Czech republic. In the theoretical part I worked with the professional literature, the applicable legal regulations and the internet links. The diploma thesis on the topic "Estimation of average doses of the population of the Czech republic from medical sources" is partition to the two parts. The introductory part of the theoretical work is dedicated to the importance of medical radiation within radiological methods and to the brief description the whole thesis. In the other part od the thesis are summarized the informations about the ionizing radiation - about his history, species, sources, interactions with the environment and biological effects on the organism. In the other part of the thesis which is devoted to radiation protection is listed the basic czech legislation which relates on the given topic. Further are in this thesis within the radiation protection listed her objectives, conception, principles, radiation protection methods, radiation monitoring and basic monitored quantities which are important in terms of the radiation protection. In the last part of the theoretical thesis is listed the medical radiation and his possibilities of use in the medical. In this thesis were to established three objectives. The first objective was to estimate the average effective doses in various examinations in the nuclear medicine and the radiodiagnosis. For selected examinations was calculated the average effective dose for patients who underwent the selected examination in January 2022. In the framework of nuclear medicine, it was an skeletal scintigraphy (96 patients), myocardial perfusion scintigraphy (51 patients), perfusion and ventilation lung scintigraphy (166 patients) and dynamic renal scintigraphy (12 patients). The results of these examinations were compared with data listed in UNSCEAR Report 2020/2021. In the famework of the radiodiagnosis, it was an CT brain natively (226 patients), abdominal CT natively (91 patients), CT chest native (33 patients) and CT of the lumbrar spine natively (46 patients). The results of these examinations were compared with data listed in UNSCEAR Report 2020/2021 and the results listed in the document "Medical radiation assessment" released by the SÚJB in the year 2021. The second objective was to find out how are numbers of examinations mentioned above in Czech republic. For this purpose I was provided with data from ÚZIS. Within this objective were estimated the collective effective doses. The third objective was estimated the relative probability of emergence of stochastic effects (the cancer). For this purpose was used the program named X-ray risk.

Radiation protection in pediatric patients is a very current topic as the use of ionizing radiation in children's medicine is an integral part of the diagnosis or treatment of many diseases. International attention is paid to radiosensitivity in children. This is because a child's organism is much more sensitive to radiation than an adult's, and many parents are afraid of exposing their child to the risks of ionizing radiation. It may also happen that they may refuse the examination, but consistent and understandable communication between experts and parents can contribute to greater trust and mental peace of both the parents and their child patient. In the theoretical part, the problem of ionizing radiation, its effects on the human organism and the use of ionizing radiation in medicine, specifically in examinations at the nuclear medicine department, are described. The diploma thesis is focused on the risks in pediatric patients who undergo an examination in which ionizing radiation is used. The main goal of the diploma thesis is to emphasize the importance of ionizing radiation in medicine and to find out how communication between parents and a specialist takes place before the examination. It also appeals to the positive benefits of the examination outweighing the risks. A part of the research investigation is to find out whether parents are aware of the examination their child is undergoing and whether it contributes to alleviating their fears about the application of ionizing radiation. The research part is processed in the form of a questionnaire survey with the parents of child patients and interviews with experts in nuclear medicine.

The topic of this bachelor thesis is "Dependence of noise in the PET image of the liver on the applied activity, weight and BMI of the patient". Positron emission tomography (PET) is currently one of the most widely used examinations in the field of oncological diseases. The goal of the bachelor thesis is to monitor the noise in the PET image of the liver during positron emission tomography (PET) with FDG (fluorodeoxyglucose) depending on the applied activity, weight and BMI of the patient. Another goal of this work is to propose an alternative algorithm taking into account BMI in order to maintain the image quality and reduce the radiation exposure associated with the examination in addition to the existing algorithm for determining the activity of the applied amount of FDG based purely on patient weight. In connection with these goals, a hypothesis was developed where, taking into account the patient's BMI in determining the activity of the applied amount of FDG, the radiation exposure associated with the examination can be reduced while maintaining the noise level. In the introduction to this bachelor's thesis, I focused on a detailed description of the principle of the PET imaging method, it´s construction and everything associated with the PET imaging method. A substantial part of the theory of this work is occupied by information related to the quality of the PET image, especially the noise level. I also specified the individual radiopharmaceuticals used in the field of PET and I focused more attention on the radiopharmaceutical FDG, which is crucial for this work. Part of this bachelor thesis also deals with the applied activity and the elements related to it, is weight and BMI. In the last part of the bachelor thesis I focused on the description of the hybrid PET / CT method. The practical part was focused on quantitative research. For this research, it was first determined what parameters will need to be found for the processing of the practical part and then data were collected from patients examined by FDG PET / CT at the PET center in the Hospital of České Budějovice a.s. for the calendar year 2021. This data was then graphically plotted and finally used for analysis. In addition to the dependence of noise on patient weight, a representation of weight on patient BMI was created. The results of the practical part showed that the noise is affected by the applied activity, weight and BMI of the patient and based on further analysis, the initial hypothesis was confirmed. The final results of this work can be further used to optimize the examination protocol in the PET center of the Hospital of České Budějovice a.s.

Currently, there is not available educational text on the subject of sources and interactions of ionizing radiation in nuclear medicine that would be adequate to the physics knowledge of students in the field of Radiologic Assistant and other related disciplines. In this thesis, there was an attempt to create a comprehensive educational text on the basis of the application of curricular process theory, which discusses the radionuclide diagnostics and therapy for radiologic assistants and other related disciplines on the basis of an analysis of the current state of scientific knowledge in the examined area. The chosen topic is described in the theoretical part of this thesis and it was adjusted for the selected group of respondents in a form of the educational text. The intelligibility of educational text was verified by the statistic research using a questionnaire survey that respects the educational text and it was presented to the students in the field of Radiological Assistant.

This bachelor thesis compares two of the main examination methods in nuclear medicine, which are SPECT and the whole body scintigraphy of the skeleton. At the whole body scintigraphy of the skeleton, some structures may overlap at different depths and thus they are not detectable. Whereas with SPECT these structures are displayed separately, their anatomical orientation is refined and the contrast of the focuses is increased. Experience shows, that number of pathological focuses, which are very well recognisable in the skeleton on the SPECT, may not be detected whatsoever or are poorly anatomically defined on the scintigraphic planar image. One research question is asked in this work: "In what percentage did SPECT brings new findings compared to the whole-body skeletal scintigraphy?" The given goal was fulfilled and the reasearch question was answerd. Images of anonymous patients with SPECT examination and whole-body scintigraphy of skeleton are used for the research, to compare the findings from the department of nuclear medicine at the hospital of České Budějovice.

In the thesis, we developed and studied a novel polymer delivery system for the DNA-intercalator bearing radioisotope iodine-125. Auger electrons emitting radioisotopes (such as iodine-125 or indium-111) are a potentially effective cancer treatment. Their use as an effective cancer therapy requires that they will be transported within close proximity of DNA, where they induce double-strand breaks leading to the cell death. This type of therapy may be even more beneficial when associated with drug delivery systems. The DNA intercalators proved to be effective carriers for the delivery of Auger electron emitters into DNA. Therefore, the new radioiodinated DNA-intercalating ellipticinium derivatives were synthesized and characterized. These compounds were linked to N-(2-hydroxypropyl) methacrylamide copolymer with narrow molecular weight distribution via acid-sensitive hydrazone linker. The structure of the linker plays a crucial role in the biological effectivity of the delivery system, so it was optimized to be stable at pH 7.4 (representing the pH of blood plasma), whereas in slightly acidic pH in endosomes after the cell internalization, the radioiodine-containing biologically active intercalator is rapidly released from its polymer carrier. The intercalating ability of the active compound was...

This thesis is focused on complications at PET/CT examinations. The complications at these examinations are either processes which complicate the progress of examination within the meaning of affection of the quality of outcome efficiency or health complications as the linear after effect of PET/CT examination. In the first example it concerns of uncooperative patients with the excessive movements during examination or complicated venous acces for giving off intravenous screening substances. In the second example the most substantial complications are allergic reaction after delivery of jodinate contrasti substance. The object of this work was to follow complications at PET/CT examinations at the department of nuclear medicine of hostpital in České Budějovice, a.s. (here in after NEMČB), to do their analysis and in case of possibilities to suggest some systemic preventive measures. At the teoretical part of work I foccused on basic information about PET/CT device, the process of examination and all the facts related with it. At the description of particular complications I used my experience from the internship directly at the department of nuclear medicine at the NEMČB. Based on the inspection of actual state of affairs was set the hypothesis: 1. The most frequent complication at the PET/CT examinations are caused by the patients who do not cooperate. For the practical part was undertaken quantitative analysis. Data acquisition was done at the department of nuclear medicine of NEMČB by analysis of documentation of performed examinations in the term from January 2019 to June 2019. Datas were found out from application documents, the complications were then divided into four categories similarly teoretical part. Datas were statisticaly and graphicaly processed. The results of the work is possible to use as a basis for better quality of screening processes at the department of nuclear medicine and equally as the study material.

The most widely used emitter in positron emission tomography is the fluorine isotope 18 F, which can bind to a number of atoms, and thus allows the formation of imaging agents for positron emission tomography. This work will summarize methods for labeling complexes containing aluminum or gallium as a central cation, which can serve as stable carriers of the positron emitter in a human body. Both of these elements have unique physical and chemical properties suitable for molecular imaging. Therefore the development of complex labeling, their structure, coordination environment and some applications in nuclear medicine will be described here.

The bachelor thesis deals with the preparation of radiopharmaceuticals for the department of nuclear medicine. The theoretical part describes the basic terminology related to radiopharmaceuticals, their production, acquisition, methods of preparation or dosage forms in which they are applied. Part of the work is also devoted to no less important effects of ionizing radiation and protection against it, which is related to the preparation of radiopharmaceuticals. The theoretical part is processed from professional publications, articles and websites in the form of literary review. The aim of this thesis was to describe the preparation of most used individual radiopharmaceuticals for certain examinations at the Department of Nuclear Medicine of the Hospital of České Budějovice, a.s. This aim was fulfilled in the practical part, where were described the individual radiopharmaceuticals, the detailed procedure of their preparation and the principles of their storage. The practical part also includes requirements for workplace equipment, cleanliness of the operational environment (clean room construction, cleanliness classes, air conditioning, requirements for workers and their work, which is based on aseptic work procedures and the principles of radiation protection. The work contributes to the knowledge of the operation and equipment of the workplace and the requirements placed on it, as well as to the understanding of the preparation of individual radiopharmaceuticals at the department of preparation of radiopharmaceuticals. The work is conceived as an educational text especially for students and staff of the field of radiology assistant. I also focused on outlining the operation and layout of the OPR, the requirements for work in this department, which is based on aseptic work and protection against ionizing radiation. Both research questions were fullfiled by this. This work can be, in my opinion, used as an educational text especially for students and staff of the field of radiology assistant.

The thesis deals with the radiation load on the staff at the Department of Nuclear Medicine in České Budějovice Hospital Plc. Its aim is to compare the radiation load on the staff of the Department of Nuclear Medicine of České Budějovice Hospital Plc before and after the installation of PET/CT gadget. My thesis includes a hypothesis in which I suppose that the radiation load of radiation has risen after the installation of the new gadget. To meet the target and verify the hypothesis I used the data which have been provided by the Department of Nuclear Medicine of České Budějovice Hospital Plc. I put the data into charts and made their graphic design. The data show that the overall radiation load on the staff has decreased thanks to the increased protection against radiation. New protection aids and gadgets have been bought to make the application of radiopharmaceuticals easier. The result of my thesis disproves the hypothesis set before the beginning of my thesis. My thesis has provided the staff of the Department of Nuclear Medicine of České Budějovice Hospital Plc with an overview of collective dosage within six years, which I recorded. By the disproof of my original hypothesis it has been acknowledged that the Hospital and the Department of Nuclear Medicine secured its staff and started to pay more attention to the protection against radiation.

The objective of the present Bachelor thesis is to determine normal values of the ratio of activity in the Region of Interest (ROI) of a healthy kidney in the 30th minute of the examination compared to the 2nd - 3 rd minutes in patients up to 18 years of age at the Nuclear Medicine Department in České Budějovice. For the purposes of comparison, values of the ratio of activity in ROI of the kidney in the 30th minute are compared with the peak in the same patients. Dynamic kidney scintigraphy with 99mTc-MAG3, generally modified by a furosemide test, is carried out in case of child patients with respect to whom simple dilatation of the pelvicalyceal system must be distinguished from obstruction. A set of 35 patients at the age of 0-18 was selected for the purposes of statistical processing in the period from 01 January 2018 to 13 November 2018, whereupon these patients underwent dynamic kidney scintigraphy with 99mTc-MAG3. As a result, 47 usable renal units were obtained. Renal units with pathological findings were removed from the set. In these renal units, the ratio of activity 30th min./3rd min. and the ratio 30th min./peak were observed. For comparison, the total of 4 selective statistical sets (VSS) were formed - a group of patients at the age of 0-18 and a more restricted group of patients at the age of 0-10 years for both ratios of activity. The collected data were subsequently used for parametric testing. The contribution of this thesis consists in the determination of normal values of the ratio of activity 30th minute/2nd - 3 rd minutes, which will be useful in differentiating mild dilatation from other pathological conditions (obstruction, reductions in function, etc.) in patients examined by dynamic kidney scintigraphy at the Nuclear Medicine Department in České Budějovice. The elementary static processing implies that normal values of the ratio of activity 30th min./3rd min. oscillate in the interval of values (0.058; 0.238) in patients up to 18 years of age, and in the interval (0,05; 0.27) in patients up to 10 years of age. For the sake of comparison, values of the ratio of activity 30th min./peak oscillate in the interval of values (0,026; 0.246) in patients up to 18 years of age, and in the interval (0.04; 0.26) in case of patients up to 10 years of age. It may be stated that values of ratios of activity 30th min./3rd min. and 30th min./peak are approximately comparable. Based on the applied double-selection t-test, the zero hypothesis was adopted, meaning that the selective statistical sets originate from the same basic statistical set on the given significance level.

The objective of this bachelor thesis is to answer the following research question: "What is the extent of normal values of Technetium-99m accumulation in the thyroid gland?" I gained the answer by collecting data and subsequently assessing results of static scintigraphy of thyroid gland examined in 34 patients at the Department of Nuclear Medicine in the hospital Nemocnice České Budějovice. The reference file of patients was collected from January to December 2017. On the basis of clinical data on the examination request form, the supervisor excluded results that showed symptoms of hypothyroidism, hyperthyroidism or thyroiditis. The anatomy and physiology of the thyroid gland and parathyroid glands are described in the introduction of the theoretical part of the bachelor thesis. The following chapter characterizes thyroid disorders. The last chapter describes the examination of thyroid gland using methods of nuclear medicine, check-up, radiopharmaceutical drugs used and making and processing an image. The practical part describes the procedure of elaborating my bachelor thesis at the Department of Nuclear Medicine in the hospital Nemocnice České Budějovice. There I worked with evaluating computer program Xeleris with the Thyroid Uptake Index application. I plotted the region of interest around the thyroid gland manually and calculated the value of accumulation in the thyroid gland with a programme. I processed the gained values statistically using formulas to count the average, standard deviation and percentile in Microsoft Excel. I fixed the percentile for 10 % and 90 %. Calculations show that a normal value of Technetium-99m accumulation in the thyroid gland ranges from 0.4 % to 1.8 % and the average is 0.85 %. This work can serve as evaluation of normal values of accumulation during examining thyroid gland at departments of nuclear medicine.

Bachelor thesis is divided into theoretical and practical part. The theoretical part is about the details of the work of the departments, which include x-ray, nuclear medicine and radiotherapy. The entire work is supplemented by my own photographs, as well as photographs from public information sources. There is also a brief history of radiology. I also stated the most important personalities of this scope and their inventions. Next, I put in the work tables and charts from the Institute of Health Information and Statistics of the Czech Republic and compared them with my results. In the practical section, I focused on creating questionnaires for doctors and radiology assistants. These questionnaires were designed for employees of branches RTG, NUM and RTO. For physicians was prepared 12 questions and for radiological assistants 14 questions. Respondents answered in the form of a check mark one or more responses. There are also questions, where the answer must be indicated in written form. Then were the collected results sorted into the different categories according to the scope. Then I transferred the resulting data in a graphical form. At the end of the practical part I commented on the data and added my own opinions and insights. The survey was carried out in the form of personally or electronic distributing the questionnaires to individual hospitals throughout the Czech Republic. The results were then delivered to me by a mail or I had to go for them into concrete hospitals personally. It depended on the willingness of a particular hospital. The work will be used for educational purposes and to raise awareness among university students and professional public.

Nuclear medicine is a medical discipline, that deals with investigational and treatment methods, used by open radioactive emitters - known as radiopharmaceuticals. At present, the methods of nuclear medicine are very used and constantly developing. This bachelor's thesis is divided into a theoretical and an empirical part. The theoretical part of the work contains the requirements for knowledge of nurses working at the nuclear medicine ward. This section discusses particularly the ionizing radiation, its biological effects, methods of nuclear medicine and, of course, radiopharmaceuticals. In this part are mentioned also the educational opportunities for nurses, which are focused mainly on postgraduate education. An important part of the nurse's work is the protection against the ionizing radiation, in this work we consider the protection of nurses and patients. In the last segment are described the most common procedures of examination and some techniques of treatment in nuclear medicine. The empirical piece of work has been processed through a qualitative approach by the help of a semi-structured interview. The interviews were conducted with nurses working at the department of nuclear medicine. The informations obtained from the nurses were analyzed and subsequently categorized. In the context of the exploratory research, was set the goal - to map the specifics of the nurse's work at the department of nuclear medicine. The results of the research survey showed, what are the specifics of the nurse's work at the nuclear medicine's department. Among the specifics of the nurse's work belongs especially theoretical knowledge, the machine operating, the preparation for actual examination and its execution, providing informations and the associated protection from ionizing radiation. The results also pointed to the lack of opportunities nurses have for education in the area of nuclear medicine and told of their satisfaction from working at this department.

Copper radionuclides possess physical properties suitable for utilization in nuclear medicine. Important part of their preparation is separation from mother elements, usually zinc or nickel. Currently used methods of separation have their limits, what opens field for finding new ways. One part of the Thesis contains preparation of simple ion exchangers and their selectivity study. The other part of the Thesis is dedicated to optimization of synthetic steps leading to new bifunctional ligands in suitable form for binding to macromolecular carriers and preparation of new set of exchangers.

In recent years, copper radioisotopes have been extensively studied for their suitable coordination and physical properties. Nuclides 61 Cu, 64 Cu and 67 Cu are used in nuclear medicine - in diagnostic as well as in therapeutic applications. The aim of the Thesis is a study of the coordination properties of divalent copper as a stepping stone for the next potential applications. The presented Thesis consists of two thematic parts. The first part deals with the synthesis of cyclam derivatives. Sixteen new macrocyclic ligands with different phosphorus acid coordinating pendant arms (phosphinate, phosphonate, germinal P-C-P) were prepared; an analogous ligand endowed by carboxylic acid pendant arm as well as tetramethylcyclam without coordinating arm were prepared for comparison. The influence of the nature of coordinating acid pendant arms on selectivity and on the rate of copper(II) complexation was studied in detail. The protonation constants of the free ligands and the stability constants of the complexes with selected transition metal ions were determined by potentiometric titrations and by 1 H and 31 P NMR spectroscopy. Kinetic properties - i.e. studies of the formation rate and kinetic inertness of the copper(II) complexes - were performed by UV-Vis spectroscopy. The formation kinetics of the selected...

Influence of the time interval from the application of radiopharmaceutical on the activity ratio of bone/backround during the skeletal scintigraphy. The presented thesis aims to demonstrate the effect of the selected time interval from the application of radiopharmaceutical until the start of whole body skeletal scintigraphy on the quality of examination of patients at the department of nuclear medicine at the Clinic of imaging methods in FN Pilsen. The ratio between the background and bone activity of patients will vary with the length of the interval between the application of radiopharmaceuticals and the beginning of imaging. We expect that with prolonging of the time interval the ratio between the background and bone activity will increase, which means a higher quality of your imaging in practise. The hypothesis of this thesis expects a differentiation of ratio between the background and bone activity depending on the time of initiating whole body scintigraphy from the time of application of radiopharmaceuticals. To determine the ratio value a reference file of males aged 25-65 years (year of birth from 1951 to 1991, the year of examination from 2013 to 2016), weighing 65-95 kg was created, where scintigraphy does not show pathology in the examined area of the skeleton or in the soft tissues on the left thigh. These patients were divided into two groups according to the time intervals between the application and the beginning of the whole body skeletal scintigraphy. The first group consists of 30 patients who were examined less than 120 minutes after the application of the radiopharmaceutical. The second group consists of 30 patients who were examined more than 120 minutes after the application of the radiopharmaceutical. Using the ROI technique, values from the areas L5, right femur and soft tissue structures on the left thigh are obtained. These values are then used to calculate the time intervals on the activity ratio of bone/backround and verify the hypothesis, which assumes that the ratio values between the above mentioned groups will be different. This difference should prove that a longer time interval between the application of the radiopharmaceutical and the beginning of scintigraphy will bring a higher quality of scintigraphic imaging. This qualitative factor will be beneficial both for patients and their physicians who have to describe these scintigrams.

Radioisotopes of copper are used in nuclear medicine for their physical properties. One step in process of preparing copper-containing radiopharmaceuticals is separation of copper radionuclides from other elements, especially zinc and nickel. The target of this Thesis is preparation of ligands based on linear tetraamine skeleton, which should be able of selective complexation and decomplexation of copper depending on pH of the solution. The Thesis contains synthesis of ligands, their NMR study and measurement of dissociation kinetics of their Cu-complexes. Powered by TCPDF (www.tcpdf.org)

Scintigraphic examination of the kidneys and urinary tract allow you to get a lot of information about the condition of the urinary tract. The main contribution of nuclear medicine today is the ability to do a precise quantitative assessment of the various functions of the kidneys and urinary tract. Currently for static scintigraphy and renal SPECT uses the nuclear medicine Tc-99m-dimercaptosuccinic acid or DMSA. For children is being used Tc-99m-DMSA activity of at least 20 MBq. Static scintigraphy is usually performed to demonstrate acute pyelonephritis. In such a renal disease arises one or more bearings with reduced accumulation of the radiopharmaceutical, wherein the scar appears as a wedge-shaped defect, which has regular edges and kidney loses its volume. Another illness diagnosed by static scintigraphy is hypoplastic kidney, which has a smooth outer edge without defects in the crust. The above diagnostic method is also used to evaluate local changes in the transplanted kidney. The practical part of this work was to answer the following questions: "What is the normal accumulation of Tc-99m-DMSA in kidneys for children?" I got the answer through the exploration and evaluation of the results from a static scintigraphy examination of the reference group of 28 kidney of children done by Department of Nuclear Medicine, Hospital Ceske Budejovice. The reference data set was collected from September 2014 to March 2015 and consist of patients aged 0 18 years. The physician determined the patients without abnormal kidney or focal renal impairment to be selected for the reference group. I worked with the renal scintigraphy program, typing in specifying data about each individual patient and subsequently plotting areas of interest on the right and the left kidney for each of them. This program evaluated the percentage of accumulation of Tc-99m-DMSA in each kidney. Such a data I enrolled into a Microsoft Excel table and used statistical calculations to determine the normal accumulation of Tc-99-DMSA in child kidney. For statistical evaluation was used the formula for the average, standard deviation and percentiles. From the thus processed values may be noted that the normal value of accumulation of Tc-99m-DMSA child kidney ranges from 10.9% to 32.9%.