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Background: Multimodal analgesia is an emerging technique.It has been consistently demonstrated to minimise opioid consumption, related side effects and vital component of enhanced recovery after surgery pathways. The current study presents use of combination of readily available medication as a part of multimodal analgesia. Balanced anaesthesia with multimodal analgesia is harmonious use of combination of agents to produce desired effects with minimal side effects of individual agents. Methods: This study was done in a tertiary health care centre, Government General Hospital, Kakinada over a duration of two months from August 2022 to September 2022. 60 adult patients of either sex of physical status ASA grade 1and 2 undergoing elective surgery under general anaesthesia were randomly allocated into Group A and Group B of 30 patients. Group 1: received Inj. Lignocaine+Inj. Paracetamol+Inj. Magnesium sulphate+Inj. Fentanyl. Group 2:received Inj. Lignocaine+Inj. Paracetamol+Inj. Magnesium sulphate+Normal saline (control group) as premedication for perioperative analgesia. Results: All patients were hemodynamically stable for first 30 minutes period of observation in Group A compared to Group B. There is clinically and statistically significant difference in the duration of analgesia in Group A compared to Group B. There is no statistically significant difference in the Numerical Rating Scale (NRS) for pain in both the groups. Conclusions: This study concluded that simple analgesia combination of multimodal analgesia regimen comprising of Inj. Lignocaine, Inj. Paracetamol and Inj. Magnesium sulphate produces safe and effective analgesia with good recovery profiles and no adverse opioid related side effects for ASA 1 and 2 patients posted under general anaesthesia.

Background: Amavata is a very challenging and burning problem in society. The clinical presentation of Amavata is closely related to the special variety of musculoskeletal disorder rheumatoid arthritis (RA). There is no medical system that is successful in providing a complete cure for the disease, so the Ayurvedic approach toward the treatment of Amavata is needed in the present era. The prevalence of RA is approximately 1% of the total population. For the management of RA in allopathic science, DMARDs & steroids are used frequently. Due to the lack of effective drugs and major problem in society, this disease for the study has been selected. Aim and Objectives: To study the efficacy of Erandbeejadi Gutika and Pippalyadi Gana Kashaya with modified Ruksha Sweda in the management of Amavata (RA). Methodology: It will be a single-center, randomized, open-clinical study. In this study, 60 clinically diagnosed patients of Amavata were selected and randomly divided into two groups by coin method. Erandbeejadi Gutika will be given in the dose of two tablets (each 500 mg) four times in a day with lukewarm water before meal for 90 days along with the modified Ruksha Pottali Sweda, while Pippalyadi Gana Kashaya will be given 50 ml two times in a day before the meal along with the modified Ruksha Pottali Sweda. Statistical analysis will be done using the Wilcoxon matched-pairs signed ranks test for the analysis of nonparametric data, while paired t-test will be used for parametric data analysis, and mann-whitney test and unpaired t-test will be used for intergroup comparison.

Background: Coronavirus disease 2019 (COVID-19) was a recent global pandemic of the era which posed a great challenge for the health care in terms of preventive, diagnostic and treatment dimensions. The seroprevalence rate of COVID IgG antibodies is very crucial in estimating the susceptibility of a particular area to the viral disease. In our study, we estimated the seroprevalence of COVID-19 in a rural area. Aims and Objectives: We aimed to estimate the seroprevalence of COVID-19 in a rural district of Tamil Nadu, 6 months after the index case. Materials and Methods: We conducted a cross-sectional study of 509 adults aged more than 18 years. From all the seven Taluks, two gram panchayats (administrative cluster of 8–10 villages) were randomly selected followed by one village through convenience. The participants were invited for the study to the community-based study kiosk set up in all the eight villages through village health committees. We collected sociodemographic characteristics and symptoms using a mobile application-based questionnaire, and we tested samples for the presence of IgG antibodies for severe acute respiratory syndrome coronavirus 2 using an electro chemiluminescent immunoassay. We calculated age-gender adjusted and test performance adjusted seroprevalence. Results: The age-and gender-adjusted seroprevalence was 8.5% (95% confidence interval [CI] 6.9–10.8%). The unadjusted seroprevalence among participants with hypertension and diabetes was 16.3% (95% CI: 9.2–25.8) and 10.7% (95% CI: 5.5–18.3), respectively. When we adjusted for the test performance, the seroprevalence was 6.1% (95% CI 4.02–8.17). The study estimated 7 (95% CI 1:4.5–1:9) undetected infected individuals for every reverse transcription polymerase chain reaction confirmed case. Infection fatality rate (IFR) was calculated as 12.38/10,000 infections as on October 22, 2020. History of self-reported symptoms and education were significantly associated with positive status (P

Teaching methods should be such that the set goals can be achieved. We should not be slaves of any one method. Teaching methods should be such that the internal powers of the students can be fully developed. For this, experiments, activities and projects and games, lectures and reasoning methods can be used. There are many methods from which we can choose those, which can meet our needs in time and in the best way.

In the present paper we have investigated Psorolin B ointment for improving the bio-mechanical property of the skin. Psorolin B ointment is proprietary Siddha formulation composed of Boswellia serrata, Wrightia tinctoria, Cynodon dactylon, Hydnocarpus laurifolia and red ochre. The bio-mechanical property/elasticity of the skin is evaluated in volar forearm region by four different methods such as applying uniaxial force, centripetal force, vacuum suction and instant retraction by pinch-pull test. The findings clearly showed that Psorolin B ointment improved the skin elasticity and dexterity of the cutaneous tissue. In our previous study we have already established the elastase and collagenase inhibitory effect of Psorolin B and it also possess strong antioxidant effect. The findings are discussed in the article.

True knot is an extremely rare condition of the umbilical cord. It affects around 0.3-1.3% of all the pregnancies. It can be loose without obstructing the blood flow to the foetus or can be tight enough to exsanguinate the foetus by compromising the blood flow towards the foetus. A 26 years old, gravida 2, para 1, live 1, with previous 1 caesarean section with hypothyroidism came at 40 weeks POG in labour. No complaints. Antenatal history was uneventful. On examination, patient was stable. Patient was explained risk and demits of TOLAC verses ERCD and opted for TOLAC. Delivered a limp baby. There was presence of one tight loop of cord around neck and one tight true knot over the umbilical cord leading to stillbirth. The umbilical cord is the only blood supply to the foetus during the antepartum and intrapartum period. If the true knot is loose, it will not lead to foetal compromise since foetal circulation is maintained. However, at the time of fetal descent through the birth canal, the knot could be tightened. The tightening knot can occlude fetal circulation resulting in an intrauterine demise. The process of delivery should be very careful and if any fetal distress or non-reactive CTG is present, then an emergency caesarean section must be done. Routine continuous cardiotocography can be the best modality to pick distress at the earliest and to achieve a good outcome of the neonate. A good ultrasonologist can detect nuchal cord and true knot during the antenatal scan.

Background: Risk of alveolar bone loss & tooth loss increases with the presence of intrabony defects. Anoraganic bovine bone mineral (ABBM) is being used in treatment of intrabony defects.Platelet-rich fibrin (PRF) is an autologous concentrate thathas an important role inpromoting soft and hard tissue healing.This study was done to compare and evaluate the healing of intra-bony defects treated with a combination of ABBM-PRF or ABBM alone.Method: Twelve patients (24 sites) with intrabony defects were selected and divided randomly in 2 groups. Subjects in Group A (Control group ) were treated with ABBM alone & subjects in Group B (test Group ) were treated with ABBM + PRF.Clinical parameters such as PPD(Probing pocket depth), CAL(Clinical attachment level), PI(plaque index), GI(gingival index), WHI(Wound healing index), VBL(Vertical Bone Level)& DD(Defect depth) at baseline, 3 and 6 months using acrylic stent.Result: Significant gain in PPD& CAL( 3.92± 0.67 to 2.00± 0.74) was seen from baseline to 6 months in test group ( p

Background: The unprecedented outbreak of a contagious respiratory disease caused by a novel coronavirus has led to a pandemic since December 2019, claiming millions of lives. Aims and Objectives: The present study was undertaken to estimate the various risk factors associated with COVID, to study the common presenting symptoms and prognosis, and to estimate the degree of association between computed tomography (CT) value in reverse transcription polymerase chain reaction (RT-PCR) with mode of disease transmission in north coastal districts of Andhra Pradesh. Materials and Methods: This was a cross-sectional study comprising of 1462 COVID-positive individuals. It is based on structured questionnaire on demographic, socioeconomic and symptoms, and correlation of clinical pattern with CT value in RT-PCR and further prognosis. Results: Diabetes (6.7%), hypertension (7.5%), and bronchial asthma (8.6%) are the main comorbid conditions. Middle (44.6%) and low socioeconomic status (47.3%) are more susceptible. Male gender (63.5%) is more affected, especially 16–30 years age group (32.4%). Vaccination offers considerable protection from infection. Contact (59.4%) with known case and travel (31%) are main factors that determine disease transmission. Blood group may not play a role in COVID susceptibility. Health careworkers (22.9%) and students (16.2%) are mostly affected. Conclusion: Bronchial asthma, hypertension, and diabetes mellitus are the predominant risk factors associated with COVID. Transmission of the disease is more by virtue of contact with the infected person than by travel.

Heart diseases are commonly caused and when neglected becomes life threatening. So, early detection of the disease is very important and for diagnosis to save lives. There can be many parameters that are to be considered to predict the heart disease. Some of them are like age, cholesterol, blood pressure levels. Etc., here we are going to implement Machine Learning model to predict heart disease.

Previous studies have identified several ICAM3 transcript variants and mainly investigated the function of the longest transcript of ICAM3 in various tumor progressions. However, the role of the other ICAM3 transcript variants remains unclear. Herein, we detected the expression of ICAM3 transcript variants 1-4 in DLBCL cells and tumor tissues, disclosed that variants 1, 3, and 4 were expressed in normal B cell lines and 3 DLBCL cell lines except SU-DHL-2 as well as tumor tissues, while variant 2 was not detected. Moreover, we found that ectopic expression of variants 1-4 enhanced cell proliferation by accelerating the cell cycle in SU-DHL2 cells

Pengabdian masyarakat ini dilatarbelakangi oleh perlunya tambahan kegiatan ekstrakurikuler dalam bidang sastra di sekolah. Pembelajaran sastra,seperti menulis karya sastra memerlukan latihan agar siswa terbiasa menulis. Dalam hal ini dilakukan kegiatan pengabdian masyarakat berupa pembinaan menulis karya sastra (puisi) secara daring. Kegiatan pengabdian secara daring dipilih karena situasi pandemi yang tidak memungkinkan untuk tatap muka. Kegiatan pengabdian kepada masyarakat di SMK Kartini Batam dilaksanakan pelatihan menulis karya sastra (puisi). Kegiatan pelatihan ini dilaksanakan terbimbing sebanyak 4 tahap. Metode dalam pengabdian ini adalah metode kuantitatif. Data dalam penelitian ini berupa hasil tes menulis puisi siswa SMK Kartini Batam. Berdasarkan hasil tes menulis puisi, kemampuan menulis puisi siswa SMK Kartini Batam sebelum pelatihan berada pada kualifikasi cukup (C) dengan rata-rata 63,81. Selanjutnya, kemampuan menulis puisi siswa SMK Kartini Batam setelah pelatihan berada pada kualifikasi baik (B) dengan rata-rata kemampuan 78,63. Berdasarkan hal tersebut dapat disimpulkan bahwa terjadi peningkatan kemampuan menulis puisi siswa dengan adanya pelatihan.

Ransomware is a type of virus that encrypts a victim's data and demands payment in exchange for it. Critical data belonging to a person or organisation is encrypted, making it impossible for them to access files, databases, or apps. In order to gain access, a ransom is asked. An automated solution based on machine learning based classification algorithms is proposed in the research to prevent fraudulent job postings on the internet. For checking fraudulent posts on the internet, many classifiers are utilised, and the results of those classifiers are compared in order to determine the optimum employment scam detection model. For the detection of fake job postings, two types of classifiers are used: single classifiers and ensemble classifiers.

In Villette, Charlotte Brontë portrays a woman’s growth in an incredibly subtle way. Her heroine goes through a lonely and painful process from awakening to transformation. Lucy Snowe possess inner strength and she rises out of difficult circumstances --- suffering, seeking, surviving and finding her career. Charlotte’s insights about love,career, marriage and life are more matured compared to her previous novels , she also presents her deeper concern and reflection on Victorian women's situation in the novel. Inspired by Lucy Snowe’s spirit, this paper briefly analyses her sterling character and how she rises from an unrecognized woman to a respected teacher.

A bandage is a standard of biomaterial used on wounds to protect from infections and to cure wounds. The adhesive bandage also known as sticking plaster protects the wound from friction, bacteria, damage, and dirt. In this study, the leaf extracts of plant (Chromolaena odorata) coated on textiles are being used as a potential drug to promote wound healing. The phytochemical screening and antimicrobial activities of the ethanolic plant leaf extracts was carried out. The leaf extracts were coated on non-woven viscose rayon fabric using Pad-dry cure method. The physical and biological parameters of the coated fabric were analyzed to determine the process of wound healing. The parameters of pH and absorbency were evaluated using the standard protocols obtained from medical textiles. The antimicrobial efficiency (standard protocol AATCC 100), cytotoxicity (MTT assay) and in vitro scratch wound assay using cell lines was studied. The results showed that developed herbal coated bio-bandage featured all the characteristics for ideal dressing. Therefore, it can be promoted as novel bio-bandage for the healing of wounds.

In order to obtain environmentally friendly nanoparticles for the biological applications, this paper explores the green route for the synthesis of gold nanoparticles via sonic bath method using Haematocarpus validus fruit extract as reducing, capping and stabilizing agent. The phytochemical screening of ethanol extract reveals secondary metabolites like anthocyanins, polyphenol, flavonoids, alkaloids and tannins. The prepared gold nanoparticles (HVGNP) were analysed using UV, FTIR, XRD, EDX and FESEM spectroscopic techniques. The antioxidant activity of synthesized HVGNP measured by the DPPH method reveals the synthesized gold nanoparticles appreciable antioxidant activity.

In medicinal plant field ethnopharmacological knowledge aggrandizes legibility for prioritizing species selection for future research opportunities. Many plant species representing the genus Onosma have been documented to be important in communities world-wide as evidenced by the numerous records on traditional medicinal and ethno-botanical information. Various species of the genus are used in the traditional medicinal systems in Europe and Asian countries especially in India, China, Turky and Pakistan. The literature on the species distribution and their characterization was compiled from different regional floras, regional revisions and databases. The information related to traditional uses, pharmacological activities and phytochemistry was systematically collected from the scientific databases including reference books, SciFinder, Scopus, PubMed and Google Scholar. Absence of comprehensive literature review on genus Onosma species led to design present study and dig the recorded documents to comparatively gauge magnitude of studies on each of the Onosma species through an exhaustive bibliographic evaluation of scientifically studied species of genus Onosma that are also taxonomically identified and are valued as traditional medicinal remedy for diseases in their countries of origin. The study hinted about lack of scientific literature on most of the species. A comprehensive bibliographic review on the geographical distribution, identification, traditional uses, phytochemistry, pharmacology and toxicology of the genus Onosma is attempted here to give insights into promising future drug discovery strategies. KEYWORDS: Onosma, Distribution, Traditional uses, Phyto-Pharmacology

Objective: A combination of hydrocortisone and tetracycline as topical ophthalmic ointment is used for skin irritations, eye infections, inflammation, skin infections, acne, and rashes. The objective of the current work is to a simple, rapid, accurate, and precise, stability-indicating reverse-phase liquid chromatographic method was developed for the simultaneous estimation of hydrocortisone and tetracycline in bulk and pharmaceutical dosage form. Methods: The separation was carried out in Discovery C18 column (250 × 4.6 mm, 5 μm) using mobile phase ratio of water (pH 2.2 adjusted with orthophosphoric acid):acetonitrile (40:60 v/v) in an isocratic elution mode with a flow rate of 1.0 ml/min at detection wavelength of 244 nm. The injection volume was 10 μl and the column temperature was set at 30°C. Results: The retention time for hydrocortisone and tetracycline was found to be 2.214 ± 0.001 min and 3.497 ± 0.001 min, respectively. Calibration curves were linear (r2=0.999) at a concentration range of 2.5–15 mg/ml for both hydrocortisone and tetracycline. The percentage recoveries were found to be 99.13–99.67% for hydrocortisone and 99.39–99.61% for tetracycline. Relative standard deviation was found to be 0.3% for both the drugs. Limit of detection and limit of quantification values of hydrocortisone and tetracycline were found to be 0.09 μg/ml and 0.27 μg/ml and 0.17 μg/ml and 0.52 μg/ml, respectively. The drugs were subjected to various stress conditions and found no interference of degraded products peak at the retention times of analyte peaks. Conclusion: A rapid and accurate reverse-phase high-performance liquid chromatographic method was developed for simultaneous estimation of hydrocortisone and tetracycline, and the method was validated as per the International Council for Harmonization guidelines. Hence, the developed method can be successfully applied for the simultaneous estimation of hydrocortisone and tetracycline in bulk and ointment formulation.

This paper is a technical review for a more deliberate paper (Bhattacharya & Lahiri, 2007) where it has been shown that on a positive cosmological scale with Λ>0 having a cosmic horizon scale ~1/√Λ, there exists the soft electric hairs for the solution having the T_00 components of the stress-energy tensor T_μν i.e., ρ=0 on black hole horizon B_H having the maximum density at black hole singularity B_S where cosmic horizon C_H and black hole horizon B_H has only been considered. KEYWORDS: Black Hole – Cosmic Horizon – TOV Limit – Stress-Energy Tensor – Positive Cosmological Constant

Reactive hyperplastic exophytic growth are seen in the oral mucosa due to chronic irritation by plaque, calculus, overhanging margins, trauma and dental appliances. Traumatic fibroma represents a focal benign hyperplasia of fibrous connective tissue origin. Here we are reporting a case of traumatic fibroma in relation to upper right posterior teeth on right buccal mucosa in a 34 year old male.

The main objective of the study to investigate the Teacher Effectiveness, Emotional Intelligence and Competence of secondary school teachers. For the present study, 480 teachers and 480 students were listed from 120 schools as a sample. The present study is an ex-post facto type of study involving descriptive survey method. Co-efficient of correlation and t-test are used to analyze the results. The main findings of the present study reveal that the co-efficient of correlation between teacher effectiveness and emotional intelligence of secondary school teachers with respect to total sample study is .70, which is significant beyond .01 levels. It indicates that the relationship between the two variables is positive. Thus a high significant positive relationship is found between teacher effectiveness and emotional intelligence.

Due to fluctuating energy prices and ever-increasing uncertainties in supply, the industrial and commercial sectors are poised to speed up introduction of energy saving mechanisms. Having badly hit by recent economic recession, the hotel industry has ever more reasons to save energy. A typical star-class hotel was chosen to conduct the energy usage optimization study presented in this paper. The hotel’s energy consumption pattern data was collected and analysed. Based on sensor information and manage information system data, cooling load requirement is correlated with the number of occupied rooms. It is shown that substantial savings can be achieved by introduction of wing operation to the hotel room allocation system. Moreover, the findings from the present study can be incorporated into a building management system (BMS) when it comes to automating the wing operations.