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Eupatorium adenophorum Spreng is an invaded species found in the Western Ghats region, which is used for many diseases in our traditional medicinal system. The essential oil of the plant leaves was examined by Gas chromatography-Mass spectroscopy and evaluated for its biological performance. The antioxidant capacity was found by DPPH radical and ABTs assays. The anticancer activity was determined by MTT assay by using Jurkat E 6.1 cancer cell line along with commercial cancer drug Etoposide. Camphene (11.34%), Bornyl acetate (8.09%), Sabinene (6.75%), Iso borneol (7.96%), were identified as major constituents. It showed remarkable antioxidant performance against DPPH radical and ABTs with IC50 values of 66.7g/mL and70.1g/mL respectively. Essential oil exhibited the strongest cytotoxic effect on Jurkat E6.1cancer cells with an IC50 value of 29g/mL compared to commercial cancer drug Etoposide with an IC50 value of 30g/mL. This one is the first type of report on the chemical constituents of E. adenophorum leaves from the Western Ghats region and its pharmacological activities. E. adenophorum plant is existing throughout the year and is easily available for essential oil isolation.