1. Lymphocyte-sensitivity to glucocorticoid correlates with the sensitivity to cyclosporin A and tacrolimus in chronic renal failure patients
- Author
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null Horigome, null Hirano, null Oka, null Takeuchi, null Sakurai, null Kozaki, null Matsuno, and null Nagao
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Pharmacology ,medicine.medical_specialty ,education.field_of_study ,Combination therapy ,business.industry ,medicine.medical_treatment ,Population ,Immunosuppression ,Gastroenterology ,Tacrolimus ,Transplantation ,Endocrinology ,Internal medicine ,Cyclosporin a ,medicine ,Prednisolone ,Pharmacology (medical) ,business ,education ,Glucocorticoid ,medicine.drug - Abstract
Aims Association between lymphocyte-sensitivity to immunosuppressants in transplant recipients in vitro and clinical outcomes has been demonstrated. In general, renal transplant recipients are treated with a combination of immunosuppressants such as either glucocorticoid/cyclosporin A (CsA) or glucocorticoid/tacrolimus (FK506) but the pharmacological complementarity of these drugs is still controversial. We examined relationships between the lymphocyte-sensitivities to these immunosuppressants. Methods We examined lymphocyte-sensitivities to prednisolone (PSL), CsA, and FK506 in vitro in a total of 190 chronic renal failure (CRF) patients and 140 healthy subjects. The lymphocyte-sensitivity was evaluated from the IC50 value against mitogen-stimulated lymphocyte-blastogenesis in vitro. Results Statistically significant correlations of the IC50 values in CRF patients between the following pairs of drugs were observed: PSL and CsA (P
- Published
- 1999
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