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Objective: To analyze modulating effect of Curcuma longa on Pancreatic Islet β-cell function and insulin resistance in alloxan induced diabetic rat model. Study Design: Experimental study. Setting: Department of Anatomy, Pharmacology and Pathology, SRMCH, T. Adam. Period: February 2019 to January 2020. Material & Methods: One hundred adult male rats were selected according to criteria and grouped A to E. Group A and B was negative and positive control rats, and C –E were diabetic experimental rats. Alloxan (120 mg/Kg body weight) was injected intraperitoneally (i.p) to induce diabetes mellitus. Curcuma longa was used in doses of 200, 300 and 500 mg/d for 28 days. Body weight, blood glucose, HbA1c, insulin and C-peptide were estimated. Insulin resistance (HOMA-IR) and β- cell function (HOMA-β) were calculated by formulae. Data was analyzed on SPSS package ver. 21.0 (IBM, incorporation, USA) (p≤ 0.05). Results: Twenty eight days therapy of Curcuma longa extract ameliorates blood glucose, A1C, serum Insulin levels and C-peptide levels. Insulin resistance (HOMA-IR) was found improved and β- cell function (HOMA-β) was augmented in in Curcuma longa treated experimental rats (P=0.0001). Conclusion: Administration of Curcuma longa positively modulates the Islet β-cell function and insulin resistance in alloxan induced diabetic rats.

Objective: To determine effects of Curcuma longa (CL) on the glycemic control, blood lipids and atherogenic index of plasma (AIP) in alloxan induced diabetic male Wistar albino rat model. Study Design: Experimental study. Setting: Department of Basic Medical Sciences, Suleman Roshan Medial College, Tando Adam, Sindh. Period: February 2019 to January 2021. Material & Methods: A sample of 100 rats was divided into negative controls (C-), positive (diabetic) control (C+), and experimental groups D, E and F. DM was induced by injecting Alloxan (120 mg/Kg body weight) intraperitoneally (i.p) to overnight fasting rats. Diabetic groups D, E, and F were treated with ethanol extract of Curcuma longa 100 mg, 300 mg and 500 mg orally daily for six weeks. Blood samples were collected for biochemical analysis. Atherogenic Index of Plasma (AIP) was calculated by log TAG/HDLc. Data analyzed on SPSS package (ver. 21.0, IBM, incorporation, USA) (p≤ 0.05). Results: Significant improvement in glycemic status and blood lipids was observed in Curcuma longa treated groups D, E and F (P=0.0001). Atherogenic index of plasma (AIP) in negative (C-) and positive (C+) control was 0.08±0.03 and 1.11 ±0.1 respectively (P=0.0001) that improved in Curcuma longa treated groups D, E and F noted as; 0.77±0.3, 0.68±0.3 and 0.62±0.4 respectively. Conclusion: Present study found ethanolic extract of Curcuma longa improves the glycemic control, lipid profile and atherogenic index of plasma (AIP) in alloxan induced diabetic rat model.

Objective: To analyze effects of turmeric in glycemic control and insulin secretagogue activity in alloxan induced diabetic rat model. Study Design: Experimental Study. Setting: Department of Surgery, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad. Period: February 2019 to January 2020. Material & Methods: A sample of 100 adult male rats was selected according to inclusion criteria. Rats were grouped as negative control (group A), positive control – diabetic rats (group B), and experimental groups C – E. Group C- was diabetic rat + 100 mg ethanol extract of turmeric, Group D- was diabetic rat + 300 mg ethanol extract of turmeric, and Group E- was diabetic rat + 500 mg ethanol extract of turmeric. Overnight fasting rats were administered Alloxan 120 mg/Kg body weight intraperitoneally (i.p) by pinching abdominal wall under skin for the induction of diabetes mellitus in the rats. Blood glucose, glycated hemoglobin A1 (A1C) and serum insulin were analyzed. Statistical analysis was performed on SPSS package (ver. 21.0, IBM, incorporation, USA) at p≤ 0.05 (Confidence interval 95%). Results: Blood glucose, A1C and serum Insulin levels were improved in turmeric treated experimental rats. Significant reduction in blood glucose and A1C were found in turmeric treated rats (P=0.0001). Serum insulin levels were found increased in turmeric treated experimental groups C – E compared to positive control B (P=0.0001). Conclusion: Administration of turmeric significantly reduced the blood glucose and A1C with increased serum insulin levels in alloxan induced diabetic rats.