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Your search keyword '"on behalf of the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)"' showing total 6 results
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6 results on '"on behalf of the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)"'

1. Bleeding events attributable to concurrent use of warfarin and other medications in high-risk elderly: meta-analysis and Italian population-based investigation

Author

Comoretto, Rosanna Irene, Rea, Federico, Lucenteforte, Ersilia, Mugelli, Alessandro, Trifirò, Gianluca, Cascini, Silvia, Roberto, Giuseppe, Chinellato, Alessandro, Filippelli, Amelia, Corrao, Giovanni, and on behalf of the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)

Published
2018
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4. NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease

Author

Roberto, G, Bartolini, C, Rea, F, Onder, G, Vitale, C, Trifirò, G, Kirchmayer, U, Chinellato, A, Lucenteforte, E, Corrao, G, Mugelli, A, Lapi, F, Gini, R, On Behalf Of The Italian Group For Appropriate Drug Prescription In The Elderly (I-Grade): Agabiti, N, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Giorgianni, F, Lombardi, N, Sorge, C, Tari, M, Vannacci, A, Vetrano, D, Caputi, AP, Vetrano, DL, Roberto, G, Bartolini, C, Rea, F, Onder, G, Vitale, C, Trifirò, G, Kirchmayer, U, Chinellato, A, Lucenteforte, E, Corrao, G, Mugelli, A, Lapi, F, Gini, R, On Behalf Of The Italian Group For Appropriate Drug Prescription In The Elderly (I-Grade): Agabiti, N, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Giorgianni, F, Lombardi, N, Sorge, C, Tari, M, Vannacci, A, Vetrano, D, Caputi, AP, and Vetrano, DL

Abstract

Objectives: To describe NSAID utilization for musculoskeletal conditions in a large cohort of Italian elderly with cerebro/cardiovascular disease, a population in which NSAIDs should be generally avoided due to the prothrombotic potential. Methods: Administrative data from five Italian geographic areas were analyzed. Patients aged ≥ 65 with a cerebro/cardiovascular event recorded between 2008 and 2011 (cohort entry) were selected. Prescription NSAIDs reimbursed for musculoskeletal conditions and dispensed during 1 year follow-up were retrieved to describe (i) prevalence of use, (ii) average amount of defined daily doses of NSAIDs claimed by users per day of follow-up, and (iii) distribution of the received daily dose (RDD) among patients with ≥ 2 dispensings. Among new users, i.e., patients without NSAID dispensings during 2 years before cohort entry, the first dispensed NSAID molecule was observed. Results: Overall, 511,989 patients were selected. Across the five geographic areas, prevalence of use ranged from 48 to 21% and average consumption ranged between 30 and 67 DDD/1000 users/day. Around 10% of patients in the overall cohort had a RDD > 1. Nimesulide (9.6%) and diclofenac (7.5%) had the highest prevalence of use. The most consumed NSAIDs were nimesulide and coxibs with 10.6 and 7.5 DDD/1000 users/day, respectively. Among new users recruited in 2011, 30% had diclofenac or a coxibs as the first prescription. Conclusions: NSAID use was common in the study cohort, particularly in central-southern areas. In contrast with current recommendations, coxibs and diclofenac were among the most prescribed active principles, even in new users. Interventions to promote appropriateness of use are warranted.

Published
2018

5. Adherence to Antidepressants and Mortality in Elderly Patients with Cardiovascular Disease.

Author

Biffi, Annalisa, Scotti, Lorenza, Rea, Federico, Lucenteforte, Ersilia, Chinellato, Alessandro, Vetrano, Davide L., Vitale, Cristiana, Agabiti, Nera, Sultana, Janet, Roberto, Giuseppe, Mugelli, Alessandro, Corrao, Giovanni, and on behalf of the Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)

Subjects
CARDIOVASCULAR disease related mortality, ANTIDEPRESSANTS, OLDER patients, DRUG prescribing, PATIENT compliance, DISEASES
Abstract

Background and Objective: Conflicting findings from studies evaluating the association between use of antidepressant drugs and mortality have been reported. We tested the hypothesis that better adherence to antidepressant therapy may reduce mortality.Methods: The cohort included 29,845 individuals aged ≥ 65 years from several Italian health units who were newly treated with antidepressant drugs after hospital discharge with a diagnosis for cardiovascular disease during 2008-2010. These individuals were observed from the first prescription until the end of data availability (i.e. 2012-2014, depending on the local database). During this period, information on (1) prescription of antidepressants and other medications and (2) death from any cause (outcome) was recorded. Proportional hazards models were fitted to estimate the association between better adherence to antidepressants (defined as proportion of days covered ≥ 75%) and outcome, by adjusting and stratifying for several covariates.Results: Patients with better adherence to antidepressants had a reduced mortality of 9% (95% CI 3-14). Patients who did not use other medicaments during follow-up had reduced mortality associated with better adherence to antidepressants of 21% (− 1-38), 14% (7-20), 20% (13-26) and 13% (7-19) for no users of antihypertensive agents, lipid-lowering agents, other cardiovascular drugs and antidiabetics, respectively.Conclusions: Better adherence to antidepressants is associated with reduced all-cause mortality, mainly in patients who did not use other pharmacological treatments. Behavioural changes to enhance adherence among the elderly with cardiovascular disease might offer important benefits in reducing their mortality. [ABSTRACT FROM AUTHOR]

Published
2018
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6. NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease

Author

Roberto, G., Bartolini, C., Rea, Federico, Onder, G., Vitale, C., Trifirò, G., Kirchmayer, U., Chinellato, A., Lucenteforte, E., Corrao, G., Mugelli, A., Lapi, F., Gini, R., Agabiti, N., Bernabei, R., Bettiol, A., Bonassi, S., Caputi, A. P., Cascini, S., Davoli, M., Fini Storchi, Marco, Giorgianni, F., Lombardi, N., Rea, F., Sorge, C., Tari, M., Vannacci, A., Vetrano, D. L., Vitale, Claudia, Roberto, G, Bartolini, C, Rea, F, Onder, G, Vitale, C, Trifirò, G, Kirchmayer, U, Chinellato, A, Lucenteforte, E, Corrao, G, Mugelli, A, Lapi, F, Gini, R, On Behalf Of The Italian Group For Appropriate Drug Prescription In The Elderly (I-Grade): Agabiti, N, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Giorgianni, F, Lombardi, N, Sorge, C, Tari, M, Vannacci, A, and Vetrano, D

Subjects
Drug Utilization, medicine.medical_specialty, Diclofenac, Pharmacoepidemiology and Prescription, NSAIDs, Population, Psychological intervention, Cardiovascular risk Coxibs Diclofenac Drug utilization Elderly NSAIDs, Disease, 030204 cardiovascular system & hematology, Coxib, 03 medical and health sciences, 0302 clinical medicine, Elderly, Internal medicine, medicine, Coxibs, Drug utilization, Humans, Pharmacology (medical), Musculoskeletal Diseases, 030212 general & internal medicine, Medical prescription, education, Aged, Aged, 80 and over, Pharmacology, education.field_of_study, business.industry, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Cardiovascular risk, NSAID, Cardiovascular Diseases, Cohort, Female, business, Nimesulide, medicine.drug
Abstract

Objectives To describe NSAID utilization for musculoskeletal conditions in a large cohort of Italian elderly with cerebro/cardiovascular disease, a population in which NSAIDs should be generally avoided due to the prothrombotic potential. Methods Administrative data from five Italian geographic areas were analyzed. Patients aged ≥ 65 with a cerebro/cardiovascular event recorded between 2008 and 2011 (cohort entry) were selected. Prescription NSAIDs reimbursed for musculoskeletal conditions and dispensed during 1 year follow-up were retrieved to describe (i) prevalence of use, (ii) average amount of defined daily doses of NSAIDs claimed by users per day of follow-up, and (iii) distribution of the received daily dose (RDD) among patients with ≥ 2 dispensings. Among new users, i.e., patients without NSAID dispensings during 2 years before cohort entry, the first dispensed NSAID molecule was observed. Results Overall, 511,989 patients were selected. Across the five geographic areas, prevalence of use ranged from 48 to 21% and average consumption ranged between 30 and 67 DDD/1000 users/day. Around 10% of patients in the overall cohort had a RDD > 1. Nimesulide (9.6%) and diclofenac (7.5%) had the highest prevalence of use. The most consumed NSAIDs were nimesulide and coxibs with 10.6 and 7.5 DDD/1000 users/day, respectively. Among new users recruited in 2011, 30% had diclofenac or a coxibs as the first prescription. Conclusions NSAID use was common in the study cohort, particularly in central-southern areas. In contrast with current recommendations, coxibs and diclofenac were among the most prescribed active principles, even in new users. Interventions to promote appropriateness of use are warranted. Electronic supplementary material The online version of this article (10.1007/s00228-018-2411-y) contains supplementary material, which is available to authorized users.

Published
2018

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