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24,664 results on '"opioid-related disorders"'

6. Opioid and benzodiazepine use in gynecologic oncology patients

Author

Levytska, Khrystyna, Pena, Savannah R, Brown, Jubilee, Yu, Ziqing, Wally, Meghan K, Hsu, Joseph R, Seymour, Rachel B, Naumann, Wendel, Beuhler, Michael, Bosse, Michael J, Gibbs, Michael, Griggs, Christopher, Gulati, Ashu, Jarrett, Steven, Leas, Daniel, Odum, Susan, Roomian, Tamar, Runyon, Michael, Saha, Animita, Matthew Sullivan, D, and Watling, Brad

Published
2023
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7. The single-cell opioid responses in the context of HIV (SCORCH) consortium

Author

Ament, Seth A, Campbell, Rianne R, Lobo, Mary Kay, Receveur, Joseph P, Agrawal, Kriti, Borjabad, Alejandra, Byrareddy, Siddappa N, Chang, Linda, Clarke, Declan, Emani, Prashant, Gabuzda, Dana, Gaulton, Kyle J, Giglio, Michelle, Giorgi, Federico M, Gok, Busra, Guda, Chittibabu, Hadas, Eran, Herb, Brian R, Hu, Wen, Huttner, Anita, Ishmam, Mohammad R, Jacobs, Michelle M, Kelschenbach, Jennifer, Kim, Dong-Wook, Lee, Cheyu, Liu, Shuhui, Liu, Xiaokun, Madras, Bertha K, Mahurkar, Anup A, Mash, Deborah C, Mukamel, Eran A, Niu, Meng, O’Connor, Richard M, Pagan, Chelsea M, Pang, Alina PS, Pillai, Piya, Repunte-Canonigo, Vez, Ruzicka, W Brad, Stanley, Jay, Tickle, Timothy, Tsai, Shang-Yi A, Wang, Allen, Wills, Lauren, Wilson, Alyssa M, Wright, Susan N, Xu, Siwei, Yang, Junchen, Zand, Maryam, Zhang, Le, Zhang, Jing, Akbarian, Schahram, Buch, Shilpa, Cheng, Christine S, Corley, Michael J, Fox, Howard S, Gerstein, Mark, Gummuluru, Suryaram, Heiman, Myriam, Ho, Ya-Chi, Kellis, Manolis, Kenny, Paul J, Kluger, Yuval, Milner, Teresa A, Moore, David J, Morgello, Susan, Ndhlovu, Lishomwa C, Rana, Tariq M, Sanna, Pietro Paolo, Satterlee, John S, Sestan, Nenad, Spector, Stephen A, Spudich, Serena, Tilgner, Hagen U, Volsky, David J, White, Owen R, Williams, Dionne W, and Zeng, Hongkui

Subjects
Pharmacology and Pharmaceutical Sciences, Medical Microbiology, Biomedical and Clinical Sciences, HIV/AIDS, Sexually Transmitted Infections, Substance Misuse, Opioids, Opioid Misuse and Addiction, Brain Disorders, Drug Abuse (NIDA only), Neurosciences, Infectious Diseases, Behavioral and Social Science, 2.1 Biological and endogenous factors, 2.6 Resources and infrastructure (aetiology), Good Health and Well Being, Animals, Humans, Analgesics, Opioid, Brain, HIV Infections, Opioid-Related Disorders, Single-Cell Analysis, Comorbidity, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of the seminal challenges in treating and studying addiction in human populations is the high prevalence of co-morbid conditions, including an increased risk of contracting a human immunodeficiency virus (HIV) infection. Of the ~15 million people who inject drugs globally, 17% are persons with HIV. Conversely, HIV is a risk factor for SUD because chronic pain syndromes, often encountered in persons with HIV, can lead to an increased use of opioid pain medications that in turn can increase the risk for opioid addiction. We hypothesize that SUD and HIV exert shared effects on brain cell types, including adaptations related to neuroplasticity, neurodegeneration, and neuroinflammation. Basic research is needed to refine our understanding of these affected cell types and adaptations. Studying the effects of SUD in the context of HIV at the single-cell level represents a compelling strategy to understand the reciprocal interactions among both conditions, made feasible by the availability of large, extensively-phenotyped human brain tissue collections that have been amassed by the Neuro-HIV research community. In addition, sophisticated animal models that have been developed for both conditions provide a means to precisely evaluate specific exposures and stages of disease. We propose that single-cell genomics is a uniquely powerful technology to characterize the effects of SUD and HIV in the brain, integrating data from human cohorts and animal models. We have formed the Single-Cell Opioid Responses in the Context of HIV (SCORCH) consortium to carry out this strategy.

Published
2024

8. Naloxone Use During Pregnancy-Data From 26 US Jurisdictions, 2019-2020.

Author

Board, Amy, DAngelo, Denise, Miele, Kathryn, Asher, Alice, Salvesen von Essen, Beatriz, Denny, Clark, Terplan, Mishka, Dunkley, Janae, and Kim, Shin

Subjects
Humans, Female, Pregnancy, Naloxone, United States, Adult, Narcotic Antagonists, Young Adult, Opioid-Related Disorders, Drug Overdose, Prevalence, Pregnancy Complications, Adolescent, Self Report
Abstract

OBJECTIVES: We aimed to determine the prevalence of self-reported naloxone use during pregnancy among people in the United States with a recent live birth. A secondary objective was to characterize people at increased risk of overdose who did and did not use naloxone. METHODS: We analyzed data from the Pregnancy Risk Assessment Monitoring System from 26 US jurisdictions that conducted an opioid supplement survey from 2019 to 2020. Respondents with increased risk of experiencing an opioid overdose were identified based on self-reported use of illicit amphetamines, heroin, cocaine, or receiving medication for opioid use disorder (MOUD) during pregnancy. Weighted prevalence estimates and 95% confidence intervals were calculated for reported naloxone use at any point during pregnancy among people with an increased risk of overdose. RESULTS: Naloxone use during pregnancy was reported by

Published
2024

22. GLP-1R Agonist Treatment for Opioid Use Disorder

Author

New York University, University of Maryland, National Institute on Drug Abuse (NIDA), and Patricia Sue Grigson, Chairperson (Academic Administrator) Neural and Behavioral Sciences

Published
2024

26. Facilitating Opioid Care Connections

Author

Center for Court Innovation, New York State Unified Court System, Center on Addiction, Columbia University, Weill Medical College of Cornell University, National Institute on Drug Abuse (NIDA), and Katherine Elkington, Associate Professor of Clinical Medical Psychology, in Psychiatry, Co-Director, Center for the Promotion of Mental Health in Juvenile Justice, Division of Child and Adolescent Psychiatry

Published
2024

49. A Bundled Intervention

Author

National Institute on Drug Abuse (NIDA) and Li Li, Full Professor

Published
2024

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