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Background: Although the radiotherapy (RT) effect is reversible in some tissues, it is progressive and permanent for the ovary. Ovary radiation exposure during breast cancer radiotherapy (BCR) may cause concern in patients and obstetricians. In this study, we evaluated ovarian radiation doses in patients who received adjuvant radiotherapy for breast cancer prospectively. Methods: Ovary doses were calculated in patients diagnosed with breast cancer (BC) and receiving RT at the Radiation Oncology clinic of Ankara Bilkent City Hospital. Helical intensity modulated radiotherapy (IMRT) planning and three-dimensional (3D) planning were performed for each patient. Results: The data of 8 patients who received BCR at 8 August 2023 and 19 September 2023 were evaluated prospectively. The median age of the patients was 57 (range 39–65), 4 (50%) had breast conserving surgery (BCS), and 4 (50%) patients underwent modified radical mastectomy (MRM). Four (50%) patients were left sided, while four (50%) patients were right sided. According to our results, the ovarian doses in adjuvant radiotherapy of breast cancer patients who received RT with the 3D technique were zero. In helical IMRT plans, the ipsilateral ovary dose was median 12 (range 10–30) centi Gray (cGy); the contralateral ovary dose was median 8 (range 5–13) cGy. In patients with MRM, ipsilateral ovary dose in helical IMRT plans was median 10 (range 10–13); in patients with BCS, it was median 15 (12–30) cGy. Conclusions: This is the first study to examine ovarian doses in breast cancer radiotherapy on patients. In our study, in which we evaluated eight patients with 2 different RT techniques, the dose values of ovaries in breast cancer radiotherapy were found to be negligible and no measurable dose was noted in 3DRT technique.

: Background and purposeCranio-spinal irradiation for medulloblastoma can impair fertility in girls. The literature indicates that an ovarian dose of 4 Gy causes permanent infertility in 30% of young females and that doses of <1.5 Gy over the whole treatment are desirable. We report a modified radiotherapy technique using a non-divergent beam edge inferiorly to reduce the ovarian dose.: Patients and methodsEight female patients with medulloblastoma had magnetic resonance imaging (MRI) studies in the treatment position to identify the position of their ovaries relative to the radiation field. The information was transferred to the radiotherapy planning system and plans were generated using conventional spinal fields and modified fields with a half beam block at the inferior border.: ResultsIdentifying the position of the ovaries by MRI enabled the dose to be estimated for the two techniques. Using a non-divergent beam inferiorly, the mean ovarian dose was reduced in all cases by a median value of 2.45 Gy (range 0.6–19.5 Gy) and the median percentage reduction was 66.8% (range 2.6–84.6%). The position of the ovary relative to the beam edge was critical in determining the dose reduction for each case. The modified technique doubled the number of patients receiving <4 Gy to a single ovary from three to six. With this alteration, three patients also had an ovary receiving <1.5 Gy whereas all exceeded this dose with conventional treatment.: ConclusionWe recommend using asymmetry at the inferior spinal border to achieve a non-divergent edge to the treatment field to reduce the dose to the ovary. Using MRI to localise the ovaries is important in estimating their dose and in assisting the counselling of patients and their families about future fertility. [Copyright &y& Elsevier]