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3 results on '"p. f., Cortese"'

1. Erratum to: The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections

Author

M. Sartelli, A. Chichom-Mefire, F. M. Labricciosa, T. Hardcastle, F. M. Abu-Zidan, A. K. Adesunkanmi, L. Ansaloni, M. Bala, Z. J. Balogh, M. A. Beltrán, O. Ben-Ishay, W. L. Biffl, A. Birindelli, M. A. Cainzos, G. Catalini, M. Ceresoli, A. Che Jusoh, O. Chiara, F. Coccolini, R. Coimbra, F. Cortese, Z. Demetrashvili, S. Di Saverio, J.J. Diaz, V. N. Egiev, P. Ferrada, G. P. Fraga, W. M. Ghnnam, J. G. Lee, C. A. Gomes, A. Hecker, T. Herzog, J. I. Kim, K. Inaba, A. Isik, A. Karamarkovic, J. Kashuk, V. Khokha, A. W. Kirkpatrick, Y. Kluger, K. Koike, V. Y. Kong, A. Leppaniemi, G. M. Machain, R. V. Maier, S. Marwah, M. E. McFarlane, G. Montori, E. E. Moore, I. Negoi, I. Olaoye, A. H. Omari, C. A. Ordonez, B. M. Pereira, G. A. Pereira Júnior, G. Pupelis, T. Reis, B. Sakakushev, N. Sato, H. A. Segovia Lohse, V. G. Shelat, K. Søreide, W. Uhl, J. Ulrych, H. Van Goor, G.C. Velmahos, K. C. Yuan, I. Wani, D. G. Weber, S. K. Zachariah, and F. Catena

Subjects
Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published
2017
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2. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

Author

Daria Van Tyne, Daniel J Park, Stephen F Schaffner, Daniel E Neafsey, Elaine Angelino, Joseph F Cortese, Kayla G Barnes, David M Rosen, Amanda K Lukens, Rachel F Daniels, Danny A Milner, Charles A Johnson, Ilya Shlyakhter, Sharon R Grossman, Justin S Becker, Daniel Yamins, Elinor K Karlsson, Daouda Ndiaye, Ousmane Sarr, Souleymane Mboup, Christian Happi, Nicholas A Furlotte, Eleazar Eskin, Hyun Min Kang, Daniel L Hartl, Bruce W Birren, Roger C Wiegand, Eric S Lander, Dyann F Wirth, Sarah K Volkman, and Pardis C Sabeti

Subjects
Genetics, QH426-470
Abstract

The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis of these adaptations is critical to intervening successfully against malaria. To that end, we created a high-density genotyping array that assays over 17,000 single nucleotide polymorphisms (∼ 1 SNP/kb), and applied it to 57 culture-adapted parasites from three continents. We characterized genome-wide genetic diversity within and between populations and identified numerous loci with signals of natural selection, suggesting their role in recent adaptation. In addition, we performed a genome-wide association study (GWAS), searching for loci correlated with resistance to thirteen antimalarials; we detected both known and novel resistance loci, including a new halofantrine resistance locus, PF10_0355. Through functional testing we demonstrated that PF10_0355 overexpression decreases sensitivity to halofantrine, mefloquine, and lumefantrine, but not to structurally unrelated antimalarials, and that increased gene copy number mediates resistance. Our GWAS and follow-on functional validation demonstrate the potential of genome-wide studies to elucidate functionally important loci in the malaria parasite genome.

Published
2011
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3. On embedding a cycle in a plane graph

Author

Pier Francesco Cortese, Giuseppe Di Battista, Maurizio Patrignani, Maurizio Pizzonia, p. f., Cortese, DI BATTISTA, Giuseppe, Patrignani, Maurizio, and Pizzonia, Maurizio

Subjects
Graph drawing, Planarity testing, Discrete Mathematics and Combinatorics, Cycle, Clustered graph, Clustered planarity, Theoretical Computer Science, Embedding
Abstract

Consider a planar drawing Gamma of a planar graph G such that the vertices are drawn as small circles and the edges are drawn as thin stripes. Consider a non-simple cycle c of G. Is it possible to draw c as a non-intersecting closed curve inside Gamma, following the circles that correspond in Gamma to the vertices of c and the stripes that connect them? We show that this test can be done in polynomial time and study this problem in the framework of clustered planarity for highly non-connected clustered graphs.

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