Search

Palladium(II) complexes with tris(2-carboxyethyl)phosphine (PdTCEP) show promise for biomedical applications due to their distinct chemical characteristics. This study explored the toxicity of PdTCEP towards normal human cells and examined its interactions with model cell membranes. Two cell types were used to evaluate cytotoxicity: human microvascular endothelial cells (HMEC-1) and red blood cells (RBCs). In HMEC-1 cells, PdTCEP reduced survival to about 80% at 15 µM, with the most significant drop—down to 40%—occurring at 40 µM. The production of reactive oxygen species (ROS) increased in a manner dependent on both dose and time, especially after 72 h of incubation. Despite these effects, PdTCEP caused only minor hemolysis in RBCs, with hemolysis levels staying below 10% even at higher concentrations. Fluorescence anisotropy measurements showed that PdTCEP minimally affects the hydrophobic core of the lipid bilayer, with slight changes observed at concentrations above 40 µM. Generalized polarization (GP) analysis indicated a slight decrease in lipid polar head packing with increasing PdTCEP concentration. Complementary FTIR analysis supported these findings by providing detailed insights into PdTCEP-membrane interactions. This research underscores PdTCEP's selective cytotoxicity and structural effects on membranes, suggesting its promise for more in-depth biological and pharmacological studies. [ABSTRACT FROM AUTHOR]

Azo dye derived from 8-hydroxyquinoline and 3-aminopyridine namely (E)-5-(pyridin-3-yldiazenyl)quinolin-8-ol (PQ8OL) and its palladium complex were prepared and was characterized by H-NMR, UV-Vis, and mass spectroscopies. The value of conductivity indicates that the palladium complex is non-ionic. The structure of PQ8OL dye has been solved from powder X-Ray by using Material Studio. The structure has been indicated to hydrazone form of PQ8OL dye. The PQ8OL has coordinated via nitrogen and oxygen atoms of quinoline. The UV-Vis transitions indicated that the palladium complex is square planer. The palladium complex appeared biological activity more than PQ8OL ligand. The prepared compounds appeared potential biological activity in the range of 0.6-2.0 mm against Staphylococcus aureus and E. coli bacteria. The PQ8OL ligand and its palladium complex showed potential inhibition where the inhibition was 1.0 and 6.0 mm for PQ8OL ligand and palladium complex respectively against Staphylococcus aureus. The inhibition for E. coli, by the ligand and its palladium complex was 2.0, and 7.0 mm, respectively. [ABSTRACT FROM AUTHOR]

Background: The aim of this research is the synthesis and characterization of coumarin-palladium complex and the investigation of the cytotoxicity of both the ligand and the complex. Methods: The palladium(II) complex (CC) was obtained in the reaction between (E)-3-(1-((4-hydroxy-3-methoxyphenyl)amino)ethylidene)-2,4-dioxochroman-7-yl-acetate (CL) and potassium-tetrachloropalladate(II) and characterized using IR and NMR spectra, experimentally and theoretically. Cytotoxicity of CL and CC were determined for human cervical carcinoma HeLa, ovarian cancer A2780, hormone dependent breast cancer MCF7, and colorectal cancer HCT116 lines. The interaction of investigated compounds with HSA was followed by spectrofluorimetric method. The binding mechanism in the active pocket was assessed via molecular docking simulations. Results: A low mean absolute error between experimental and theoretical data proved that the optimized structure corresponded to the experimental one. Both compounds showed a satisfactory selectivity index towards neoplastic cells. The binding affinity of tested compounds to the HSA were confirmed. The molecular docking showed a much lower change in the Gibbs free energy of binding for CC compared to CL. Conclusions: The obtained results revealed that CL and CC exhibit significant effects on several cancer cell lines and good binding properties to HSA, while molecular docking discovered that CC has the most pronounced activity against alpha-fetoprotein. [ABSTRACT FROM AUTHOR]

The PdII complex bis{(S)-(−)-N-[(biphenyl-2-yl)methylidene]1-(4-methoxyphenyl)ethanamine-κN}dichloridopalladium(II), [PdCl2(C22H21NO)2], crystallizes in the monoclinic Sohncke space group P21 with a single molecule in the asymmetric unit. The coordination environment around the palladium is slightly distorted square planar. The N—Pd—Cl bond angles are 91.85 (19), 88.10 (17), 89.96 (18), and 90.0 (2)°, while the Pd—Cl and Pd—N bond lengths are 2.310 (2) and 2.315 (2) Å and 2.015 (2) and 2.022 (6) Å, respectively. The crystal structure features intermolecular N—H...Cl and intramolecular C—H...Pd interactions, which lead to the formation of a supramolecular framework structure.

The (S)-(+)-1-(4-bromophenyl)-N-[(4-methoxyphenyl)methylidene]ethylamine ligand, C16H16BrNO, (I), was synthesized through the reaction of 4-methoxyanisaldehyde with (S)-(−)-1-(4-bromophenyl)ethylamine. It crystallizes in the orthorhombic space group P212121 belonging to the Sohncke group, featuring a single molecule in the asymmetric unit. The refinement converged successfully, achieving an R factor of 0.0508. The PdII complex bis{(S)-(+)-1-(4-bromophenyl)-N-[(4-methoxyphenyl)methylidene]ethylamine-κN}dichloridopalladium(II), [PdCl2(C16H16BrNO)2], (II), crystallizes in the monoclinic space group P21 belonging to the Sohncke group, with two molecules in the asymmetric unit. The central atom is tetracoordinated by two N atoms and two Cl atoms, resulting in a square-planar configuration. The imine moieties exhibit a trans configuration around the PdII centre, with average Cl—Pd—N angles of approximately 89.95 and 90°. The average distances within the palladium complex for the two molecules are ∼2.031 Å for Pd—N and ∼2.309 Å for Pd—Cl.

Introduction/Justification: Oral squamous cell carcinoma is considered one of the most prevalent subtypes of head and neck cancers. Treatments include surgical resection, radiotherapy, and chemotherapy in the cases of patients with advanced squamous cell carcinoma (SCC). Cisplatin, or cis-diamminedichloridoplatinum(II), has been used for treatment of several types of cancer worldwide since 1978 including advanced head and neck SCC. The successful use of cisplatin led to the development of second-generation platinum-based drugs, with emphasis on carboplatin and oxaliplatin, which have been used for cancer treatment worldwide. Nevertheless, patients treated with platinum drugs as cisplatin are subjected to adverse effects as nephrotoxicity, and the search for new chemotherapeutic agents with reduced side effects is crucial. After the discovery of the platinum anticancer drugs, new metal-based compounds of copper, silver, gold, ruthenium, palladium and iridium were synthesized and evaluated as potential anticancer agents. Padeliporfin (Tookad®Soluble) was the first palladium(II) complex used in vascular targeted photochemotherapy for low-risk prostate cancer treatment, which also confirms the potential of use of this metal in the synthesis of new chemotherapeutic agents. In this context, our research group has dedicated efforts in the search of novel gold, silver, platinum and palladium complexes for treatment of cancer, with emphasis on SCC. One of the silver complexes with the anti-inflammatory drug nimesulide recently prepared in our group demonstrated in vitro and in vivo activity over SCC cells. Objectives: This study aimed to present the in vitro anti-proliferative activities over SCC of a water-soluble palladium(II) complex containing a cysteine derivative as a chelating ligand. Materials and Methods: SCC of tongue (SCC4 and SCC15) and a non-tumoral cell line (HaCat, immortalized keratinocyte) were used in this study. The cells were cultivated following methodology previously described in the literature. Results: The palladium(II) complex inhibited proliferation of SCC15 cells with a GI50 (concentration of a drug that reduces cell growth by 50%) of 40.28 µg mL 1 but low selectivity was observed when compared to HaCat cells (GI50: 28.33 µg mL 1). On the other hand, the complex did not inhibit SCC4 cell proliferation (GI50 > 250 µg mL 1). Conclusion: The palladium(II) complex seems to be indicated for treatment of SCC of tongue, but further studies are envisaged to understand the selectivity of the complex over the considered SCC lines and propose its possible mechanism of action. Acknowledgements: This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq #309800/2021-8; #429463/2018-9), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) for the Cancer Theranostics Innovation Center (CancerThera), CEPID FAPESP #2021/10265-8), and International Atomic Energy Agency (IAEA) technical cooperation projects for development of Latin American Countries (IAEA/TCLAC: EX-BRA6033-2401375).

The (S)-(+)-1-(4-bromophenyl)-N-[(4-methoxyphenyl)methylidene]ethylamine ligand, C16H16BrNO, (I), was synthesized through the reaction of 4-methoxyanisaldehyde with (S)-(-)-1-(4-bromophenyl)ethylamine. It crystallizes in the orthorhombic space group P212121 belonging to the Sohncke group, featuring a single molecule in the asymmetric unit. The refinement converged successfully, achieving an R factor of 0.0508. The PdII complex bis{(S)-(+)-1-(4-bromophenyl)-N-[(4-methoxyphenyl)methylidene]ethylamine-κN}dichloridopalladium(II), [PdCl2(C16H16BrNO)2], (II), crystallizes in the monoclinic space group P21 belonging to the Sohncke group, with two molecules in the asymmetric unit. The central atom is tetracoordinated by two N atoms and two Cl atoms, resulting in a square-planar configuration. The imine moieties exhibit a trans configuration around the PdII centre, with average Cl--Pd--N angles of approximately 89.95 and 90°. The average distances within the palladium complex for the two molecules are ~2.031 Å for Pd--N and ~2.309 Å for Pd--Cl. [ABSTRACT FROM AUTHOR]

In the title complex salt, [Pd(C10H8N2)(C12H12N2O2)](CF3SO3)2, the palladium(II) atom is fourfold coordinated by two chelating ligands, 2,2′-bipyridine and 4,4′-dimethoxy-2,2′-bipyridine, in a distorted square-planar environment. In the crystal, weak π–π stacking interactions between the 2,2′-bipyridine rings [centroid-to-centroid distances = 3.8984 (19) Å] and between the 4,4′-dimethoxy-2,2′-bipyridine rings [centroid-to-centroid distances = 3.747 (18) Å] contribute to the alignment of the complex cations in columns parallel to the b-axis direction.

The title complex, [PdCl2(C9H13N)2], comprises a single molecule in the asymmetric unit. The PdII atom is tetracoordinated by two N atoms from two trans-aligned organic ligands and two Cl ligands, forming a square-planar metal coordination environment. The distances from the ortho-H atoms on the phenyl ring to the central PdII atom fall within the range 4.70–5.30 Å, precluding any significant intramolecular Pd...H interactions.

The interest in the antineoplastic and binding properties shown by the bis-maltol polyamine family, particularly Malten and Maltonis, prompted us to study the Pd2+ complexes of these latter from both a biological and metallo-receptor point of view. The Malten-Pd2+ complex can lodge hard species such as Sr2+ in its coordination-driven preorganized pocket, as confirmed by X-ray diffraction. UV–Vis and NMR data showed that Malten-Pd2+ forms even at acidic pH and exists in aqueous solution in a wide range of pH. The mononuclear complex is stable enough not to release Pd2+ in solution for a long period of time (at least one week), thus Malten-Pd2+, similarly to Maltonis-Pd2+, is suitable to be tested in biological analyses. Studies on the U937 cell line revealed that the effect on cell survival reduction induced by Malten is partially lost in Malten-Pd2+, while no differences where monitored between the effects of Maltonis-Pd2+ and Maltonis, suggesting that the availability of free maltol moieties, that is retained in Maltonis-Pd2+, but not in Malten-Pd2+, is crucial to guarantee the biological activity of these compounds. The formation of stable mononuclear Pd2+ complexes of bis-maltol polyamines Malten and Maltonis was studied by UV–Vis and NMR spectroscopies and single crystal X-ray diffraction. When studied on the U937 cell line they revealed that the availability of free maltol functions is crucial for their antineoplastic activity. [Display omitted] • The synthesis of Malten was optimized to be faster and more green. • The formation of a stable mononuclear Malten-Pd2+ complex involved the maltol rings. • Malten-Pd2+ revealed able to act as a metallo-receptor for hard species. • Synthesis of Pd2+-complexes allowed to deepen the biological mechanism of action. • Availability of free maltols is crucial for the biological activity. [ABSTRACT FROM AUTHOR]

The interaction of palladium(II) chloride with 2-heteroylidene of betulonic acid (prepared via the condensation with pyridine-2-carbaldehyde, pyridine-3-carbaldehyde, pyridine-4-carbaldehyde, or quinoline-2-carbaldehyde) has been studied. Two ligands and one complex have been prepared for the first time; their structures have been confirmed by 2D NMR spectroscopy and high-resolution mass spectroscopy. The E-configuration of triterpenoid 2-heteroylidenes has been confirmed for the first time. Cytotoxic activity of the compounds with respect to the А549 cell line has been assessed. [ABSTRACT FROM AUTHOR]

We report the crystal structure of bis[N-(4-bromophenyl)pyridine-2-carboxamidato]Palladium (C1) which was isolated from the reaction of aqueous potassium tetrachloropalladate(II) and N-(4-bromophenyl)-pyridine-2-carboxamide in dichloromethane under nitrogen flow. The structure was characterised by the following spectroscopic methods 1H NMR, FT-IR and X-ray diffraction. [ABSTRACT FROM AUTHOR]

A new palladium(II) complex, [Pd(LSEt)Cl] (C1) with benzothiazole based ONS donor pincer ligand (HLSEt) was synthesized (where, HLSEt = 2-(benzothiazol-2-yl)-6-(((2-(ethylthio)phenyl)imino)methyl)phenol). Interaction of C1 with CT DNA was investigated, and its binding constant was found to be 4.0×105 M−1. The proficiency of ethidium bromide (EB) displacement from its EB-CTDNA complex by C1 was performed by the fluorescence quenching method, and Stern-Volmer quenching constant (Ksv) was found to be 4.3×105 M−1. Similarly, the interaction of C1 with BSA protein was investigated by UV-Vis and fluorescence methods. The apparent association constant (Ka) and Ksv were determined (Ka = 2.8×104 M−1 and Ksv = 5.5×104 M−1). In vitro cytotoxicity of the complex, [Pd(LSEt)Cl] (C1), towards human gastric cancer cell lines (AGS) was assessed by the MTT assay method. The half maximal inhibitory concentration (IC50) of C1 (9.55 ± 1.23 µM) towards AGS cancer lines was found to be lower than cisplatin (23.13 ± 1.03 µM). Herein, new palladium(II) complex, [Pd(LSEt)Cl] (C1) with benzothiazole-based ONS donor pincer ligand (HLSEt) was synthesized and characterized by several spectroscopic techniques. Interaction of C1 with CT DNA and BSA protein was investigated by UV-Vis and fluorescence methods. In vitro cytotoxicity of the complex toward human gastric cancer cell lines (AGS) was evaluated by the MTT assay method. The half maximal inhibitory concentration (IC50) of the palladium(II) complex (9.55±1.23 µM) was found to be less compared to cisplatin (23.13±1.03 µM) towards AGS cancer lines. [ABSTRACT FROM AUTHOR]

This study addresses a novel palladium dihalide complex, cis-[Pd(PCAH)Cl2] (C1), as a promising anticancer agent. XRD analysis reveals a deformed square planar geometry stabilized by hydrogen bonds and π•••π interactions. The M-Cl bonds in C1 demonstrate susceptibility to nucleophilic substitution by 2,2'-bipyridine (Bpy), with kinetic parameters evaluated using spectrophotometry. Fluorometric and spectrophotometric investigations demonstrate that C1 binds to CT DNA and protein with an avidity of around 105 M-1. The interaction with DNA is multifaceted, employing covalent bonding and intercalation, as supported by viscosity measurements. Fluorescence lifetime experiments illustrate that C1 produces static dampening of BSA fluorescence, implying structural adjustments near the tryptophan residue, further corroborated by spectroscopic analyses. The pair's (BSA and C1) FRET distance has also been computed. In vitro cytotoxicity tests suggest that C1 selectively suppresses the growth of breast carcinoma, MDA-MB-231 with IC50 = 20 ± 2.64 μM, while showing minimal effects on non-cancerous HEK-293 cells. The mechanism of action includes the creation of ROS, leading to mitochondrial apoptosis, as evidenced by various assays, including annexin-V-FITC/PI labeling. Overall, compound C1 exhibits encouraging promise as a selective anticancer drug with a ROS-triggered apoptotic mechanism, particularly effective against breast carcinoma MDA-MB-231 cells., (© 2025 Wiley‐VCH GmbH.)

Reactions of isocyanates/isothiocyanates with primary and secondary phosphines without solvent at room temperature afforded phosphinecarboxamide/phosphinecarbothioamide, respectively, in excellent yields. Furthermore, palladium complex Pd(COD)Cl2 was allowed to react with Ph2PC(O)NHPh (1a) to afford [Pd{Ph2PC(O)NHPh-κP}2Cl2] (3). On the other hand, the reaction of Pd(COD)Cl2 with 1 eq. of Ph2PC(S)NHPh (2a) afforded [PdCl2{Ph2PC(S)NHPh-κP,S}] (4). In the case of a 1:2 molar ratio, [PdCl{Ph2PC(S)NHPh-κP,S}{Ph2PC(S)NHPh-κP}]Cl (5) was formed. The newly obtained compounds were fully characterized using multielement NMR measurements and elemental analyses. In addition, the molecular structures of Ph2PC(O)NH(CH2)2Cl (1j), Ph2PC(S)NHPh(4-Cl) (2c), and 3–5 were determined using single-crystal X-ray diffraction. [ABSTRACT FROM AUTHOR]

Three palladium(II) complexes with amino-amidato-phenolato-type tridentate ligands were synthesized and characterized by 1H NMR spectroscopy and X-ray crystallography. The strategic arrangement of a hydrogen-bond donor and acceptor adjacent to the substitution site of the PdII complex allowed the selective coordination of nucleosides. Among two pyrimidine-nucleosides, cytidine and 5-methyluridine, cytidine was successfully coordinated to the PdII complex while 5-methyluridne was not. On the other hand, both purine-nucleosides, adenosine and guanosine, were coordinated to the PdII complex. As purines have several coordination sites, adenosine afforded three kinds of coordination isomers expected from the three different donors. However, guanosine afforded a sole product according to the ligand design such that the formation of double intramolecular hydrogen-bond strongly induced the specific coordination by N1-position of guanine moiety. Furthermore, the preference of the nucleosides was evaluated by scrambling reactions. It was found that the preference of guanosine is nearly twice as high as adenosine and cytidine, owing to the three-point interaction of a coordination bond and two hydrogen bonds. These results show that the combination of a coordination and hydrogen bonds, which is reminiscent of the Watson–Crick base pairing, is an effective tool for the precise recognition of nucleosides. [ABSTRACT FROM AUTHOR]

Treatment with transition metal complexes is an efficient method to fight with cancer. Therefore, a new transition metal complex formulated as [Pd(1, 3-pn)(acac)]Cl (pn and acac stand for propylendiamine and acetylacetonate, respectively) was synthesized and analyzed using 1H NMR, Fourier transform infrared, electronic absorption spectroscopy techniques as well as elemental analysis and conductivity measurement. The geometry optimization, frontier molecular orbital (FMO) analysis, molecular electrostatic potential (MEP), natural bond orbital (NBO) analysis and nonlinear optical (NLO) property were accomplished by density functional theory (DFT) at B3LYP level with 6-311G(d,p)/aug-cc-pVTZ-PP basis set. Preliminary determination of antitumor activity and lipophilicity of this metal complex was performed experimentally and the promising results were obtained. This encouraged us to study the interaction and binding mode/modes of this complex with DNA as the primary receptor for the chemotropic drugs and BSA as the transporter protein in the circulatory system. For this reason, the binding of newly made complex was assessed in-vitro under physiological state using experimental and in-silico molecular modeling studies. So, the CT-DNA binding study of this complex was explored using spectrofluorometric as well as spectrophotometric techniques, viscosity and gel electrophoresis experiments. Furthermore, fluorescence, UV–Vis, F o ¨ rster resonance energy transfer and circular dichroism studies were carried out for BSA binding. The experimental and computational interaction studies showed that [Pd(1, 3-pn)(acac)]Cl complex binds to the minor groove of CT-DNA and interacts with BSA by van der Waals forces and hydrogen bond. [ABSTRACT FROM AUTHOR]

Two novel palladium(II)–amino acid complexes, [Pd(Ala)2]·H2O (PA) and [Pd(Val)2].H2O (PV) (Ala = alanine; Val = valine) were synthesized and characterized through FTIR, UV/Vis, 1H-NMR spectroscopies, CHN analysis, X-ray crystallography and molar conductivity measurement. Furthermore, cytotoxicity of Pd(II) complexes against human leukemia cancer cell line, MOLT4 showed promising cancer cell death (CC50 = 0.71 ± 0.046 µM for PA; CC50 = 0.85 ± 0.063 µM for PV) that were less than cisplatin (1.59 ± 0.25 µM). Moreover, the interaction of both the complexes with DNA and BSA was studied using UV–Vis absorption and emission spectroscopic techniques that demonstrated the bindings occurred via van der Waals forces and hydrogen bond. Furthermore, the fluorescence titration showed that static quenching mechanism plays predominate role in binding process. All results showed that both complexes have more binding tendency to DNA in compared to BSA that can be a significant achievement for further medical purposes as a potential antitumor candidate. Finally, molecular docking simulation was performed for PA and PV complexes with DNA and BSA and demonstrated both complexes bind to the groove of DNA mainly by hydrogen bond and interact with site I of BSA via hydrogen bond as well. [ABSTRACT FROM AUTHOR]

Synthesis, reactivity, characterization, and catalytic activities of a series of palladium(II) complexes containing the thiazolinyl‐picolinamide derived pincer ligand is reported. Treatment of 2‐aminobenzonitrile with cysteamine and subsequent treatment with 2‐picolinic acid afforded the thiazolinyl‐picolinamide derived tridentate pincer ligand N∩N∩N (2). Treatment of 2 either with (COD)PdCl2 or PdCl2 in 1 : 1 ratio afforded the palladium(II) complex [(κ3‐N∩N∩N)PdCl] (3). A reaction between Pd(OAc)2 and 2 in equimolar ratio in dichloromethane gave [(κ3‐N∩N∩N)Pd(η1‐OAc)] (4) which on further treatment with triflic acid in acetonitrile produced the [(κ3‐N∩N∩N)Pd(N≡C−CH3)]OTf (5). The complex 5 was further treated with auxiliary ligands to produce the cationic heteroleptic palladium complexes, [(κ3‐N∩N∩N)Pd(NC5H5)]OTf (6), [(κ3‐N∩N∩N)Pd(NC5H4CN)]OTf (7), and [(κ3‐N∩N∩N)Pd(NC5H4NMe2)]OTf (8), respectively. The newly synthesized compounds were characterized by 1H and 13C{1H} NMR spectroscopic techniques and the molecular structures of 2–4, 6 and 8 were established. The catalytic activity of palladium(II) complexes (3–8) were evaluated for the acylative Suzuki coupling reaction between aryl carboxylic acids and arylboronic acids to yield unsymmetrically substituted biaryl ketones. The effect of reaction conditions viz., solvent, base, temperature, catalyst loading were evaluated, and complex 4 was found to be an excellent catalyst with a maximum TOF of 19.8 min−1. [ABSTRACT FROM AUTHOR]

The title compound, [Pd(C14H10N4)2](NO3)2·CH3CN, consists of a cationic PdII complex, two anions and one lattice solvent molecule, all in general positions. In the complex, the PdII cation is four-coordinated in a slightly distorted square-planar geometry defined by the four N atoms of two bidentate 2,3-di-2-pyridylpyrazine ligands. The complex, anions and solvent molecule are linked by weak C—H...O intermolecular hydrogen bonds. In the crystal, the complex molecules are stacked in columns along the a axis.

The title complex, [Pd(NO3)(C15H11N3)]NO3, comprises a cationic PdII complex and a nitrate anion. In the complex, the PdII cation is four-coordinated in a distorted square-planar coordination geometry defined by the three N atoms of the tridentate 2,2′:6′,2′′-terpyridine ligand and one O atom from the NO3− anion. In the crystal, the complex molecules are stacked in columns along the a axis being connected by π–π stacking [closest inter-centroid separation between pyridyl rings = 3.878 (3) Å]. The connections between columns and anions to sustain a three-dimensional architecture are C—H...O hydrogen bonds.

During the synthesis of 1,10‐phenanthroline derivatives sterically hindered in the 2 and/or 9 positions, serendipity led to the discovery of a new substitution pattern on phenanthroline with good and reproducible yields. When toluene was used as a solvent and the aryl‐lithio reagents generated with tBuLi, after a first substitution at the 2 position, a benzyl substituent was regioselectively introduced at the 7 position. It is proposed that the benzyllithium reagent is formed by reaction with the solvent and that the steric hindrance on the intermediates controls the nucleophilic addition. Among the complexes prepared (Pd(II), Cu(I)) with these new ligands, a chiral copper(I) complex exhibits spontaneous resolution in the solid state. [ABSTRACT FROM AUTHOR]

• New cyclometalated bimetallic palladium(II) complexes are synthesized via C H bond activation. • Square planar geometries of the complexes are confirmed by X-ray crystallography. • Electronic structure and UV–vis spectra are interpreted by DFT and TDDFT calculations. • Interaction with CT DNA are studied by UV–vis and fluorescence method. • Palladium(II) complexes exhibit potential anti-cancer activity towards AGS cancer cell lines. Herein, we report the synthesis, characterization and in vitro anticancer activity of two μ -Cl and μ -O bridged dimeric cyclometalated palladium(II) complexes having general formula [Pd 2 (L1)Cl 2 ] (1) and [Pd 2 (L2)Cl 2 ] (2). The complexes are synthesized via palladium assisted aromatic C H bond activation of coordinating ligands (HL1/HL2) and thoroughly characterized by spectroscopic techniques. X-ray crystal structure analysis has confirmed the square planar geometry of the complexes. DFT and TDDFT results have interpreted the electronic structure and solution spectra of the complexes. Cytotoxicity of the complexes was studied by in vitro model with human gastric cancer cell lines (AGS). Cytotoxicity investigation reveals that the complexes have promising anti-cancer activity, with IC 50 values of 13.03 µM and 17.86 µM for 1 and 2 , respectively. UV–vis and fluorescence techniques are used to examine how the complexes interact with CT DNA. Fluorescence-based competitive binding analysis with ethidium bromide (EB) indicates that the complexes effectively displace EB from the EB-DNA complex. Herein, we report the synthesis of two μ -Cl and μ -O bridged dimeric palladium(II) complexes (1 / 2) via metal assisted aromatic C H bond activation. Geometries of the complexes are confirmed by single crystal X-ray diffraction method. Electronic structure and solution spectra of the complexes are interpreted by DFT and TDDFT calculations. In vitro cytotoxic activity of the complexes against human AGS gastric cancer cell lines by MTT colorimetric assay exhibit promising anti-cancer activities with IC 50 values of 13.03 µM and 17.86 µM for palladium(II) complexes 1 and 2 respectively. The interaction of the complexes with CT DNA are investigated by UV–vis and fluorescence methods. [Display omitted] [ABSTRACT FROM AUTHOR]

In the title compound, [Pd(C7H3NO4)(C10H8N2)]·H2O, the PdII cation is four-coordinated in a distorted square-planar coordination geometry defined by the two N atoms of the 2,2′-bipyridine ligand, one O atom and one N atom from the pyridine-2,6-dicarboxylate anion. The complex and solvent water molecule are linked by intermolecular hydrogen bonds. In the crystal, the complex molecules are stacked in columns along the a axis.

In the title compound, [Pd(C10H24N4)]I2·H2O, the PdII ion is four-coordinated in a slightly distorted square-planar coordination environment defined by four N atoms from a 1,4,8,11-tetraazacyclotetradecane ligand. The cationic complex, two I− anions and the solvent water molecule are linked through intermolecular hydrogen bonds into a three-dimensional network structure.

A palladium(II) complex, [Pd(L)Cl] (1) with a new ONS donor azo–thioether ligand (L) (where L = 2,4-dihydroxy-5-((2-(methylthio)phenyl)diazenyl)(phenyl)(phenyl)methanone) is successfully synthesized. The ligand and complex are thoroughly characterized by several spectroscopic techniques. The geometry of the complex is confirmed by single-crystal X-ray analysis. Electronic structure and spectral properties are interpreted by DFT and TDDFT calculations. The interaction of the complex with CT DNA was investigated by UV-vis method and binding constant is found to be 5.42 × 104 M−1. Competitive binding titration with ethidium bromide (EB) by fluorescence titration method was carried out to understand the efficiency of the complex to displace EB from EB-DNA complex. From fluorescence titration Stern-Volmer dynamic quenching constants, Ksv was calculated and is found to be 4.15 × 104 M−1. Cyclic voltammogram of the complex exhibits significant shifting of the reduction couple to the negative potential region and decrease in current height in the presence of CT DNA. SYNOPSIS A palladium(II) complex, [Pd(L)Cl] (1) with a new ONS donor azo–thioether ligand (L) (where L = 2,4-dihydroxy-5-((2-(methylthio)phenyl)diazenyl)(phenyl)(phenyl)methanone) is successfully synthesized and characterized. The geometry of the complex is confirmed by single-crystal X-ray analysis. Electronic structure and spectral properties are interpreted by DFT and TDDFT calculations. The interaction of the complex with CT DNA is investigated by UV-vis, fluorescence and cyclic voltammetric method. [ABSTRACT FROM AUTHOR]

In the present study, an asymmetric tetradentate NOON Schiff base ligand 2,2′-((4-methyl-1,2-phenylene)bis(nitrilomethylylidene))bis(4-chlorophenol) (H2L) was synthesized by condensation of 4-methylphenylenediamine with 5-chlorosalicylaldehyde. The Ni(II) and Pd(II) Schiff base complexes were synthesized from the reaction of Ni(OAc)2·4H2O and Pd(OAc)2 with the Schiff base ligand (H2L) in methanol and acetonitrile, respectively. The ligand and its complexes were characterized by FT-IR, 1H NMR, UV-Vis spectroscopy, and elemental analyses. Moreover, the crystal structure of the ligand and Pd(II) complex has been determined by single-crystal X-ray crystallography. The single-crystal X-ray analysis of PdL complex demonstrated a four-coordinated complex by two nitrogen atoms and two phenolate groups. In addition, DFT and TD-DFT calculations were done using M06-2X and B3LYP levels of theory along with Def2-TZVP and ATZP basis sets for ligand and its complexes. Theoretical IR and nature of electronic transition in TD-TDFT data were analyzed by frequency and NBO-CMO calculations. [ABSTRACT FROM AUTHOR]

The synthesis of a novel ligand bis(3-methoxysalicylidene)-4-methylbenzene-1,2-diamine (H2L) has been carried out by the condensation of 4-methylbenzene-1,2-diamine with 3-methoxysalicylaldehyde. The Ni(II) and Pd(II) Schiff base complexes have been synthesized from the reaction of Ni(OAc)2·4H2O and Pd(OAc)2 with the Schiff base ligand (H2L) in methanol and acetonitrile, respectively. The ligand and its complexes have been characterized by elemental analyses, FT-IR, 1H-NMR and UV–Vis spectroscopy. Moreover, the crystal structure of the ligand has been determined by single crystal X-ray crystallography. To have better understanding of electronic transitions of the ligand and its complexes, density functional theory (DFT) calculations have been performed. The geometries and electronic properties of the compounds have been obtained with the M062X level at Def2-TZVP basis set. Additionally, NBO analysis has been performed to interpret electronic transitions by determining their included occupied and virtual orbitals. The theoretical parameters confirmed the suggested structure of complexes. The spectroscopic data obtained from DFT calculations show acceptable agreement with the experimental results. [ABSTRACT FROM AUTHOR]

Abstract A Pd(II) complex of tetradentate Schiff base ligand, bis(5-methoxysalicylidene)-4-methyl benzene-1,2-diamine (H 2 L) was prepared from Pd(OAc) 2 in refluxing acetonitrile. The complex was characterized using FT-IR, lH NMR, 13C{1H} NMR spectroscopic techniques, elemental analyses (CHN). Also, its molecular structure was determined by single-crystal X-ray diffraction. The crystal structure data showed a tetradentate mode of coordination for Schiff base, through N 2 O 2 donor sets. In addition, DFT calculations at M06-2X/Def2-TZVP level of theory were conducted to obtain electronic and structural properties of the studied species. NBO-CMO analysis combined with TD-DFT method was done to interpret electronic transitions by determining their included occupied and virtual orbitals. NBO-CMO data show that there are MMCT and LMCT in the studied complex. All theoretical data are in line with the experimental results. Highlights • Synthesis, characterization and spectral properties of new Pd(II) Schiff base complex. • Geometry distorted square-planar around Pd(II). • Structural and DFT studies of the new Pd(II) complex. [ABSTRACT FROM AUTHOR]

The syntheses of tetradentate ligand, meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid (H2-1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and B16F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cisplatin, the exception was concentrations above 62.5 μM of platinum(IV) complex in the B16F1 cell line.

In the title complex, [Pd(SCN)2(C5H4N)2], the PdII ion has a trans-N2S2 square-planar coordination sphere defined by two pyridine ligands and two S-bound SCN− anions. The PdII cation lies on an inversion centre, thus the asymmetric unit contains one half of the complex, the PdN2S2 moiety is exactly planar and the two pyridine rings are parallel. In the crystal, the complex molecules are stacked in columns along the a-axis direction.

Abstract The synthesis, as well as the spectroscopic and structural characterization of three analogous palladium(II) complexes, [Pd{(Ph 2 P) 2 N( t Bu)-κ2 P,P ´}X 2 ], X = Cl, Br, I, is presented. X-ray crystallography studies revealed a similar square planar PdP 2 X 2 first coordination sphere among the three complexes. The catalytic reactivity of these complexes was tested in the Suzuki-Miyaura coupling reaction, showing that the X = Cl, Br, complexes are more active than the X = I analogue. The differences in the catalytic reactivity within this series of complexes, as well as comparisons with similar palladium(II) catalysts reported in the literature, are discussed with respect to the different electronegativity of the three halogens and the strong +I inductive effect of the ligand's t Bu group. Graphical abstract Image 1 Highlights • The synthesis and characterization of the analogous palladium(II) complexes [Pd{(Ph 2 P) 2 N( t Bu)-κ2 P,P ´}X 2 ], X = Cl, Br, I, is presented. • These complexes exhibit similar square planar coordination spheres and the expected differences in the Pd−X bond lengths. • Effects of the X− ligand and the t Bu group, on the catalytic reactivity of the complexes in the Suzuki-Miyaura reaction. [ABSTRACT FROM AUTHOR]

Phenylalanine ester-introduced palladium(II) and platinum(II) complexes were synthesized. Taking advantage of the formation of Schiff bases by amino acids as an intermediate, the pyridylimine moiety coordinated to a metal center. Single crystals of each complex were obtained successfully, and their molecular structures were clarified in detail. The Pd(II) complex showed remarkable cytotoxicity compared to the Pt(II) complex. [ABSTRACT FROM AUTHOR]

Abstract Novel, simple and efficient catalytic system based on a polymer supported Pd complex of 2,6-bis(benzimidazolyl)pyridine, Pd(PS BBP)Cl 2 , was found to be highly active for Suzuki–Miyaura cross-coupling of aryl halides with phenylboronic acids under mild conditions. The catalyst was characterized by CHN analyses, thermogravimetric analyses, BET surface area measurements, ICP-OES, FT-IR and electronic spectral studies. The effect of solvent, base, temperature and catalyst concentration on the coupling reaction of iodobenzene with phenylboronic acid was also investigated. A variety of functional groups are tolerated. The novel catalyst could be recovered in a facile manner from the reaction mixture and could be reused up to seven times without significant loss of catalytic activity. Graphical abstract Image 1 Highlights • A novel polymer supported Pd(II) complex was prepared and characterized. • Geometry of complex on polymer support was confirmed by elemental analyses, IR, TGA and Electronic spectrum. • Non free radical mechanism was studied. • Catalyst was reused for seven times. [ABSTRACT FROM AUTHOR]

Graphical abstract Highlights • New Pd(II) complexes have been synthesized and characterized. • The CT-DNA and BSA protein interaction of these compounds studied. • The ligand and complexes were docked with BSA protein. • Cytotoxicity against human lung (A-549) and breast (MCF-7) cancer cell lines carried out. Abstract Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect. [ABSTRACT FROM AUTHOR]

The new palladium(II) complexes [Pd(L 1 /L 2 )Cl] ( 1 / 2 ), with ONS donor azo-thioether ligands (HL 1 /HL 2 ), have been successfully synthesized. The complexes were thoroughly characterized by several spectroscopic techniques. The distorted square planar geometries of the complexes were confirmed by single crystal X-ray analysis. The electronic structures, redox and spectral properties are interpreted by DFT and TDDFT calculations. The interaction of the complexes with CT DNA was investigated by the UV–Vis method and the binding constant was found to be 3.56 × 10 4  M −1 for 1 and 5.72 × 10 4  M −1 for 2 . A competitive binding titration with ethidium bromide (EB) by the fluorescence titration method revealed that the complexes efficiently displace EB from the EB–DNA system and the Stern–Volmer dynamic quenching constant, K sv , was found to be 1.28 × 10 4  M −1 and 2.04 × 10 4  M −1 for 1 and 2 respectively. [ABSTRACT FROM AUTHOR]

Three different palladium(II) complexes with ligands containing nitrogenized aromatic rings were investigated theoretically as model to obtain the computational band gap energies. The results demonstrated promising possibility for designing palladium(II) complexes with photocatalytic properties at visible light irradiation. Deliberated products were synthesized via grafting on the silica-coated Fe3O4 magnetic nanoparticles (Fe3O4@SiO2). Formation of complexes on the surface of Fe3O4@SiO2, as insoluble and reusable photocatalysts, was proved by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric (TGA), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), transmission electron microscope (TEM), and scanning electron microscopy (SEM) analyses. The trend of the band gap energies of prepared structures was calculated via experimental and theoretical methods. The photocatalytic capability of these nanoparticles was investigated in degradation of 2,4-dichlorophenol by means of HPLC analysis. A tentative reaction mechanism for the formation of intermediates was proposed.ᅟ [ABSTRACT FROM AUTHOR]

In this research, the Suzuki-Miyaura coupling reaction catalyzed by a palladium(II) complex containing bis(imidazolium) ligand, Pd(BIM), immobilized on graphene oxide (GO) as heterogeneous, recyclable and active catalyst is reported. The catalyst, Pd(BIM)@GO, was characterized by FT-IR, diffuse reflectance UV-Vis spectroscopy, ICP, field emission scanning electron microscopy, energy-dispersive X-ray analysis, and elemental analysis. It was demonstrated that the GO-supported palladium(II) complex can act as an efficient catalyst and is reusable several times without a significant loss of their catalytic activity. [ABSTRACT FROM AUTHOR]

Schiff base metal complexes are considered promising chemotherapeutic agents due to their potential application in cancer therapy. The current work sought to synthesize a brand-new Schiff base ligand obtained from 2-hydroxybenzohydrazide and (E)− 1-(2-(p-tolyl)hydrazono)propan-2-one with metal ions which included Pd(II) and Zn(II) ions. Elemental analyses, FT-IR, mass spectra, 1H NMR, UV-Vis spectrometer, and computational analysis characterized the compound's structure. In vitro, the breast cancer cell line (MCF-7) was tested for its sensitivity to Schiff base (HL) and its Pd(II) and Zn(II) complexes. The half-maximal inhibitory concentration IC 50 of the compounds was determined and used to perform the comet assay, which was carried out to reveal the photo-induced DNA damaging ability of the compounds of individual cells. Moreover, the compounds' effects on antioxidant defense systems of enzymes in cells: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities and oxidant Malondialdehyde (MDA) were examined in MCF-7 cells. The Pd(II) complex displayed approximately the same IC 50 as Cisplatin, while Zn(II) complex had better activity than Cisplatin with very low IC 50 , 1.40 μg/ml. Significant alterations in SOD, CAT, GPx, and MDA production were discovered, inducing oxidative stress, enlarging ROS production, and reducing the antioxidant amount. This change was approximately similar in most compounds. Consequently, it promoted apoptosis, particularly the Zn(II) complex, which demonstrated an improved impact because of its ability to influence the antioxidant defense systems of enzymes, mostly SOD and GPx, besides increasing MDA levels. It can be concluded that Zn(II) complex is the most effective anticancer drug since it induced a very similar genotoxic effect as Cisplatin and has a very low IC 50 value. • New Schiff base ligand obtained from 2-hydroxybenzohydrazide and (E)− 1-(2-(p-tolyl)hydrazono)propan-2-one was synthesized. • The new Schiff base ligand contained metal ions which included Pd(II) and Zn(II) ions. • Zn(II) complex was the most effective anticancer drug. [ABSTRACT FROM AUTHOR]

A simple and efficient catalytic system based on a Pd complex of 4-aminoantipyrine, 4-AAP–Pd(II), was found to be highly active for Suzuki–Miyaura cross-coupling of aryl iodides and bromides with phenylboronic acids under mild reaction conditions. Good to excellent product yields from the cross-coupling reaction can be achieved when the reaction is carried out in ethanol, in the open air, using low loading of 4-AAP–Pd(II) as a precatalyst, and in the presence of aqueous K2CO3 as the base. A variety of functional groups are tolerated.

A palladium(II) complex {systematic name: dichlorido[1,3-di-tert-butyl-2,4- bis(tert-butylamino)-1,3,2λ5,4λ5-diazadiphosphetidine-2,4-diselone-k²Se,Se']palladium(II)}, cis-[PdCl2{I}], (II), containing a bis(selenium) ligand based on cyclodiphosph(V)azane, cis-[(tBuNH)(Se)P('-NtBu)2P(Se)(NHtBu)], (I), has been synthesized and structurally characterized. The crystal structure of complex II reveals that the ligand chelates through selenium donors with the natural bite-angle of 110.54 (1)° and a Pd--Se bond distance of 2.444 (1) Å. The coordination around PdII shows a slightly distorted square-planar geometry, as indicated by the angle between the [PdCl2] and [PdSe2] planes of 5.92 (3)°. In the crystal, the molecules are interlinked through weak N--H. . .l and C-- H. . .l hydrogen-bonding interactions. [ABSTRACT FROM AUTHOR]

A monomeric PdII complex bearing a mixed carbocyclic/N-heterocyclic carbene ligand and two bromides was reacted with an excess of elemental iodine, which resulted in the surprising removal of one bromide ligand and dimerization of the mixed-carbene complex to form di-μ-bromido-bis{[1-(cyclohepta-2,4,6-trien-2-yl-1-ylidene-κ C1)-3-(2,6-diisopropylphenyl)imidazol-2-ylidene]palladium(II)} bis(pentaiodide) dichloromethane monosolvate, [Pd2Br2(C22H24N2)2](I5)2·CH2Cl2. The dimeric complex features a slightly distorted square-planar core of two PdII centres bridged by two bromide ligands, which lie in the same plane as the seven- and five-membered rings of the bidentate carbene ligand. The counter-ions in the single crystal were found to be pentaiodide monoanions featuring their typical V-shape, whereas for the bulk material, a mixture of Br/I interhalides is proposed. [ABSTRACT FROM AUTHOR]

New complexes of nickel(II) and palladium(II) were synthesized using the ferrocenyl imine ligand, which was formed by the condensation of 2-aminothiophenol and acetylferrocene. This bidentate Schiff base ligand was coordinated to the metal ions through the NS donor atoms. Monomeric complexes of nickel(II) and palladium(II) were synthesized by the reactions of the Schiff base ligand with nickel(II) and palladium(II) chloride in a 2:1 M ratio. In these complexes, the thiol group was deprotonated and coordinated to the metals. The molar conductivity values of the complexes in DMSO showed the presence of non-electrolyte species. The fluorescence characteristics of the Schiff base ligand and its complexes were studied in DMSO. The synthesized complexes were characterized by FT-IR, 1H NMR, UV-vis spectroscopy, elemental analysis, and conductometry. Furthermore, the binding interactions of the complexes with DNA were investigated by electronic absorption spectroscopy, and the intrinsic binding constant ( Kb) was calculated. Moreover, viscosity and melting temperature ( Tm) were investigated in order to further explore the nature of interactions between the complexes and DNA. [ABSTRACT FROM AUTHOR]

Complex [Pd(4,4′-bit)Cl] ( 1) is synthesized by the reaction of PdCl and 4,4′-bithiazole (4,4′-bit) in acetonitrile and crystallized by vapor diffusion of methanol into a dimethyl sulfoxide solution of the complex. This complex is thoroughly characterized by elemental analysis, IR, H NMR, UV-Vis, and luminescence spectroscopy and its structure is studied by the single crystal X-ray diffraction method. The X-ray structure determination shows that in the structure of this complex, the Pd(II) atom is fourcoordinated in a slightly distorted square-planar configuration by two nitrogen atoms from a bidentate 4,4′-bithiazole ligand and two chloride ions. [ABSTRACT FROM AUTHOR]

The new coumarine derivative, 3-(1-(3-hydroxypropylamino)ethylidene)chroman-2,4-dione, and corresponding palladium(II) complex have been synthesized and characterized by microanalysis, infrared, 1 H and 13 C NMR spectroscopy. The structure of the ligand, solved using a monocrystal X-ray structural analysis, consists of two crystallographic different pseudocentrosymmetrically related molecules of 3-(1-(3-hydroxypropylamino)ethylidene)chroman-2,4-dione, while the structure of the square-planar palladium(II) complex was proposed on the basis of DFT calculations. The palladium(II) complex decreased viability of U251 human glioma and B16 mouse melanoma cells in a dose and time dependent manner, while its ligand exhibited only moderate cytotoxicity. [ABSTRACT FROM AUTHOR]

We report the synthesis and characterization of a novel 4-(dimethylamino)pyridinium-substituted η3-cycloheptatrienide-Pd complex which is free of halide ligands. Diacetonitrile{η3-[4-(dimethylamino)pyridinium-1-yl]cycloheptatrienido}palladium(II) bis(tetrafluoroborate), [Pd(C2H3N)2(C14H16N2)](BF4)2, was prepared by the exchange of two bromide ligands for noncoordinating anions, which results in the empty coordination sites being occupied by acetonitrile ligands. As described previously, exchange of only one bromide leads to a dimeric complex, di-μ-bromido-bis({η3-[4-(dimethylamino)pyridinium-1-yl]cycloheptatrienido}palladium(II)) bis(tetrafluoroborate) acetonitrile disolvate, [Pd2Br2(C14H16N2)2](BF4)2·2CH3CN, with bridging bromide ligands, and the crystal structure of this compound is also reported here. The structures of the cycloheptatrienide ligands of both complexes are analogous to the dibromide derivative, showing the allyl bond in the β-position with respect to the pyridinium substituent. This indicates that, unlike a previous interpretation, the main reason for the formation of the β-isomer cannot be internal hydrogen bonding between the cationic substituents and bromide ligands. [ABSTRACT FROM AUTHOR]

Reaction of ligand, L-Ch 2 Ph with Na 2 PdCl 4 in acetonitrile yielded palladium(II) complex, [Pd(L)Cl] via C S bond cleavage. It is characterized by several spectroscopic techniques and the structure is confirmed by single crystal X-ray study. The complex exhibits quasi-reversible oxidation couple at 0.86 V corresponds to ligand based thiophenolato to thiyl radical oxidation. Electronic structure, solution spectrum and redox properties are interpreted by DFT and TDDFT calculations. [ABSTRACT FROM AUTHOR]

The unsymmetricalα-diimine ligand N-{2-[2,6-bis(propan-2-yl)phenylimino]- pentan-3-ylidene}-2,6-bis(propan-2-yl)aniline, [ArN =C(Me)-(Et)C NAr] [Ar = 2,6-(iPr)2C6H3], (I), and the corresponding palladium complex, cis-(N- {2-[2,6-bis(propan-2-yl)phenylimino]pentan-3-ylidene}-2,6-bis(propan-2-yl)aniline)- dichloridopalladium(II) 1,2-dichloroethane monosolvate, [PdCl2(C29H42- N2)].C2H4Cl2 or cis[PdCl2{I}], (II), have been synthesized and characterized. The crystal and molecular structure of the palladium(II) complex have been established by single-crystal X-ray diffraction. The compound crystallized along with a 1,2-dichloroethane solvent of crystallization. The coordination plane of the PdII atom shows a slight tetrahedral distortion from square-planar, as indicated by the dihedral angle between the PdCl2 and PdN2 planes of 4.19 (8)°. The chelate ring is folded along the N...N vector by 7.1 (1)°. [ABSTRACT FROM AUTHOR]