Search

An improved understanding of the computed tomographic (CT) features for malignant versus benign oral tumors would be helpful for guiding prognosis and treatment planning decisions in dogs. This retrospective, multi-center, observational study compared the CT features of malignant and benign tumors in 28 dogs with 31 oral masses. Malignant tumors were present in 20 dogs, including malignant melanoma (n = 14), squamous cell carcinoma (SCC, n = 4), adenocarcinoma (n = 1), and fibrosarcoma (n = 1). Eight dogs had benign tumors, including giant cell granuloma (n = 2), peripheral odontogenic fibroma (n = 2), acanthomatous ameloblastoma (n = 2), plasmacytoma (n = 1), and oncocytoma (n = 1). Common CT features of malignant tumors included heterogeneous enhancement, tumor invasion into the adjacent bone, tooth loss, and ipsilateral mandibular lymphadenopathy. Malignant tumors were significantly larger than benign tumors. Bone lysis was found in benign tumors (n = 4) such as acanthomatous ameloblastoma, giant cell granuloma, and plasmacytoma. The bone lysis was a well-defined geographic area regardless of malignancy and tumor type. In periosteal reactions, amorphous patterns were seen in both malignant (n = 2) and benign tumors (n = 2); the latter subgroup also showed solid patterns. Bone expansion (n = 2) was identified in malignant melanoma and acanthomatous ameloblastoma. Findings supported a diagnosis of possible malignancy for dogs with oral tumors having the following CT characteristics: large size, heterogeneous contrast enhancement pattern, bone lysis, tooth loss, and ipsilateral lymphadenopathy. However, there was a considerable overlap of CT findings among the different types of oral tumors and between benign and malignant tumors. Histological evaluation therefore remains necessary for definitive diagnosis.

Odontogenic lesions are well described in domestic cats, but published literature describing these lesions in nondomestic felids is limited. This study reports oral lesions in 109 captive, non-domestic felids. Ten cases of odontogenic lesions were diagnosed, including 9 with fibromatous epulis of periodontal ligament origin (FEPLO) and one odontogenic cyst in a cougar. FEPLO was common in lions. FEPLO did not recur after surgical removal in any of the 3 cases for which follow-up information was available. Increased occurrences of oral papillomas in snow leopards and eosinophilic granulomas in tigers were identified, which is consistent with the reported literature. With the exception of oral papillomas in snow leopards and FEPLO in lions, the spectrum of oral lesions in nondomestic felids was similar to what is reported in domestic cats, with squamous cell carcinoma being the most common oral malignancy, and stomatitis/gingivitis/glossitis accounting for approximately one third of all cases. Rare diagnoses with one case each included hemangioma, fibrosarcoma, melanoma, cleft palate, and glossal amyloidosis.

A case of peripheral ossifying fibroma (POF) in the anterior mandible of a 63-year-old woman is described. The 17 x 23 x 16mm nodular mass was sessile, displaced teeth and had a non-ulcerated, pink surface. Due to the variations in radiographic, clinical and pathological appearance, initially the diagnosis of peripheral odontogenic fibroma was reached. Complex nomenclature and variation in clinical, radiological and pathological appearance of POF and similar masses is discussed.

Objectives Peripheral odontogenic fibroma (POF) is a relatively rare odontogenic tumor of the gingiva. Although its histological differential diagnosis from fibrous epulis (FE) is important, no study has reported the differences in their expression of immunohistochemical markers. Here, we compared the expression of tumor markers that are frequently used for the differential diagnosis of fibroproliferative lesions between POF and FE. Methods Forty cases were selected, including 20 POF and 20 FE cases. CD34, B cell lymphoma (Bcl)-2, and Ki-67 were used as markers for immunohistochemical examination. The positive cell ratio was calculated, and Mann-Whitney U test was performed for statistical analysis. Results POF and FE were negative for CD34 expression but showed Bcl-2 and Ki-67 expression. The ratio of Bcl-2- and Ki-67-positive cells was significantly higher in POF than in FE (p Conclusions POF is CD34 negative, and Bcl-2 and Ki-67 positive-cell ratio differs between POF and FE, suggesting that these proteins may serve as immunohistochemical markers for the differential diagnosis of POF.

In neoplasms Peripheral Odontogenic Tumors(POT) are one of the rare to occur on gingiva, among them, Peripheral Odontogenic Fibroma (POdF) is the most common. A plethora of lesions sharing similar clinical features, makes the diagnosis difcult. POdF is a benign, slow-growing, smooth, exophytic, painless lesion but it may show diverse clinical presentation as erythematous, lobulated, rapidly growing mass which might be tender on palpation overlapping the features with various inammatory gingival conditions to even a gingival squamous cell carcinoma.This results into diagnostic enigma. Histopathologoical examination plays a vital role in these type of cases. Discussed here is a case of POdF mimicking gingival squamous cell carcinoma. Histopathological investigation showed presence of odontogenic epithelium and dystrophic calcication which are the pathognomonic features of POdF. After surgical removal,POdF is seen to recur but, the exact recurrence rate cannot be estimated due to scarcity of reported cases.

Summary: Fibromatous epulis is a rare tumour in horses which is analogous to the same condition in dogs and peripheral odontogenic fibromas in man. The nomenclature is varied throughout the veterinary literature, but these tumours are most correctly known as peripheral odontogenic fibromas. Although these lesions are benign, they have a high recurrence rate in other species, so wide local excision is important to give the best possible prognosis.

Peripheral ossifying fibromas (POFs) and peripheral odontogenic fibromas (POdFs) appear clinically similar but of different histogenesis. The novel marker SATB2 is involved in regulation of osteoblastic differentiation and phenotype. However, SATB2 expression has not been previously explored in POFs and POdFs. Given the potential for mineralized tissue formation in POFs and POdFs, and to more clarify the phenotype of the lesional cells, this study was aimed to immunohistochemically investigate SATB2 expression in POFs and POdFs. Fourteen cases of POF and POdF (7 cases each) were selected, stained for SATB2 immunohistochemically, and scored according to the percentage of positive lesional cells (0, no staining; 1 +

Peripheral odontogenic fibroma (POF) is an uncommon finding in the mouth of cats. Few cases have been reported in the literature. The present report describes an adolescent, male-castrated domestic shorthair cat with POFs at the rostral upper and lower jaws that were treated via marginal excision including removal of underlying bone. Despite the high incidence of recurrence reported in the literature, recheck examinations up to 11 months postoperatively did not show regrowth of the gingival masses. Thus, marginal excision including removal of underlying bone appears to be a viable treatment option for POF in cats.

Background: The incidence and frequency of odontogenic cysts and tumors depends on the different geographic location. Odontogenic cysts and tumors are lesions that arise from the tooth apparatus or its remnants. The purpose of this study was to determine the prevalence of odontogenic cysts and tumors over a period of 5 years 9 months and to compare our results with other published studies. Aim and Objective: The purpose of this study was to evaluate the prevalence of odontogenic cysts and tumors diagnosed at the Department of Oral Pathology, M.M. College of Dental Sciences & Research, Mullana (Ambala) and to compare the results with findings in the literature. Materials and Method: Data of odontogenic cysts and tumors diagnosed during 2014 to 2019 (till September) w4ere collected from the files of the Oral Pathology Department, M.M. College of Dental Sciences & Research, Mullana (Ambala). Results: Out of the total 71 cases of odontogenic cysts, most prevalent odontogenic cysts were found to be radicular cysts (n=42, %= 59.1%), followed by dentigerous cysts (n=17, %=23.9%) and odontogenic keratocyst (n=12, %=16.9%). Among the odontogenic tumors out of 49 cases reported, the most prevalent was ameloblastoma (n=28, %=57.1%) followed by, ameloblastic fibroma (n=06, %=12.2%), odontoma (n=05,%=10.2%), adenomatoid odontogenic tumor (n=03, %=6.1%), peripheral odontogenic fibroma (n=02, %=4.08%), ameloblastic carcinoma (n=02, %=4.08%), odontogenic fibroma (n=02, %=4.08%) and odontogenic myxofibroma (n=01, %=2.04%). The anterior and posterior portion of the body of mandible was the most common site for both odontogenic cysts and tumors. The age group for odontogenic cysts ranged from 07 to 72 years of age, whereas for the odontogenic cysts the range was 10 to 75 years of age. The male to female ratio for the odontogenic cysts was 1:1.2, whereas for the odontogenic tumors it was found to be having more female predilection with the ratio of 1:1.3. Conclusion: The prevalence of odontogenic cysts was similar to that reported in the literature, with incidence of radicular cysts seen most frequently. In case of odontogenic tumors the findings vary to the reported literature with ameloblastoma being more commonly reported.

To present the clinical presence, histopathological features, and management of a rare peripheral odontogenic fibroma (POF) case. A 32-year-old male patient was referred to the clinic complaining of a localized gingival enlargement of the anterior maxillary region. Initial periodontal treatment was delivered and the patient was informed about proper oral hygiene. After the initial periodontal treatment, the lesion was surgically excised while preserving the marginal line. POF was diagnosed based on clinical and histopathological findings. Normal mechanical oral hygiene was established in the postoperative period. No recurrence was observed during this follow-up period, and the patient was included in the maintenance phase. POF was treated with local excision and the prognosis was excellent. Regular follow-ups are very important for such patients after surgery. How to cite this article: Alan R, Can B, Kilinc F. Peripheral Odontogenic Fibroma: A Rare Case Report. Int Dent Res 2018;8(1):45-9. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

The extraosseous/peripheral odontogenic fibroma (E/POF) is a benign mesenchymal odontogenic tumour found on the gingival surface with clinical characteristics identical to those of reactive lesions. A histopathological analysis is the only method for determining the difference between reactive lesions and these neoplastic lesions, whose recurrence potential varies between 38.9% and 50%, highlighting the importance of correct diagnosis. The following report describes an E/POF case with a clear cells component, as well as a long-term follow-up treatment, which we emphasise due to its potential for recurrence.

A 10 yr old intact female German shepherd dog presented with a large peripheral odontogenic fibroma and malignant melanoma on her lower jaw. The tumor was resected with a unilateral subtotal rostral hemimandibulectomy. After the mandible was removed, it was devitalized intraoperatively by freezing it in liquid nitrogen. It was subsequently reimplanted. New bone tissue formed in the gap between the frozen bone and the host bone. The regenerated bone contained osteocytes, osteoblasts, and blood vessels. The cosmetic appearance of the dog was preserved. The dog had normal mastication. The malignant melanoma recurred rostral of the left canine tooth at 159 days after the reconstruction surgery. A subtotal hemimandibulectomy was consequently performed. This is the first reported case of mandibular reconstruction using a liquid nitrogen-treated autograft in a dog with oral tumors.

Gingival growths are one of the most frequently encountered lesions in the oral cavity. A plethora of lesions can be seen having similar clinical presentation, making diagnosis a dilemma. Peripheral odontogenic tumors are rare neoplasms to occur on gingiva, the most common among them being the peripheral odontogenic fibroma (POdF). The POdF is a benign, slow-growing, exophytic lesion. Although considered to have a recurrence potential after excision, the actual recurrence rate is not known due to paucity of reported cases. Presented here is a case of a rare neoplasm mimicking an inflammatory gingival lesion with review of the available literature. How to cite this article Khot K, Deshmane S, Bagri-Manjrekar K, Khot P. Peripheral Odontogenic Fibroma: A Rare Tumor mimicking a Gingival Reactive Lesion. Int J Clin Pediatr Dent 2017;10(1):103-106.

Peripheral ossifying fibroma (POF) is by far the most common of the reactive fibro-osseous processes affecting the gingiva.1 Histologically, POF shows a wide spectrum, the types and patterns of calcification and ossification varying in both amount and appearance, mostly depending on the stage of development, although the diagnosis is straightforward nevertheless.1 Here we describe two rare findings in mature lesions of POF: transepithelial elimination (TEE) of bony sequestrae (case 1) and multiple inclusions of odontogenic epithelium in the intervening fibrous stroma (case 2). Our working hypotheses were that case 1 gave rise to florid pseudoepitheliomatous hyperplasia (PEH) that could have been potentially misdiagnosed as squamous cell carcinoma (SCC), whereas case 2 showed overlap of microscopic features with peripheral odontogenic fibroma (POdF), making the differential diagnosis challenging. This article is protected by copyright. All rights reserved.

There appears to be similarities between the clinical appearances of different types of gingival overgrowths. The WHO type peripheral odontogenic fibroma (POdF) is an unusual benign odontogenic neoplasma of the gingiva. It is considered to be an extraosseous counterpart of the central odontogenic fibroma (COF). Among all biopsy specimens, POdF comprehend only upto 0.05%. Odontogenic fibromas are rare but still they provide a noteworthy diagnostic and therapeutic challenge. Along with clinical, radiographic appearance, and histologic features, a sound knowledge on biologic behavior of rare gingival overgrowths would ensure an accurate diagnosis of tumor pathology. We present here a case report of POdF that occurred in a young female patient in anterior interdental region displacing the tooth. Platelet rich fibrin (PRF) was used to stimulate soft tissue healing. Two year follow up showed satisfactory healing with no recurrence.

Peripheral odontogenic fIbroma (POF) is a rare odontogenic tumor. It resembles clinically with other peripheral exophytic lesions like pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell granuloma. Hence, needs to be differentiated from such other lesions. Histopathological examination being the only diagnostic approach for peripheral odontogenic fibroma, which can provide a basis for treatment and prognosis evaluation. This case report presents a rare clinical case of a 14-year-old female patient with a palatal overgrowth along the maxillary incisors, which was diagnosed as peripheral odontogenic fibroma.

Pathological dental conditions in zoo animals are frequently encountered, although under-reported in the veterinary literature. Teeth fractures are commonly encountered in carnivores and often require specialised endodontic intervention. This paper describes gingivectomy of a peripheral odontogenic fibroma of the left maxillary gingivae; crown lengthening of the left mandibular canine; and pulpectomies of complicated crown fractures of the left maxillary canine tooth (204), left mandibular canine tooth (304) and left third maxillary incisor (203) in an adult jaguar (Panthera onca). Follow-on dental examination at 18 months and postoperative radiographs at 24 months found no evidence of further dental pathology. Dental examination and prophylaxis are essential components of the examination procedure. There are limited opportunities to make routine clinical assessments in zoo animals. The availability of specialised materials, equipment and specialised veterinary assistance are limitations as relevant to zoological dentistry today as when described by Fowler in 1986.

Congenital granular cell epulis (CGCE) is an uncommon lesion of unclear pathogenesis. It occurs predominantly in female newborns with a predilection site of the maxillary alveolar ridge. The mass enlarges prenatally but the growth arrests after birth. Histologically, CGCE is characterized by a proliferation of polygonal cells with eosinophilic, granular cytoplasm and eccentric, bland-appearing nuclei. It closely resembles adult granular cell tumor (GCT) microscopically and S-100 immunostain is often helpful in distinguishing the two (S-100-positive in GCT and S-100-negative in CGCE). Clinically, the lesion should also be distinguished from entities such as infantile myofibroma, rhabdomyoma, melanotic neuroectodermal tumor of infancy, peripheral odontogenic fibroma, and neurofibroma. CGCE demonstrates an excellent prognosis and has not been associated with any syndromes/genetic defects or malignant transformation. Clinicians and pathologists should be familiar with this rare entity and its differential diagnosis for accurate diagnosis and management.

Isolated lesions of gingiva arise in succession to the hyperinflammatory reactions in response to the underlying local irritants. Despite their overlapping clinical and histological features, these lesions are distinctive regarding their biological behavior. Recurrence has been reported after surgical excision because of the incomplete removal of underlying local irritants. This article describes the clinical and histological features of four localized gingival lesions, adding a note on their molecular pathogenesis and surgical management.

Patient: Male, 35-year-old Final Diagnosis: Central odontogenic fibroma Symptoms: Asymptomatic Medication:— Clinical Procedure: Enucleation • surgery removal Specialty: Dentistry Objective: Rare disease Background: Odontogenic fibroma is a rare mesenchymal odontogenic tumor. It can be classified as central odontogenic fibroma (COF) or peripheral odontogenic fibroma (POF) based on clinical features. There are several variants of COF, including amyloid, ossifying, and giant cell. It grows slowly and exhibits painless cortical expansion of the jawbone. Radiographically, COF appears as a radiolucent unilocular or multilocular lesion with well-defined borders. COF may be associated with unerupted or displaced teeth and root resorption. Case Report: A 35-year-old man was referred to our hospital for submandibular swelling. Panoramic radiography and contrast-enhanced computed tomography revealed a unilocular area of bone resorption with a well-defined border and equal enhancement from the canine to first molar on the right side of the mandible. Root resorption of the first premolar and root separation of the first and second premolars were also evident. The lesion was asymptomatic. Histopathological examination of a biopsy of the lesion was suggestive of OF. Enucleation of the tumor, curettage of the bone around the tumor, and extraction of the premolar were then performed. Histopathological examination of the tumor showed fibrous connective tissue with inactive-looking odontogenic epithelial islands and strands, amyloid deposit, intercalation of Langerhans cells into the tumor epithelium, and no calcification. The final diagnosis of amyloid variant of COF was made. The postoperative course is going well. Conclusions: Herein we describe and discuss the clinical, radiological, and pathological features of the amyloid variant of COF. This report will enhance understanding of this extremely rare variant.

Peripheral odontogenic fibroma (POF) is defined as a benign neoplasm of the jaws of odontogenic ectomesenchymal origin. It is considered an uncommon neoplasm that affects patients in a wide age group, with certain predominance in girls and women. It appears as a firm, slow-growing, and usually sessile mass that affects the gingiva, is of firm consistency, and is covered by apparently normal mucosa. The objective of this study was to report a case of FOP in a 17-year-old male patient with a localized gingival swelling in the region of the left canine. It was present for 3 years and had slowly grown, causing displacement of the teeth. Radiography of the involved area did not reveal bone loss. The lesion was removed by surgical excision, and the POF was diagnosed based on clinical and histopathologic findings. Regular follow-ups are very important for such patients after surgery.