1. Thiocarbonyl Derivatives of Natural Chlorins: Synthesis Using Lawesson's Reagent and a Study of Their Properties.
- Author
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Pogorilyy, Viktor, Ostroverkhov, Petr, Efimova, Valeria, Plotnikova, Ekaterina, Bezborodova, Olga, Diachkova, Ekaterina, Vasil'ev, Yuriy, Pankratov, Andrei, and Grin, Mikhail
- Subjects
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CHLORINS , *CHEMICAL stability , *PHARMACEUTICAL chemistry , *AQUEOUS solutions , *METAL complexes , *MACROCYCLIC compounds - Abstract
The development of sulfur-containing pharmaceutical compounds is important in the advancement of medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation of sulfur-containing groups or individual sulfur atoms into their structure are not neglected, either. In this work, a synthesis of sulfur-containing derivatives of natural chlorophyll a using Lawesson's reagent was optimized. Thiocarbonyl chlorins were shown to have a significant bathochromic shift in the absorption and fluorescence bands. The feasibility of functionalizing the thiocarbonyl group at the macrocycle periphery by formation of a Pt(II) metal complex in the chemotherapeutic agent cisplatin was shown. The chemical stability of the resulting conjugate in aqueous solution was studied, and it was found to possess a high cytotoxic activity against sarcoma S37 tumor cells that results from the combined photodynamic and chemotherapeutic effect on these cells. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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