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Herbal medicines are used by patients with IBD despite limited evidence. We present a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating treatment with herbal medicines in active ulcerative colitis (UC). A search query designed by a library informationist was used to identify potential articles for inclusion. Articles were screened and data were extracted by at least two investigators. Outcomes of interest included clinical response, clinical remission, endoscopic response, endoscopic remission, and safety. We identified 28 RCTs for 18 herbs. In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26). There was a significantly higher rate of clinical remission for CL (RR 2.58, 95% CI 1.18-5.63), but not for AP (RR 1.31, 95% CI 0.86-2.01). Higher rates of endoscopic response (RR 1.56, 95% CI 1.08-2.26) and remission (RR 19.37, 95% CI 2.71-138.42) were significant for CL. CL has evidence supporting its use as an adjuvant therapy in active UC. Research with larger scale and well-designed RCTs, manufacturing regulations, and education are needed.

Introduction: Recurrent urinary tract infections (UTIs) are common in individuals with neurogenic lower urinary tract dysfunction (NLUTD) and greatly affect their quality of life. There is currently no established prophylactic measure based on evidence. We have therefore evaluated the effects of a horseradish root and nasturtium herb product on the frequency of UTIs in a retrospective cohort. Methods: Clinical data of patients with chronic NLUTD who were receiving the phytotherapeuticum for at least 12 months were analyzed. The number of UTIs was categorized as no UTIs, sporadic UTIs (1–2/year) and recurrent UTIs (≥3/year). The change in the annual number of patient-reported symptomatic UTIs and antibiotic prescriptions was investigated. Results: Data of 43 individuals (mean age 49 ± 13 years, median NLUTD duration 17.9 years) were analyzed. The proportion of individuals with recurrent UTIs decreased significantly (p < 0.0001) from 58.1% (42.1–73.0%) to 23.3% (11.8–38.6%) during phytotherapy, whereas the proportion of individuals without UTIs increased significantly (p = 0.001) from 14.0% (5.3–27.9%) to 39.5% (25.0–55.6%). In addition, there was a significant (p = 0.008) decrease in the number of antibiotic prescriptions. Conclusion: Prophylactic treatment with horseradish root and nasturtium herb seems to be a promising option for the prevention of UTIs. [ABSTRACT FROM AUTHOR]

Three new diterpenoid alkaloids (1, 2, 3) and seventeen known (4–20) compounds were isolated from the whole plant of Delphinium sherriffii Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound 5 exhibited the strongest cytotoxicity (IC50 = 8.97 μM) against Sf9 cell line. [ABSTRACT FROM AUTHOR]

The emergence of diseases is one of the main obstacles to the shrimp industry when it comes to intensive aquaculture practices. Ecytocnucleospora hepatopenaei (EHP) is one of the shrimp microsporidia known to cause growth retardation and white discoloration associated with musculature, thereby decreasing shrimp production yield. Prolonged use of chemotherapeutic agents in bulk quantities may result in drug-resistant pathogenic microbes, toxic, and residual sedimentation in aquatic ecosystems. In this present study, Melaleuca cajuputi leaf extract (MCLE) was extracted, and an acute toxicity test was carried out to determine a 96-h median lethality concentration (LC50). The behavior of shrimp was also observed after exposure to MCLE to determine their responses. The microsporidian-infected Litopenaeus vannamei was obtained from the shrimp farm in Terengganu, Malaysia, and the isolation and identification of EHP were performed using the Percoll-gradient method and polymerase chain reaction (PCR), respectively. Subsequently, the MCLE at 10, 20, and 30% of 96-h LC50 were exposed to the isolated EHP to determine their antimicrosporidian potential and the morphological changes were viewed under scanning electron microscopy (SEM). Results showed that the 96-h LC50 of MCLE to L. vannamei was recorded to be 162.14 mg L−1. Behavior responses were observed in L. vannamei after exposure to MCLE including agitation, swimming erratically, gasping at the water surface constantly, lethargy, and color changes in abdominal segments and carapace, and the severity was proportional with the MCLE concentrations. All MCLE concentrations cause inhibition to EHP, with 48.6 mg L−1 causing severe impairment on the EHP cell membrane. The finding could be useful to find natural antimicrosporidian therapeutics as an alternative to combat EHP in shrimp farms. [ABSTRACT FROM AUTHOR]

Himachal Pradesh is one of the most species-rich regions in the world and a key center for the origin and diversity of numerous plant species. Ethnobotanical research is essential for exploring these diverse biological resources for medicinal uses. This study aimed to record the traditional knowledge of the tribal communities in Himachal Pradesh concerning the use of medicinal plants for treating diseases in humans and livestock. Despite this richness, there is a lack of detailed documentation about the use of therapeutic plants in this area. The indigenous communities in this region rely on traditional knowledge of medicinal plants, making it a valuable resource for further pharmacological and phytochemical research. The ethnobotanical surveys were conducted from August 2022 to July 2023, and our fieldwork took place in four districts (Kullu (1279 m), Mandi (760 m), Hamirpur (780 m) and Kangra (1200–1300 m) under various villages. The ethnobiological data was gathered through field surveys, open interviews, discussions, and semi-structured questionnaires conducted with 193 tribal participants aged 40 to 80 years. Informants were chosen using the randomized household interview and snowball sampling methods. The study documented 64 plants from 39 families, among which 58 species are angiosperms, 5 species are pteridophytes and one species is bryophyte utilized for therapeutic purposes. Rosaceae, Lamiaceae, and Ranunculaceae were the most used medicinal herb families. Rubus ellipticus (0.75) and Trillium govanianum (0.74) demonstrated the highest UV (Use value) values. The ICF (Informant Consensus factor) value revealed that nervous system disorders-related ailments were the most treated. This study explored the ethnobiological information of therapeutic flora from riparian vegetation within tribal communities while also assessing the present state of research and the practical application of their medicinal information. It underscores the potential for additional research to delve deeper into the indigenous properties of their therapeutic floras and emphasizes the importance of preserving their traditional medicinal wisdom. [ABSTRACT FROM AUTHOR]

In this study, the effects of physicochemical and biochemical digestion conditions on β-arbutin stability and bioaccessibility were investigated. β-Arbutin, at doses that correspond to its natural occurrence in plant materials (i.e., 1–100 mg), was subjected to gastric and intestinal electrolyte treatments (application of physicochemical factors) or the whole digestion process (application of physicochemical and biochemical factors). Its content in in vitro bioaccessible fractions was determined using high-performance liquid chromatography (HPLC), and percentage bioaccessibility was calculated. The study shows very high stability and bioaccessibility of β-arbutin in a wide range of applied concentrations. Especially at doses ≥7.5 mg, bioaccessibility was close to 100% regardless of the stage of digestion and the type of treatment (electrolyte treatment or the whole digestion process). The assessment of phytochemicals in terms of their stability and interactions with the digestion environment can help in the future evaluation of their applicability for therapeutic purposes. The high bioaccessibility of β-arbutin within its multifunctional biological activity makes it a promising substance for phytomedicinal applications. [ABSTRACT FROM AUTHOR]

Objective: Children are frequently afflicted with common colds due to the wide range of circulating cold viruses and their developing immune systems. Given their susceptibility to such illnesses, there is a growing interest in exploring natural alternatives to conventional drug therapy. Traditional medicine offers a rich tradition of utilizing herbal remedies for the treatment of colds. This review aims to identify and evaluate the efficacy of herbal medicines for treating colds in children. Methods: This systematic review employed a comprehensive search strategy to identify relevant literature on the use of herbal medicines for treating common colds in children. Authoritative scientific databases, including Google Scholar, SID, Magiran, and Scopus, were systematically searched using the following keywords: 'common cold, children,' 'traditional medicine,' 'herbal medicine,' and 'treatment.' Irrelevant articles were excluded from the review process. Results: The review identified a range of herbal medicines traditionally employed for the treatment of common colds in children. These include Tilia cordata (linden), Glycyrrhiza glabra (licorice), Sambucus nigra (elderberry), Melaleuca alternifolia (tea tree oil), Hyssopus officinalis (hyssop), Inula helenium (elecampane), Plantago lanceolata (plantain), Althea officinalis (marshmallow), Eucalyptus globulus (eucalyptus), Citrus limonum (lemon), and Allium sativum (garlic), among others. Conclusion: Several medicinal plants possess antibacterial, anti-inflammatory, and antiviral properties that may be beneficial for children. The plants identified in this review, owing to their antimicrobial and antiviral activities, hold potential for alleviating the symptoms of common colds in pediatric populations. [ABSTRACT FROM AUTHOR]

New alternatives for controlling resistant populations of gastrointestinal nematodes are being studied, including the use of plant compounds and biological control with nematophagous fungi. The objective of this study was to evaluate the in vitro anthelmintic effect of linalool and its association with the fungus Duddingtonia flagrans (isolated AC001) in controlling gastrointestinal nematodes in sheep. The ovicidal activity of linalool was assessed via the Egg Hatch Test (EHT), and the larvicidal activity of linalool, alone and in combination with D. flagrans conidia, was evaluated via the Larval Motility Inhibition Test (LMIT) on infective larvae (L3). In the EHT, 100% inhibition occurred (at 1.25 and 2.5 mg/mL), with an LC50 of 0.49 mg/mL. In the LMIT, linalool alone inhibited 100% of larval motility (at 4% and 8%), with an LC50 of 0.42% or 4.2 mg/mL. In the combination of linalool with D. flagrans, there was a significant reduction in larvae, starting at 24 h, with 100% reduction after 14 days, thus being more effective in reducing L3 compared to the use of the fungus alone. It is concluded that linalool exhibits ovicidal and larvicidal activity, and its association with D. flagrans enhances the fungal predation capacity and potentiates anthelmintic efficacy. [ABSTRACT FROM AUTHOR]

The phytochemical composition, anti-oxidant and cytotoxic potential of Simarouba glauca leaf extracts were examined. The anti-oxidant activity was determined by DPPH, PM and FRAP assays. The determination of cell viability was performed by MTT assay. The acetone and methanol extracts showed higher anti-oxidant capacities than other extracts. The methanol and acetone extracts inhibited PA1 ovarian cancer cell growth in a dose-dependent manner with IC50 values 106.67 ± 1.53 μg/ml−1 and 124.43 ± 3.04 μg/ml−1, respectively, compared to the standard drug Doxorubicin (IC50 = 2.91±0.03 μg/ml−1). The selectivity of the plant proved to have a promising anti-cancer potential by inhibiting PA1 ovarian cancer cell lines. [ABSTRACT FROM AUTHOR]

A cross-sectional analytical design was set up to collect data about medicinal plants' use through a Google Forms survey. Out of the 16,379 individuals surveyed in Honduras, treatment for anxiety and dermatological problems was more frequent at an older age. Treatments for symptoms of fever, cough, diarrhea, abdominal pain, and joint pain were more common at an older age and those residing in rural areas received treatment for asthmatic problems. The population chose the use of medicinal plants as an alternative for the treatment of symptoms or illnesses due to economic factors or limited access to health-care service. [ABSTRACT FROM AUTHOR]

The medicinal plant usage by Jaunsari tribe in Chakrata forest of Dehradun district, India were documented. The study area was divided into five elevation gradients. The data was collected through interviews with local communities to document medicinal plants and their uses, while simultaneously assessing their ecological characteristics. A total of 105 plant species from 47 families were documented, with treatments identified for 43 ailment types. Thirteen different plant parts were recorded for their medicinal properties. Asteraceae had highest number of recorded plants. Herbaceous plants constituted the majority, accounting for 42%, followed by shrubs at 29%. The richness of medicinal trees and shrubs declined with increasing elevation while medicinal herb richness displayed positive correlation with elevation. The study identified three IUCN red-listed plant species in the study area. [ABSTRACT FROM AUTHOR]

Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19-epi-rhynchophylloside A (1), 7-epi-rhynchophylloside A (2), and 7-epi-anthocephalusine A (3), were isolated from the hook-bearing branches of Uncaria rhynchophylla. The structures and absolute configurations of 1–3 were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids 1 and 3 showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index. [ABSTRACT FROM AUTHOR]

Three new cyclopentanoid monoterpenes, neopiscrocins A–C (1–3), together with 14 known compounds (4–17), were isolated from the roots of Picrorhiza scrophulariiflora. The structres of these compounds were elucidated on the basis of their spectroscopic data. All compounds were evaluated for cytotoxicity against six human tumor cell lines (PC9, PANC1, HCT-116, Hep-G2, BGC-823, and MCF-7), hepatoprotective activity and anti-inflammatory activity. [ABSTRACT FROM AUTHOR]

Background: Impaired gastric accommodation is one of the most frequent symptoms of functional dyspepsia. The safety and efficacy of conventional treatments remain to be proven and alternative herbal therapies have been proposed to alleviate gastrointestinal symptoms. This preclinical study examined the role of herbal Amara extract (containing Artemisia absinthium, Centaurium erythraea, Cichorium intybus, Gentiana lutea, Juniperus communis, Achillea millefolium, Peucedanum ostruthium, Salvia officinalis, and Taraxacum extracts) on gastric (fundus) accommodation and the possible implication of muscarinic receptors in its regulation. Methods: The effect of Amara extract on fundus motility was investigated in organ baths of smooth muscle strips isolated from the fundus of guinea pigs, and the role of the muscarinic receptor pathway was evaluated using functional and radioligand binding assays in cell lines expressing the M2 or M3 muscarinic receptor. Key Results: Amara extract inhibited carbachol‐induced contraction of guinea pig smooth muscle strips in a dose‐dependent manner. This relaxant effect was not affected by the M3 antagonist J‐104129. Amara extract also inhibited M2, but not M3, receptor activity in CHO‐K1 cells (IC50 219 μg mL−1), and specifically bound the M2 receptor (IC50 294 μg mL−1). Of the nine herbal components of Amara extract, Juniperus communis, P. ostruthium, and Salvia officinalis inhibited M2 receptor activity (IC50 32.0, 20.8, and 20.1 μg mL−1, respectively), and P. ostruthium was sufficient to reverse carbachol‐induced ex vivo contraction of guinea pig fundic smooth muscles. Conclusion and Inferences: Amara extract relaxes gastric smooth muscles by inhibiting the M2 muscarinic receptor. This study suggests the potential benefit of Amara extract for patients with impaired gastric accommodation. [ABSTRACT FROM AUTHOR]

Acetaminophen (APAP) overdose is one of the most common causes of acute liver injury. The current standard-of-care treatment for APAP hepatotoxicity, N-acetyl-l-cysteine, is highly effective when administered early after overdose, but loses efficacy in later-presenting patients. As a result, there is interest in the identification of new treatments for APAP overdose patients. Natural products are a promising source of new treatments because many are purported to have hepatoprotective effects. In fact, a great deal of research has been done to identify natural products that can protect against APAP-induced liver injury. However, serious concerns have been raised about the rigor and human relevance of these studies. Here, we systematically reviewed the APAP-natural product literature from 2013 to 2023 to determine the veracity of these concerns and the scope of the potential problem. The results substantiate the concerns that have been previously raised and point to concrete steps that can be taken to improve APAP-natural product research. [ABSTRACT FROM AUTHOR]

Introduction: Seasonal allergic rhinitis (SAR) is a common health condition that is associated with an increased risk for bronchial asthma. Besides conventional medicine, treatments from traditional, complementary and integrative medicine are widely used by individuals with SAR. This review aims to systematically summarize evidence on the efficacy, effectiveness, and safety of European/Western phytotherapy (PT) and medications from anthroposophic medicine (AM) in individuals with SAR. Methods: Four electronic databases were screened for clinical studies published between January 1990 and March 2023. The results were qualitatively synthesized and the study quality was assessed. Results: In total, 14 studies were included, 11 from European/Western PT and three from AM. About half of the studies were rated as being of sufficient quality. The most frequently studied plant was Petasites hybridus (butterbur), showing beneficial effects on immunological parameters, subjective symptoms, and nasal airflow. Beneficial immunological and clinical effects were also shown for an herbal preparation combining Citrus limonis (lemon) and Cydonia oblonga (quince). The medications examined by studies of sufficient quality were judged to be safe. Conclusion: In summary, this systematic review highlights two herbal preparations, one from European/Western PT and one from AM, that appear to be promising options in the treatment of SAR. [ABSTRACT FROM AUTHOR]

This clinical study aimed to assess the effectiveness and safety of Vuong Hoat (VH) natural health supplement for reducing the negative impact of low back pain, improving the quality of life, and enhancing functional activities in patients with lumbar degenerative disc disease (LDD). The open-label, randomized, controlled clinical trial involved 60 patients suffering from low back pain caused by LDD. The participants were randomly assigned to either a study group (SG) comprising 30 subjects or a control group (CG) comprising 30 subjects. Patients in the CG received treatment with electro-acupuncture, while those in the SG were administered VH in conjunction with the same electro-acupuncture protocol for 28 days. The clinical progression and tolerability of both groups were compared based on seven objective measurements: visual analog scale index, Schober test, fingertip-to-floor distance, spinal flexion, spinal extension, spinal tilt, and spinal rotation. After 14 days of treatment, the SG showed a significant improvement in overall outcomes compared to the CG. Specifically, 43.3% of SG patients achieved very good results, 53.3% had good results, and 3.4% had moderate results, whereas corresponding figures for the CG were 6.7%, 76.7%, and 16.6%, respectively (P <.05). After 28 days of treatment, both groups demonstrated a shift toward very good results, with the SG continuing to show better outcomes than the CG (P <.05). In the SG, the very good results increased to 76.7%, good results decreased to 20%, and moderate results were 3.3%. On the other hand, the CG had 46.7% very good results, 43.3% good results, and 10% moderate results. Notably, no side effects were reported from the VH treatments during the study. The findings of this study indicate that VH health supplement is a safe and effective approach for managing low back pain and limited spinal movement in patients with LDD. [ABSTRACT FROM AUTHOR]

The efficacy of Zerumbone (ZER) against mixed biofilms of fluconazole-resistant Candida albicans (ATCC 96901) and Streptococcus mutans (UA159) was evaluated. Biofilms were cultivated on acrylic resin specimens for 48 h, with alternating supplementation of glucose and sucrose. ZER's ability to inhibit biofilm formation (pre-treatment) and eradicate mature biofilms (post-treatment) was assessed. Control groups were treated with Chlorhexidine (CHX), Nystatin (NYS), Penicillin (ATB), and distilled water. The efficacy was measured by colony forming units (CFU/mm2) counts, biomass and biofilm's matrix components quantification (water-soluble polysaccharides [WSP], alkali-soluble polysaccharides [ASPs], proteins, and extracellular DNA [eDNA]). Data were analyzed by one-way ANOVA with Tukey's or Gammes-Howell post-hoc test for normal data and Kruskal-Wallis test for data that did not meet the assumption of normality (α = 0,05). In the biofilm inhibition assay, ZER decreased total microbiota (C. albicans + S. mutans) (2.7 log10; p < 0.005), C. albicans (1.4 log10; p < 0.038) and S. mutans (1.9 log10; p < 0.048) counting (vs control group), and biofilm components [insoluble proteins: 37% (p < 0.001); WSP: 13% (p < 0.042); ASP: 46% (p < 0.001); eDNA: 11% (p < 0.048)]. Post-treatment with ZER reduced total microbiota (3.2 log10; p < 0.001), C. albicans (3 log10; p < 0.001) and S. mutans (2 log10; p < 0.001) counting (vs control group), and biofilm components [soluble proteins: 20% (p < 0.001); WSP: 20% (p < 0.001); ASP: 51% (p < 0.001); and eDNA: 33% (p < 0.001)]. The positive control groups demonstrated similar or lower efficacy than ZER under all experimental conditions. ZER demonstrates efficacy against mixed biofilms by reducing C. albicans and S. mutans counting and disrupting the extracellular matrix in both assays. [ABSTRACT FROM AUTHOR]

Type 2 diabetes mellitus (T2DM), a metabolic disorder, has the hallmarks of persistent hyperglycemia, insulin resistance, and dyslipidemia. Protein‐tyrosine phosphatase 1B (PTP1B) was found to be overexpressed in many tissues in the case of T2DM and involved in the negative regulation of insulin signaling. So, PTP1B inhibition can act as a therapeutic target for T2DM. Numerous studies claimed the anti‐inflammatory, hypoglycemic, hepatoprotective, and hypolipidemic activities of Dodonaea viscosa. Previously, we generated the high‐fat diet (HFD)‐low dose streptozotocin (STZ)–induced diabetic male mice model and treated it with a PTP1B inhibitor (5, 7‐dihydroxy‐3, 6‐dimethoxy‐2‐ (4‐methoxy‐3‐ (3‐methyl‐2‐enyl) phenyl)‐4H‐chromen‐4‐one), isolated from Dodonaea viscosa. In the current study, we aimed to investigate the De novo lipogenesis, adipocyte differentiation, augmentation of lipoproteins clearance, fatty acid uptake, antilipolysis activity, and hepatic steatosis of PTP1B inhibition in adipose and liver tissues of the HFD‐STZ–induced diabetic mice model. We found the retrieval of normal morphology of adipocytes and hepatocytes in the compound‐treated group. The biochemical parameters showed the gradual reduction of LDL, VLDL, TC, and TG in the serum of the compound‐treated group. To further test our hypothesis, real‐time PCR was performed, and data revealed the reduction of PTP1B and other inflammatory markers in both tissues, showing enhanced expression of insulin signaling markers (INSR, IRS1, IRS2, and PI3K). Our compound upregulated the adipogenic (PPARγ), lipogenic (SREBP1c, FAS, ACC, and DGAT2), lipoprotein clearance (LPL, LDLR, and VLDLR), fatty acid uptake (CD36 and FATP1), and lipid droplet forming (FSP27 and perilipin‐1) markers expressions in adipocytes and downregulated in hepatocytes. Furthermore, we found elevated cholesterol efflux (in adipose and liver) and decreased lipolysis in adipocytes and elevated in hepatocytes. Hence, we can conclude that our compound protects the adipocytes from abrupt lipolysis and stimulates adipocyte differentiation. In addition, it plays a hepatic protective role by shifting clearance and uptake of lipoproteins and fatty acids to the peripheral tissues and retrieving the fatty liver condition. [ABSTRACT FROM AUTHOR]

Background: While more and more people tend to use herbal products thinking they are safer than conventional western medicine, the reality is other. If natural products are bio-active and possess potential therapeutic activities, then the benefit/risk balance should be considered like any other health product. Some herbs are known to have the potential to interact with patient's treatment and to cause adverse drug reactions. While these are scarce, they are potentially harmful, and can lead to major sequels and even death in some cases. Despite these known facts, little guidelines about how to evaluate the risk of interaction and to handle them exist in literature. Notably, few scales allowing to assess the risk of a specific combination of herbs and drugs exist. Method: We propose a new scoring method BABINE (Boosting Analysis of Bibliography for herb- drug INteraction Evaluation) and discuss a scale to evaluate this risk based on iterative rounds of experts' discussion. Results: After 6 rounds of case reports/clinical studies evaluation, we analyzed and synthesized criteria identified as important by the experts and developed a corresponding evaluation scale. Conclusion: Even if our scale greatly simplifies pharmacological events, we believe it provides a robust and transparent way to rapidly assess the risk of adverse event. [ABSTRACT FROM AUTHOR]

Central nervous system disorders impact over 1.5 billion individuals globally, with neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases being particularly prominent. These conditions, often associated with aging, present debilitating symptoms including memory loss and movement difficulties. The growing incidence of neurological disorders, alongside a scarcity of effective anti-amyloidogenic therapies, highlights an urgent need for innovative treatment methodologies. Nanoparticles (NPs), derived from medicinal plants and characterized by their favorable pharmacological properties and minimal side effects, offer a promising solution. Their inherent attributes allow for successful traversal of the blood–brain barrier (BBB), enabling targeted delivery to the brain and the modulation of specific molecular pathways involved in neurodegeneration. NPs are crucial in managing oxidative stress, apoptosis, and neuroinflammation in ND. This study reviews the efficacy of green-synthesized nanoparticles in conjunction with various medicinal plants for treating neurodegenerative diseases, advocating for further research to refine these formulations for enhanced clinical applicability and improved patient outcomes. [ABSTRACT FROM AUTHOR]

Objective: To explore the therapeutic effects of phellodendrine on non-compression lumbar disc herniation (NCLDH). Methods: The Sprague Dawley rat model of NCLDH was established via autologous caudal nucleus pulposus transplantation. Behavioral observations and neurological function scoring were conducted in Sprague Dawley rats, and the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured via enzyme-linked immunosorbent assay (ELISA). Real-time quantitative polymerase chain reaction (RT‒qPCR) was used to detect the expression of nuclear factor kappa-B (NF-κB) p65 mRNA in L5 nerve roots and surrounding tissues. Western blotting was used to assess the protein expression of NF-κB p65 and TNF-α. Immunofluorescence and immunohistochemical analyses were performed to investigate the distribution and expression of the NF-κB p65 protein in the L5 nerve and its surrounding tissues. Results: In this animal study, phellodendrine was found to downregulate the expression of p65 mRNA, decrease the release of inflammatory factors, and alleviate motor dysfunction caused by lumbar disc herniation(LDH). Therefore, the phellodendrine technique has potential value for the treatment of NCLDH. Conclusion: In this animal experiment, phellodendrine was found to significantly reduce the expression level of p65 mRNA, decrease the release of inflammatory cytokines, and alleviate lumbar disc pain. Clinical trial number: Not applicable. [ABSTRACT FROM AUTHOR]

Psoriasis is a chronic, systemic, immune-mediated, inflammatory skin disease associated with significant comorbidities. Globally, there are an estimated 60 million people living with psoriasis (PLwP). There is a growing body of evidence on the role of diet in psoriasis management, and demand for dietary advice is high. However, there are no specific, evidence-based dietary guidelines. This scoping review summarises the literature on use and effectiveness of diet in the management of psoriasis to improve understanding of the evidence and assist PLwP and healthcare professionals (HCPs) to discuss diet. The findings were categorised into three themes: (1) dietary intakes of PLwP, (2) the perceived role of diet in psoriasis management and (3) dietary approaches to manage psoriasis symptoms. In cross-sectional studies PLwP were reported to have higher fat and lower fibre intakes compared with controls, and lower psoriasis severity was associated with higher fibre intake. However, research is limited. PLwP perceive diet to have an impact on symptoms and make dietary modifications which are often restrictive. Systematic reviews and RCTs found certain dietary approaches improved symptoms, but only in specific populations (e.g. PLwP with obesity and PLwP with coeliac disease), and evidence for supplement use is inconclusive. The grey literature provides limited guidance to PLwP; focusing on weight loss and associated comorbidities. Larger, controlled trials are required to determine dietary approaches for psoriasis management, especially in PLwP without obesity and non-coeliac PLwP. Further understanding of diet modification, information acquisition and experiences among PLwP will enhance holistic care for psoriasis management. [ABSTRACT FROM AUTHOR]

Introduction: Joint pain is widespread among elderly and is usually accompanied by stiffness that increases with daily activities. Ginger has been found to have similar properties to Non Steroidal Antii-inflammatory Drugs (NSAIDs) in reducing pain and inflammation associated with musculoskeletal conditions. Aim: To investigate the effect of ginger oil massage on joint pain in elderly inmates in old age homes. Materials and Methods: The study adopted a quasi-experimental one-group pretest post-test design and the study was conducted in the old age home Bengaluru, Karnataka, India, from October 2020 to April 2021. Purposive sampling technique was used to select 30 inmates of an old age home located in Bangalore and having joint pain with a score of >1 on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale. The demographic proforma and the WOMAC were used to collect the data. A skin test was performed, to check for any sensitivity reactions and massage using ginger essential oil diluted in coconut oil was administered on the knee joint on alternate days, for six sessions extending over a period of two weeks. The post-test was assessed after third and final (6th) session of massage. Repeated Measures (RM) Analysis of Variance (ANOVA) was computed to determine the difference in pre and post-test WOMAC scores and a significance level of p<0.05 and a confidence interval of 95% was considered to indicate a statistically significant difference. Results: The mean age of the elderly was 69.500±7.505 years with a range 61-82 years. Repeated measure ANOVA demonstrated a significant difference in the second (13.10±5.38) and first post-test WOMAC scores (14.10±6.19) compared to the mean pretest WOMAC score (37.97±12.83) (F=121.14, p<0.001), indicating that ginger oil massage was effective in reducing joint pain among the elderly. Conclusion: Ginger oil massage resulted in the reduction of knee pain and joint stiffness among elderly and therefore, can be a used as an alternative therapy for the elderly with joint pain. [ABSTRACT FROM AUTHOR]

Agrimonia eupatoria L. (AE) has a rich tradition of use in wound healing improvement across various cultures worldwide. In previous studies, we revealed that Agrimonia eupatoria L. water extract (AE) possesses a rich polyphenolic composition, displaying remarkable antioxidant properties. Our investigations also demonstrated that lipophosphonoxin (LPPO) exhibited antibacterial efficacy in vitro while preserving the proliferation and differentiation of fibroblasts and keratinocytes. Building upon our prior findings, in this study, we intended to examine whether a combination of AE and LPPO could enhance skin wound healing while retaining antibacterial attributes. The antibacterial activity of AE/LPPO against Staphylococcus aureus was evaluated, alongside its effects on fibroblast-to-myofibroblast transition, the formation of extracellular matrix (ECM), and endothelial cells and keratinocyte proliferation/phenotype. We also investigated AE/LPPO's impact on TGF-β1 and VEGF-A signaling in keratinocytes/fibroblasts and endothelial cells, respectively. Additionally, wound healing progression in rats was examined through macroscopic observation and histological analysis. Our results indicate that AE/LPPO promotes myofibroblast-like phenotypic changes and augments ECM deposition. Clinically relevant, the AE/LPPO did not disrupt TGF-β1 and VEGF-A signaling and accelerated wound closure in rats. Notably, while AE and LPPO individually exhibited antibacterial activity, their combination did not lead to synergism, rather decreasing antibacterial activity, warranting further examination. These findings underscore substantial wound healing improvement facilitated by AE/LPPO, requiring further exploration in animal models closer to human physiology. [ABSTRACT FROM AUTHOR]

In the present study, Curcuma longa (CL) hydrolate and the probiotic Lactobacillus plantarum (LP) were provided as dietary supplements to Nile tilapia. One hundred ninety-two juvenile tilapias (2.25 ± 0.14 g and 4.5 ± 0.10 cm) were distributed in sixteen experimental units, and four experimental groups were established: CL [CUR]: fish fed a diet supplemented with CL hydrolate at 2.5%; probiotic [PRO]: a diet supplemented with LP; LP + CL [COMB]: diet supplemented with the LP strain cultivated in media supplemented with 2.5% CL hydrolate; and control [CTRL]: diet without supplementation. After 70 days, the final average weight was significantly greater in the PRO group (33.26 ± 1.12 g) than in the CTRL and CUR groups, whereas the specific growth rate was significantly greater in the PRO and COMB groups than in the CTRL and CUR groups. Feed conversion decreased significantly in the PRO group (1.03 ± 0.11). Dietary supplementation did not change the body composition of tilapia. Leukocyte and lymphocyte counts were greater in the PRO treatment than in the CTRL group. Compared with those in the CTRL group, total serum protein was significantly increased in the PRO group. Immunoglobulins were higher in the COMB and PRO groups. In the experimental challenge, all the fish in the treated groups presented lower cumulative mortality rates. The combination of LP and CL improved the growth parameters of Nile tilapia. [ABSTRACT FROM AUTHOR]

The new natural products reported in 2023 in peer-reviewed articles in journals with good reputations were reviewed and analyzed. The advances made by Asian research groups in the field of natural products chemistry in 2023 were summarized. Compounds with unique structural features and/or promising bioactivities originating from Asian natural sources were discussed based on their structural classification. [ABSTRACT FROM AUTHOR]

Alzheimer's disease is the predominant type of dementia, representing 60-80% of all dementia cases. It is characterised by a degenerative brain condition that leads to a decline in cognitive abilities, memory loss, impaired thinking, reasoning, and behavioural changes. It is a degenerative condition that deteriorates progressively over time, with dementia symptoms gradually worsening over a span of several years. Alzheimer's disease is also considered a metabolic condition due to a multitude of pathophysiological alterations and an array of risk factors like cognitive inactivity, sedentary behaviour, obesity, diabetes, high cholesterol, hypertension, and other factors. Nutritional and herbal medicine play various roles in improving cognitive health via mechanisms such as promoting brain and nerve function, improving cardiometabolic health, supporting energy metabolism, regulating immune system function, reducing inflammation, and having antioxidant effects. This article briefly overviews Alzheimer's disease, discussing its pathophysiology and risk factors. It emphasises the clinical considerations and the role of nutritional medicine and herbal medicine in the management of Alzheimer's disease and cognitive health. [ABSTRACT FROM AUTHOR]

BACKGROUND: Maca extract may regulate oxidative stress and muscle damage after exhaustive endurance exercise (EEE); however, its impact on these physiological activities remains obscure. OBJECTIVE: To examine the effects of Maca extract supplementation on oxidative stress, muscle damage and aerobic capacity after EEE. METHODS: Twenty healthy men were assigned to Maca or placebo groups and received two doses per day for 12 weeks. Pre- and post-EEE tests assessed levels of oxidative stress and muscle damage. The EEE test also recorded metrics such as time to exhaustion, peak oxygen consumption, and maximal and average heart rates. RESULTS: Post-exercise, there was no significant difference in oxidative stress markers between the Maca and placebo groups. However, the Maca group exhibited lower stress levels at both Post-4 and Post-24 in comparison to Post-0, while the placebo group only displayed a decrease at Post-4. Notably, Maca extract supplementation immediately increased catalase activity at Post-0. Though muscle damage markers did not significantly differ, the slope of CK elevation in the Maca group appeared lower than the Placebo group, suggesting Maca's potential in preventing muscle damage. However, no differences were noted on aerobic capacity markers. CONCLUSIONS: Maca extract may have some beneficial effects on reducing oxidative stress and possibly muscle damage after EEE. [ABSTRACT FROM AUTHOR]

Acute liver injury (ALI) is an injury to liver tissue caused by viruses, drugs, alcohol, and oxygen deprivation, and is one of the most common and serious clinical disorders. Hydroxytyrosol (HT) is a naturally occurring polyphenolic compound isolated from forsythia and has excellent anti-inflammatory properties. However, the effect and mechanisms of HT in ALI remain unclear. We used the LPS/D-GalN induced experimental ALI mouse model and AML12 cells to reveal the efficacy and potential mechanisms of HT in ALI, and HE staining was used for the evaluation of pathologies. A biochemical assay was used to detect changes in liver function, RNA-seq was conducted to reveal the underlying mechanisms of HT for ALI, and WB, RT-qPCR, and IF were used to assess the effects of HT action. Furthermore, an in vitro ALI model against HT in AML12 cells induced by LPS/D-GalN was used to assess the HT protection mechanism. HT significant alleviated LPS/D-GalN-induced ALI in the mice by suppressing inflammatory. In terms of RNA-seq, HT improved the TNF, ECM-receptor interaction, and PI3K/AKT signaling pathway, and it downregulated the mRNA levels of VCAM-1, CXCL5, TNF-α and IL-6 in the liver. Mechanically, HT alleviated LPS/D-GalN in the mice by targeting TNF-α, thereby inhibiting the TNF-α/PI3K/AKT signaling pathway. [ABSTRACT FROM AUTHOR]

The use of complementary and alternative medicine (CAM) has increased. Phytotherapy, also known as herbal medicine, is one of the CAM therapies that involves using medicinal plants and plant-derived substances. This study aims to evaluate the use of phytopharmaceuticals and the factors associated with their use in patients with Systemic sclerosis (SSc). Our study is designed as a survey and consists of two parts with 32 questions. The first part gathers demographic data with 14 questions, and the second part assesses participants' knowledge about phytotherapy with 18 questions. The questionnaire was administered face-to-face to patients with SSc who consented to participate. One hundred participants completed the survey. Fifty-two (52%) participants had diffuse sclerosis. Raynaud's phenomenon affected 97 (97%) participants; 53 (53%) participants suffered from lung involvement, and 64 (64%) had musculoskeletal system involvement. A total of 55 (55%) participants had used phytopharmaceuticals after SSc diagnosis. Phytotherapy users and non-users had similar demographic and clinical characteristics in terms of age, gender, disease duration, type of SSc, organ involvement, and education level. Participants mostly used the following phytopharmaceuticals: 23 participants used Camellia sinensis (green tea), 16 used Hypericum perforatum, and 12 used Curcuma longa (curcumin). The most improved symptoms with phytopharmaceuticals were musculoskeletal system findings and skin thickness, as stated by participants. A significant portion of SSc patients used phytopharmaceuticals in their disease duration. Although patients stated that they benefited from phytopharmaceuticals, studies on the effectiveness of these treatments are insufficient. [ABSTRACT FROM AUTHOR]