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4 results on '"plectrabarbene"'

1. Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts

Author

Nawal M. Al Musayeib, Musarat Amina, Gadah Abdulaziz Al-Hamoud, Gamal A. Mohamed, Sabrin R.M. Ibrahim, and Samah Shabana

Subjects
Plectranthus barbatus, Labiatae, plectrabarbene, abietane diterpene, acetylcholinesterase inhibition, molecular docking, Organic chemistry, QD241-441
Abstract

A new abietane diterpene namely plectrabarbene (2), together with two known compounds: sugiol (1) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (3) have been isolated from the aerial parts of Plectranthus barbatus Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes (1–3) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil.

Published
2020
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2. Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts

Author

Sabrin R.M. Ibrahim, Musarat Amina, Gadah Abdulaziz Al-Hamoud, Samah Shabana, Gamal A. Mohamed, and Nawal M. Al Musayeib

Subjects
Stereochemistry, Pharmaceutical Science, Labiatae, 010402 general chemistry, 01 natural sciences, acetylcholinesterase inhibition, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, lcsh:Organic chemistry, Drug Discovery, Plectranthus barbatus, Humans, Plectranthus, Physical and Theoretical Chemistry, 030304 developmental biology, Abietane, 0303 health sciences, Molecular Structure, biology, Plant Extracts, Organic Chemistry, Active site, molecular docking, Plant Components, Aerial, biology.organism_classification, 0104 chemical sciences, Molecular Docking Simulation, chemistry, Chemistry (miscellaneous), Docking (molecular), plectrabarbene, Abietanes, biology.protein, Molecular Medicine, Cholinesterase Inhibitors, Diterpenes, Diterpene, abietane diterpene
Abstract

A new abietane diterpene namely plectrabarbene (2), together with two known compounds: sugiol (1) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (3) have been isolated from the aerial parts of Plectranthus barbatus Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes (1&ndash, 3) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil.

Published
2020
Full Text
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3. Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts.

Author

Al Musayeib, Nawal M., Amina, Musarat, Al-Hamoud, Gadah Abdulaziz, Mohamed, Gamal A., Ibrahim, Sabrin R.M., and Shabana, Samah

Subjects
*ABIETANE, *PLECTRANTHUS, *MOLECULAR docking, *LAMIACEAE, *DITERPENES
Abstract

A new abietane diterpene namely plectrabarbene (2), together with two known compounds: sugiol (1) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (3) have been isolated from the aerial parts of Plectranthus barbatus Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes (1–3) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
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4. Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts.

Author

Musayeib NMA, Amina M, Al-Hamoud GA, Mohamed GA, Ibrahim SRM, and Shabana S

Subjects
Abietanes isolation & purification, Cholinesterase Inhibitors isolation & purification, Diterpenes chemistry, Diterpenes isolation & purification, Humans, Molecular Docking Simulation, Molecular Structure, Plant Extracts chemistry, Abietanes chemistry, Cholinesterase Inhibitors chemistry, Plant Components, Aerial chemistry, Plectranthus chemistry
Abstract

A new abietane diterpene namely plectrabarbene ( 2 ), together with two known compounds: sugiol ( 1 ) and 11,14-dihydroxy-8,11,13-abietatrien-7-one ( 3 ) have been isolated from the aerial parts of Plectranthus barbatus Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes ( 1 - 3 ) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil.

Published
2020
Full Text
View/download PDF

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