7,752 results on '"pterygium"'
Search Results
2. Epidemiologic characteristics and the change of surgical methods of pterygium and pseudopterygium from 2013 to 2019 in China: A retrospective analysis
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Wang, Jingyi, Cao, Kai, Li, Shang, Su, Bingnan, Jin, Zibing, Pan, Zhiqiang, Tian, Lei, Shi, Weiyun, and Jie, Ying
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- 2023
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3. Clinical Outcomes of Sutured Versus Sutureless Conjunctival Autograft in Primary Pterygium Excision
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Amal Sherif Sayed Abdelrehim, Resident at Ophthalmology department, Faculty of medicine, Assiut University
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- 2024
4. RMP-A03 Ocular Suspension in Patients With Pterygium
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WuXi Clinical
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- 2024
5. Design and Development of a Mobile Application for Accessible Pterygium Screening Using Pre-trained Deep Learning Models
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Withunchettanan, Thanabodee, Charoenruengkit, Werayuth, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Sombattheera, Chattrakul, editor, Weng, Paul, editor, and Pang, Jun, editor
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- 2025
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6. Chapter 6 - Conjunctiva
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- 2025
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7. Mehri Turki Webbed Neck Classification
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Imen Turki Mehri, MD, Principal investigator
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- 2024
8. Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression.
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Li, Mei-Li, Pang, Kun, Qiao, Lei, Guan, Zhi-Qiang, Gong, Chao-Ju, Li, Song-Tao, Tang, Zhi-Ming, Zhang, Yi-Ling, and Ding, Ji-Cun
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CELL migration , *CHINESE medicine , *FIBROBLASTS , *RESVERATROL , *PTERYGIUM - Abstract
AbstractPrimary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2. [ABSTRACT FROM AUTHOR]
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- 2025
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9. Effects of ranibizumab on microvasculature, oxidative stress and recurrence in primary pterygium surgery.
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Yap, Jin Yi, Tai, Evelyn Li Min, Kueh, Yee Cheng, Salleh, Salzihan, and Ibrahim, Mohtar
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Purpose: To evaluate the effects of pre-operative ranibizumab injection on microvascular density (MVD), 8-hydroxyguanosine (8-OHdG) and recurrence after surgical excision of primary pterygium. Method: This was a prospective cohort interventional study involving 52 patients with primary pterygium divided equally into control and intervention groups. The intervention group received 0.5 mg ranibizumab two weeks prior to pterygium excision surgery. All participants had pterygium excision with autologous conjunctival graft under local anaesthesia. Excised pterygium tissues were evaluated for MVD and 8-OHdG. Each participant was monitored for recurrence up to 2 years after intervention. Pearson chi-square and Fisher exact tests were used to examine the differences between both groups. Results: The intervention group demonstrated significantly lower MVD (p < 0.001) and recurrence rates (p < 0.001). In the intervention group, 53.8% (n = 14) of patients had MVD 1 + , and 46.2% (n = 12) had MVD 2 + , which was notably lower than the control group, where 53.8% (n = 14) of patients had MVD 3 + and 4 +. No significant difference in 8-OHdG scores was observed between the groups (p = 0.482). In the intervention group, 84.6% (n = 22) of patients had an 8-OHdG score of 3 + , while 76.9% (n = 20) of patients in the control group also had 8-OHdG scores of 3 +. 46.2% (n = 12) of patients from the control group experienced recurrent pterygium, while no cases of pterygium recurrence were observed in the intervention group. Reduction in MVD was significantly associated with lower frequency of pterygium recurrence (p = 0.004). Conclusion: Pre-operative intralesional ranibizumab decreases pterygium recurrence rate after surgical excision via modulation of vascularity. Ranibizumab may be considered as an adjunctive treatment in pterygium surgery with high risk of recurrence. [ABSTRACT FROM AUTHOR]
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- 2025
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10. Cohesin Complex Interacting with Promoters of MMP Genes for in Pterygium Occurrence.
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Han, Shichao, Zhu, Wei, and Guo, Qianqian
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TRANSCRIPTION factors , *MATRIX metalloproteinases , *RNA interference , *GENE expression , *SMALL interfering RNA - Abstract
AbstractPurposeMethodsResultsConclusionPterygium is a common ocular surface disease characterized by a high recurrence rate and unknown etiology.In this study, we investigated the upregulation of matrix metalloproteinase genes, including MMP1, MMP2, MMP3, MMP7, MMP9, MMP11, MMP12, MMP13, MMP23B, and MMP28, in pterygium tissue using RNA sequencing, Western blotting, and immunohistochemistry.Employing the MEME tool, we identified a conserved DNA motif within the promoter regions of these matrix metalloproteinase genes. Mass spectrometry analysis revealed an interaction between the cohesin complex and this motif. Disrupting the cohesin complex through RNA interference of RAD21 cohesin complex component or structural maintenance of chromosomes 3 in primary pterygial fibroblasts led to decreased matrix metalloproteinase gene expression and reduced recruitment of twist family bHLH transcription factor 1 and transcription factor 4 to matrix metalloproteinase gene promoters.Overall, our findings suggest a novel epigenetic mechanism regulating matrix metalloproteinase transcription in pterygium. [ABSTRACT FROM AUTHOR]
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- 2025
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11. Klimawandel und Augenoberflächenerkrankungen.
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Schilcher, A. V. and Geerling, G.
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Copyright of Die Ophthalmologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2025
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12. Inhibition of pterygium cell fibrosis by the Rho kinase inhibitor.
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Dai, Jiannong, Rayana, Naga Pradeep, Peng, Michael, Sugali, Chenna Kesavulu, Harvey, Devon H., Dhamodaran, Kamesh, Yu, Eric, Dalloul, Joseph M., Liu, Shaohui, and Mao, Weiming
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PRIMARY cell culture , *CYTOLOGY , *VISION , *PTERYGIUM , *KINASE inhibitors , *WOUND healing , *FIBRONECTINS - Abstract
Pterygium is an ocular disease in which the conjunctival tissue invades the cornea. When the pterygium tissue reaches the pupillary region, the visual function of the patient is affected. Currently, surgical removal is the only effective treatment. However, the recurrence rate of pterygium after surgery can be high. Pterygium is also a health disparity issue since it is more prevalent in the Hispanic and Latino American population. In this study, we determined if the Rho kinase inhibitor can be used to prevent pterygium recurrence since its anti-fibrosis effects have been reported in other cell and tissue types. We cultured primary pterygium cells from pterygium tissues from Hispanic and Latino American, African American, Caucasian, and Asian donors, and used those cells for viability assays, scratch assays, migration assays, and immunostaining of F-actin, fibronectin, collagen I and α smooth muscle actin. We found that the Rho kinase inhibitor Y27632 decreased cell viability, wound healing, cell migration, as well as the expression of extracellular matrix and myofibroblast markers in cultured pterygium cells. We believe that Rho kinase inhibitors are a potential post-surgical treatment to prevent pterygium recurrence. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Effect of Pterygium Surgery on Precorneal Tear Film.
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Chava, Preethi and B. R., Usha
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SLIT lamp microscopy , *DRY eye syndromes , *INTRAOCULAR pressure , *PTERYGIUM , *VISUAL acuity - Abstract
INTRODUCTION Pterygium is a common disease of the ocular surface characterized by the invasion of fibrovascular tissue from the bulbar conjunctiva onto the cornea. It can cause chronic ocular irritation, tear film disturbances, induced astigmatism, and decreased vision secondary to growth over the visual axis. OBJECTIVES To assess precorneal Tear film before and after pterygium surgery. METHOD This prospective observational study was done on all consecutive patients with pterygium came to ophthalmology OPD at R L Jalappa hospital in kolar from August 2022 to December 2023. A total of 39 eyes were included in each group of which 12 were males and 27 females. All the patients subjected for detail visual acuity (VA) assessment, slit lamp examination, intraocular pressure (IOP) estimation, tear film function tests and underwent Pterygium excision with conjunctival limbal autograft. They were followed post-operatively 1 week, 4 weeks and 6weeks. RESULTS Majority of the patients were females (69.2%), while 30.8% were males with average age (in years) as 51.33 years. Majority had Type 2 (51.3%), followed by Type 3 (26.6%) and Type 1 (23.1%). Schimers test 1 was significantly decreased in the affected eye compared to control eye at pre-op and 1 week following post-op. There was no significant difference in the ST1 at 4 weeks and 6 weeks between the affected and control eyes. Schimers test 2 was significantly decreased in the affected eye compared to control eye at pre-op, one week and four weeks following post-op. There was no significant difference in the ST-2 at 6 weeks between the affected and control eyes. TBUT was significantly decreased in the affected eye compared to control eye at pre-op, and 4 weeks following post-op. There was no significant difference in the TBUT at 1 week and 6 weeks between the affected and control eyes. TMH was significantly lower in the affected eye than the control eye at pre-op, and 1 week following post-op. No significant difference in the TMH at 4 weeks and 6 weeks between the affected and control eyes was noticed. Comparision of schirmers test 1, schirmers 2, TBUT and TMH at 1week, 4 week & 6 weeks between preop and post op in type 1 pterygium, among the affected eye, the tear film function significantly improved. CONCLUSION Our research found that after the pterygium was removed, the measurements, such as Schirmers and Tear Break-up Time (TBUT), showed improvement over time. After a month after the operation in the affected eye, the Schirmers and Tear Break-up Time were almost as close to the control eye's values. This suggests that the dry eye symptoms related to the pterygium got better after the surgery. Nonetheless, our research did not include a long-term check-up to explore if the pterygium would come back and how it might affect the tear film's function. [ABSTRACT FROM AUTHOR]
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- 2024
14. Ocular safety of 222‐nm far‐ultraviolet‐c full‐room germicidal irradiation: A 36‐month clinical observation.
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Sugihara, Kazunobu, Kaidzu, Sachiko, Sasaki, Masahiro, Ichioka, Sho, Sano, Ichiya, Hara, Katsunori, and Tanito, Masaki
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VISUAL acuity , *REFRACTIVE errors , *ULTRAVIOLET lamps , *ENDOTHELIAL cells , *PTERYGIUM , *IRRADIATION - Abstract
The ocular safety of 222‐nm far‐ultraviolet‐C (UV‐C) irradiation, widely recognized for its germicidal properties, was evaluated in a clinical setting to assess its long‐term health effects on the human eye. This prospective observational study involved a 36‐month follow‐up of physicians working in an ophthalmic examination room equipped with 222‐nm UV‐C lamps. Initially, a 12‐month observation showed no signs of acute or chronic ocular damage. To further substantiate these findings, the study period was extended to 36 months, during which four participants underwent regular ocular examinations, including assessments of visual acuity, refractive error, and corneal endothelial cell density. The irradiation dose was meticulously controlled to remain within the previous threshold limit of 22 mJ/cm2 over an 8‐h period, as advised by the ACGIH prior to 2022. Results indicated no significant changes in these parameters, suggesting no clinically significant ocular hazards associated with prolonged exposure to 222‐nm UV‐C irradiation under real‐world conditions. Additionally, no delayed side effects, such as pterygium, keratopathies, or cataracts, were observed. Our study supports the safe use of 222‐nm UV‐C for microbial disinfection in occupied environments and provides a robust foundation for updated safety guidelines. [ABSTRACT FROM AUTHOR]
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- 2024
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15. In vivo confocal microscopy findings about ocular surface recovery in patients following pterygium excision combined with conjunctival autograft.
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Xu, Mi, Shen, YunZhi, Zhang, ZhengWei, Sun, HongJuan, and Sun, Song
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Purpose: To study cellular and neural changes around the donor and recipient areas after pterygium excision combined with autologous conjunctival transplantation using corneal confocal microscopy, we evaluated the postoperative impact of this surgical procedure. Methods: Patients with primary pterygium located on the nasal side who visited the Department of Ophthalmology of Wuxi Second People's Hospital between April and August 2023 were enrolled. Age-matched healthy eyes were included as the control group. IVCM was performed in the affected eyes, 6 months after pterygium excision. The images of the central conjunctival cells in the recipient and donor areas, the cells of each layer of the cornea around the recipient and donor area (around 2 mm from the nasal and upper corneal margins), and the structures of the corneal margins were recorded in the affected eyes and statistically compared with the corresponding areas in the control eyes. Results: Seventeen eyes of 14 patients with primary pterygium located on the nasal side (mean 64 ± 8.74 years old), and 17 eyes of nine patients as age-matched normal controls were included. Compared with those of normal eyes, the density of corneal pterygoid epithelium around the recipient area (5104 ± 599 cells/mm
2 vs. 5700 ± 515 cells/mm2 , P < 0.01) and the central conjunctival epithelial cells in the recipient areas (3984 ± 453 cells/mm2 vs. 4834 ± 244 cells/mm2 , P < 0.01) were significantly lower 6 months postoperatively. However, the superficial stromal, deep stromal, and endothelial cell densities around the recipient area exhibited no significant differences (P > 0.05). Highly illuminated basal cells were visible at the nasal corneal margin, with an irregular intersection of fibrous tissue with corneal epithelial cells. More dendritic Langerhans cell infiltration was seen in the junctional area. Compared with those in the normal eyes, the densities of the corneal pterygoid epithelium (4896 ± 428 cells/mm2 vs. 5557 ± 367 cells/mm2 , P < 0.01), deep stromal cells (337 ± 65 cells/mm2 vs. 419 ± 39 cells/mm2 , P < 0.01), endothelial cells (2305 ± 170 cells/mm2 vs. 2547 ± 212 cells/mm2 , P < 0.01) around the donor area and the central conjunctival epithelial cells (3700 ± 446 cells/mm2 vs. 4282 ± 272 cells/mm2 , P < 0.01) in the donor area were significantly lower 6 months postoperatively. However, no significant differences were observed in superficial stromal cell density (P > 0.05). A slight wavy interfacial intersection was visible on the superior corneal margin, with some of the highlighted basal cells visible. Conclusions: Pterygium excision combined with autologous conjunctival transplantation with corneal stem cells can better promote the repair of most corneal cells around the recipient area and fence-like structures of the corneal rim 6 months postoperatively, but there may be some damage to the corneal conjunctival structures around the donor area. [ABSTRACT FROM AUTHOR]- Published
- 2024
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16. Evaluation of the clinical efficacy of modified LSC transplantation plus BCL implantation in the treatment of pterygium.
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Li, Ying, Meng, Linxia, Gong, Liyan, Wang, Xiao, Yang, Xiaoding, and Li, Tao
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LIMBAL stem cells ,CONTRAST sensitivity (Vision) ,STEM cell transplantation ,EYE drops ,SLIT lamp microscopy - Abstract
Objective: To explore the clinical efficacy of modified limbal stem cell transplantation(Modified LSC transplantation) and bandage contact lens(BCL) implantation in pterygium surgery. Methods: A total of 479 patients with primary pterygium who were admitted to our hospital from March 2019 to March 2023 were randomly divided into three groups: the normal group (Group A: 89 patients), the control group (Group B: 195 patients), and the modified group (Group C: 195 patients). Each group received different intervention measures. Group A did not undergo surgical treatment and were required to follow up as outpatients. Group B received LSC transplantation combined with interrupted suturing plus BCL, whereas Group C received modified LSC transplantation combined with BCL. The degree of corneal irritation symptoms, wound healing and graft status under slit lamp, incidence and recurrence rate of complications, tear film rupture time, tear secretion test, intraocular pressure, ocular surface inflammation response(IL-1β, PGE2, TNF-α, VEGF), and visual quality were compared and analyzed at various time points after surgery. Results: Compared with those in the Group B, patients in the Group C experienced faster normalization of corneal epithelium recovery, fewer corneal irritation symptoms, and better wound healing. The break-up time (BUT) of the tear film at 1 week to 1 year postoperatively was significantly greater in the Group C than Group B, with values approaching those of Group A by 3 months (P < 0.05). The Schirmer test results revealed a similar trend to that of the BUT. Further analysis of intraocular pressure (IOP) at different time points revealed no significant differences among the three groups at postoperative Day 1. However, due to the use of corticosteroid eye drops postoperatively, IOP was greater in both the Group B(17.24 ± 2.12 mmHg) and Group C (17.02 ± 2.37 mmHg) than Group A (13.92 ± 1.57 mmHg) at 1 week. By 1 month, Group C had a lower IOP (15.77 ± 1.63 mmHg) than Group B(17.78 ± 2.41 mmHg). There were no significant differences in IOP among the three groups from 3 months to 1 year (P > 0.05). The ELISA results indicated that the expression levels of the ocular surface inflammatory factors IL-1β, TNF-α, PEG2, and VEGF in the Group C were lower than those in Group B from 1 week to 1 year post surgery. Under both natural light and low-light conditions (spatial frequency/6 cd), Group C had better best-corrected visual acuity and contrast sensitivity than Group B at 1 week to 1 year postoperatively. Additionally, Group C had lower corneal higher-order aberrations (including astigmatism, spherical aberrations, and total higher-order aberrations) and superior vision-related quality of life scores at 1 year postoperatively than Group B, with statistically significant differences (P < 0.05). Conclusion: Modified LSC transplantation combined with BCL implantation provided superior treatment outcomes for patients with pterygium, which was worthy of further clinical promotion. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Duration of Bare Sclera Pterygium Surgery Combined with Mitomycin C with and Without Tranexamic Acid: A Randomized Double-Blind Controlled Trial.
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Kovalis, Nevo, Graffi, Shmuel, Safuri, Shadi, Shapira, Yinon, Ben-David, Geulah, and Mimouni, Michael
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MITOMYCIN C , *TRANEXAMIC acid , *OPERATIVE surgery , *TREATMENT effectiveness , *PTERYGIUM , *VISUAL acuity - Abstract
Purpose: To evaluate the efficacy of subconjunctival tranexamic acid (TXA) in reducing intraoperative bleeding, shortening surgery duration, and improving postoperative outcomes in pterygium surgery. Methods: In this double-blind, randomized controlled trial, 50 eyes of 50 patients undergoing pterygium surgery were randomly assigned to receive either subconjunctival injection of 0.25 mL of 5% TXA (TXA group, n = 25) or an equivalent volume of saline (control group, n = 25). Baseline characteristics, including age, gender, working environment, allergies, preoperative logMAR best-corrected visual acuity, and systemic anticoagulant or antiplatelet therapy, were similar between the groups. The primary outcome measures were intraoperative bleeding, surgery duration, and the number of eye spears used. Secondary outcome measures included postoperative visual acuity and pterygium recurrence rates at 3 years post-surgery. Results: No significant differences were observed between the TXA group and the control group in terms of surgery duration (445.3 ± 94.8 s vs. 423.5 ± 80.6 s, P = 0.40), the number of eye spears used (3.5 ± 2.4 vs. 3.5 ± 2.6, P = 0.97), or the weight of absorbed blood (1.94 ± 1.40 grams vs. 1.90 ± 1.25 grams, P = 0.91). Additionally, there were no significant differences in postoperative visual acuity (0.14 ± 0.13 logMAR vs. 0.20 ± 0.19 logMAR, P = 0.39) or pterygium recurrence rates at 3 years post-surgery (8.0% vs. 4.4%, P = 0.60). Subconjunctival TXA injection was safe, with no reported adverse events or complications associated with its use. Conclusion: Subconjunctival injection of TXA did not significantly reduce intraoperative bleeding, shorten surgery duration, or improve postoperative outcomes in pterygium surgery. The intervention was safe and well-tolerated, but further research is warranted to explore alternative interventions or modifications to the surgical technique that may improve outcomes in pterygium surgery. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Comparison of Biomarkers Playing a Role in Pterygium Development in Pterygium and Recurrent Pterygium Tissues.
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Eroğul, Özgür and Şen, Serkan
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TRANSFORMING growth factors-beta , *ENZYME-linked immunosorbent assay , *MATRIX metalloproteinases , *TISSUE remodeling , *GROWTH factors - Abstract
Background/Objectives: Pterygium is a nonneoplastic elastotic degeneration characterized by subepithelial growth. It manifests as an ocular lesion originating from the bulbar conjunctiva, extending to the corneal surface, and reaching the visual axis in some cases. Although the exact cause is unknown, prolonged exposure to ultraviolet radiation is considered the most significant contributing factor. Chronic irritation and actinic damage are likely responsible for the typical fibrovascular reactions observed in pterygium. Additionally, growth factors, cytokines, and matrix metalloproteinases play roles in the pathogenesis of pterygium. This study compared recurrent and primary pterygium cases at the molecular level to gain new insights into the etiology of pterygium. Methods: Total protein was extracted from surgical samples of patients with primary and recurrent pterygium, and the levels of transforming growth factor beta 1 (TGF-β1), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), IL-8, and IL-10 were analyzed using the enzyme-linked immunosorbent assay technique. Target gene expression levels were analyzed using the ΔΔCt method after cDNA synthesis from isolated RNA, with normalization to GAPDH and quantification performed with SYBR Green PCR Master Mix. Results: Among the studied cytokines, IL-10 levels were higher in primary pterygium than in recurrent pterygium (722.0 ± 600.9/421.4 ± 266.8) (p = 0.0054). Other cytokines (IL-6, IL-8, IL-1β, and TGF-β1) were detected at similar levels in both primary and recurrent pterygium (p = 0.2986). Additionally, the TGF-β1 gene expression was found to be significantly upregulated in recurrent pterygium tissue compared to primary pterygium tissue (p = 0.034). Conclusions: This increase suggests that TGF-β1 may contribute to the recurrence mechanisms of pterygium through processes such as fibroblast activation and tissue remodeling. The higher levels of IL-10 in primary pterygium compared to recurrent pterygium indicate an enhanced early protective response aimed at limiting pterygium progression and controlling the inflammatory process. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Artificial intelligence and external photographs in ophthalmology: a systematic review.
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Ka Hei Lai, Kenneth, Sze Ching Lo, Carmen, Han Wang, Xiaoyan Hu, Ali Abdulla Aljufairi, Fatema Mohamed, Sebastian, Jake Uy, Chi Pui Pang, and Kam Lung Chong, Kelvin
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THYROID eye disease ,ARTIFICIAL intelligence ,DIABETIC retinopathy ,OPHTHALMOLOGY ,PTERYGIUM - Abstract
We systematically reviewed the literature regarding the use of artificial intelligence trained with external photographs, defined as unprocessed clinical images taken from cameras and slit-lamps, for measurement of eyelid/periorbital parameters and detection and classification of multiple ophthalmic diseases including blepharoptosis, thyroid eye disease, eyelid tumors, keratitis, trachoma, pterygium, diabetic retinopathy, cataract, strabismus, and other oculofacial disorders. [ABSTRACT FROM AUTHOR]
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- 2024
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20. An evaluation of quality and usefulness of information on YouTube videos about pterygium and its treatment.
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Azizagaoglu, Bahadir, Asena, Leyla, and Altinors, Dilek Dursun
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SOCIAL media ,PATIENT experience ,PATIENTS' attitudes ,PATIENT education ,MEDICAL societies - Abstract
Purpose: We aimed to evaluate the quality of information available on YouTube regarding the basic information, examination, diagnosis, and treatment of pterygium. Methods: An online YouTube search was performed on January 10, 2023, for the following three terms: pterygium surgery, pterygium surgery for patients, and pterygium surgery patient education. The first 50 videos were evaluated for each term. Videos were evaluated using three checklists (the modified DISCERN criteria, the Journal of the American Medical Association [JAMA] criteria, and the Global Quality Score [GQS]). Videos were classified into three groups according to the source of the upload: Group 1, doctors; Group 2, profit-oriented clinics; and Group 3, independent users. Results: After the exclusion of duplicate videos, a total of 133 videos were included for analysis. Sixty-nine (51.9%) videos were uploaded by physicians/doctors, 54 (40.6%) by profit or non-profit-oriented clinics, and 10 (7.5%) by independent users including patients and content creators. The JAMA score was significantly lower in videos uploaded by patients and content creators when compared to videos uploaded by doctors and clinics (p<0.001). All quality scores including the DISCERN score, GQS, and JAMA score were significantly lower in videos describing patient experiences (p<0.001, p<0.001, and p=0.011, respectively), when compared to narrated surgery videos and informative videos. The highest positive correlation was observed between the DISCERN score and the GQS. View rates were significantly correlated with the number of likes. In addition, videos with higher subscriber numbers tended to have a significantly higher number of likes and a higher GQS. Conclusion: Health-related videos on social media platforms, which serve as informational resources, need to be produced by more qualified professionals, and the information they include needs to be objectively provided regarding all available treatment options, potential side effects, and the healing process. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Influencing factors for whole-eye astigmatism after pterygium excision combined with autologous limbal stem cell transplantation
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He Yanru, Li Wanyue, Liu Jia, Wang Yingwei, and Zhang Zifeng
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pterygium ,autologous limbal stem cell transplantation ,anterior segment optical coherence tomography ,maximum invasion depth of pterygium into the cornea ,astigmatism ,influencing factor ,Ophthalmology ,RE1-994 - Abstract
AIM: To explore the factors affecting the whole-eye astigmatism after pterygium excision combined with autologous limbal stem cell transplantation.METHODS: A retrospective analysis was conducted on the medical records of 42 patients(42 eyes)with primary pterygium admitted in the ophthalmology department of Xijing Hospital from January 2023 to October 2023. They underwent pterygium excision combined with autologous limbal stem cell transplantation. The maximum invasion depth of pterygium into the cornea was measured with anterior segment optical coherence tomography(AS-OCT)before operation, the length of the pterygium invading cornea, the width of the limbus and the area of the invading cornea were measured during the operation, and three-dimensional values of corneal astigmatism of anterior segment, index of surface variance(ISV), index of vertical asymmetry(IVA), best corrected visual acuity(BCVA)and whole-eye astigmatism were collected before and at 1 mo after surgery. Patients with astigmatism ≤0.50 D or >0.50 D of the whole eye at 1 mo after surgery were assigned to group A and B, respectively. The differences of clinical data before and at 1 mo after surgery between the two groups, and the correlation between pre-operative clinical indicators and whole-eye astigmatism were analyzed. The decision tree algorithm was performed to explore the influencing factors of whole-eye astigmatism at 1 mo postoperatively.RESULTS: The maximum invasion depth of pterygium in the group A was significantly less than that in the group B [80.00(40.00, 180.00)μm vs 175.00(123.00, 190.00)μm, P=0.002]. Preoperative BCVA(LogMAR), whole-eye astigmatism, cornea astigmatism, ISV, IVA and maximum invasion depth of pterygium were positively correlated with whole-eye astigmatism at 1 mo after surgery(rs=0.317, P=0.041; rs=0.545, P0.50 D at 1 mo after operation was higher with maximum invasion depth of pterygium into the cornea >95 μm than that with ≤95 μm. Among the patients with whole-eye astigmatism >2.63 D before operation, the probability of residual whole-eye astigmatism >0.50 D was 88.9%, and the predictive model AUC was 0.804.CONCLUSION: The whole-eye astigmatism after pterygium resection is mainly affected by the maximum invasion depth of pterygium into the cornea and preoperative whole-eye astigmatism. When the maximum invasion depth of pterygium into the corneal is >95 μm and the whole-eye stigmatism is >2.63 D before surgery, the patient should receive surgical treatment as soon as possible in order to obtain good clinical benefits.
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- 2025
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22. Analysis of risk factors for recurrence after pterygium excision
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Chen Changfeng, Ni Qin, and Xuan Guangcheng
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pterygium ,excision ,corneal astigmatism ,tear film break-up time ,recurrence ,risk factor ,Ophthalmology ,RE1-994 - Abstract
AIM: To analyze the risk factors for recurrence after pterygium excision and the influence on corneal astigmatism and tear film break-up time.METHODS:Retrospective study. A total of 110 pterygium patients(110 eyes)admitted to our hospital from January 2020 to January 2023 were selected, including 77 primary pterygium patients(77 eyes)and 33 recurrent pterygium patients(33 eyes). Pterygium excision was performed in all patients. The corneal astigmatism and tear film break-up time of patients with pterygium were measured before and after operation. The recurrence of pterygium was analyzed and the risk factors of recurrence were analyzed.RESULTS:In this study, 8 eyes with pterygium recurred after excision, and the recurrence rate was 7.3%. There was no difference in corneal astigmatism of all patients before and after surgery(2.02±0.32 vs 2.00±0.32 D, P>0.05), and there was a difference in tear film break-up time(9.55±1.24 vs 13.46±2.56 s, P
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- 2025
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23. Co-host ncRNA MIR503HG/miR-503-5p antagonistically interfere with the crosstalk between fibroblasts and microvascular endothelial cells by affecting the production of LMW FGF2 in pterygium
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Yue-Qi Yuan, Xing-Yuan Yan, Fang Zheng, and Ming Yan
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pterygium ,mir503hg ,mir-503-5p ,fibroblast growth factor 2 ,angiogenesis ,Ophthalmology ,RE1-994 - Abstract
AIM: To explore the effect of co-host non-coding RNA (ncRNA) MIR503HG/miR-503-5p on the angiogenesis of pterygium. METHODS: MIR503HG/miR-503-5p/fibroblast growth factor 2 (FGF2) expression levels in pterygium tissues, control conjunctival tissues, and human pterygium fibroblasts (HPF) were examined by reverse transcription-polymerase chain reaction (qRT-PCR) and immunohistochemical methods. Effects of MIR503HG/miR-503-5p on low molecular weight FGF2 (LWM FGF2), migration and angiogenesis of human retinal microvascular endothelial cells (HRMEC) were determined in an HPF and HRMEC co-culture model using Western blots, wound healing assay, Matrigel-based tube formation assay, and Transwell assay. RESULTS: MIR503HG/miR-503-5p/FGF2 pathway was actively increased in pterygium tissue and there was a negative correlation between the expression of the two ncRNAs. FGF2 expression level was positively correlated with MIR503HG and negatively correlated with miR-503-5p. Overexpressed MIR503HG/miR-503-5p did not affect the migration and angiogenesis of HRMECs cultured separately, but significantly affected migration and angiogenesis of HRMEC in HPF and HRMEC co-culture models. Western blotting revealed that MIR503HG/miR-503-5p overexpression significantly increased LMW FGF2 expression in HPF. CONCLUSION: MIR503HG/miR-503-5p inhibits HRMEC migration and angiogenic function by interfering with the interaction between HPF and endothelial cells via reducing LMW FGF2 in HPF.
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- 2025
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24. To evaluate the efficacy of subconjunctival bevacizumab injection in vascular pterygium before surgical excision in preventing recurrence comparing with bare sclera technique
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Nusrat Shaheen, Abdul Gafoor Ahmed, Sheikh Sajjad, Wasim Rashid, and Aamir Rashid
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bevacizumab ,pterygium ,recurrence ,Ophthalmology ,RE1-994 - Abstract
Introduction: Despite the growing body of evidence supporting the efficacy of subconjunctival bevacizumab injection, questions remain regarding its comparative effectiveness against conventional surgical techniques. Aims and Objectives: The aim of the study was to evaluate the efficacy of subconjunctival bevacizumab injection before pterygium surgery with bare sclera technique in preventing postoperative reoccurrence. Materials and Methods: The present study was a comparative, randomized prospective study. Patients included were divided into two groups of 50 patients each. Patients in Group A received bevacizumab 2.5 mg/0.1 ml, and patients in Group B received subconjunctival balanced salt solution 0.1 ml. The primary outcome was recurrence of pterygium at 6 weeks and 6 months. Results: The total number of patients was 100. The mean age was 36.9 ± 8.67 years. The left eye was involved in more, i.e., 61 than the right eye 39. Majority of patients in Group A, i.e., 30 (60%) and in Group B 31 (62%) had Grade 2 pterygium, followed by Grade 3 pterygium in 17 (34%) in Group A and 15 (30%) in Group B. The recurrence rate at 6 weeks was 6% (3 patients) in Group A while it was 22% (11 patients) in Group B (P = 0.021). The recurrence rate at 6 months was 8% (4 patients) in Group A while it was 26% (13 patients) in Group B (P = 0.017). Conclusion: Subconjunctival injection of bevacizumab before surgery of pterygium is safe and effective in terms of recurrence and the complication rate for primary or recurrent pterygium treatment.
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- 2025
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25. Evaluation of the clinical efficacy of modified LSC transplantation plus BCL implantation in the treatment of pterygium
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Ying Li, Linxia Meng, Liyan Gong, Xiao Wang, Xiaoding Yang, and Tao Li
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Pterygium ,Modified LSC transplantation ,Bandage Contact Lens ,Treatment efficacy ,Ophthalmology ,RE1-994 - Abstract
Abstract Objective To explore the clinical efficacy of modified limbal stem cell transplantation(Modified LSC transplantation) and bandage contact lens(BCL) implantation in pterygium surgery. Methods A total of 479 patients with primary pterygium who were admitted to our hospital from March 2019 to March 2023 were randomly divided into three groups: the normal group (Group A: 89 patients), the control group (Group B: 195 patients), and the modified group (Group C: 195 patients). Each group received different intervention measures. Group A did not undergo surgical treatment and were required to follow up as outpatients. Group B received LSC transplantation combined with interrupted suturing plus BCL, whereas Group C received modified LSC transplantation combined with BCL. The degree of corneal irritation symptoms, wound healing and graft status under slit lamp, incidence and recurrence rate of complications, tear film rupture time, tear secretion test, intraocular pressure, ocular surface inflammation response(IL-1β, PGE2, TNF-α, VEGF), and visual quality were compared and analyzed at various time points after surgery. Results Compared with those in the Group B, patients in the Group C experienced faster normalization of corneal epithelium recovery, fewer corneal irritation symptoms, and better wound healing. The break-up time (BUT) of the tear film at 1 week to 1 year postoperatively was significantly greater in the Group C than Group B, with values approaching those of Group A by 3 months (P 0.05). The ELISA results indicated that the expression levels of the ocular surface inflammatory factors IL-1β, TNF-α, PEG2, and VEGF in the Group C were lower than those in Group B from 1 week to 1 year post surgery. Under both natural light and low-light conditions (spatial frequency/6 cd), Group C had better best-corrected visual acuity and contrast sensitivity than Group B at 1 week to 1 year postoperatively. Additionally, Group C had lower corneal higher-order aberrations (including astigmatism, spherical aberrations, and total higher-order aberrations) and superior vision-related quality of life scores at 1 year postoperatively than Group B, with statistically significant differences (P
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- 2024
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26. Comparison of Recurrence Between Mini-SLET and Limbal-Conjunctival Autograft Techniques in Primary Pterygium
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Enrique Graue, Head of the Cornea and Refractive Surgery Department
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- 2024
27. A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium
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- 2024
28. Nail lesions in red squamous lichen planus: a review of the literature
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R. V. Saranyk and T. A. Gosteva
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lichen planus ,onychorrhexis ,pterygium ,trachyonychia ,Medicine (General) ,R5-920 - Abstract
Background. Lichen planus is a chronic inflammatory disease affecting the mucous membranes, skin and its appendages. Nail lesions in lichen planus are quite common, which leads to a negative psychological and physical impact on patients. In addition to nail lesions against the background of the underlying disease, there are also isolated forms in which only the nail plates are affected in patients with lichen planus without involving the skin and mucous membranes. Changes in the nail plates in lichen planus can be irreversible, destroying the nail plate itself and the entire nail apparatus.Objective. The aim of this article was to study the most common nail lesions in lichen planus.Materials and methods. In the period from April to July 2024, we analyzed publications from the PubMed and eLibrary databases devoted to nail lesions in lichen planus. The search queries included "Nail lichen planus", "Lichen planus", "Nail lichen planus", "Trachionychia", "Twenty nail dystrophy", "Dermoscopy nail lichen planus".Results. The study revealed that the most common nail lesions in lichen planus are longitudinal grooves, general dystrophic changes in the nails in the form of their fragility, onychorrhexis and trachyonychia. It was also noted that lichen planus is characterized by severe irreversible changes in the nails, such as anonychia and pterygium. In the course of this work, we noted the evolution of pathological changes in the nails in lichen planus. This observation can be useful in the diagnostic search and choice of treatment tactics in the early stages of the lesion.Conclusion. Timely diagnosis of pathological changes in the nails in lichen planus is crucial in choosing patient management tactics. The development of irreversible lesions of the nail plates in lichen planus should be prevented by treating earlier pathological changes.
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- 2024
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29. Pattern of Spheroidal Degeneration of Cornea and Its Association with Other Eye Diseases at Anterior Segment Clinic in Menelik II Tertiary Referral Hospital
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Tesfay K and Shibeshi MA
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corneal opacity ,pseudoexfoliation ,pterygium ,outdoor ,spheroidal degeneration of cornea ,stage ,Ophthalmology ,RE1-994 - Abstract
Kiros Tesfay, Menen Ayalew Shibeshi Department of Ophthalmology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Kiros Tesfay, Email kirostesfay@ymail.comPurpose: The purpose of the study was to assess the pattern of spheroidal degeneration of cornea (SDC) and its association with other eye diseases at the anterior segment clinic (ASC) in Menelik II Tertiary Referral Hospital.Methods: A hospital-based prospective descriptive study was conducted at ASC, in Menelik II Tertiary Referral Hospital, from May 2021 to September 2022. All enrolled patients meeting the inclusion criteria were selected and assessed with a structured questionnaire. Descriptive analysis was used to describe the study variables in terms of frequency and percentage. The results were presented using tables and figures.Results: Out of 62 cases of SDC, 48 (77.4%) were male and 14 (22.6%) were female. It was more prevalent in the age groups of 60– 69 and 70– 79. Most respondents had outdoor activity (91.9%). A total of 24.2% of patients were found to have Stage I; 35.5% were found to have Stage II; and 40.3% were in Stage III. Posterior subcapsular cataract (PSC) was found in 10 (16.1%) SDC cases, post-trachomatous corneal opacity (CO) in 10 (16.1%) SDC cases, and non-trachomatous CO in 8 (12.9%) SDC cases, but none of them had an association with SDC.Conclusion: Between May 2021 and September 2022, sixty-two cases of SDC were found at the ASC in Menelik II Tertiary Referral Hospital. The data showed a preponderance of SDC in males and older subjects. Stage III and primary types are the leading presentations. It was observed predominantly in individuals who spent most of their time outdoors. Pterygium, corneal opacity, pseudoexfoliation (PXF), PSC, and glaucoma were noted; however, none of these had a significant association with SDC.Keywords: corneal opacity, pseudoexfoliation, pterygium, outdoor, spheroidal degeneration of cornea, stage
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- 2024
30. Comparison of Samfilcon A and Balafilcon A Bandage Contact Lenses in Reducing Postoperative Symptoms After Pterygium Surgery
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Yao TY, Wang JS, Xie HT, and Zhang MC
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bandage contact lenses ,pterygium ,pain ,visual analog scale ,samfilcon a ,balafilcon a. ,Ophthalmology ,RE1-994 - Abstract
Tian-Yu Yao, Jia-Song Wang, Hua-Tao Xie, Ming-Chang Zhang Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaCorrespondence: Hua-Tao Xie; Ming-Chang Zhang, Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Tel +86-27-85726662, Email huataoxie@hust.edu.cn; mingc_zhang@hust.edu.cnObjective: To compare differences in postoperative pain, foreign body sensation, photophobia, and lacrimation between balafilcon A and samfilcon A bandage contact lenses (BCLs) in the early stage following pterygium surgery.Methods: A total of 66 eyes with pterygium conjunctival grafts fixed with sutures were included in this study, comprising 32 eyes fixed with samfilcon A and 34 eyes fixed with balafilcon A. Demographic data, postoperative corneal epithelialization time, and subjective discomfort, such as pain (using the visual analog scale [VAS]), were recorded and compared.Results: Significant differences were noted in VAS scores between the first day (P< 0.01) and the second day post-surgery (P=0.03), suggesting that patients experienced less pain after wearing samfilcon A. However, no significant differences were observed in corneal epithelialization time, VAS score before lens removal, foreign body sensation, photophobia, lacrimation, insomnia, and demographic data between the two groups. Finally, only two balafilcon A patients required nonsteroidal analgesics.Conclusion: After pterygium surgery, samfilcon A BCL was associated with lower pain levels compared with balafilcon A BCL and could assist in reducing postoperative discomfort in patients and concurrently improving patient satisfaction.Keywords: bandage contact lenses, pterygium, pain, visual analog scale, samfilcon A, balafilcon A
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- 2024
31. Expression and correlation analysis of P53 and mTOR in pterygium
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Zhang Fanglin, Zhao Xinrong, Wan Huijuan, Hua Yun, and Cai Yan
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p53 ,mtor ,pterygium ,correlation analysis ,Ophthalmology ,RE1-994 - Abstract
AIM: To detect the expression of P53 and mTOR in pterygium tissues and healthy conjunctival tissues, and to explore the relationship between the expression of P53 and mTOR, and the relationship between the expression of P53 and mTOR and the important clinical features of pterygium.METHODS: The surgical specimens of 43 patients(43 eyes)who underwent pterygium excision and autologous conjunctival transplantation in the First Affiliated Hospital of Shihezi University from November 2022 to May 2023 were collected. Healthy conjunctiva group was selected from the healthy conjunctival tissue that originated from the temporal conjunctiva of 13 patients. Totally 10 pterygium specimens and 6 normal conjunctival specimens were selected and the qPCR was used to detect the mRNA expression levels of P53 and mTOR in pterygium and normal conjunctival tissues. Another 33 cases of pterygium and 7 cases of normal conjunctival tissues were collected and the expression of P53 and mTOR in pterygium and normal conjunctival tissues were detected by immunohistochemistry. IPP6.0 software was used to calculate the average optical density, the correlation between the expression levels of P53 and mTOR, and the correlation between the expression levels of P53 and mTOR and the important clinical features of pterygium were analyzed.RESULTS: According to qPCR results, the mRNA expression levels of TP53 and mTOR in the pterygium group were significantly higher than those in the healthy conjunctiva group(all P 3 h was higher than that in the group of outdoor activity time ≤3 h(P 2 mm was higher than that in the group of pterygium head invasive limbal distance ≤2 mm(P 40 years and ≤40 years(P>0.05). There was no significant difference in the expression of mTOR between the groups of outdoor activity time > 3 h and ≤3 h, the group of pterygium head invasion distance > 2 mm and ≤2 mm, and the group of > 40 years old and ≤40 years old(all P>0.05). The expression of P53 was positively correlated with the duration of outdoor activities(r=0.484, P0.05).CONCLUSION: The overexpression of P53 and mTOR in pterygium showed a positive correlation, suggesting that the abnormal expression of P53 and mTOR may play a role in the pathogenesis of pterygium, which provides an experimental basis for further exploring the pathogenesis of pterygium; the expression of P53 is positively correlated with the time of outdoor activities and the distance of pterygium invasion. The P53 plays a role in evaluating the severity of pterygium, and provides new ideas for the clinical diagnosis and treatment of pterygium.
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- 2024
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32. Efficacy of epidermal growth factor in suppressing inflammation and proliferation in pterygial fibroblasts through interactions with microenvironmental M1 macrophages
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Soo Jin Lee, Ahra Koh, Seung Hyeun Lee, and Kyoung Woo Kim
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EGF ,Exosome ,Inflammation ,Proliferation ,Pterygial fibroblast ,Pterygium ,Medicine ,Science - Abstract
Abstract The protein epidermal growth factor (EGF), which plays a crucial role in promoting cell proliferation and survival, has recently demonstrated potential in reducing inflammation. In this study, we examined the impact of EGF on the anti-inflammatory and anti-proliferative properties of pterygium, a prevalent hypervascular proliferative disease affecting the ocular surface. In surgically excised tissues, markers for fibrotic and inflammatory signals, including VIM, ACTA2, FAP, MMP2, VCAM1, ICAM1, CD86, IL6, and IL1B were upregulated in the pterygium body stroma compared to the normal conjunctival stroma. EGF exerted anti-inflammatory and anti-vasculogenic effects on pterygial fibroblasts when co-cultured with M1 macrophages. Moreover, exosomes derived from EGF-preconditioned M1 macrophages suppressed the heightened inflammatory and vasculogenic signals in pterygial fibroblasts induced by exosomes from M1 macrophages. Paradoxically, the proliferation of pterygial fibroblasts was inhibited by EGF in the in vitro microenvironment with M1 macrophages, despite EGF being known as a growth factor. EGF-preconditioning of M1 macrophages rescued the increased proliferation of pterygial fibroblasts induced by exosomes from M1 macrophages. In conclusion, our findings demonstrate that EGF effectively mitigates inflammation and proliferation in pterygial fibroblasts within a microenvironment containing M1 macrophages.
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- 2024
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33. Corneal steep island formation after primary pterygium surgery.
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Ha, Dong Hee and Kim, Kyoung Woo
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ROOT-mean-squares , *PTERYGIUM , *CORNEA , *ASTIGMATISM , *LONGITUDINAL method , *OPTICAL coherence tomography - Abstract
Aims: This study aimed to report corneal steep island (CSI) formation following primary pterygium surgery and to identify preoperative pterygium morphological features that predict the likelihood of CSI. Methods: A total of 93 eyes from 84 subjects with primary nasal pterygium, who underwent pterygium excision combined with conjunctival-limbal autograft, were included in this retrospective longitudinal cohort study. CSI was defined using anterior segment swept-source optical coherence tomography (AS SS-OCT). Eyes were divided into two groups: those with postoperative CSI formation (Group 1) and those without postoperative CSI (Group 2). We compared postoperative anterior corneal astigmatism (ACA, in diopters [D]) and root mean square (RMS) values of anterior corneal lower-order (LoA) and higher-order aberrations (HoA) between the groups. Baseline clinical severity grades of pterygium based on the pre-established pterygium body morphology and vascularity, ACA, and AS SS-OCT-guided pterygium morphological profiles (horizontal invasion length [HIL, mm], height [μm], thickness (μm), and residual corneal thickness [RCT]/central corneal thickness [CCT] ratio [RCT/CCT]) were also compared. Results: Postoperative CSI occurred in 26 eyes (28.0%) with a maximum follow-up duration of 22.9±27.4 months. Group 1 exhibited significantly higher postoperative anterior corneal RMS LoA and HoA, as well as the RMS values of the 4th to 6th orders. Although clinical severity grades of pterygium did not differ between groups, baseline ACA was higher in Group 1 (4.56±5.49 D vs. 2.70±3.80 D, P = 0.009). HIL (4.49±0.84 mm vs. 3.77±1.29 mm, P = 0.010) was higher in Group 1, while pterygium height (930.8±84.4 μm vs. 999.3±128.0 μm, P = 0.015) and RCT/CCT ratio (1.07±0.13 vs. 1.14±0.16, P = 0.049) were lower in Group 1. Conclusions: CSI may develop after primary pterygium surgery, particularly in patients with relatively higher preoperative ACA, longer HIL, and shorter height. Given that CSI can significantly increase both lower and higher-order aberrations, it is crucial to anticipate CSI probability and inform patients before surgery. [ABSTRACT FROM AUTHOR]
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- 2024
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34. The efficacy and safety of continuous blanket suture for severe recurrent pterygium with symblepharon.
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Ma, Huixiang, Shen, Jiahui, Chen, Xuhao, Ye, Xianfeng, Xu, Shuxia, and Zhang, Zongduan
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PATIENT safety ,PTERYGIUM ,SCIENTIFIC observation ,TREATMENT effectiveness ,RETROSPECTIVE studies ,STYE ,SUTURING ,CONJUNCTIVA ,OPHTHALMIC surgery ,DISEASE relapse ,CASE studies - Abstract
Background: Managing recurrent pterygium combined with symblepharon presents significant challenges in ophthalmology. Clinicians aim to reconstruct the ocular surface, alleviate eye movement restrictions, and minimize recurrence risks. Objective: Evaluation of efficacy and safety of continuous blanket sutures (CBS) for fixation of large autologous conjunctival grafts in patients with severe recurrent pterygium with symblepharon. Methods: Retrospective, observational case series. Thirty-nine patients (40 eyes) were included, all with severe recurrent pterygium with symblepharon. During surgery, CBS was employed to affix large autologous conjunctival grafts to the exposed sclera, aiming to restore the ocular surface to smoothness as much as possible. All patients were followed up for more than one year. Main outcome measures include the rate of recurrence, improvement of eye movement, and intraoperative and postoperative complications. Results: Nearly all patients exhibited a smooth ocular surface and largely restored physiological structures during the follow-up period. There were no graft loss or contraction cases until the last follow-up, with only three eyes experiencing a pterygium recurrence (recurrence rate 7.5%, 3/40). Preoperative eye movement limitations improved significantly from 2.10 ± 0.71 (range 1–3) to 0.33 ± 0.53 (range 0–2; p < 0.001) post-surgery. Other postoperative complications included varying degrees of corneal scarring and a single instance of conjunctival granulomatous hyperplasia (1 eye, 2.5%). Conclusion: When addressing severe recurrent pterygium with Symblepharon, using CBS to secure large autologous conjunctival grafts during surgery can achieve favorable postoperative outcomes. This surgical method is safe and feasible and effectively rebuilds a smooth ocular surface, improves the appearance of the ocular surface, and reduces the recurrence rate of pterygium after excision. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Walking Ability After Microsurgical Reconstruction of Pediatric Popliteal Pterygium Syndrome—A Case Report.
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Aman, Martin, Thielen, Mirjam, Kneser, Ulrich, and Harhaus, Leila
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- *
NERVE grafting , *CONGENITAL disorders , *PERONEAL nerve , *TIBIAL nerve , *PTERYGIUM - Abstract
Background: Popliteal pterygium syndrome (PPS) is a rare congenital disorder characterized by orofacial, cutaneous, musculoskeletal, and genital anomalies. Surgical interventions are necessary to address the severe knee flexion contracture and equinovarus deformity, but there are no established treatment guidelines. Methods: We present the case of a one-year-old patient with PPS and discuss the challenges in managing the knee deformity. The surgical option chosen for the unilateral knee contracture of 80° consisted of skin management by a large Z-plasty, lengthening of popliteal vessels by grafts, lengthening of the tibial and peroneal nerves by autografts and allografts, capsular releases, and tendon releases to improve mobility and preserve foot sensibility. Results: With a three-year follow-up, the surgical interventions resulted in proper ability to walk freely. Wearing of a foot orthesis was necessary to balance the leg length differences and support the midfoot deformity. Furthermore, sensation of the foot could be restored in terms of touch sensibility and perfusion was always stable during growth. Discussion: The treatment of PPS requires a multidisciplinary approach, considering the rarity and complexity of the syndrome. Surgical interventions aim to release contractures, correct deformities, and preserve foot sensibility. Each treatment option has its advantages and disadvantages, highlighting the need for individualized care. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Comparison of postoperative topical interferon-α2b versus intraoperative mitomycin C for pterygium recurrence prevention: a randomized clinical trial.
- Author
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Akbari, Mitra, Moghadam, Reza Soltani, Leili, Ehsan Kazemnezhad, Medghalchi, Abdolreza, and Mahmoudi, Hadi
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- *
MITOMYCIN C , *CLINICAL trials , *PTERYGIUM , *INTERFERONS , *INTERFERON alpha - Abstract
Purpose: To evaluate the effect of postoperative interferon-alpha 2b (IFN-α2b) ophthalmic drops versus intraoperative mitomycin-c (MMC) on preventing pterygium recurrence. Methods: This prospective randomized clinical trial was conducted on patients who were candidates for pterygium surgery. A total of 75 patients were included in the study from December 2021 to December 2022, of which 64 patients (one eye each) were examined and analyzed based on the inclusion criteria. Then the patients were randomly assigned to control groups, intra-operative MMC (32 patients) and the intervention group, IFN-α2b drops after the operation (32 patients). All patients underwent pterygium surgery using the rotational conjunctival flap method. Results: In terms of pterygium grading, 8 (12.5%), 25 (39.06%), and 31 (48.44%) eyes were in grades 1, 2, and 3, respectively. The average size of the pterygium was 3.6 ± 0.7 mm. The grade and size of pterygium had the same distribution in the two groups. There was no statistically significant difference between the two groups in the level of post-operative clinical inflammation. The present study showed no significant difference in complications between the two groups (p = 0.999). The recurrence rate in the control group was 9.4% (3 eyes), and 0% (no recurrence) in the intervention group (p = 0.119). Conclusions: interferon-alpha 2b group did not show a statistically significant difference in preventing pterygium recurrence compared to the mitomycin C group. The post-surgery administration of IFN-α 2b drops can effectively prevent pterygium recurrence with a comparable and even more compelling effect than MMC during surgery. Key message: What is known: • Mitomycin-C is applied intra-operatively to reduce the recurrence risk of pterygium. What is new: • Interferon alpha-2b drops after pterygium surgery can prevent pterygium recurrence with a comparable effect and maybe even more effective than MMC during surgery. • There was no statistically significant difference between the intraoperative MMC and postoperative IF alpha-2b groups in the level of post-operative clinical inflammation and complications. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Timing optimization for primary pterygium excision with conjunctival‐limbal autograft to restore the corneal optical properties.
- Author
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Ha, Dong Hee and Kim, Kyoung Woo
- Subjects
- *
OPTICAL coherence tomography , *RECEIVER operating characteristic curves , *ROOT-mean-squares , *CORNEA , *PTERYGIUM - Abstract
Purpose: To propose the optimal value of baseline corneal astigmatism and pterygial morphological profiles for primary pterygium surgery to restore the corneal optical properties. Methods: We analysed 93 eyes from 84 subjects with nasal‐only primary pterygium who underwent pterygium excision with conjunctival‐limbal autograft and were assessed perioperatively using anterior segment swept‐source optical coherence tomography (AS SS‐OCT). We collected data on anterior corneal astigmatism (ACA) and root mean square (RMS) values for anterior corneal lower‐ (LoA) and higher‐order aberrations (HoA) as corneal optical properties using AS SS‐OCT. Using preoperative ACA and four pterygial morphological profiles (horizontal invasion length [HIL], height, thickness and the ratio of residual corneal thickness [RCT] to central corneal thickness [CCT]) measured in AS SS‐OCT, we plotted receiver operating characteristic (ROC) curves. These curves aimed to determine cut‐off values predicting a perioperative decrease exceeding 50% in ACA, RMS LoA and RMS HoA, as well as postoperative residual ACA higher than 1.25D. Results: Preoperative ACA > 1.42D (AUC = 0.934) and >3.60D (AUC = 0.946) proved most effective in identifying subjects with perioperative decrease exceeding in ACA and RMS LoA, respectively. HIL > 3.34 mm (AUC = 0.941) was most effective in distinguishing subjects with perioperative reduction exceeding 50% in RMS HoA. Preoperative ACA > 5.78D (AUC = 0.776) and HIL > 5.03 mm (AUC = 0.700) significantly distinguished subjects with postoperative residual ACA higher than 1.25D. Conclusion: Optimizing the restoration of corneal astigmatism and aberrations after pterygium surgery may be facilitated by determining the optimal surgical timing based on preoperative ACA and HIL values. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Agminated Eruptive Melanocytic Nevi and Nail Changes Following Toxic Epidermal Necrolysis in a Pediatric Patient: A Case Report and Systematic Review of the Literature.
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Jaros, Scott C., Morrell, Dean S., and Nieman, Elizabeth L.
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TOXIC epidermal necrolysis , *NEVUS , *CHILD patients , *SKIN diseases , *PATIENT monitoring - Abstract
ABSTRACT Eruptive melanocytic nevi (EMN) have been reported in the setting of immunosuppression, chemotherapy, and bullous skin disease, including less commonly, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). This case report presents a 4‐year‐old girl who developed agminated EMN and nail changes after TEN. A systematic review of the literature supports clinically appropriate follow‐up of EMN, as there is no reports of malignancy in EMN following SJS/TEN, nor reports of pediatric melanoma arising within EMN of any etiology. Further study of the possible correlation of nail changes with the development of EMN and better characterization of the dermoscopic features of EMN could improve monitoring and care of these patients. [ABSTRACT FROM AUTHOR]
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- 2024
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39. Bi‐allelic variants in MYH3 cause recessively‐inherited arthrogryposis.
- Author
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Morali, Burcin, Miranda, Valancy, Raelson, John, Grimard, Guy, Glavas, Peter, Audibert, François, Dumont, Nicolas A., Barone, Julia, Bamshad, Michael, Lemyre, Emmanuelle, and Campeau, Philippe M.
- Subjects
- *
DNA sequencing , *GENETIC variation , *ARTHROGRYPOSIS , *HUMAN abnormalities , *PTERYGIUM - Abstract
Arthrogryposis is a clinical feature defined by congenital joint contractures in two or more different body areas which occurs in between 1/3000 and 1/5000 live births. Variants in multiple genes have been associated with distal arthrogryposis syndromes. Heterozygous variants in MYH3 have been identified to cause the dominantly‐inherited distal arthrogryposis conditions, Freeman–Sheldon syndrome, Sheldon–Hall syndrome, and multiple pterygium syndrome. In contrast, MYH3 variants underlie both dominantly and recessively inherited Contractures, Pterygia, and Spondylocarpotarsal Fusion syndromes (CPSFS) which are characterized by extensive bony abnormalities in addition to congenital contractures. Here we report two affected sibs with distal arthrogryposis born to unaffected, distantly related parents. Sequencing revealed that both sibs were homozygous for two ultra‐rare MYH3 variants, c.3445G>A (p.Glu1149Lys) and c.4760T>C (p.Leu1587Pro). Sequencing and deletion/duplication analysis of 169 other arthrogryposis genes yielded no other compelling candidate variants. This is the first report of biallelic variants in MYH3 being implicated in a distal arthrogryposis phenotype without the additional features of CPSFS. Thus, akin to CPSFS, both dominant and recessively inherited distal arthrogryposis can be caused by variants in MYH3. [ABSTRACT FROM AUTHOR]
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- 2024
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40. Association between Tomographic Characteristics of Pterygium and Preoperative Anterior and Posterior Topography Measured by Anterior Segment Optical Coherence Tomography.
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Aguilar-González, Marina, España-Gregori, Enrique, Pascual-Camps, Isabel, Pinazo-Durán, M. Dolores, and Peris-Martínez, Cristina
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OPTICAL coherence tomography , *SURFACE topography , *CORNEAL topography , *PTERYGIUM , *ASTIGMATISM - Abstract
Background: The utilities of anterior segment optical coherence tomography (AS-OCT) for characterization, differential diagnosis, postoperative monitoring, and evaluation/comparison of surgical techniques in pterygium are described. Through AS-OCT, it is also possible to study the corneal astigmatic effect of pterygium. Our purpose is to study the associations between the anatomical characteristics of pterygium and the corneal topography through AS-OCT. Methods: Fifty eyes with primary pterygium in a tertiary hospital were evaluated before surgery by measuring 10 anatomical variables of pterygium and 13 topographic variables using AS-OCT (Casia 2; Tomey Corp., Nagoya, Japan). Statistical analysis was used to study the association between them. Results: Pterygium classified as flat pattern exhibited lower preoperative values of flat keratometry (K1), real flat keratometry (K1r), average keratometry (AvgK), and real average keratometry (AvgKr) compared to nodular ones. The flat pattern showed greater cylinder (CYL) and real cylinder (CLYr) values. The horizontal corneal invasion proportionally increased CYL and CYLr. Overall, larger anatomical pterygium measurements (limbus thickness (LimbusT), central pterygium thickness (CentreT), head pterygium thickness (HeadT), epithelial thickness at 1 mm (EpitT1mm), stromal thickness at 1 mm (stromT1mm), total thickness at 1 mm (TotalT1mm), total thickness at 2 mm (TotalT2mm), and total thickness at 3 mm (TotalT3mm)) resulted in lower anterior K1, K1r, AvgK, and AvgKr, and posterior K1 and AvgK values. CentreT was greater in astigmatisms against the rule than in oblique ones. Conclusions: This study demonstrates associations between preoperative topography and the NF (nodular or flat) classification of pterygium and its anatomical measurements assessed by AS-OCT. [ABSTRACT FROM AUTHOR]
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- 2024
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41. Popliteal Pterygium Syndrome with a Family History of Van der Woude Syndrome: A Case Report.
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Mishra, Jiten Kumar, Sahu, Shamendra Anand, Saha, Aparajita, Sindhuja, Abi, Rahmi, Jalaz Joezer, and Valsalan, Abhijith
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PTERYGIUM ,GENITALIA ,HEEL bone ,REHABILITATION ,NEUROVASCULAR surgery - Abstract
Popliteal pterygium syndrome (PPS) is a rare inherited disorder involving the face, limbs, and genitalia. The most prominent and handicapping deformity associated with this syndrome is Popliteal pterygium. Popliteal pterygium is a contracture band that extends from ischial tuberosity to calcaneum. It is a dense fibrous band difficult to correct surgically. We report a case of PPS with her two other family members diagnosed with Van der Woude syndrome. Single-stage surgical release is ineffective due to shortened neurovascular and surrounding soft tissues. Multimodality treatment with surgical release and motivated parents may help these children to rehabilitate. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Efficacy of epidermal growth factor in suppressing inflammation and proliferation in pterygial fibroblasts through interactions with microenvironmental M1 macrophages.
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Lee, Soo Jin, Koh, Ahra, Lee, Seung Hyeun, and Kim, Kyoung Woo
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The protein epidermal growth factor (EGF), which plays a crucial role in promoting cell proliferation and survival, has recently demonstrated potential in reducing inflammation. In this study, we examined the impact of EGF on the anti-inflammatory and anti-proliferative properties of pterygium, a prevalent hypervascular proliferative disease affecting the ocular surface. In surgically excised tissues, markers for fibrotic and inflammatory signals, including VIM, ACTA2, FAP, MMP2, VCAM1, ICAM1, CD86, IL6, and IL1B were upregulated in the pterygium body stroma compared to the normal conjunctival stroma. EGF exerted anti-inflammatory and anti-vasculogenic effects on pterygial fibroblasts when co-cultured with M1 macrophages. Moreover, exosomes derived from EGF-preconditioned M1 macrophages suppressed the heightened inflammatory and vasculogenic signals in pterygial fibroblasts induced by exosomes from M1 macrophages. Paradoxically, the proliferation of pterygial fibroblasts was inhibited by EGF in the in vitro microenvironment with M1 macrophages, despite EGF being known as a growth factor. EGF-preconditioning of M1 macrophages rescued the increased proliferation of pterygial fibroblasts induced by exosomes from M1 macrophages. In conclusion, our findings demonstrate that EGF effectively mitigates inflammation and proliferation in pterygial fibroblasts within a microenvironment containing M1 macrophages. [ABSTRACT FROM AUTHOR]
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- 2024
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43. 含白藜芦醇培养基培养的人眼结膜和胸部皮肤病理性 瘢痕成纤维细胞增殖凋亡侵袭迁移情况观察.
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张艺龄, 唐志铭, 乔磊, 宫朝举, 李美丽, 庞昆, and 丁继存
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Objective To observe the proliferation, apoptosis, invasion, and migration of human ocular conjunctival pterygium (ocular pathological scar) fibroblasts and human anterior thoracic skin pathological scars (skin-derived pathological scars) fibroblasts cultured in resveratrol-containing medium, in order to investigate the effects of resveratrol on the proliferation, apoptosis, invasion, and migration of human ocular pathological scar fibroblasts and skin-derived pathological scar fibroblasts. Methods Primary human ocular pathological scar fibroblasts and skin-derived pathological scar fibroblasts were isolated by tissue block adherent method. The cell viability (OD value) of human ocular and skin-derived pathological scar fibroblasts was detected by CCK-8 when the cells were cultured in media containing 0 (control), 1, 2, 4, 8, 16, 32, 64,128 and 256 µg/mL resveratrol for 48 h. Human ocular pathological scar fibroblasts and skin-derived pathological scar fibroblasts were cultured with 0 and 75 µg/mL resveratrol for 8 h, and the apoptosis rate was measured by Tunel method. These two kinds fibroblasts were cultured in 0 and 30 µg/mL resveratrol media for 48 h, and the migration and invasion abilities of the cells (the number of invasive migratory cells) were observed. Results The OD values of human ocular pathological scar fibroblasts cultured in media containing 128 and 256 µg/mL resveratrol decreased (both P<0. 05), and the OD values of skin-derived pathological scar fibroblasts cultured in media containing 64, 128, and 256 µg/ mL resveratrol all decreased (all P<0. 05), in comparison with those at 0 µg/mL resveratrol. Compared with those at 0 µg/mL resveratrol, the apoptosis rates of human ocular pathological scar fibroblasts and skin-derived pathological scar fibroblasts cultured in 75 µg/mL resveratrol medium increased (all P<0. 05), and the number of invasion and migration cells of human ocular pathological scar fibroblasts and skin-derived pathological scar fibroblasts cultured in medium containing 30 µg/mL resveratrol became smaller (all P<0. 01) . Conclusions Human ocular pathological scar fibroblasts and skin-derived pathological scar fibroblasts cultured in resveratrol-containing medium have reduced viability, invasion, and migration abilities, and increased apoptosis rate. Resveratrol can significantly inhibit the proliferation, invasion, and migration and promote the apoptosis of human ocular pathological scar fibroblasts and skin-derived pathological scar fibroblasts. [ABSTRACT FROM AUTHOR]
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- 2024
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44. A Performance Evaluation of Convolutional Neural Network Architectures for Pterygium Detection in Anterior Segment Eye Images.
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Moreno-Lozano, Maria Isabel, Ticlavilca-Inche, Edward Jordy, Castañeda, Pedro, Wong-Durand, Sandra, Mauricio, David, and Oñate-Andino, Alejandra
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CONVOLUTIONAL neural networks , *ANTERIOR eye segment , *DEEP learning , *PTERYGIUM , *OPHTHALMOLOGY - Abstract
In this article, various convolutional neural network (CNN) architectures for the detection of pterygium in the anterior segment of the eye are explored and compared. Five CNN architectures (ResNet101, ResNext101, Se-ResNext50, ResNext50, and MobileNet V2) are evaluated with the objective of identifying one that surpasses the precision and diagnostic efficacy of the current existing solutions. The results show that the Se-ResNext50 architecture offers the best overall performance in terms of precision, recall, and accuracy, with values of 93%, 92%, and 92%, respectively, for these metrics. These results demonstrate its potential to enhance diagnostic tools in ophthalmology. [ABSTRACT FROM AUTHOR]
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- 2024
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45. COMPARAÇÃO DAS TÉCNICAS CIRÚRGICAS NO TRATAMENTO DO PTERÍGIO: ANÁLISE DAS TAXAS DE RECIDIVAS.
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SANTOS PEREIRA, ANTOMIR, ALBUQUERQUE PONTES, AÍDA, BELARMINO DA SILVA, JOÃO VITOR, FERNANDES DE CARVALHO, LARA, and DE LUCENA BEZERRA, HAROLDO
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Pterygium is a common ocular disorder that can result in eye irritation and loss of corneal transparency. Surgical treatment is the main intervention for pterygium removal, with various techniques aimed at minimizing recurrence rates. This review compares the effectiveness of surgical techniques for pterygium treatment in terms of recurrence rates, including the bare sclera technique and conjunctival autograft using biological glue, sutures, and autologous blood. Articles were reviewed from the PubMed, SciELO, and LILACS databases, using the keywords: pterygium surgery, conjunctival autograft with glue or fibrin glue or biological glue or sutures or autologous blood, bare sclera, recurrence. The bare sclera technique showed a recurrence rate of 11%, while the conjunctival autograft technique using biological glue, sutures, and autologous blood demonstrated average recurrence rates of 3.75%, 6.5%, and 6.96%, respectively. The conjunctival autograft technique with biological glue presented the lowest recurrence rates, followed by conjunctival autograft with sutures, autologous blood, and bare sclera. Some studies found no significant difference between the recurrence rates of the suture and biological glue techniques, highlighting the need for further research. [ABSTRACT FROM AUTHOR]
- Published
- 2024
46. Successful Management of Extensively Drug Resistant Pseudomonas aeruginosa-Infectious Scleritis after Pterygium Surgery.
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Dalal, Samruddhi, Murthy, Somasheila I., Deogaokar, Ketan, Joseph, Joveeta, and Roy, Sanhita
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PSEUDOMONAS aeruginosa , *EYE drops , *SCLERITIS , *DRUG resistance , *DISEASE progression , *PTERYGIUM - Abstract
Introduction and purpose: We report a case of extensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) scleritis after pterygium surgery. Methods: Case report. Results: A 58-year-old farmer presented with a 40-day history of severe pain, swelling, and blurred vision after a pterygium excision was performed at another institute. The patient was on multiple medications with no relief. The examination showed a nasally located scleral thinning in his right eye, with ulceration and infiltrates. Microbiology revealed Pseudomonas aeruginosa, which showed intermediate sensitivity to colistin only. The patient was administered topical (0.19%) and intravenous colistin and dexamethasone. There was a rapid reduction in symptoms, and the lesions healed over the next 2 months. Conclusions: To the best of our knowledge, this is the first case report of XDR-PA scleritis. We suggest the possibility of evolving drug resistance caused by the iatrogenic use of antibiotics during the early stages of the disease course. [ABSTRACT FROM AUTHOR]
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- 2024
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47. Assessment of Corneal Tomographic Changes after Pterygium Excision Using Autologous Graft Surgery by Pentacam.
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Abdelhamid, Doaa A., Abdelghany, Ahmed. A., Ahmed, Moataz A., and Ali, Mahmoud A.
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TRANSPLANTATION of organs, tissues, etc. , *AUTOTRANSPLANTATION , *ASTIGMATISM , *PTERYGIUM , *CONJUNCTIVA , *PHOTOREFRACTIVE keratectomy - Abstract
Background: Pterygium is atriangular fibroelastic degeneration of the conjunctiva and subconjunctival tissue. Methods: quasi experimental study, comprising 52 patients aged from 35 to 60 during perid from April 2021 to April 2022 who underwent pterygium excision and autologus conjunctival graft. A total of 52 participants were enrolled and followed before and after 1 and 3 months after surgery by pentacam Scheimpflug camera . Results: there were significant changs in keratometric astigmatism at 1 month and 3 months compared with preoperative mean keratometric astigmatism, and there were statistically significant reduction in mean refractive astigmatism at 1 month and3 months postoperatively compared with preoperative mean refractive astigmatism. Also, a significant increase of spherical power of the cornea, there were statistically significant increase in average K1 at 1 month 3 months postoperatively compared with preoperative average K, There were statistically significant increase in average K 2 after 1 month,3 months, postoperatively compared with preoperative average K2, The mean BCVA was 0.31(0.13 SD) equivalent Decimal value preoperatively and improved significantly at 1 month postoperatively 0.48 (0.13 SD) equivalent Decimal value, P <0.001) and 3 months postoperatively 0.60( 0.13 SD), P <0.001) when compared with preoperative values. Conclusions: pterygium excision was associated with significant improvement in astigmatism. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Contribution of Radiation Sensitive Protein 51 Genotypes to Pterygium Risk in a Taiwanese Population.
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NING-YI HSIA, PEI-SHIN HU, CHIN-LIANG CHUANG, MEI-CHIN MONG, HUNG-CHIH CHEN, CHIA-WEN TSAI, YUN-CHI WANG, JAW-CHYUN CHEN, DA-TIAN BAU, and WEN-SHIN CHANG
- Abstract
Background/Aim: In current literature, there is a notable lack of studies investigating the role of radiationsensitive protein 51 (RAD-51) in pterygium diagnosis. Nevertheless, reports indicate elevated expression levels of RAD-51 among recurrent pterygium cases compared to those with primary pterygium. However, the genomic involvement of RAD-51 has yet to be explored in any population. This study aimed to assess the contribution of RAD-51 genotypes to pterygium risk in a representative Taiwanese population. Materials and Methods: RAD-51 rs1801320 genotyping was successfully conducted in a Taiwanese cohort comprising 140 pterygium cases and 280 non-pterygium controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology. Results: The distribution of RAD-51 rs1801320 genotypes (GG, CG, and CC) in the pterygium group (70.0%, 25.7%, and 4.3%, respectively) did not significantly differ from that in the nonpterygium group (73.6%, 23.6%, and 2.8% for GG, CG, and CC genotypes, respectively; p for trend=0.6337). Carriers of the variant CG and CC RAD-51 rs1801320 genotypes exhibited 1.15- and 1.58-fold increased pterygium risk, respectively (95%CI=0.72-1.84 and 0.53-4.67, p=0.6552 and p=0.5914, respectively). In the dominant model, there appeared to be a slight association between variant genotypes CG and CC and pterygium risk (OR=1.19, 95%CI=0.76-1.87, p=0.0223). Allelic analysis revealed that the RAD-51 rs1801320 variant C allele was not significantly linked to pterygium risk (17.1% versus 14.6%, OR=1.20, 95%CI=0.82-1.78, p=0.3991). Conclusion: Variant genotypes at RAD-51 rs1801320 were firstly identified to associate with susceptibility to pterygium among Taiwanese individuals. Nonetheless, these findings warrant validation in larger and more diverse populations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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49. Modified protocol for pterygium surgery without blades and electrocoagulation
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Huimin Ge, Guofan Cao, Jian Wang, and Shu Zhang
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pterygium ,surgical removal ,blunt separation ,recurrence ,electrocoagulation ,Medicine (General) ,R5-920 - Abstract
PurposeTo evaluate the efficacy, safety, and outcomes of a blade- and cautery-free surgical protocol for pterygium removal.MethodsPterygium removal surgery was done in 69 eyes (67 patients; 24 males and 43 females) who were followed up for at least 6 months. The surgery was characterized by blunt separation of the pterygium from the head to the limbal arc using the tip of Vannas scissors and modified procedures, such as transpositional flapping and suture closure. Neither a blade nor a cautery was used.ResultsThe reported subjects were 60.7 years old on average, and most of them had primary pterygium (66 out of 69). The proposed surgical protocol was simple to perform, requiring an average operation time of 18.7 min which was shorter than that of the suture and fibrin glue groups mentioned in relevant reports. Post-anesthesia pain was relieved quickly 1 day after surgery without the use of pain killers. During the follow-up period of 11.3 ± 3.1 months, recurrence of pterygium requiring additional surgery was seen in only three eyes (4.3%).ConclusionThe potential of the examined protocol as an easy, efficient, and reliable approach was demonstrated.
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- 2025
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50. Efficacy of Sub-Conjunctival Injection of Mitomycin C Versus Bevacizumab in Pterygium Treatment: Pakistani Population
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Amber khalid, Sharjeel Sultan, Aveen Fatima, Ayesha Khalid, and Maryam Shifa
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Pterygium ,Mitomycin C ,Bevacizumab ,Biochemistry ,QD415-436 ,Dentistry ,RK1-715 ,Therapeutics. Pharmacology ,RM1-950 ,Medicine (General) ,R5-920 - Abstract
Background: Pterygium is a progressive fibrovascular tissue that affects the conjunctiva and cornea. The aim of the study was to compare the efficacy of Sub-conjunctival injection of Mitomycin C versus Bevacizumab in pterygium treatment focusing on their impact on recurrence rates to improve postoperative outcomes. Methods: The Randomized clinical trial was conducted in the Ophthalmology department of Ziauddin University over 8 months. 54 patients aged above 18 with grade 2 or 3 pterygium were divided into 2 groups of 27. Group A received a Subconjunctival injection of Mitomycin C while Group B received Bevacizumab. Patients were monitored at 1st and 3rd week post injection followed by pterygium excision 1 month later. The postoperative follow-up was conducted at the 1st, 3rd, and 6th months to assess improvement in symptoms and recurrence. The data was analyzed using SPSS version 23; the Chi-square test and Paired T-test were applied with a significance level of p < 0.05. Results: The study analyzed data from 54 patients with pterygium, having a mean age of 42.03±8.23 years, with a male-to-female ratio of 3:1. The common symptoms were Redness (40.74%), itching (27.8%), and decreased visual acuity (31.4%). Post-injection outcome in terms of pterygium vascularity and thickness was better in group B. The recurrence rates at the 6th-month post excision were 1 (7.4%) and 3 (18.5%) in group B. Conclusion: Mitomycin C as an adjuvant treatment demonstrates superior efficacy in reducing pterygium recurrence and improving postoperative vision, compared to Bevacizumab.
- Published
- 2025
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