1. Characteristics and outcomes of patients hospitalized for COVID-19 in France: The Critical COVID-19 France (CCF) study
- Author
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Benjamin Perin, Orianne Weizman, Thibaut Pommier, C. Chaumont, Julie Pastiero, Théo Pezel, Vassili Panagides, Pascale Chemaly, Nathalie Noirclerc, A. Darmon, Marine Mevelec, Sophie Ribeyrolles, Gauthier Giordano, Cyril Zakine, Diane Chavignier, Victor Waldmann, Thomas Delmotte, Antoine Deney, Laura Geneste, Wassima Marsou, Willy Sutter, Thomas Levasseur, Joffrey Cellier, Antonin Trimaille, Guillaume Bonnet, C Fauvel, Nacim Ezzouhairi, Baptiste Duceau, Clément Karsenty, Iris Ma, Sabir Attou, Delphine Mika, Audrey Sagnard, Pierre Guilleminot, Ariel Cohen, and Alexandre Gautier
- Subjects
Male ,Pediatrics ,CAD, coronary artery disease ,Comorbidity ,030204 cardiovascular system & hematology ,qSOFA, quick Sequential Organ Failure Assessment ,0302 clinical medicine ,Risk Factors ,Hospital Mortality ,030212 general & internal medicine ,Cardiovascular risk factors ,COVID-19, coronavirus disease 2019 ,Aged, 80 and over ,Hazard ratio ,General Medicine ,Middle Aged ,ICU, intensive care unit ,CT, computed tomography ,Death ,Intensive Care Units ,Characteristics ,Treatment Outcome ,Cardiovascular Diseases ,Hypertension ,Cohort ,Female ,France ,Cardiology and Cardiovascular Medicine ,CCF, Critical COVID-19 France ,Adult ,medicine.medical_specialty ,SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 ,Article ,03 medical and health sciences ,Intensive care ,Diabetes mellitus ,Diabetes Mellitus ,medicine ,Humans ,Obesity ,Pandemics ,Aged ,Dyslipidemias ,Inpatients ,SARS-CoV-2 ,business.industry ,Public health ,COVID-19 ,medicine.disease ,Confidence interval ,Kidney Failure, Chronic ,business - Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a public health crisis. Only limited data are available on the characteristics and outcomes of patients hospitalized for COVID-19 in France. Aims: To investigate the characteristics, cardiovascular complications and outcomes of patients hospitalized for COVID-19 in France. Methods: The Critical COVID-19 France (CCF) study is a French nationwide study including all consecutive adults with a diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection hospitalized in 24 centres between 26 February and 20 April 2020. Patients admitted directly to intensive care were excluded. Clinical, biological and imaging parameters were systematically collected at hospital admission. The primary outcome was in-hospital death. Results: Of 2878 patients included (mean ± SD age 66.6 ± 17.0 years, 57.8% men), 360 (12.5%) died in the hospital setting, of which 7 (20.7%) were transferred to intensive care before death. The majority of patients had at least one (72.6%) or two (41.6%) cardiovascular risk factors, mostly hypertension (50.8%), obesity (30.3%), dyslipidaemia (28.0%) and diabetes (23.7%). In multivariable analysis, older age (hazard ratio [HR] 1.05, 95% confidence interval [CI] 1.03−1.06; P < 0.001), male sex (HR 1.69, 95% CI 1.11−2.57; P = 0.01), diabetes (HR 1.72, 95% CI 1.12−2.63; P = 0.01), chronic kidney failure (HR 1.57, 95% CI 1.02−2.41; P = 0.04), elevated troponin (HR 1.66, 95% CI 1.11−2.49; P = 0.01), elevated B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide (HR 1.69, 95% CI 1.0004−2.86; P = 0.049) and quick Sequential Organ Failure Assessment score ≥ 2 (HR 1.71, 95% CI 1.12−2.60; P = 0.01) were independently associated with in-hospital death. Conclusions: In this large nationwide cohort of patients hospitalized for COVID-19 in France, cardiovascular comorbidities and risk factors were associated with a substantial morbi-mortality burden.
- Published
- 2021