1. Bioinspired organocatalytic asymmetric reactions
- Author
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Mauro Comes Franchini, Mariafrancesca Fochi, Luca Bernardi, Alfredo Ricci, L. Bernardi, M. Fochi, M. Comes Franchini, and A. Ricci
- Subjects
organocatalytic asymmetric reaction ,Stereochemistry ,Oxyanion ,reminiscent of natural enzyme ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,Biomimetic Materials ,Catalytic Domain ,Molecule ,Urea ,Physical and Theoretical Chemistry ,Amination ,Substrate Interaction ,Chemistry ,Organic Chemistry ,Esterases ,Thiourea ,Hydrogen Bonding ,Stereoisomerism ,multiple hydrogen-bonds ,Combinatorial chemistry ,Cyclization ,Serine Proteases ,Protein Binding - Abstract
Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.
- Published
- 2012