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26 results on '"retina disease"'

1. Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.

Author

Srivastava, Dhiraj, Gowribidanur-Chinnaswamy, Pavithra, Gaur, Paras, Spies, Maria, Swaroop, Anand, and Artemyev, Nikolai O.

Subjects
*TRANSCRIPTION factors, *LEUCINE zippers, *RETINAL diseases, *PROMOTERS (Genetics), *GENETIC transcription, *PHOTORECEPTORS
Abstract

Two retinal transcription factors, cone-rod homeobox (CRX) and neural retina leucine zipper (NRL), cooperate functionally and physically to control photoreceptor development and homeostasis. Mutations in CRX and NRL cause severe retinal diseases. Despite the roles of NRL and CRX, insight into their functions at the molecular level is lacking. Here, we have solved the crystal structure of the CRX homeodomain in complex with its cognate response element (Ret4) from the rhodopsin proximal promoter region. The structure reveals an unexpected 2:1 stoichiometry of CRX/Ret4 and unique orientation of CRX molecules on DNA, and it explains the mechanisms of pathogenic mutations in CRX. Mutations R41Q and E42K disrupt the CRX protein-protein contacts based on the structure and reduce the CRX/Ret4 binding stoichiometry, suggesting a novel disease mechanism. Furthermore, we show that NRL alters the stoichiometry and increases affinity of CRX binding at the rhodopsin promoter, which may enhance transcription of rod-specific genes and suppress transcription of cone-specific genes. [Display omitted] • Crystal structure of the CRX homeodomain in complex with its Ret4 response element • Complex displays a 2:1 stoichiometry and a unique orientation of CRX on the DNA • The CRX/Ret4 structure helps to elucidate the mechanisms of pathogenic CRX mutations • NRL alters the stoichiometry and strengthens CRX binding to the rhodopsin promoter Srivastava et al. determined the crystal structure of the CRX homeodomain in complex with its Ret4 response element from the rhodopsin promoter. This study provides structural insights into the recognition of DNA by CRX, its function, and the cooperative DNA binding by CRX and NRL. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Differential Susceptibility of Retinal Neurons to the Loss of Mitochondrial Biogenesis Factor Nrf1.

Author

Kiyama, Takae, Chen, Ching-Kang, Zhang, Annie, and Mao, Chai-An

Subjects
*MITOCHONDRIA formation, *MITOCHONDRIA, *PHOTORECEPTORS, *CENTRAL nervous system, *EUKARYOTIC cells, *NEURONS, *CELL death
Abstract

The retina, the accessible part of the central nervous system, has served as a model system to study the relationship between energy utilization and metabolite supply. When the metabolite supply cannot match the energy demand, retinal neurons are at risk of death. As the powerhouse of eukaryotic cells, mitochondria play a pivotal role in generating ATP, produce precursors for macromolecules, maintain the redox homeostasis, and function as waste management centers for various types of metabolic intermediates. Mitochondrial dysfunction has been implicated in the pathologies of a number of degenerative retinal diseases. It is well known that photoreceptors are particularly vulnerable to mutations affecting mitochondrial function due to their high energy demand and susceptibility to oxidative stress. However, it is unclear how defective mitochondria affect other retinal neurons. Nuclear respiratory factor 1 (Nrf1) is the major transcriptional regulator of mitochondrial biogenesis, and loss of Nrf1 leads to defective mitochondria biogenesis and eventually cell death. Here, we investigated how different retinal neurons respond to the loss of Nrf1. We provide in vivo evidence that the disruption of Nrf1-mediated mitochondrial biogenesis results in a slow, progressive degeneration of all retinal cell types examined, although they present different sensitivity to the deletion of Nrf1, which implicates differential energy demand and utilization, as well as tolerance to mitochondria defects in different neuronal cells. Furthermore, transcriptome analysis on rod-specific Nrf1 deletion uncovered a previously unknown role of Nrf1 in maintaining genome stability. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Binary Function of ARL3-GTP Revealed by Gene Knockouts

Author

Hanke-Gogokhia, Christin, Frederick, Jeanne M., Zhang, Houbin, Baehr, Wolfgang, COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, REZAEI, NIMA, Series Editor, Ash, John D., editor, Anderson, Robert E., editor, LaVail, Matthew M., editor, Bowes Rickman, Catherine, editor, Hollyfield, Joe G., editor, and Grimm, Christian, editor

Published
2018
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4. Clinical analysis of intravitreal injection of Conbercept combined with 532-laser treating Coats disease in adulthood

Author

Li Jiang, Jin Li, and Wei Peng

Subjects
conbercept, coats disease in adulthood, retina disease, Ophthalmology, RE1-994
Abstract

AIM: To analyze clinical observation and the efficiency of intravitreal conbercept combined with 532-laser on Coats disease in adulthood. METHODS: This was an retrospective analysis. Six eyes from 6 patients(5 males and 1 female)with coats disease diagnosed by fundus fluorescein angiography(FFA)and optical coherence tomography(OCT)were enrolled. Before the injection, best-corrected visual acuity(BCVA)of early treatment of diabetic retinopathy study(ETDRS), non-contact tonometer, ophthalmoscope, fundus photography, FFA, and OCT were examined. The initial average visual acuity(ETDRS letters)were 51.17±15.15. The initial average central retina thickness(CRT)was 303.30±107.87μm. All affected eyes were treated with intravitreal conbercept 0.05mL(10mg/mL)combined with 532-laser. Patients were followed up for 6 to 12mo, with a mean duration of 7.33±1.26mo. Post-treatment BCVA were compared with baseline using repeat analysis. RESULTS: The mean BCVA showed significant improvement during 1 wk, 1, 3mo post-treatment and the latest follow up(PCONCLUSION: Coats disease in adulthood more likely to have lower symptom and have a better response on treatment. Intravitreal conbercept combined with 532-laser significantly improve visual acuity and absorb the subretina fluid.

Published
2017
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5. Differential Susceptibility of Retinal Neurons to the Loss of Mitochondrial Biogenesis Factor Nrf1

Author

Takae Kiyama, Ching-Kang Chen, Annie Zhang, and Chai-An Mao

Subjects
Organelle Biogenesis, Nuclear Respiratory Factor 1, General Medicine, mitochondrial biogenesis, Nrf1, photoreceptor degeneration, bipolar cells, ganglion cells, transcriptome, RNA-seq, retina disease, Retina, Mitochondria, Retinal Neurons
Abstract

The retina, the accessible part of the central nervous system, has served as a model system to study the relationship between energy utilization and metabolite supply. When the metabolite supply cannot match the energy demand, retinal neurons are at risk of death. As the powerhouse of eukaryotic cells, mitochondria play a pivotal role in generating ATP, produce precursors for macromolecules, maintain the redox homeostasis, and function as waste management centers for various types of metabolic intermediates. Mitochondrial dysfunction has been implicated in the pathologies of a number of degenerative retinal diseases. It is well known that photoreceptors are particularly vulnerable to mutations affecting mitochondrial function due to their high energy demand and susceptibility to oxidative stress. However, it is unclear how defective mitochondria affect other retinal neurons. Nuclear respiratory factor 1 (Nrf1) is the major transcriptional regulator of mitochondrial biogenesis, and loss of Nrf1 leads to defective mitochondria biogenesis and eventually cell death. Here, we investigated how different retinal neurons respond to the loss of Nrf1. We provide in vivo evidence that the disruption of Nrf1-mediated mitochondrial biogenesis results in a slow, progressive degeneration of all retinal cell types examined, although they present different sensitivity to the deletion of Nrf1, which implicates differential energy demand and utilization, as well as tolerance to mitochondria defects in different neuronal cells. Furthermore, transcriptome analysis on rod-specific Nrf1 deletion uncovered a previously unknown role of Nrf1 in maintaining genome stability.

Published
2022

6. Identifying the factors for improving quality of oral fluorescein angiography

Author

Manuel J. Amador-Patarroyo, Nicolás Molano-González, Tiezhu Lin, Shyamanga Borooah, Amit Meshi, William R. Freeman, Jorge A. Díaz-Rojas, Kevin Chen, and Kunny Dans

Subjects
Male, Mydriatics, Scoring system, Food intake, Physiology, Image quality, Cross-sectional study, Visual Acuity, Administration, Oral, Image analysis, Imaging, Eating, 0302 clinical medicine, Observational study, Fluorescein Angiography, Priority journal, Aged, 80 and over, Staining, Cross-Over Studies, medicine.diagnostic_test, Macula, Fasting, Middle Aged, Fluorescein angiography, Sensory Systems, Patient safety, Body mass, Fluorescein, Female, Radiology, Diagnostic tests/investigation, Human, medicine.medical_specialty, Dye, Major clinical study, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Retinal Diseases, Optical coherence tomography, Fluorescence angiography, medicine, Humans, Medical specialist, Clinical significance, Personal experience, Fluorescent Dyes, Aged, Pharmacology, business.industry, Macular degeneration, Retinal Vessels, Pupil, 030208 emergency & critical care medicine, medicine.disease, Ophthalmology, Angiography, 030221 ophthalmology & optometry, Retina disease, business
Abstract

AimTo evaluate the quality of oral fluorescein angiography (FA) in relation to food intake.MethodsThis is an observational, case-crossover study. We collected information from patients undergoing routine oral FA for retinal disease at the Shiley Eye Institute. Eighty patients (160 eyes) were analysed. Fasting and non-fasting images of the same patient were recorded, compared and analysed for different image quality parameters and clinical relevance by experienced retina specialists.ResultsWhen analysing the images, intergrader agreement was moderate to good with a Kappa averaging 0.60 (0.5–0.85). When patients were fasting pre-imaging, better angiography quality scores were achieved when compared with images taken when patients were non-fasting (mean 0.84 vs 0.72, pConclusionFasting oral FA provided significantly better quality images as well as faster optimal imaging times when compared with non-fasting oral FA. By improving its overall quality, oral FA could be a useful adjunctive examination to optical coherence tomography (OCT) and OCT angiography in patients who require FA studies but who have difficult access or refuse an invasive procedure.

Published
2019
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7. Single-Dose Tafenoquine to Prevent Relapse ofPlasmodium vivaxMalaria

Author

Kalehiwot M Wubie, Marcus V. G. Lacerda, Françoise Brand, Kim Fletcher, Alemseged Abdissa, Nillawan Buathong, Elizabeth Hardaker, Harald Noedl, Victoria M Rousell, Ermias Diro, Jörg-Peter Kleim, Monica R. F. Costa, Brian Angus, John J Breton, Alejandro Llanos-Cuentas, Lynda Kellam, Reginaldo Z Mia, Marcelo A M Brito, Martin Casapia, Hans-Peter Beck, Fe Espino, Raul Chuquiyauri, Wuelton Marcelo Monteiro, Rezika Mohammed, Donna D Clover, Fernando Val, Sisay Getie, Justin A. Green, Dhelio Batista Pereira, Daniel Yilma, Stephan Duparc, Mauro Shugiro Tada, Cherinet Abebe, Ahmed Zeynudin, Siôn W. Jones, Khadeeja Mohamed, David L. Saunders, Cletus O Ugwuegbulam, Gavin C. K. W. Koh, Chanthap Lon, and Srivicha Krudsood

Subjects
Male, double blind procedure, drug safety, Primaquine, Kaplan Meier method, Tafenoquine, Philippines, Plasmodium vivax, Kaplan-Meier Estimate, tafenoquine, Parasitemia, aminoquinoline derivative, 030204 cardiovascular system & hematology, chloroquine, Hemoglobins, chemistry.chemical_compound, 0302 clinical medicine, Chloroquine, Peru, Secondary Prevention, 030212 general & internal medicine, Antimalarial Agent, disease free survival, methemoglobin, relapse, glucose 6 phosphate dehydrogenase, parasite clearance, biology, adult, Plasmodium vivax malaria, single drug dose, food and beverages, clinical trial, General Medicine, Thailand, enzyme activity, Intention to Treat Analysis, G6PD protein, human, female, Cytochrome P-450 CYP2D6, priority journal, retinal hypopigmentation, Aminoquinolines, disease severity, Drug Therapy, Combination, Cambodia, hypopigmentation, Brazil, recurrence risk, medicine.drug, combination drug therapy, Adolescent, hematocrit, Glucosephosphate Dehydrogenase, Disease-Free Survival, Article, Antimalarials, 03 medical and health sciences, Pharmacotherapy, Double-Blind Method, retina disease, parasitic diseases, Malaria, Vivax, medicine, Humans, controlled study, human, procedures, cytochrome P450 2D6, dizziness, keratopathy, treatment duration, phase 3 clinical trial, antimalarial agent, isolation and purification, business.industry, statistical model, fungi, hemoglobin, medicine.disease, biology.organism_classification, major clinical study, Virology, purl.org/pe-repo/ocde/ford#3.02.00 [https], phase 2 clinical trial, Logistic Models, multicenter study, chemistry, randomized controlled trial, placebo, Ethiopia, business, metabolism, Malaria
Abstract

Background Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed “radical cure”). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for the radical cure of P. vivax. Methods This multicenter, double-blind, double-dummy, parallel group, randomized, placebo-controlled trial was conducted in Ethiopia, Peru, Brazil, Cambodia, Thailand, and the Philippines. We enrolled 522 patients with microscopically confirmed P. vivax infection (>100 to Results In the intention-to-treat population, the percentage of patients who were free from recurrence at 6 months was 62.4% in the tafenoquine group (95% confidence interval [CI], 54.9 to 69.0), 27.7% in the placebo group (95% CI, 19.6 to 36.6), and 69.6% in the primaquine group (95% CI, 60.2 to 77.1). The hazard ratio for the risk of recurrence was 0.30 (95% CI, 0.22 to 0.40) with tafenoquine as compared with placebo (P Conclusions Single-dose tafenoquine resulted in a significantly lower risk of P. vivax recurrence than placebo in patients with phenotypically normal G6PD activity. (Funded by GlaxoSmithKline and Medicines for Malaria Venture; DETECTIVE ClinicalTrials.gov number, NCT01376167. opens in new tab.)

Published
2019
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8. Hallazgos clínicos en retinosis pigmentaria por examen visual, campimetría y retinografía en Colombia

Author

García Dávila, Keissy Juliette, Vélez Muskus, Vladimiro José, Narváez Rumié, Olivia Margarita, Trujillo Güiza, Martha Liliana, García Dávila, Keissy Juliette, Vélez Muskus, Vladimiro José, Narváez Rumié, Olivia Margarita, and Trujillo Güiza, Martha Liliana

Abstract

Retinitis pigmentosa (RP) comprises a group of degenerative diseases of the retina affecting the visual field and function. It characterizes by a night blindness and loss of the peripheral visual field. It usually appears prematurely in the youth years. This article aims to describe the eye and visual clinical findings in 12 patients with retinitis pigmentosa. Twelve RP patients were evaluated using a visual examination, campimetry and retinography. It was found that 50% of the patients had hypermetropic astigmatism and 42% had myopic astigmatism. In 41.7%, a bigger accumulation of pigment was found in the higher area of the retina, showing a visual acuity between 20/400 and light perception. A third part of the sample showed deep low vision and a sensitiveness threshold ≤ 18 db. Relative scotoma was more frequent, although visual acuity between 20/400 and PL of 25%, and 41.7% of the patients had absolute scotoma in the right and left eyes, respectively. The use of vision correction in patients with relative scotoma led to improvement in 41.7% and 33.3% (right eye and left eye). All of them showed waxen pallor in the optic disc and 92% showed arteriolar attenuation. It is concluded that the typical signs in the eye fundus of RP subjects include waxen pallor of the optical disc, pigmentation in the form of bone spicules, arteriolar attenuation, visual field ≤ 10° central, like seeing through a tunnel. Patients with deep low vision showed a bigger accumulation of pigment in the peripheral higher retina, a sensitiveness threshold below 18 dB, and absolute scotoma., La retinosis pigmentaria (RP) comprende un grupo de enfermedades degenerativas de la retina que afectan la función y el campo visual. Se caracteriza por ceguera nocturna y pérdida de campo visual periférico, y suele tener debut precoz y juvenil. Este artículo tiene como propósito describir los hallazgos clínicos visuales y oculares en 12 pacientes con retinosis pigmentaria. Para esto, se evaluaron 12 pacientes con RP, mediante examen visual, campimetría y retinografía. Se halló que el 50 % de los pacientes presentó astigmatismo hipermetrópico y 42 %, astigmatismo miópico. Un mayor acúmulo de pigmento en zona superior de retina se observó en el 41,7 %, con agudeza visual entre 20/400 y percepción luminosa. Un tercio de la muestra presentó baja visión profunda y umbral de sensibilidad ≤ a 18db. El escotoma relativo fue más frecuente, aunque en agudezas visuales entre 20/400 y PL el 25 % y 41,7 % de los pacientes presentaron escotoma absoluto en ojo derecho e izquierdo respectivamente. El uso de corrección en pacientes con escotoma relativo generó mejoría en el 41,7 % y 33,3 % (ojo derecho e izquierdo). Todos presentaron palidez cérea del disco óptico y el 92 % atenuación arteriolar. Se concluyó que los signos característicos del fondo ocular de los participantes con RP fueron palidez cérea de disco óptico, pigmentación en forma de espículas óseas, atenuación arteriolar, campo visual ≤10° centrales con visión en túnel. Los pacientes con baja visión profunda presentaron mayor acúmulo de pigmento en retina superior periférica, umbral de sensibilidad menor de 18dB y escotomas de tipo absoluto.

Published
2020

9. Interplay between reactive oxygen species and autophagy in the course of age-related macular degeneration

Author

Nita, Małgorzata and Grzybowski, Andrzej

Subjects
0303 health sciences, 03 medical and health sciences, Ophthalmology, Oxidative stress, Age-related macular degeneration, Autophagy, 030311 toxicology, Review Article, Reactive oxygen species, Retina disease
Abstract

Pathological biomolecules such as lipofuscin, methylglyoxal-modified proteins (the major precursors of advanced glycationend products), misfolding protein deposits and dysfunctional mitochondria are source of oxidative stress and act as strong autophagic stimulators in age-related macular degeneration. Disturbed autophagy accelerates progression of the disease, since it leads to retinal cells’ death and activates inflammation by the interplay with the NLRP3 inflammasome complex. Vascular dysfunction and hypoxia, as well as circulating autoantibodies against autophagy regulators (anti-S100A9, anti-ANXA5, and anti-HSPA8, A9 and B4) compromise an autophagy-mediated mechanism as well. Metformin, the autophagic stimulator, may act as a senostatic drug to inhibit the senescent phenotype in the age-related macular degeneration. PGC-1α , Sirt1 and AMPK represent new therapeutic targets for interventions in this disease., EXCLI Journal;Vol. 19. 2020, pp. 1353-1371

Published
2020

10. The role of OCT-A in retinal disease management

Author

Rodríguez, Francisco J., Staurenghi, Giovanni, Gale, Richard, and On behalf of the Vision Academy Steering Committee

Subjects
Fluorescein angiography, optical coherence, genetic structures, Review Article, Review, Diagnostic Techniques, Ophthalmological, Clinical practice, Medical decision making, Procedures, 01 natural sciences, chemistry.chemical_compound, 0302 clinical medicine, Diabetic macular edema, Polypoidal choroidal vasculopathy, Pathology, Non-invasive, Fluorescein Angiography, Disease management (health), Age related macular degeneration, Tomography, Priority journal, medicine.diagnostic_test, Diagnostic test, Imaging modality, OCT-A, Retinal diseases, Sensory Systems, Algorithm, Clinical Practice, Retina vein occlusion, Screening, Tomography, Optical Coherence, Human, Retina detachment, medicine.medical_specialty, Blood vessel permeability, Retina, 010309 optics, 03 medical and health sciences, Cellular and Molecular Neuroscience, Retinal Diseases, Image processing, Optical coherence tomography, Fluorescence angiography, 0103 physical sciences, medicine, Humans, Medical physics, Oct-a, ophthalmological, Diagnostic techniques, Modality (human–computer interaction), business.industry, Subretinal neovascularization, Retinal, Optical coherence tomography angiography, Microangiography, eye diseases, Visual system examination, Clinical trial, Ophthalmology, chemistry, 030221 ophthalmology & optometry, Publication, sense organs, Retina disease, business
Abstract

Optical coherence tomography angiography (OCT-A) is a non-invasive, non-dye-based imaging modality that has the potential to enhance our understanding of retinal diseases. While this rapidly advancing imaging modality offers great potential, there is a need for community-wide understanding of the range of technologies and methods for interpreting the images, as well as a need to enhance understanding of images from disease-free eyes for reference when screening for retinal diseases. Importantly, clinical trials have been designed without OCT-A-based endpoints; therefore, caution is required when making treatment decisions based on OCT-A imaging alone. With this in mind, a full understanding of the advantages and limitations of OCT-A will be vital for effective development of the technique within the field of ophthalmology. On behalf of the Vision Academy Steering Committee (sponsored by Bayer), this publication summarizes the views of the authors on the current use of OCT-A imaging and explores its potential for future applications in research and clinical practice. © 2018, The Author(s).

Published
2018
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11. Increased choroidal thickness: a new feature to monitor age-related macular degeneration recurrence

Author

Laurent Kodjikian, Emilie Agard, Philippe Denis, Hussam El-Chehab, Corinne Dot, Zainab Machkour‐Bentaleb, Maud Mendes, Thibaud Mathis, V. Bouteleux, Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Hydrosystèmes et Bioprocédés (UR HBAN), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), and Hydrosystèmes et bioprocédés (UR HBAN)

Subjects
0301 basic medicine, choroidal thickness, Male, Vascular Endothelial Growth Factor A, systolic blood pressure, genetic structures, intervention study, recurrent disease, very elderly, Angiogenesis Inhibitors, mixed age related macular degeneration, [SPI.MAT]Engineering Sciences [physics]/Materials, chemistry.chemical_compound, dry retina, 0302 clinical medicine, Recurrence, 80 and over, Prospective Studies, Fluorescein Angiography, Tomography, Aged, 80 and over, medicine.diagnostic_test, aflibercept, clinical trial, Organ Size, VEGFA protein, Sensory Systems, 3. Good health, medicine.anatomical_structure, spectral domain optical coherence tomography, priority journal, Intravitreal Injections, Female, Tomography, Optical Coherence, retina neovascularization, prospective study, medicine.medical_specialty, diagnostic imaging, age related macular degeneration, subretinal neovascularization, bevacizumab, polypoidal choroidal vasculopathy, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Optical coherence tomography, Ophthalmology, Age related, retina disease, choroidal neovascularization type 3, medicine, choroidal neovascularization type 1, follow up, Humans, choroidal neovascularization type 2, human, ranibizumab, antagonists and inhibitors, Aged, Retina, optical coherence tomography, business.industry, Choroid, diastolic blood pressure, reticular pseudodrusen, Retinal, retinal angiomatous proliferation, fluorescence angiography, Macular degeneration, intravitreal drug administration, medicine.disease, major clinical study, eye diseases, clinical feature, 030104 developmental biology, Blood pressure, angiogenesis inhibitor, multicenter study, chemistry, vasculotropin A, Optical Coherence, 030221 ophthalmology & optometry, Wet Macular Degeneration, pathology, Enhanced depth imaging, sense organs, business, Follow-Up Studies
Abstract

cited By 0; Purpose: The main objective of this study was to assess choroidal thickness (CT) changes during an exudative recurrence of age-related macular degeneration (AMD). Methods: A real-life prospective non-interventional 9-month study was conducted in two centers in consecutive patients with exudative AMD between November 2016 and July 2017. CT was measured manually in both eyes based on enhanced-depth imaging spectral-domain optical coherence tomography at different follow-up visits scheduled in the morning. Results: A total of 134 patients were included. Ninety-five patients presented at least one episode, defined by a follow-up visit under controlled condition (dry retina) followed by a visit for exudative recurrence. A total of 119 episodes were analyzed. The mean CT change in the treated eye was + 8.45 ± 13.52 μm (p < 0.001) and + 5.62 ± 14.77 μm (p = 0.009) respectively in the subfoveal area and nasal area. No significant change in CT was observed in the fellow eye. No significant association between CT changes and treatment, number of intravitreal injections, and blood pressure was observed. Conclusion: CT increased in case of exudative recurrence of neovascular AMD. The increase was mild but significant. Thus, CT could be used as a monitoring criterion, like the central retinal thickness, in AMD management. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

Published
2019
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12. Further observations on a bilateral IRVAN syndrome case

Author

Francisco Rodríguez, Alvaro Rodriguez, and Willy Carpio-Rosso

Subjects
Fluorescein angiography, Retinal artery, Visual acuity, optical coherence, genetic structures, Intraocular pressure, medicine.medical_treatment, Retinal Artery, Visual Acuity, Fundus (eye), Procedures, 0302 clinical medicine, Irvan syndrome, Observational study, Optic disk, Fluorescein Angiography, Tomography, Laser Coagulation, medicine.diagnostic_test, Syndrome, Eye fundus, Divergent strabismus, Retrospective study, Wide-field angiography, Female, Retina fovea, medicine.symptom, Fundus oculi, Laser coagulation, Retina vasculitis, Tomography, Optical Coherence, Human, Adult, Vasculitis, medicine.medical_specialty, Vitritis, Fundus Oculi, Retinal aneurysms, Clinical article, Biomicroscopy, Article, Neuroretinitis, Ophthalmoscopy, Uveitis, 03 medical and health sciences, Young Adult, Retinal vasculitis, Retina fluorescein angiography, Retina neovascularization, Retina artery, Ophthalmology, Fluorescence angiography, Case report, medicine, Humans, Epithelium hyperplasia, Retrospective Studies, Retinal Vasculitis, Optical coherence tomography, business.industry, Retinitis, Follow up, medicine.disease, Aneurysm, eye diseases, Retrospective studies, Central scotoma, Young adult, Angiography, 030221 ophthalmology & optometry, sense organs, business, Retina disease, Complication, 030217 neurology & neurosurgery
Abstract

Purpose: Reporting clinical features of the late course of the disease after long-term follow-up in a bilaterally affected patient with idiopathic retinitis, vasculitis, retinal aneurysms and neuroretinitis (IRVAN) and new peripheral retinal findings on wide-field angiography and multimodal imaging. Methods: This was a retrospective observational study, based on current diagnostic studies including wide-field fluorescein angiography, optical coherence tomography (OCT) and treatment of aneurysms with argon laser photocoagulation. Results: A 21-year-old female with bilateral IRVAN syndrome—stage 2 in the right eye and stage 3 in the left eye—previously treated bilaterally with laser photocoagulation for retinal macroaneurysms and ischemic areas between 1985 and 1992. Follow-up interrupted on two occasions, with subsequent fundus re-examinations confirming the prevention of retinal neovascularization in both eyes, as recently evidenced on wide-field angiography. Conclusions: A case of bilateral IRVAN disease with multiple retinal aneurysms, neuroretinitis and peripheral capillary nonperfusion successfully treated with laser photocoagulation, maintaining normal visual acuity in one eye and preventing retinal neovascular complications. © 2018, Springer Science+Business Media B.V., part of Springer Nature.

Published
2019

13. Single-cell RNA sequencing: A new opportunity for retinal research.

Author

You M, Rong R, Zeng Z, Li H, Xia X, and Ji D

Subjects
Gene Expression Profiling, RNA genetics, Sequence Analysis, RNA, Transcriptome, Retina, Single-Cell Analysis
Abstract

Single-cell RNA sequencing (scRNA-seq) is a technology for single-cell transcriptome analysis that can be used to characterize complex dynamics of various retinal cell types. It provides deep scrutiny into the gene expression character of diverse cell types, lending insight into all the biological processes being carried out. The scRNA-seq is an alternative to regular RNA-seq, which does not achieve cellular heterogeneity. The retina, is a part of the central nervous system (CNS) and consists of six types of neurons and several types of glial cells. Studying retinal cell heterogeneity is important for understanding retinal diseases. Currently, scRNA-seq is employed to assess retina development and retinal disease pathogenesis and has improved our understanding of the relationship between the retina, its visual pathways, and the brain. Moreover, this technology provides new ideas on the sensitivity and molecular mechanisms of cell subtypes involved in retinal-related diseases. The application of scRNA-seq technology has given us a deeper understanding of the latest advancements and challenges in retinal development and diseases. We advocate scRNA-seq as one of the important tools for developing novel therapies for retinal diseases. This article is categorized under: RNA Methods > RNA Analyses in Cells RNA in Disease and Development > RNA in Development RNA in Disease and Development > RNA in Disease., (© 2021 Wiley Periodicals LLC.)

Published
2021
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14. Ultra widefield imaging of the retina [Imagen de retina de campo ultra-amplio]

Author

José Gerardo García Aguirre

Subjects
retina, genetic structures, age related macular degeneration, eye fundus, ultra widefield imaging, retina image, eye diseases, Article, retina examination, diabetic retinopathy, 7 INGENIERÍA Y TECNOLOGÍA, retina disease, uveitis, retina blood vessel occlusion, sense organs, human
Abstract

Purpose To review the evolution and usefulness of ultra widefield images of the retina. Method Literature review. Results The ability to obtain images of the ocular fundus is one of the greatest breakthroughs in our specialty. This ability has refined over time, from obtaining images with a field of 30 degrees, to obtaining images that exceed 150 degrees using equipment such as the Optos Daytona (Optos, Dunfermline, United Kingdom) or the Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany). These images are extremely useful to evaluate diseases such as diabetic retinopathy, retinal vascular occlusions, pediatric retinal pathology, posterior uveitis, and even diseases which classically affect the macula such as age-related macular degeneration. Conclusion Ultra widefield images of the retina have revolutionized the way we study and understand retinal pathology. As technology for obtaining these images becomes more accessible, it will surely become part of the routine evaluation of retinal diseases. © 2016 Sociedad Mexicana de Oftalmología

Published
2017

15. Multicenter study of pars plana vitrectomy for optic disc pit maculopathy: MACPIT study

Author

Sengul Ozdek, Levent Akduman, Z Kapran, Dilek Guven, Sami Yilmaz, Gungor Sobaci, Berkant Kaderli, M Y Teke, Y B Unver, Ali Hakan Durukan, O Oz, I Dogan, Süleyman Kaynak, Ümit Übeyt Inan, Remzi Avci, Maltepe Üniversitesi, Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı., and Kaderli, Berkant

Subjects
Fluorocarbon, Retina maculopathy, Male, Visual acuity, Limiting membrane, genetic structures, Detachment, Physiology, retrospective study, medicine.medical_treatment, Coloboma, Retinoschisis, Optic Disk, Surgical approach, Visual Acuity, Vitrectomy, Pathogenesis, Procedures, 0302 clinical medicine, Laser treatment, Best corrected visual acuity, Long-term outcomes, Gas tamponade, Eye Abnormalities, Treatment outcome, Child, Prospective cohort study, Tomography, Perflutren, Fluorocarbons, Optical coherence, Middle Aged, Multicenter study, Eye malformation, Clinical trial, Perfluoroethane, medicine.anatomical_structure, Macular thickness, Coherence tomography, Female, Retina fovea, Abnormalities, medicine.symptom, Tomography, Optical Coherence, Human, Optic disc, Adult, Pars plana, medicine.medical_specialty, Adolescent, Clinical article, Sulfur Hexafluoride, Gauge vitrectomy, Endotamponade, Pathophysiology, Article, 03 medical and health sciences, Retinal Diseases, Ophthalmology, Correspondence, medicine, Humans, Aged, Retrospective Studies, Optical coherence tomography, business.industry, Pars plana vitrectomy, Nerve, Surgical technique, Retrospective cohort study, Follow up, medicine.disease, eye diseases, Ophthalmoscopy, 030221 ophthalmology & optometry, Maculopathy, sense organs, Retina disease, business, 030217 neurology & neurosurgery, Optic disc pit maculopathy, Follow-Up Studies
Abstract

WOS: 000410594600003, PubMed ID: 28731058, Purpose To evaluate surgical intervention with pars plana vitrectomy (PPV) for correction of optic disc pit maculopathy (ODP-M). Patients and methods Retrospective chart review from 13 centres of 51 eyes of 50 patients with ODP-M who underwent PPV between 2002-2014. Anatomic and final best-corrected visual acuity (BCVA) outcomes were evaluated for all cases with different adjuvant techniques. Results There were 23 males and 27 females with median age 25.5 (6-68) years. Preoperative median foveal thickness was 694.5 (331-1384) mu m and improved to 252.5 (153-1405) mu m. Median BCVA improved from 20/200 (20/20000 to 20/40) to 20/40 (20/2000 to 20/20) with 20/40 or better in 31 eyes. Complete retinal reattachment was achieved in 44 eyes (86.3%) at 7.1 (5.9) months. The good surgical outcomes were achieved in different adjuvant groups. Median follow-up was 24 (6 to 120) months. Conclusions These results confirm the long-term effectiveness of PPV for ODP-M. Prospective studies are needed to determine the effectiveness of any adjuvant technique in improving the success of PPV for ODP-M.

Published
2017

16. Ultra widefield imaging of the retina [Imagen de retina de campo ultra-amplio]

Author

García-Aguirre G., Henaine-Berra A., Fromow-Guerra J., Martínez-Castellanos M.A., Salcedo-Villanueva G., and Morales-Cantón V.

Subjects
retina, genetic structures, age related macular degeneration, eye fundus, ultra widefield imaging, retina image, eye diseases, Article, retina examination, diabetic retinopathy, retina disease, uveitis, retina blood vessel occlusion, sense organs, human
Abstract

Purpose To review the evolution and usefulness of ultra widefield images of the retina. Method Literature review. Results The ability to obtain images of the ocular fundus is one of the greatest breakthroughs in our specialty. This ability has refined over time, from obtaining images with a field of 30 degrees, to obtaining images that exceed 150 degrees using equipment such as the Optos Daytona (Optos, Dunfermline, United Kingdom) or the Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany). These images are extremely useful to evaluate diseases such as diabetic retinopathy, retinal vascular occlusions, pediatric retinal pathology, posterior uveitis, and even diseases which classically affect the macula such as age-related macular degeneration. Conclusion Ultra widefield images of the retina have revolutionized the way we study and understand retinal pathology. As technology for obtaining these images becomes more accessible, it will surely become part of the routine evaluation of retinal diseases. © 2016 Sociedad Mexicana de Oftalmología

Published
2017

17. Late development of a lamellar macular hole after the spontaneous separation of vitreoretinal traction: Case report

Author

Marcela Valencia, Alvaro Rodriguez, Francisco Rodríguez, and Claudia Castaño

Subjects
0301 basic medicine, Male, Retinal perforations, optical coherence, genetic structures, medicine.medical_treatment, Visual Acuity, Tissue Adhesions, Vitrectomy, Lens implant, Vitreomacular traction, Vitreous Detachment, Procedures, Retina macula hole, Vitreous body detachment, chemistry.chemical_compound, 0302 clinical medicine, Observational study, Best corrected visual acuity, Pathology, Macular hole, Tomography, Priority journal, Follow-up, Epiretinal Membrane, General Medicine, Retinal diseases, Retrospective study, medicine.anatomical_structure, Diagnostic imaging, Retina fovea, medicine.symptom, Epiretinal membrane, Tissue adhesion, Tomography, Optical Coherence, Human, Pars plana, medicine.medical_specialty, Visual acuity, Follow-up studies, Article, Cataract, Separation, 03 medical and health sciences, Retinal Diseases, Ophthalmology, Case report, medicine, Humans, Metamorphopsia, Macular edema, Vitreous body, Vitreous detachment, Retrospective Studies, Aged, Phacoemulsification, Optical coherence tomography, business.industry, Spontaneous, Ocriplasmin, Follow up, Retinal Perforations, medicine.disease, eye diseases, Surgery, Vitreous Body, Retrospective studies, 030104 developmental biology, chemistry, 030221 ophthalmology & optometry, sense organs, business, Retina disease, Vitreoretinopathy, Complication, Follow-Up Studies, Tissue adhesions
Abstract

Purpose To report a case of epiretinal macular membrane and a lamellar macular hole developing after the spontaneous separation of an idiopathic vitreoretinal traction. Methods Retrospective, observational, long follow-up of a case evaluated and documented with optical coherence tomography and managed with current therapies including pars plana vitrectomy. Results Good anatomic and functional results with stable 20/30 best-corrected visual acuity. Conclusions The natural course of idiopathic vitreomacular traction has been documented during prolonged observation after its spontaneous separation from the fovea leading to the development of an epiretinal membrane and a lamellar macular hole.

Published
2016

18. Advances in Drug Design Based on the Amino Acid Approach: Taurine Analogues for the Treatment of CNS Diseases

Author

Ednir de Oliveira Vizioli, Man Chin Chung, Jean Leandro dos Santos, Priscila Longhin Bosquesi, Paulo Renato Yamasaki, Pedro Malatesta, and Universidade Estadual Paulista (Unesp)

Subjects
aniline 2 sulfinic acid, Taurine, CLogP, anticonvulsive agent, lcsh:Medicine, lcsh:RS1-441, Pharmaceutical Science, blood brain barrier, Review, Pharmacology, digestive system cancer, low drug dose, chemistry.chemical_compound, acamprosate, central nervous system tumor, dose response, Drug Discovery, lipophilicity, analogs, Glycine receptor, homotaurine, 4 aminobutyric acid A receptor, glutaurine, bipolar disorder, brain edema, chemistry.chemical_classification, alcoholism, alcohol, aminocyclohexaenesulfonic acid, drug receptor binding, n methyl thiomorpholine 1,1 dioxide, piperidine 3 sulfinic acid, thiomorpholine 1,1 dioxide, hyperthermia, Glutaurine, Amino acid, unclassified drug, Parkinson disease, tau 15, Biochemistry, Homotaurine, neuromodulation, Molecular Medicine, neuroprotection, anticonvulsant activity, ethanolamine sulfate, Alzheimer disease, CNS, hypothermia, taurine, excitotoxicity, drug potency, amino acid, amino acid substitution, 2 phthalimidoethanesulfonamide derivative, dimethyltaurine, drug design, seizure, central nervous system disease, review, taurine derivative, taurocholic acid, Neuroprotection, lcsh:Pharmacy and materia medica, toxicity testing, retina disease, spinal cord compression, 2 aminoethylphosphonic acid, human, trimethyltaurine, cysteic acid, Taurine transport, structure activity relation, nonhuman, lcsh:R, Taurocholic acid, brain ischemia, valproyltaurinamide derivative, drug efficacy, tauropyrone, drug structure, chemistry, taurolidine, drug synthesis, glycine receptor, n pivaloyltaurine, statistical parameters, taurepar, 2 aminoethylmethylsulfone, Analogs
Abstract

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:27:06Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:42:27Z : No. of bitstreams: 1 2-s2.0-84869206693.pdf: 345052 bytes, checksum: af1f663f5bb60b9d0121f6ed18b7e210 (MD5) Made available in DSpace on 2014-05-27T11:27:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-10-23 Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the amino acid taurine (2-aminoethanesulfonic acid) this is not true. Due its special physicochemical properties, taurine is unable to cross the blood-brain barrier. In addition of injured taurine transport systems under pathological conditions, CNS supplementation of taurine is almost null. Taurine is a potent antioxidant and anti-inflammatory semi-essential amino acid extensively involved in neurological activities, acting as neurotrophic factor, binding to GABA A/glycine receptors and blocking the excitotoxicity glutamate-induced pathway leading to be a neuroprotective effect and neuromodulation. Taurine deficits have been implicated in several CNS diseases, such as Alzheimer's, Parkinson's, epilepsy and in the damage of retinal neurons. This review describes the CNS physiological functions of taurine and the development of new derivatives based on its structure useful in CNS disease treatment.&; 2012 by the authors; licensee MDPI, Basel, Switzerland. Lapdesf-Laboratory of Drug Design School of Pharmaceutical Sciences University of São Paulo State (UNESP), Rodovia Araraquara-Jaú Km1, CEP 14.801-902, Araraquara, SP Lapdesf-Laboratory of Drug Design School of Pharmaceutical Sciences University of São Paulo State (UNESP), Rodovia Araraquara-Jaú Km1, CEP 14.801-902, Araraquara, SP

Published
2012
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19. Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes.

Author

Srikanth V.K., Lukoshkova E.V., Veloudi P., Blizzard L., McCartney P., Sharman J.E., Head G.A., Hughes A.D., Srikanth V.K., Lukoshkova E.V., Veloudi P., Blizzard L., McCartney P., Sharman J.E., Head G.A., and Hughes A.D.

Abstract

Blood pressure variability is associated with macrovascular complications and stroke, but its association with the microcirculation in type II diabetes has not been assessed. This study aimed to determine the relationship between blood pressure variability indices and retinal arteriolar diameter in non-diabetic and type II diabetes participants. Digitized retinal images were analysed to quantify arteriolar diameters in 35 non-diabetic (aged 52 +/- 11 years; 49% male) and 28 type II diabetes (aged 61 +/- 9 years; 50% male) participants. Blood pressure variability was derived from 24-h ambulatory blood pressure. Arteriolar diameter was positively associated with daytime rate of systolic blood pressure variation (p = 0.04) among type II diabetes participants and negatively among non-diabetics (p = 0.008; interaction p = 0.001). This finding was maintained after adjusting for age, sex, body mass index and mean daytime systolic blood pressure. These findings suggest that the blood pressure variability-related mechanisms underlying retinal vascular disease may differ between people with and without type II diabetes.Copyright © SAGE Publications.

Published
2016

20. Interplay between reactive oxygen species and autophagy in the course of age-related macular degeneration.

Author

Nita M and Grzybowski A

Abstract

Pathological biomolecules such as lipofuscin, methylglyoxal-modified proteins (the major precursors of advanced glycationend products), misfolding protein deposits and dysfunctional mitochondria are source of oxidative stress and act as strong autophagic stimulators in age-related macular degeneration. Disturbed autophagy accelerates progression of the disease, since it leads to retinal cells' death and activates inflammation by the interplay with the NLRP3 inflammasome complex. Vascular dysfunction and hypoxia, as well as circulating autoantibodies against autophagy regulators (anti-S100A9, anti-ANXA5, and anti-HSPA8, A9 and B4) compromise an autophagy-mediated mechanism as well. Metformin, the autophagic stimulator, may act as a senostatic drug to inhibit the senescent phenotype in the age-related macular degeneration. PGC-1α , Sirt1 and AMPK represent new therapeutic targets for interventions in this disease., (Copyright © 2020 Nita et al.)

Published
2020
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21. LONG-TERM EFFECT OF INTRAVITREAL TRIAMCINOLONE IN THE NONPROLIFERATIVE STAGE OF TYPE II IDIOPATHIC PARAFOVEAL TELANGIECTASIA

Author

María Hsu, J. Fernando Arevalo, Teodoro Evans, Maria H. Berrocal, Juan G. Sanchez, Lihteh Wu, and Francisco Rodríguez

Subjects
Male, Injection, Fluorescein angiography, Fovea Centralis, Intraocular pressure, Triamcinolone acetonide, Visual acuity, genetic structures, medicine.medical_treatment, Juxtafoveolar telangiectasis, Visual Acuity, Lens implant, Type 2 idiopathic parafoveal telangiectasia, Intraocular lens, Triamcinolone, Triamcinolone Acetonide, Retinal vessels, Glucocorticoid, Fovea centralis, Pathology, Treatment outcome, Fluorescein Angiography, Middle aged, Perifoveal telangiectasia, Macular telangiectasia, Retina blood vessel, General Medicine, Middle Aged, Acetonide, Multicenter study, Retinal diseases, Clinical trial, Retrospective study, Treatment Outcome, Parafoveal telangiectasis, Cataract extraction, Telangiectasia, Female, Retina fovea, medicine.symptom, Human, medicine.drug, Adult, medicine.medical_specialty, Clinical article, Article, Cataract, Injections, Retinal Diseases, Fluorescence angiography, Ophthalmology, medicine, Humans, Telangiectasis, Disease severity, Glucocorticoids, Macular edema, Vitreous body, Aged, Retrospective Studies, Phacoemulsification, business.industry, Retinal Vessels, Follow up, medicine.disease, eye diseases, Drug effect, Retrospective studies, Vitreous Body, sense organs, Retina disease, business, Controlled study
Abstract

PURPOSE: To report the visual outcomes and ocular complications of intravitreal triamcinolone acetonide (IVTA) in the treatment of the nonproliferative stage of type II idiopathic parafoveal telangiectasia (IPT). METHODS: Retrospective, multicenter, uncontrolled interventional case series of 19 eyes of 14 consecutive patients with the nonproliferative stage of IPT that had undergone at least one intravitreal injection of 4 mg of triamcinolone acetonide. Demographic, medical, and ocular data were obtained through chart review. The main outcome measures included best-corrected visual acuity at several timepoints of follow up and ocular complications. RESULTS: At baseline the mean logMAR visual acuity was 0.83 ± 0.41 (Snellen 20/135, range 0.3-2). After an average follow-up of 21.2 months (range 6-44 months), the mean logMAR visual acuity remained essentially unchanged from baseline. At 3 months, the logMAR visual acuity was 0.86 ± 0.44 (Snellen 20/145, P = 0.8378), at 6 months 0.86 ± 0.42 (Snellen 20/145, P = 0.8149), at 12 months 0.87 ± 0.46 (Snellen 20/148, P > 0.9999), at 18 months 0.84 ± 0.35 (Snellen 20/138, P = 0.8385), and at the last follow-up 0.82 ± 0.44 (Snellen 20/132, P = 0.9301). Seven eyes were reinjected once. Ten of 19 eyes (53%) developed cataract (3 eyes underwent phacoemulsification and intraocular lens implantation) and 7 of 19 eyes (37%) had an elevated intraocular pressure, none of which required surgical treatment. CONCLUSION: IVTA does not seem to improve visual acuity in most eyes with the nonproliferative stage of IPT. © The Ophthalmic Communications Society, Inc.

Published
2008
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22. Effectiveness and safety of dexamethasone implants for post-surgical macular oedema including Irvine-Gass syndrome: The EPISODIC study

Author

Bellocq, David, Korobelnik, Jean-François, Burillon, Carole, Voirin, Nicolas, Dot, Corinne, Souied, Eric, Conrath, John, Milazzo, Solange, Massin, Pascale, Baillif, Stéphanie, Kodjikian, Laurent, Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Hôpital de la Timone [CHU - APHM] (TIMONE), Université Paris Diderot - Paris 7 (UPD7), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Bordeaux [Bordeaux], Hop Instruct Armees Desgenettes, Partenaires INRAE, Centre Hospitalier Intercommunal de Créteil (CHIC), CHU Amiens-Picardie, and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
Male, drug safety, genetic structures, absence of side effects, Irvine Gass syndrome, retrospective study, very elderly, Visual Acuity, eye disease, drug implant, Dexamethasone, [SPI.MAT]Engineering Sciences [physics]/Materials, Postoperative Complications, Vitrectomy, nonsteroid antiinflammatory agent, 80 and over, postoperative complication, pathophysiology, Aged, 80 and over, Drug Implants, clinical article, adult, clinical trial, Epiretinal Membrane, Middle Aged, Sensory Systems, 3. Good health, Treatment Outcome, priority journal, epiretinal membrane peeling, Intravitreal Injections, central macular thickness, Female, France, cataract extraction, triamcinolone, post surgical macular edema, Article, Macular Edema, Retina, Cellular and Molecular Neuroscience, retina disease, follow up, Humans, human, outcome assessment, Glucocorticoids, Intraocular Pressure, Aged, Retrospective Studies, Phacoemulsification, vasculotropin inhibitor, Retinal Detachment, antiglaucoma agent, intravitreal drug administration, eye diseases, drug efficacy, Vitreous Body, Ophthalmology, acetazolamide, multicenter study, physiology, glucocorticoid, observational study, pathology
Abstract

cited By 17; International audience; Aim To assess the effectiveness and safety of intravitreal dexamethasone implants for treating post-surgical macular oedema, including Irvine-Gass syndrome refractory to first-line treatments. Methods Descriptive, observational, retrospective, consecutive, uncontrolled, multicentre, national case series. 50 patients were included in the study between March 2011 and June 2013 with a minimum 6 months follow-up. At baseline, each patient received a dexamethasone implant 0.7 mg (Ozurdex). Best-corrected visual acuity (BCVA), central subfield macular thickness (CSMT), and intraocular pressure (IOP) were measured at baseline and then monthly. The main outcome measure was the mean change in BCVA (in ETDRS letters (Early Treatment Diabetic Retinopathy Study): L) Results Baseline mean±SD BCVA was 55.7±15.4 L. At month 2, BCVA was 71.8±10.5 L and 61.2% of patients had an increase of more than 15 letters. Baseline mean CSMT was 544±117.2 μm and this decreased to 302 μm at month 2. Anatomic and functional recurrences were both first detected from month 3 and continued throughout follow-up, with values consistently above baseline. The peak in IOP was reached in month 1 with mean IOP of 15.3±4.6 mm Hg. Of the 39/50 patients followed up for 12 months, 49% received a second injection. The anatomic and functional response and safety patterns were similar to that obtained with the first intravitreal injection, demonstrating Ozurdex's reproducibility. However, more than half of the patients followed-up for at least 1 year presented neither functional nor anatomical recurrence. Conclusions Ozurdex would appear to be an interesting alternative therapy for treating post-surgical macular oedema, including Irvine-Gass syndrome refractory to first-line treatments.

Published
2015
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23. Spectral domain optical coherence tomography findings of patients under treatment for pediatric acute lymphoblastic leukemia

Author

Basak Can, Oner Gelisken, Adalet Meral Güneş, Meral Yildiz, Ozgur Yalcinbayir, Melike Sezgin Evim, Birol Baytan, Uludağ Üniversitesi/Tıp Fakültesi/Oftalmoloji Bölümü., Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematoloji Anabilim Dalı., Yalçınbayır, Özgür, Baytan, Birol, Can, Başak, Evim, Melike Sezgin, Yıldız, Meral, Güneş, Adalet Meral, AAH-6625-2021, and AAH-1885-2021

Subjects
Male, Methotrexate, Cytarabine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Turkey, genetic structures, Cross-sectional study, Tomography, optical coherence, Posterior pole, Nerve fiber layer, Optic disk, Acute lymphoblastic leukemia, Retinal ganglion cells, Leukemia relapse, Treatment response, Procedures, Pediatrics, Eye examination, Phenylephrine, Tropicamide, 0302 clinical medicine, Maintenance therapy, Pathology, Child, Children, Pre B iymphocyte, Priority journal, Retina ganglion cell, Subclinical infection, Incidence, Refraction error, Combined modality therapy, Retina macula lutea, Nerve fiber, Retinal diseases, Retrospective study, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cross-sectional studies, Female, Retina fovea, Macula lutea, Human, Adult, medicine.medical_specialty, Adolescent, Child, preschool, Clinical article, Precursor cell lymphoblastic leukemia-lymphoma, Nerve fibers, Optical coherence tomography device, Retinal nerve fiber layer thickness, Article, Spectral domain optical coherence tomography, 03 medical and health sciences, Ophthalmology, medicine, Ophthalmic manifestations, Humans, Bone marrow, Clinical evaluation, Mortality, Multimodality cancer therapy, High risk population, Pilot study, Central macular thickness, Optical coherence tomography, Choroid, business.industry, Retrospective cohort study, Leukemia remission, eye diseases, Surgery, Retrospective studies, Choroidal thickness, Preschool child, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Involvement, sense organs, Retina disease, business, Controlled study, Complication
Abstract

PURPOSE To investigate the use of spectral domain optical coherence tomography (SD-OCT) findings in pediatric acute lymphoblastic leukemia (ALL) patients. METHODS Children that were diagnosed with precursor B-cell ALL and classified as belonging to the medium-risk group for relapse were selected for this study. Individuals who were in. continuous remission and on maintenance therapy were included in the study group. Cases that had central nervous system involvement were excluded. Age-matched, otherwise healthy children were selected for the control group. Each study participant underwent a comprehensive eye examination and SD-OCT evaluation. Thickness measurements were made within the retinal nerve fiber layer (RNFL), central macula, posterior polar, and peripapillary choroid. RESULTS A total of 112 eyes of 56 children were included: 54 eyes in the study group and 58 in the control group. Compared to the control group, subfoveal and temporal choroidal thicknesses of the posterior pole were significantly thinner in the study group (P < 0.005). Similarly, peripapillary choroidal thicknesses were significantly thinner in most sectors of the study group (P < 0.005). There were no major differences between groups in terms of central macular thicknesses and overall RNFL thicknesses. CONCLUSIONS Evidence of choroidal attenuation was found in this subgroup of pediatric ALL patients. Further studies are warranted to clarify the utility of SD-OCT in detecting subclinical ocular involvement and monitoring treatment response and risk of relapse in patients with pediatric leukemia.

Published
2017
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24. Retinal abnormalities in membranoproliferative glomerulonephritis type ii ('dense deposit disease'): A high risk of visual loss, clue to the diagnosis and pathogenesis and monitoring.

Author

Savige J., Mack H.G., Symons A., Amos L., Colville D., Savige J., Mack H.G., Symons A., Amos L., and Colville D.

Abstract

Purpose: Dense deposit disease (DDD) is an inherited disease characterised by progressive renal failure, dense deposits in the GBM, partial lipodystrophy, and retinal drusen. Some patients have homozygous or compound heterozygous mutations in the Complement Factor H (CFH) gene, as well as C3NeF and low C3 levels. Other genes are not known. We describe here clinical features in 6 patients from a single centre with DDD who were examined by an ophthalmologist and underwent retinal imaging. Method(s): The patients were 3 males and 3 females, with a median age of 49 years (range 38 to 79), from 5 families. (One male and one female were brother and sister.) The average age at renal diagnosis was 26 years (range14 - 45). All individuals had hypertension. Four patients had renal transplants, and two still had normal renal function. At least 4 had lipodystrophy. Two patients underwent extensive investigations including ERG and EOG and one had a fluorescein angiogram. Five had OCT. Result(s): All 6 patients had bilateral retinal drusen. These were small and punctate in one individual and mainly large and soft in the other 5. They were bilateral and extended from the macula to the periphery. They were brighter on autofluorescence and fluorescein angiography. All but one of the patients had some impaired night vision on close questioning, and some had retinal atrophy on funduscopy, retinal images or OCT. Retinal imaging and OCT demonstrated local areas of retinal atrophy in all patients. One patient (the 79 year old) (Sylvestri et al 2009 Grade 6) had severe vision loss with extensive geographic atrophy and retinal haemorrhage, a subretinal neovascular membrane, and subretinal serous exudation. One milder patient had previously undiagnosed keratoconus. Conclusion(s): Dense deposit disease affects the retina in all patients, and patients are symptomatic with loss of night vision from early on. They all have drusen and with time retinal atrophy develops together with further reti

Published
2013

25. Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease

Author

Frost, Shawn, Kanagasingam, Yogi, Sohrabi, Hamid, Vignarajan, J, Bourgeat, P, Salvado, Olivier, Villemagne, Victor, Rowe, Christopher, Macaulay, S Lance, Szoeke, Cassandra, Ellis, Kathryn A, Ames, David, Masters, Colin L, Rainey-Smith, Stephanie, Martins, Ralph N, Frost, Shawn, Kanagasingam, Yogi, Sohrabi, Hamid, Vignarajan, J, Bourgeat, P, Salvado, Olivier, Villemagne, Victor, Rowe, Christopher, Macaulay, S Lance, Szoeke, Cassandra, Ellis, Kathryn A, Ames, David, Masters, Colin L, Rainey-Smith, Stephanie, and Martins, Ralph N

Abstract

The earliest detectable change in Alzheimer's disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P=0.01 and P=0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments.

Published
2013

26. Age-related macular disease in rural southern Italy

Author

C. Carresi, S. Pagliarini, Bertrand Piguet, Alan C. Bird, Richard Wormald, Antonietta Moramarco, C. Balacco-Gabrieli, and Kulwant S. Sehmi

Subjects
Male, Rural Population, medicine.medical_specialty, Fundus Oculi, Eye disease, Population, age-related maculopathy (arm), retina disease, risk assessment, rural population, Pilot Projects, Retinal Drusen, Fundus (eye), Drusen, Macular Degeneration, Epidemiology, medicine, Photography, Prevalence, Humans, education, Aged, Aged, 80 and over, education.field_of_study, business.industry, Macular degeneration, Middle Aged, medicine.disease, eye diseases, Diet, Ophthalmology, Cross-Sectional Studies, Italy, Maculopathy, Optometry, Female, Rural area, business, Demography
Abstract

Objective: To report the prevalence of age-related maculopathy (ARM) in Salandra, a small, isolated southern Italian community, to test the hypothesis that an environmental factor, scarce in such a remote community but ubiquitous in modern industrial societies, might modify the risk of developing ARM. Design: Population-based cross-sectional survey. Main Outcome Measures: Prevalence of advanced age-related macular degeneration (ARMD) (geographic atrophy or exudative maculopathy) and ARM (large, soft drusen or retinal pigment epithelium changes, or both) defined by fundus biomicroscopy and 30° stereoscopic macular photography. Self-sustenance was assessed by interview of participants and local shop retailers. The degree of genetic isolation was computed using a model that fits the genetic population structure with the frequency distribution of surnames in the community. Results: A full ophthalmic examination was undertaken in 366 (63.5%) of 576 eligible participants, 354 (96.7%) of whom had clinical or photographic assessment for the presence of ARMD and 310(84.6%) of whom had drusen characteristics graded on color transparencies for ARM. The overall prevalence of ARMD was 1.1%. Drusen larger than 50 μm and more numerous than 10 were found in 4.5% of subjects. Salandra was the birthplace of 87.2% of participants and for 77.3% of both parents of each subject. People in the community tended to consume homegrown products. Conclusion: The prevalence of ARM may be lower in this self-sustained farming community than elsewhere in the industrialized world.

Published
1997

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