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Porous polycaprolactone (PCL) bone scaffolds were prepared by selective laser sintering and chitosan/hydroxyapatite(CS/HA) suspension was prepared by in situ synthesis. The CS/HA was attached to the surface of the PCL scaffold by vacuum immersion, low speed centrifugation and freezing gel, to improve the biocompatibility and cell proliferation activity of the PCL scaffolds. The phase and porous structure of the composite scaffolds were observed by X ray diffraction (XRD) and scanning electron microscopy (SEM). The compressive strength and Young's modulus of the scaffolds were measured, the water contact angles on the surface of the scaffolds were measured and the biological properties of the composite scaffolds were studied by in vitro cell experiments. The experimental results show that hydroxyapatite (HA) is prepared by in situ synthesis, and CS/HA gel adhered well to the surface of PCL bone scaffold. The hydrophilicity of the surface of the PCL scaffold is improved by CS/HA, and the biocompatibility and cell proliferation activity of them are greatly enhanced.

PLA(a biodegradable material) and HA(the main inorganic component) were used as research objects. In order to obtain the optimal parameters of SLS parts of composite materials, the SLS process of pure PLA was optimized firstly. It is found that the tensile strength of pure PLA prepared by SLS are over 23 MPa when the laser energy density range is as 0.040~0.075 J/mm2, and the highest strength is as 27.28 MPa. The PLA/HA composites with different HA contents were processed with laser energy density of 0.040 J/mm2, laser power of 12 W and scanning speed of 1 500 mm/s, to study the influences of HA contents on the microstructure and mechanics properties of PLA/HA composites. The experimental results show that the composite with 10% mass fraction HA has the best mechanics properties and micromorphology. The water contact angle tests also exhibit that the contact angles of the materials decrease from 69.52° to 57.96°, which indicate that the hydrophilicity of the materials is improved. [ABSTRACT FROM AUTHOR]

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