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Dąbrowska Justyna, Wójcik Magdalena, Szarpak Julita, Bator Damian, Milanowska Joanna, Nieścior Hubert. Theories of the pathogenesis of schizophrenia. Journal of Education, Health and Sport. 2020;10(8):332‑339. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.039 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.039 https://zenodo.org/record/3996262 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2020. Revised: 05.08.2020. Accepted: 22.08.2020. Theories of the pathogenesis of schizophrenia Justyna Dąbrowska1*, Magdalena Wójcik1, Julita Szarpak1, Damian Bator1, JoannaMilanowska2, Hubert Nieścior1 (1) Student Science Club at the Department of Applied Psychology, Medical University of Lublin (2) Department of Applied Psychology, Medical University of Lublin * E-mail address: jdabrowska00@gmail.com ORCID ID: Justyna Dąbrowska https://orcid.org/0000-0002-1356-6965 Magdalena Wójcik https://orcid.org/0000-0002-0999-6284 Julita Szarpak https://orcid.org/0000-0002-5091-0235 Damian Bator https://orcid.org/0000-0002-8464-932X Joanna Milanowska https://orcid.org/0000-0001-9741-1583 Hubert Nieścior, https://orcid.org/0000-0002-4709-4396 Abstract Introduction: Schizophrenia is one of the most serious and frightening of all mental illnesses. It affects almost 1% of the population worldwide. The main concept and treatment of schizophrenia are based on the dopaminergic hypothesis. However, accumulating evidence has shown that the core pathophysiology of schizophrenia might involve dysfunction in dopaminergic, glutamatergic, serotonergic, and gamma-aminobutyric acid signaling. The aim of the study: The purpose of this systemic review was to collect and analyse current and new information on the pathogenesis of schizophrenia. Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed database was carried out using the following keywords: schizophrenia, dopamine hypothesis, serotoninergic hypothesis, hypothesis of schizophrenia . Description of the state of knowledge: There are evidence that pathogenesis of schizophrenia include dysfunction in dopaminergic, serotoninergic, GABAergic, glutamatergic systems. The use of drugs that act on any of these systems reduces the symptoms of the disease. Nicotinic receptors may also be the target for drugs in treatment of schizophrenia. Studies about the role of nicotinic receptors in pathogenesis of schizophrenia show that it normalize many of the sensory processing deficits found in schizophrenia. Summary: Despite the fact that current concept and treatment are still based on the dopaminergic hypothesis of the disease, existing theories and each new theory, open up different ways for treating schizophrenia. Considering that schizophrenia is one of the most serious and frightening of all mental illnesses and has major public health implications, more research about pathogenesis and ways of treatment is needed. Key words: schizophrenia, dopamine hypothesis, serotoninergic hypothesis, hypothesis of schizophrenia