22 results on '"the EMAS study group"'
Search Results
2. Genetic determinants of serum testosterone concentrations in men.
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Ohlsson, Claes, Wallaschofski, Henri, Lunetta, Kathryn L, Stolk, Lisette, Perry, John RB, Koster, Annemarie, Petersen, Ann-Kristin, Eriksson, Joel, Lehtimäki, Terho, Huhtaniemi, Ilpo T, Hammond, Geoffrey L, Maggio, Marcello, Coviello, Andrea D, EMAS Study Group, Ferrucci, Luigi, Heier, Margit, Hofman, Albert, Holliday, Kate L, Jansson, John-Olov, Kähönen, Mika, Karasik, David, Karlsson, Magnus K, Kiel, Douglas P, Liu, Yongmei, Ljunggren, Osten, Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Meitinger, Thomas, Mellström, Dan, Melzer, David, Miljkovic, Iva, Nauck, Matthias, Nilsson, Maria, Penninx, Brenda, Pye, Stephen R, Vasan, Ramachandran S, Reincke, Martin, Rivadeneira, Fernando, Tajar, Abdelouahid, Teumer, Alexander, Uitterlinden, André G, Ulloor, Jagadish, Viikari, Jorma, Völker, Uwe, Völzke, Henry, Wichmann, H Erich, Wu, Tsung-Sheng, Zhuang, Wei Vivian, Ziv, Elad, Wu, Frederick CW, Raitakari, Olli, Eriksson, Anna, Bidlingmaier, Martin, Harris, Tamara B, Murray, Anna, de Jong, Frank H, Murabito, Joanne M, Bhasin, Shalender, Vandenput, Liesbeth, and Haring, Robin
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EMAS Study Group ,Chromosomes ,Human ,X ,Humans ,Testosterone ,Sex Hormone-Binding Globulin ,Nuclear Proteins ,Body Mass Index ,Polymorphism ,Single Nucleotide ,Alleles ,Adult ,Aged ,80 and over ,Middle Aged ,Male ,Genome-Wide Association Study ,Aged ,and over ,Chromosomes ,Human ,X ,Polymorphism ,Single Nucleotide ,Genetics ,Developmental Biology - Abstract
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as
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- 2011
3. Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study
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Overman, Margot J., Pendleton, Neil, O’Neill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Rastrelli, Giulia, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Lee, David M., Correa, Elon S., Ahern, Tomas, Verschueren, Sabine M. P., Antonio, Leen, Gielen, Evelien, Rutter, Martin K., Vanderschueren, Dirk, Wu, Frederick C. W., Tournoy, Jos, and The EMAS Study Group
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- 2017
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4. Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS)
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Han, Thang S., Correa, Elon, Lean, Michael E. J., Lee, David M., O’Neill, Terrence W., Bartfai, György, Forti, Gianni, Giwercman, Aleksander, Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Rutter, Martin K., Vanderschueren, Dirk, Huhtaniemi, Ilpo T., Wu, Frederick C. W., Casanueva, Felipe F., and and the EMAS Study Group
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- 2017
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5. Age-Related Changes in General and Sexual Health in Middle-Aged and Older Men: Results from the European Male Ageing Study (EMAS)
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Corona, Giovanni, Lee, David M., Forti, Gianni, O'Connor, Daryl B., Maggi, Mario, O'Neill, Terence W., Pendleton, Neil, Bartfai, Gyorgy, Boonen, Steven, Casanueva, Felipe F., Finn, Joseph D., Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E.J., Punab, Margus, Silman, Alan J., Vanderschueren, Dirk, Wu, Frederick C.W., and the EMAS Study Group
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- 2010
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6. Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men
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Roshandel, Delnaz, Holliday, Kate L., Pye, Stephen R., Ward, Kate A., Boonen, Steven, Vanderschueren, Dirk, Borghs, Herman, Huhtaniemi, Ilpo T., Adams, Judith E., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C., Thomson, Wendy, O’Neill, Terence W., and The EMAS Study Group
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- 2011
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7. Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study
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Pye, Stephen R., Almusalam, Bader, Boonen, Steven, Vanderschueren, Dirk, Borghs, Herman, Gielen, Evelien, Adams, Judith E., Ward, Kate A., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Labrie, Fernand, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C. W., O’Neill, Terence W., and The EMAS Study Group
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- 2011
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8. Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European men
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Ward, K. A., Pye, S. R., Adams, J. E., Boonen, S., Vanderschueren, D., Borghs, H., Gaytant, J., Gielen, E., Bartfai, G., Casanueva, F. F., Finn, J. D., Forti, G., Giwercman, A., Han, T. S., Huhtaniemi, I. T., Kula, K., Labrie, F., Lean, M. E. J., Pendleton, N., Punab, M., Silman, A. J., Wu, F. C. W., O’Neill, T. W., and The EMAS study group
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- 2011
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9. Gonadal sex steroid status and bone health in middle-aged and elderly European men
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Vanderschueren, D., Pye, S. R., Venken, K., Borghs, H., Gaytant, J., Huhtaniemi, I. T., Adams, J. E., Ward, K. A., Bartfai, G., Casanueva, F. F., Finn, J. D., Forti, G., Giwercman, A., Han, T. S., Kula, K., Labrie, F., Lean, M. E. J., Pendleton, N., Punab, M., Silman, A. J., Wu, F. C. W., O’Neill, T. W., Boonen, S., and The EMAS Study Group
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- 2010
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10. Influence of Lifestyle Factors on Quantitative Heel Ultrasound Measurements in Middle-Aged and Elderly Men
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Pye, Stephen R., Devakumar, Vinodh, Boonen, Steven, Borghs, Herman, Vanderschueren, Dirk, Adams, Judith E., Ward, Kate A., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C. W., O’Neill, Terence W., and EMAS Study Group
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- 2010
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11. Genetic determinants of serum testosterone concentrations in men.
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Claes Ohlsson, Henri Wallaschofski, Kathryn L Lunetta, Lisette Stolk, John R B Perry, Annemarie Koster, Ann-Kristin Petersen, Joel Eriksson, Terho Lehtimäki, Ilpo T Huhtaniemi, Geoffrey L Hammond, Marcello Maggio, Andrea D Coviello, EMAS Study Group, Luigi Ferrucci, Margit Heier, Albert Hofman, Kate L Holliday, John-Olov Jansson, Mika Kähönen, David Karasik, Magnus K Karlsson, Douglas P Kiel, Yongmei Liu, Osten Ljunggren, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Thomas Meitinger, Dan Mellström, David Melzer, Iva Miljkovic, Matthias Nauck, Maria Nilsson, Brenda Penninx, Stephen R Pye, Ramachandran S Vasan, Martin Reincke, Fernando Rivadeneira, Abdelouahid Tajar, Alexander Teumer, André G Uitterlinden, Jagadish Ulloor, Jorma Viikari, Uwe Völker, Henry Völzke, H Erich Wichmann, Tsung-Sheng Wu, Wei Vivian Zhuang, Elad Ziv, Frederick C W Wu, Olli Raitakari, Anna Eriksson, Martin Bidlingmaier, Tamara B Harris, Anna Murray, Frank H de Jong, Joanne M Murabito, Shalender Bhasin, Liesbeth Vandenput, and Robin Haring
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Genetics ,QH426-470 - Abstract
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as
- Published
- 2011
- Full Text
- View/download PDF
12. Polymorphisms in genes involved in the NF-κB signalling pathway are associated with bone mineral density, geometry and turnover in men.
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Delnaz Roshandel, Wendy Thomson, Stephen R Pye, Steven Boonen, Herman Borghs, Dirk Vanderschueren, Ilpo T Huhtaniemi, Judith E Adams, Kate A Ward, Gyorgy Bartfai, Felipe F Casanueva, Joseph D Finn, Gianni Forti, Aleksander Giwercman, Thang S Han, Krzysztof Kula, Michael E Lean, Neil Pendleton, Margus Punab, Frederick C Wu, Kate L Holliday, Terence W O'Neill, and EMAS Study Group
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Medicine ,Science - Abstract
INTRODUCTION:In this study, we aimed to investigate the association between single nucleotide polymorphisms (SNPs) within two genes involved in the NF-κB cascade (GPR177 and MAP3K14) and bone mineral density (BMD) assessed at different skeletal sites, radial geometric parameters and bone turnover. METHODS:Ten GPR177 SNPs previously associated with BMD with genome-wide significance and twelve tag SNPs (r(2)≥0.8) within MAP3K14 (±10 kb) were genotyped in 2359 men aged 40-79 years recruited from 8 centres for participation in the European Male Aging Study (EMAS). Measurement of bone turnover markers (PINP and CTX-I) in the serum and quantitative ultrasound (QUS) at the calcaneus were performed in all centres. Dual energy X-ray absorptiometry (DXA), at the lumbar spine and hip, and peripheral quantitative computed tomography (pQCT), at the distal and midshaft radius, were performed in a subsample (2 centres). Linear regression was used to test for association between the SNPs and bone measures under an additive genetic model adjusting for study centre. RESULTS:We validated the associations between SNPs in GPR177 and BMD(a) previously reported and also observed evidence of pleiotrophic effects on density and geometry. Rs2772300 in GPR177 was associated with increased total hip and LS BMD(a), increased total and cortical vBMD at the radius and increased cortical area, thickness and stress strain index. We also found evidence of association with BMD(a), vBMD, geometric parameters and CTX-I for SNPs in MAP3K14. None of the GPR177 and MAP3K14 SNPs were associated with calcaneal estimated BMD measured by QUS. CONCLUSION:Our findings suggest that SNPs in GPR177 and MAP3K14 involved in the NF-κB signalling pathway influence bone mineral density, geometry and turnover in a population-based cohort of middle aged and elderly men. This adds to the understanding of the role of genetic variation in this pathway in determining bone health.
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- 2011
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13. The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men.
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Kate L Holliday, Stephen R Pye, Wendy Thomson, Steven Boonen, Herman Borghs, Dirk Vanderschueren, Evelien Gielen, Ilpo T Huhtaniemi, Judith E Adams, Kate A Ward, Gyorgy Bartfai, Felipe Casanueva, Joseph D Finn, Gianni Forti, Aleksander Giwercman, Thang S Han, Krzysztof Kula, Fernand Labrie, Michael E J Lean, Neil Pendleton, Margus Punab, Frederick C W Wu, Terence W O'Neill, and EMAS study group
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Medicine ,Science - Abstract
Genome-wide association studies (GWAS) have identified 6q25, which incorporates the oestrogen receptor α gene (ESR1), as a quantitative trait locus for areal bone mineral density (BMD(a)) of the hip and lumbar spine. The aim of this study was to determine the influence of this locus on other bone health outcomes; calcaneal ultrasound (QUS) parameters, radial peripheral quantitative computed tomography (pQCT) parameters and markers of bone turnover in a population sample of European men.Eight single nucleotide polymorphisms (SNP) in the 6q25 locus were genotyped in men aged 40-79 years from 7 European countries, participating in the European Male Ageing Study (EMAS). The associations between SNPs and measured bone parameters were tested under an additive genetic model adjusting for centre using linear regression.2468 men, mean (SD) aged 59.9 (11.1) years had QUS measurements performed and bone turnover marker levels measured. A subset of 628 men had DXA and pQCT measurements. Multiple independent SNPs showed significant associations with BMD using all three measurement techniques. Most notably, rs1999805 was associated with a 0.10 SD (95%CI 0.05, 0.16; p = 0.0001) lower estimated BMD at the calcaneus, a 0.14 SD (95%CI 0.05, 0.24; p = 0.004) lower total hip BMD(a), a 0.12 SD (95%CI 0.02, 0.23; p = 0.026) lower lumbar spine BMD(a) and a 0.18 SD (95%CI 0.06, 0.29; p = 0.003) lower trabecular BMD at the distal radius for each copy of the minor allele. There was no association with serum levels of bone turnover markers and a single SNP which was associated with cortical density was also associated with cortical BMC and thickness.Our data replicate previous associations found between SNPs in the 6q25 locus and BMD(a) at the hip and extend these data to include associations with calcaneal ultrasound parameters and radial volumetric BMD.
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- 2011
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14. Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS)
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Han, TS, Correa, E, Lean, MEJ, Lee, DM, O'Neill, TW, Bartfai, G, Forti, G, Giwercman, A, Kula, K, Pendleton, N, Punab, M, Rutter, MK, Vanderschueren, D, Huhtaniemi, IT, Wu, FCW, Casanueva, FF, and and the EMAS Study Group
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Gerontology ,Adult ,Male ,Aging ,Waist ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Environment ,Body Mass Index ,Fat distribution ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,RA0421 ,medicine ,Prevalence ,Humans ,030212 general & internal medicine ,Obesity ,Prospective Studies ,Prospective cohort study ,Socioeconomic status ,Life Style ,Body mass index ,Adiposity ,Aged ,Odds ratio ,Middle Aged ,medicine.disease ,Circumference ,Diet ,Europe ,Geography ,Cohort ,Waist circumference ,Health promotion ,Original Article ,Demography - Abstract
Diversity in lifestyles and socioeconomic status among European populations, and recent socio-political and economic changes in transitional countries, may affect changes in adiposity. We aimed to determine whether change in the prevalence of obesity varies between the socio-politically transitional North-East European (Łódź, Poland; Szeged, Hungary; Tartu, Estonia), and the non-transitional Mediterranean (Santiago de Compostela, Spain; Florence, Italy) and North-West European (Leuven, Belgium; Malmö, Sweden; Manchester, UK) cities. This prospective observational cohort survey was performed between 2003 and 2005 at baseline and followed up between 2008 and 2010 of 3369 community-dwelling men aged 40-79 years. Main outcome measures in the present paper included waist circumference, body mass index and mid-upper arm muscle area. Baseline prevalence of waist circumference ≥ 102 cm and body mass index ≥ 30 kg/m2, respectively, were 39.0, 29.5 % in North-East European cities, 32.4, 21.9 % in Mediterranean cities, and 30.0, 20.1 % in North-West European cities. After median 4.3 years, men living in cities from transitional countries had mean gains in waist circumference (1.1 cm) and body mass index (0.2 kg/m2), which were greater than men in cities from non-transitional countries (P = 0.005). North-East European cities had greater gains in waist circumference (1.5 cm) than in Mediterranean cities (P
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- 2016
15. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study
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McCabe, Paul S., Pye, Stephen R., Mc Beth, John, Lee, David M., Tajar, Abdelouahid, Bartfai, Gyorgy, Boonen, Steven, Bouillon, Roger, Casanueva Freijo, Felipe, Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Huhtaniemi, Ilpo T., Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C., O’Neill, Terence W., EMAS Study Group, and Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina
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Chronic Widespread pain ,Epidemiology ,Depression ,Chronic pain ,Obesity ,Vitamin D - Abstract
Background The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. Methods Three thousand three hundred sixty nine men aged 40–79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. Results Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5 %) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (
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- 2016
16. Age-Related Changes in General and Sexual Health in Middle-Aged and Older Men: Results from the European Male Ageing Study (EMAS)
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Giovanni Corona, David M. Lee, Gianni Forti, Daryl B. O’Connor, Mario Maggi, Terence W. O’Neill, Neil Pendleton, Gyorgy Bartfai, Steven Boonen, Felipe F. Casanueva, Joseph D. Finn, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Michael E.J. Lean, Margus Punab, Alan J. Silman, Dirk Vanderschueren, Frederick C.W. Wu, and null the EMAS Study Group
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Adult ,Male ,Gerontology ,Cross-sectional study ,Health Status ,Sexual Behavior ,Urology ,Endocrinology, Diabetes and Metabolism ,Comorbidity ,Personal Satisfaction ,Endocrinology ,Erectile Dysfunction ,Quality of life ,Lower urinary tract symptoms ,Humans ,Medicine ,media_common.cataloged_instance ,Obesity ,Sexual Dysfunctions, Psychological ,European union ,Life Style ,Aged ,Reproductive health ,media_common ,Depressive Disorder ,business.industry ,Age Factors ,Middle Aged ,medicine.disease ,Health Surveys ,Europe ,Sexual Dysfunction, Physiological ,Psychiatry and Mental health ,Cross-Sectional Studies ,Sexual dysfunction ,Erectile dysfunction ,Reproductive Medicine ,Cardiovascular Diseases ,Quality of Life ,medicine.symptom ,business ,Sexual function - Abstract
Introduction. Limited information is available concerning the general and sexual health status of European men. Aim. To investigate the age-related changes in general and sexual health in middle-aged and older men from different countries of the European Union. Methods. This is a cross-sectional multicenter survey performed on a sample of 3,369 community-dwelling men aged 40-79 years old (mean 60 +/- 11 years). Subjects were randomly selected from eight European centers including centers from nontransitional (Florence [Italy], Leuven [Belgium], Malmo [Sweden], Manchester [United Kingdom], Santiago de Compostela [Spain]) and transitional countries (Lodz [Poland], Szeged [Hungary], Tartu [Estonia]). Main Outcome Measures. Different parameters were evaluated including the Beck's Depression Inventory for the quantification of depressive symptoms, the Short Form-36 Health Survey for the assessment of the quality of life (QoL), the International Prostate Symptom Score for the evaluation of lower urinary tract symptoms, and the European Male Ageing Study sexual function questionnaire for the study of sexual function. Results. More than 50% of subjects reported the presence of one or more common morbidities. Overall, hypertension (29%), obesity (24%), and heart diseases (16%) were the most prevalent conditions. Around 30% of men reported erectile dysfunction (ED) and 6% reported severe orgasmic impairment, both of which were closely associated with age and concomitant morbidities. Only 38% of men reporting ED were concerned about it. Furthermore, concern about ED increased with age, peaking in the 50-59 years age band, but decreased thereafter. Men in transitional countries reported a higher prevalence of morbidities and impairment of sexual function as well as a lower QoL. Conclusion. Sexual health declined while concomitant morbidities increased in European men as a function of age. The burden of general and sexual health is higher in transitional countries, emphasizing the need to develop more effective strategies to promote healthy aging for men in these countries. Corona G, Lee DM, Forti G, O'Connor DB, Maggi M, O'Neill TW, Pendleton N, Bartfai G, Boonen S, Casanueva FF, Finn JD, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean MEJ, Punab M, Silman AJ, Vanderschueren D, Wu FCW, and EMAS Study Group. Age-related changes in general and sexual health in middle-aged and older men: Results from the European Male Ageing Study (EMAS). J Sex Med 2010;7:1362-1380.
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- 2010
17. Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: Prospective results from the EMAS.
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Rastrelli, Giulia, O'Neill, Terence W., Ahern, Tomas, Bártfai, György, Casanueva, Felipe F., Forti, Gianni, Keevil, Brian, Giwercman, Aleksander, Han, Thang S., Slowikowska‐Hilczer, Jolanta, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Antonio, Leen, Tournoy, Jos, Vanderschueren, Dirk, Maggi, Mario, Huhtaniemi, Ilpo T., Wu, Frederick C. W., and the EMAS study group
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TESTOSTERONE ,HYPOGONADISM ,SEX hormones ,IMPOTENCE ,SYMPTOMS - Abstract
Summary: Objective: Limited evidence supports the use of free testosterone (FT) for diagnosing hypogonadism when sex hormone–binding globulin (SHBG) is altered. Low total testosterone (TT) is commonly encountered in obesity where SHBG is typically decreased. We aimed to assess the contribution of FT in improving the diagnosis of symptomatic secondary hypogonadism (SH), identified initially by low total testosterone (TT), and then further differentiated by normal FT (LNSH) or low FT (LLSH). Design: Prospective observational study with a median follow‐up of 4.3 years. Patients: Three thousand three hundred sixty‐nine community‐dwelling men aged 40‐79 years from eight European centres. Measurements: Subjects were categorized according to baseline and follow‐up biochemical status into persistent eugonadal (referent group; n = 1880), incident LNSH (eugonadism to LNSH; n = 101) and incident LLSH (eugonadism to LLSH; n = 38). Predictors and clinical features associated with the transition from eugonadism to LNSH or LLSH were assessed. Results: The cumulative incidence of LNSH and LLSH over 4.3 years was 4.9% and 1.9%, respectively. Baseline obesity predicted both LNSH and LLSH, but the former occurred more frequently in younger men. LLSH, but not LNSH, was associated with new/worsened sexual symptoms, including low desire [OR = 2.67 (1.27‐5.60)], erectile dysfunction [OR = 4.53 (2.05‐10.01)] and infrequent morning erections [OR = 3.40 (1.48‐7.84)]. Conclusions: These longitudinal data demonstrate the importance of FT in the diagnosis of hypogonadism in obese men with low TT and SHBG. The concurrent fall in TT and FT identifies the minority (27.3%) of men with hypogonadal symptoms, which were not present in the majority developing low TT with normal FT. [ABSTRACT FROM AUTHOR]
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- 2018
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18. Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men
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Ohlsson, Claes, Nilsson, Maria E., Tivesten, Åsa, Ryberg, Henrik, Mellström, Dan, Karlsson, Magnus K., Ljunggren, Östen, Labrie, Fernand, Orwoll, Eric S., Lee, David M., Pye, Stephen R., O'Neill, Terence W., Finn, Joseph D., Adams, Judith E., Ward, Kate A., Boonen, Steven, Bartfai, Gyorgy, Casanueva, Felipe F., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzystof, Lean, Michael E. J., Pendleton, Neil, Punab, Margus, Vanderschueren, Dirk, Wu, Frederick C. W., EMAS Study Group, and Vandenput, Liesbeth
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Male ,medicine.medical_specialty ,Medicin och hälsovetenskap ,Bone density ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Population ,030209 endocrinology & metabolism ,Context (language use) ,Endocrinology and Diabetes ,Biochemistry ,Medical and Health Sciences ,Mass Spectrometry ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Bone Density ,Internal medicine ,medicine ,Humans ,education ,Aged ,Immunoassay ,Bone mineral ,education.field_of_study ,Estradiol ,JCEM Online: Advances in Genetics ,medicine.diagnostic_test ,biology ,Chemistry ,Biochemistry (medical) ,C-reactive protein ,Gold standard (test) ,Middle Aged ,C-Reactive Protein ,030220 oncology & carcinogenesis ,Cohort ,biology.protein - Abstract
Context: Immunoassay-based techniques, routinely used to measure serum estradiol (E2), are known to have reduced specificity, especially at lower concentrations, when compared with the gold standard technique of mass spectrometry (MS). Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men. Objective: Our objective was to compare immunoassay and MS measurements of E2 levels in men and evaluate associations with clinical phenotypes. Design and Setting: Middle-aged and older male subjects participating in the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (n = 2599), MrOS US (n = 688), and the European Male Aging Study (n = 2908) were included. Main Outcome Measures: Immunoassay and MS measurements of serum E2 were compared and related to bone mineral density (BMD; measured by dual energy x-ray absorptiometry) and ankle-brachial index. Results: Within each cohort, serum E2 levels obtained by immunoassay and MS correlated moderately (Spearman rank correlation coefficient rS 0.53–0.76). Serum C-reactive protein (CRP) levels associated significantly (albeit to a low extent, rS = 0.29) with immunoassay E2 but not with MS E2 levels. Similar associations of immunoassay E2 and MS E2 were seen with lumbar spine and total hip BMD, independent of serum CRP. However, immunoassay E2, but not MS E2, associated inversely with ankle-brachial index, and this correlation was lost after adjustment for CRP. Conclusions: Our findings suggest interference in the immunoassay E2 analyses, possibly by CRP or a CRP-associated factor. Although associations with BMD remain unaffected, this might imply for a reevaluation of previous association studies between immunoassay E2 levels and inflammation-related outcomes.
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- 2013
19. Thyroid hormones and male sexual function
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Jannini, Eaf, Corona, G, Wu, F, Forti, G, Lee, D, O'Connor, D, O'Neill, T, Pendleton, N, Bartfai, G, Boonen, S, Casanueva, F, Finn, J, Giwercman, A, Han, T, Huhtaniemi, I, Kula, K, Lean, M, Punab, M, Vanderschueren, D, Jannini, E, Mannucci, E, Maggi, M, and EMAS Study Group
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Settore MED/13 - Endocrinologia - Published
- 2012
20. Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study.
- Author
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EMAS study group, Overman, Margot J., Laurent, Michaël R., Gielen, Evelien, Tournoy, Jos, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E.J., Punab, Margus, Lee, David M., Correa, Elon S., Ahern, Tomas, Wu, Frederick C.W., Verschueren, Sabine M.P., Vanderschueren, Dirk, Antonio, Leen, Pendleton, Neil, Rutter, Martin K., and O'Neill, Terence W
- Abstract
Objective: Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists.Methods: Over a mean of 4.4 years (SD ± 0.3), men aged 40-79 years from the multicenter European Male Ageing Study were recruited. Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay.Results: Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models the presence of baseline MetS was not associated with cognitive decline over time (p > 0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β = -0.42, p < 0.05) and the DSST (β = -0.39, p < 0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline.Conclusion: No evidence was found for a relationship between MetS or inflammation and cognitive decline in this sample of aging men. However, glycemia was negatively associated with visuoconstructional abilities and processing speed. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
21. Interactions Between Depression and Lower Urinary Tract Symptoms: The Role of Adverse Life Events and Inflammatory Mechanisms. Results From the European Male Ageing Study.
- Author
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Castellini, Giovanni, Wu, Frederick C. W., Finn, Joseph D., O'Neill, Terrence W., Lean, Michael E. J., Pendleton, Neil, Rastrelli, Giulia, Rutter, Martin K., Gacci, Mauro, Ricca, Valdo, Maggi, Mario, OʼNeill, Terrence W, and EMAS Study Group
- Published
- 2016
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22. Cohort profile: the European Male Ageing Study.
- Author
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Lee, David M, Pye, Stephen R, Tajar, Abdelouahid, O'Neill, Terence W, Finn, Joseph D, Boonen, Steven, Bartfai, Gyorgy, Casanueva, Felipe F, Forti, Gianni, Giwercman, Aleksander, Han, Thang S, Huhtaniemi, Ilpo T, Kula, Krzysztof, Lean, Michael E J, Pendleton, Neil, Punab, Margus, Silman, Alan J, Vanderschueren, Dirk, Wu, Frederick C W, and EMAS study group
- Published
- 2013
- Full Text
- View/download PDF
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