1. Prenatal and childhood exposure to ambient air pollution and cognitive function in school-age children: Examining sensitive windows and sex-specific associations
- Author
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Guilbert, Ariane, Bernard, Jonathan Y., Peyre, Hugo, Costet, Nathalie, Hough, Ian, Seyve, Emie, Monfort, Christine, Philippat, Claire, Slama, Rémy, Kloog, Itai, Chevrier, Cécile, Heude, Barbara, Ramus, Franck, Lepeule, Johanna, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Ben-Gurion University of the Negev (BGU), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire de sciences cognitives et psycholinguistique (LSCP), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS), This work as well as AG were funded by the Fondation de France (PAND-Alp grant 00089597).The EDEN cohort was supported by the Foundation for Medical Research, the National Agency for Research, the National Institute for Research in Public Health (IRESP: TGIR cohorte santé. 2008 program), the French Ministry of Health, the French Ministry of Research, the Inserm Bone and Joint Diseases National Research and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, the French National Institute for Population Health Surveillance, the French National Institute for Health Education, the European Union FP7 programs (FP7/2007–2013, HELIX, ESCAPE, ENRIECO, Medall projects), the Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients), the French Agency for Environmental Health Safety, MutuelleGénérale de l’Education Nationale, the French National Agency for Food Security and the French-speaking Association for the Study of Diabetes and Metabolism.This study in the PELAGIE cohort was mainly supported by Inserm, the French National Research Agency (ANR-10-PRSP-0007) and the French Agency for Food, Environmental and Occupational Health and Safety (ANSES APR EST, 2009). The initial fundings of the PELAGIE cohort were Inserm, the French Ministries of Health, Labor, and Research, the French National Institute for Public Health Surveillance, the National Agency for Research, the French Agency for Environmental Health Safety (Afsset/ANSES), the European programs Hi-WATE and ENRIECO, and the Research Institute of Public Health.FR and HP received support under the program 'Investissements d’Avenir' launched by the French Government and implemented by ANR with the references ANR-17-EURE-0017 and ANR-10-IDEX-0001-02.The funders contributed to data collection but had no role in the design and conduct of the study, analysis, and interpretation of the data, preparation, review, or approval of the manuscript, and decision to submit the manuscript for publication. The opinions, results, and conclusions herein are those of the authors and do not reflect the official policy or position of the funding sources., ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010), ANR-17-EURE-0017,FrontCog,Frontières en cognition(2017), and ANR-10-PRSP-0007,PEPSY(2010)
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DLNM ,PM ,IQ ,Pregnancy ,[SDV]Life Sciences [q-bio] ,Neurodevelopment ,NO(2) - Abstract
International audience; BACKGROUND: Combined effect of both prenatal and early postnatal exposure to ambient air pollution on child cognition has rarely been investigated and sensitive periods of sensitivity are unknown. This study explores the temporal relationship between pre- and postnatal exposure to PM(10), PM(2.5), NO(2) and child cognitive function. METHODS: Using validated spatiotemporally resolved exposure models, pre- and postnatal daily PM(2.5), PM(10) (satellite based, 1 km resolution) and NO(2) (chemistry-transport model, 4 km resolution) concentrations at the mother’s residence were estimated for 1271 mother-child pairs from the French EDEN and PELAGIE cohorts. Scores representative of children’s General, Verbal and Non-Verbal abilities at 5-6 years were constructed based on subscale scores from the WPPSI-III, WISC-IV or NEPSY-II batteries, using confirmatory factor analysis (CFA). Associations of both prenatal (first 35 gestational weeks) and postnatal (60 months after birth) exposure to air pollutants with child cognition were explored using Distributed Lag Non-linear Models adjusted for confounders. RESULTS: Median exposure from conception until the 60th month of life was 19.3 μg/m(3) for PM(10), 12.4 μg/m(3) for PM(2.5) and 16.9 μg/m(3) for NO(2). Increased maternal exposure to both PM(10) and PM(2.5) between the 5th and the 11th gestational weeks was related to higher General, Verbal and Non-verbal abilities among males. On the contrary, increased maternal exposure to PM(10) between the 22nd and 29th gestational weeks was associated with lower General and Non-verbal abilities among males. Similar trends were observed for PM(2.5). No significant sensitive exposure windows were detected for postnatal exposure, NO(2) or among females. DISCUSSION: These results suggest poorer cognitive development among males at 5-6 years following increased maternal exposure to PM(10) during mid-pregnancy. Apparent protective associations observed for early prenatal exposure to PM(10) and PM(2.5) are unlikely to be causal and might be due to live birth selection bias.
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- 2023