45,741 results on '"thyrotropin"'
Search Results
2. Clinical hypothyroidism in a cat associated with sulfonamide administration for the management of intracranial nocardiosis.
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Halman, CF, Gavaghan, BJ, and Korman, RM
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MAGNETIC resonance imaging , *THYROTROPIN , *SYMPTOMS , *NOCARDIOSIS , *DNA sequencing , *LEVOTHYROXINE - Abstract
A 2‐year‐old cat was referred for suspected generalised seizure activity and reclusive behaviour, with a history of non‐resolving facial abscess. Magnetic resonance imaging (MRI) revealed a contrast enhancing lesion occupying the left calvarium and adjacent peripheral tissues. The intracranial lesion was causing significant mass effect, with oedema and transtentorial herniation. Nocardia nova was isolated from the lesion and identified by DNA sequencing. Treatment consisted of debridement via craniotomy and ventral bulla osteotomy, and combination antibiotic therapy with clarithromycin, amoxycillin and trimethoprim‐sulfonamide (sulfadoxine parenterally, then sulfadiazine orally). After several weeks of antibiotic therapy, the cat developed weakness, bicavitary effusion, myxoedema, non‐regenerative anaemia and azotaemia. Total thyroxine (TT4) was below the detectable limit and canine thyroid stimulating hormone (cTSH) assay was markedly elevated at 7.53 ng/mL (reference interval 0.15–0.3 ng/mL). Discontinuation of sulfonamides and administration of levothyroxine resulted in resolution of clinical signs. The cat was subsequently able to discontinue levothyroxine, with recovery of euthyroid state. To the authors' knowledge, this is the first report of clinical hypothyroidism in a cat treated with sulfonamide antibiotics and may influence antimicrobial selection and monitoring during therapy. This report also described the management of an atypical presentation of nocardiosis with intracranial extension. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Antenatal screening for thyroid dysfunction: pre-term birth, low birth-weight, and growth restriction.
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Dhaifalah, Ishraq, Havalova, Jana, Langova, Dagmar, and Cuckle, Howard
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SMALL for gestational age , *THYROTROPIN , *THYROID diseases , *ASYMPTOMATIC patients , *LOGISTIC regression analysis , *IODINE deficiency - Abstract
Objective: To assess pre-term birth, low birth-weight and growth restriction according to maternal thyroid screening results and subsequent treatment. Methods: This is a nonintervention nested case-control study derived from 10,052 asymptomatic women previously screened during the first trimester marker with anti-thyroid peroxidase antibodies, serum thyroid stimulating hormone, and free thyroxine. Screening results had been classified as positive with one or more markers outside the normal range and referred to an endocrinologist. Cases were 512 women with positive results and information on recommended treatment: 204 thyroxine, propylthiouracil or surgery, and 308 no treatment or only iodine. Controls were a sequential sample of 1292 women with negative results. All cases and controls had information on gestation at delivery or birth-weight. Outcome measures were pre-term birth (<37 weeks), low birth-weight (<2.5 kg) and, for singletons, small for gestational age (SGA; <10th percentile). Results: Among singleton pregnancies, there was a higher prevalence of both pre-term birth (risk ratio (RR) 1.69, 95% confidence interval (CI) 1.21–2.36, p <.002) and low birth-weight (RR 1.72, 95% CI 1.13–2.62, p <.02) in cases compared with controls. An increase in low birth-weight was also present in term pregnancies, but not significant (RR 1.80, 95% CI 0.78–4.14, p =.16), and there was no difference in SGA prevalence (1.24, 95% CI 0.93–1.65, p =.14). Among cases there was no significant difference in these rates according to treatment even after logistic regression, allowing for the individual screening marker levels and maternal weight. Conclusions: Women with positive thyroid screening results are at increased risk of pre-term birth regardless of thyroid dysfunction or subsequent treatment. An association with low birth-weight is probably secondary to early delivery. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Relationship between impaired sensitivity to thyroid hormones and MAFLD with elevated liver enzymes in the euthyroid population.
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Zeng, Haixia, Liu, Jianping, and Zhang, Yuying
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THYROID gland physiology , *METABOLIC disorders , *RISK assessment , *THYROXINE , *MATHEMATICAL variables , *FATTY liver , *ACADEMIC medical centers , *ASPARTATE aminotransferase , *LOGISTIC regression analysis , *DESCRIPTIVE statistics , *THYROID hormones , *GAMMA-glutamyltransferase , *ODDS ratio , *ALANINE aminotransferase , *RESEARCH , *FATTY acids , *THYROTROPIN , *CONFIDENCE intervals , *DISEASE risk factors , *DISEASE complications - Abstract
Objective: There is a delicate interplay between thyroid hormones and thyrotropin (TSH) and metabolic homeostasis. However, the role of thyroid hormone sensitivity in metabolic health, particularly in relation to metabolic dysfunction-associated fatty liver disease (MAFLD) and associated complications such as elevated liver enzymes and free fatty acid (FFAs) has not been elucidated in euthyroid populations. Methods: A total of 3929 euthyroid adults from the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University were included in this study. Thyroid hormone sensitivity indices were calculated by thyroid feedback quantile-based index (TFQI), TSH index (TSHI) and thyrotropin thyroxine resistance index (TT4RI). Associations between thyroid hormones sensitivities and risk of MAFLD, MAFLD with elevated liver enzymes, MAFLD with elevated FFAs were assessed with logistic regression. Results: After adjustment for multiple risk factors, adjusted odds ratio (AOR) of the fourth versus the first TFQIFT4 quartile for MAFLD, MAFLD with elevated liver enzymes, and MAFLD with elevated FFAs were 1.778 (95% CI 1.378, 2.293), 1.466 (1.105, 1.945), and 1.936 (1.479, 2.534), respectively (all p<0.001). Per 1 SD in TFQIFT4, ORs increased 2.27 (95% CI 1.74, 2.97) for MAFLD, 2.05 (1.51, 2.78) for MAFLD with elevated liver enzymes, and 2.43 (1.82, 3.24) for MAFLD with elevated FFAs. The other sensitivity to thyroid hormones indices showed similar associations for MAFLD and MAFLD with elevated liver enzymes. Conclusions: These findings have important implications for understanding the role of thyroid hormone sensitivity in metabolic health, particularly in relation to MAFLD and associated complications such as elevated liver enzymes and FFAs. TFQIFT4, TFQIFT3, TSHI and TT4RI can be used as new indicators for predicting MAFLD and MAFLD with elevated liver enzymes. [ABSTRACT FROM AUTHOR]
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- 2024
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5. The TSH Receptor Antibody Reactome Contributes to Retro-Orbital Inflammation.
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Morshed, Syed, Mansoori, Maryam, and Davies, Terry F
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RECEPTOR antibodies ,THYROID eye disease ,THYROTROPIN ,INFLAMMATION ,CELL death ,THYROID cancer ,RETROPERITONEAL fibrosis - Abstract
The thyroid eye disease (TED) of Graves disease is associated with high titers of stimulating TSH receptor antibodies, retro-orbital inflammation, fibroblast release of cytokines and chemokines, and adipogenesis, which in turn leads to proptosis, muscle fibrosis, and dysfunction. Part of this scenario is the induction of fibroblast proliferation and autophagy secondary to synergism between the TSH receptor (TSHR) and the insulin-like growth factor-1 receptor (IGF-1R). While TED is well associated with thyroid-stimulating antibodies to the TSHR, which is also well expressed on fibroblasts, in fact the TSHR reactome has a variety of TSHR antibodies with varying biological activity. Therefore, we have now evaluated the possible role of neutral TSHR antibodies (N-TSHR-mAbs), directed at the hinge region of the TSHR, which do not induce cell proliferation but are known to have effects on multiple proteins in thyroid cells including stress-related signaling molecules. We examined the consequences of an N-TSHR-mAb acting on TSHR-expressing fibroblasts and found marked cell stress, which initiated signaling pathways involving inflammasome activation. This response ended in widespread cell death by pyroptosis through activation of caspase 8 and gasdermin D. Hence, not only can stimulating TSHR autoantibodies influence TED inflammation but the N-TSHR antibodies, representing more of the reactome, may also exaggerate the retro-orbital inflammatory response seen in TED. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Analysis of risk factors for autoimmune thyroid disease based on blood indicators and urinary iodine concentrations.
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Liu, Jianning, Feng, Zhuoying, Gao, Ru, Liu, Peng, Meng, Fangang, Fan, Lijun, Liu, Lixiang, and Du, Yang
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LOGISTIC regression analysis ,ALCOHOL drinking ,THYROTROPIN ,THYROID diseases ,FACTOR analysis - Abstract
Objective: The aim of this study was to elucidate the relationships between thyroid hormones, lifestyle factors, biochemical markers, and autoimmune thyroid disease (AITD), thereby identifying the factors influencing the development of these diseases. Methods: The study encompassed 517 patients with AITD and 549 patients with non-autoimmune thyroid disease. Demographic and clinical data were collected, and various laboratory indicators, including urinary iodine and thyroid hormones, were measured and compared between the groups. Lasso regression was employed to select the independent variables, while logistic regression analysis determined the factors associated with the development of AITD. Results: The prevalence of drinking alcohol history, median urinary iodine, and TSH concentrations proved significantly greater in the AITD group compared to the control group, while FT3 levels demonstrated lower values within the AITD group (p<0.05). Furthermore, there was a significant difference in the distribution of iodine nutrition status between the two groups (p<0.05). Both univariate and multivariate logistic regression analyses revealed significant associations among excessive iodine intake, drinking alcohol history, TSH, FT3, and the development of AITD. Conclusions: Excessive iodine intake and drinking alcohol history are implicated in an augmented risk of developing AITD. The prevention of AITD may necessitate the regular monitoring of TSH and FT3 concentrations. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Development and Validation of a Prediction Model for Co‐Occurring Moderate‐to‐Severe Anxiety Symptoms in First‐Episode and Drug Naïve Patients With Major Depressive Disorder.
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Huang, Xiao, Zhang, Xiang-Yang, and Xia, Xue
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MENTAL depression , *RECEIVER operating characteristic curves , *ATTEMPTED suicide , *THYROTROPIN , *PATIENTS' families - Abstract
Background: Moderate‐to‐severe anxiety symptoms are severe and common in patients with major depressive disorder (MDD) and have a significant impact on MDD patients and their families. The main objective of this study was to develop a risk prediction model for moderate‐to‐severe anxiety in MDD patients to make the detection more accurate and effective. Methods: We conducted a cross‐sectional survey and tested biochemical indicators in 1718 first‐episode and drug naïve (FEDN) patients with MDD. Using machine learning, we developed a risk prediction model for moderate‐to‐severe anxiety in these FEDN patients with MDD. Results: Four predictors were identified from a total of 21 variables studied by least absolute shrinkage and selection operator (LASSO) regression analysis, namely psychotic symptoms, suicide attempts, thyroid stimulating hormone (TSH), and Hamilton Depression Scale (HAMD) total score. The model built from the four predictors showed good predictive power, with an area under the receiver operating characteristic (ROC) curve of 0.903 for the training set and 0.896 for the validation set. The decision curve analysis (DCA) curve indicated that the nomogram could be applied to clinical practice if the risk thresholds were between 13% and 40%. In the external validation, the risk threshold was between 14% and 40%. Conclusion: The inclusion of psychotic symptoms, suicide attempts, TSH, and HAMD in the risk nomogram may improve its utility in identifying patients with MDD at risk of moderate‐to‐severe anxiety. It may be helpful in clinical decision‐making or for conferring with patients, especially in risk‐based interventions. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Thyroid hormone levels in patients with bipolar disorder: a systematic review and meta-analysis.
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Liu, Shanshan, Chen, Xiaoai, Li, Xiaotao, and Tian, Limin
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BIPOLAR disorder , *THYROXINE , *MEDICAL information storage & retrieval systems , *RESEARCH funding , *META-analysis , *CHI-squared test , *THYROID hormones , *TRIIODOTHYRONINE , *SYSTEMATIC reviews , *MEDLINE , *MEDICAL databases , *THYROTROPIN , *MANIA , *ONLINE information services , *CONFIDENCE intervals , *MENTAL depression , *SENSITIVITY & specificity (Statistics) , *DISEASE progression - Abstract
Purpose: To investigate the difference in blood (serum/plasma) thyroid hormone (TH) levels, including thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), free thyroxine (FT4), and free triiodothyronine (FT3), in bipolar disorder (BD) during different mood episodes (depression and mania) compared with healthy control (HC) and between manic episodes (BD-M) and depressive episodes (BD-D). Methods: As of September 1, 2024, the electronic databases PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, China Science and Technology Journal Database, Wanfang Database, and Clinical Trials. Gov were systematically searched with no language limitations. Standardized mean differences (SMD) with 95% confidence interval (CI) were summarized using a random effects model. The chi-squared-based Q test and the I2 test assessed the size of heterogeneity. Results: The 21 studies included a total of 3696 participants, Of the 2942 BD patients, 1583 were in depressive episodes 1359 were in manic episodes. The status of measuring blood TH levels included 2 studies in plasma and 19 in serum. Combined with the results of the sensitivity analyses, we obtained the following relatively reliable results: serum T3 (SMD: -0.63, 95%CI: -1.09 to -0.17) and FT3 (SMD: -0.42, 95%CI: -0.83 to -0.00) levels decreased significantly in BD-D compared to HC; serum T3 (SMD: -0.91, 95%CI: -1.49 to -0.32) levels decreased significantly and serum FT4 (SMD: 0.37, 95%CI: 0.14 to 0.60) levels increased significantly in BD-M than in HC; serum T3 (SMD: 0.87, 95%CI: 0.24 to 1.49) and FT3 (SMD: 0.27, 95%CI: 0.13 to 0.42) levels demonstrated a significant elevation in BD-M compared to BD-D. In the group of euthyroidism, apart from serum FT4 (SMD: 0.21, 95%CI: -0.15 to 0.58) levels showed no significant difference between BD-M and HC, other results above remained consistent. Conclusion: Serum T3 and FT3 levels decreased significantly in BD-D compared to HC. Serum T3 levels decreased significantly and serum FT4 levels increased significantly in BD-M compared to HC. Serum T3 and FT3 levels increased significantly in BD-M than in BD-D. The temporality of changes in TH levels and BD progression demands further longitudinal studies to illustrate. Trial registration: Number and date of registration for prospectively registered trials No. CRD42022378530. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Modelling Functional Thyroid Follicular Structures Using P19 Embryonal Carcinoma Cells.
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Najjar, Fatimah, Milbauer, Liming, Wei, Chin-Wen, Lerdall, Thomas, and Wei, Li-Na
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EMBRYONIC stem cells , *STEM cell culture , *THYROID diseases , *THYROTROPIN , *CELL differentiation - Abstract
Thyroid gland diseases remain clinical challenges due to the lack of reliable in vitro models to examine molecular pathways of thyrocytes development, maturation, and functional maintenance. This study aimed to develop in vitro thyrocytes model using a stem cell culture, P19 embryonal carcinoma which requires no feeder layer, differentiation into mature and functional thyrocytes that allow molecular and genetic manipulation for studying thyroid diseases. The procedure utilizes Activin A and thyroid stimulating hormone (TSH) to first induce embryoid body endoderm formation enriched in thyrocyte progenitors. Following dissociating embryoid bodies, thyrocyte progenitors are plated in Matrigel as monolayer cultures that allows thyrocyte progenitors mature to functional thyrocytes. These thyrocytes further maturate to form follicle-like structures expressing and accumulating thyroglobulin that can be secreted into the medium upon TSH stimulation. Thyrocyte differentiation-maturation process is monitored by the expression of essential transcriptional factors and thyrocyte-specific functional genes. Further, the applicability of this system is validated by introducing a siRNA control. Following molecular manipulation, the system can still be guided to differentiate into mature and functional thyrocytes. This system spans a time frame of 14 days, suitable for detailed molecular studies to dissect pathways and molecular players in thyrocytes development and functional maintenance. [ABSTRACT FROM AUTHOR]
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- 2024
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10. A New Mathematical Approach for Hashimoto's Thyroiditis in Children.
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Pompa, Marcello, De Gaetano, Andrea, Borri, Alessandro, Farsetti, Antonella, Nanni, Simona, D'Orsi, Laura, and Panunzi, Simona
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AUTOIMMUNE thyroiditis , *THYROTROPIN , *THYROID gland , *SODIUM iodide , *IODIDE peroxidase - Abstract
Hashimoto's thyroiditis (HT) is a prevalent autoimmune disorder marked by chronic inflammation of the thyroid gland, predominantly affecting children and adolescents. In a previous study, we developed a "maximal" mathematical model of thyroid physiology to simulate the complex interactions within the thyroid gland. The present research introduces an enhanced version of the "maximal" model, integrating the pathophysiological impacts of HT. It specifically models the adverse effects of thyroid peroxidase (TPO) and thyroglobulin (Tg) antibodies (TPOAb and TgAb) on TPO, Tg, sodium iodide symporter (NIS), albeit indirectly, and thyroid volume. Additionally, we present a new "minimal" model offering a streamlined interpretation of thyroid physiology and pathophysiology, designed for faster computational analysis while maintaining essential physiological interactions. Both models were fitted against longitudinal clinical data from patients with HT, assessing the concentrations of Thyroid Stimulating Hormone (TSH), Thyroxine (T4), and thyroid volume over 36 months, in both untreated patients and those receiving levothyroxine (LT4) treatment. The adaptation of the models to data shows that both of them accurately reproduce the available observed clinical outcomes, with the "maximal" model providing more detailed physiological insights but requiring extensive data and longer computation times. In contrast, the "minimal" model, despite exhibiting less realistic TSH oscillations, offers rapid parameter estimation and may be more feasible in clinical settings. These models hold significant potential as tools for detailed study and management of HT, enabling simulations of disease progression and therapeutic responses, thus paving the way for personalized treatment strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Clinical patterns of metabolic syndrome in young, clinically stable, olanzapine-exposed patients with schizophrenia.
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Ma, Jun, Zhang, Lin, Huang, Zhengyuan, and Wang, Gaohua
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METABOLIC syndrome risk factors , *RISK assessment , *HDL cholesterol , *PREDICTIVE tests , *BODY mass index , *LONG QT syndrome , *HYPERLIPIDEMIA , *T-test (Statistics) , *PREDICTION models , *OLANZAPINE , *LOGISTIC regression analysis , *MULTIPLE regression analysis , *SCHIZOPHRENIA , *DISEASE prevalence , *DESCRIPTIVE statistics , *SEVERITY of illness index , *ANTIPSYCHOTIC agents , *CHI-squared test , *METABOLIC syndrome , *URIC acid , *COMPARATIVE studies , *THYROTROPIN , *DATA analysis software , *OBESITY , *ADULTS ,DRUG therapy for schizophrenia - Abstract
Background: Schizophrenia (SCZ) is a chronic, disabling mental illness with a high disease burden and is often comorbid with metabolic syndrome (MetS). The aim of this study was to determine the prevalence of MetS in young, clinically stable, olanzapine-exposed patients with SCZ and to explore predictive factors affecting the development and severity of MetS. Methods: A total of 274 patients with SCZ who met the inclusion criteria were enrolled in this study, and their demographic data and general clinical information were collected. Concurrently, patients were assessed for psychopathology, illness severity, and antipsychotic drug–related adverse effects. Results: The prevalence of MetS in the target population was 35.77%, and the MetS subtype of abdominal obesity + high triglycerides + low level of high-density lipoprotein cholesterol accounted for the majority of patients in the MetS subgroup. Binary logistic regression showed that body mass index (BMI), uric acid (UA), thyroid-stimulating hormone, and QT-c interval could significantly and positively predict the development of MetS. Multiple linear regression showed that olanzapine concentration, BMI, and UA could significantly and positively predict higher MetS scores. Conclusion: This study reports the clinical patterns of MetS in young, clinically stable, olanzapine-exposed patients with SCZ and identifies the correlations influencing the development and severity of MetS. These findings could potentially be applied toward the prevention of and intervention in MetS. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Longitudinal assessment of thyroid function in dogs with hypoadrenocorticism: Clinical outcomes and prevalence of autoantibodies.
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Sieber‐Ruckstuhl, Nadja S., Riond, Barbara, Fracassi, Federico, Kuemmerle‐Fraune, Claudia, Meunier, Solène, Hofmann‐Lehmann, Regina, Reusch, Claudia E., Mueller, Claudia, Hofer‐Inteeworn, Natalie, and Boretti, Felicitas S.
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ADDISON'S disease , *THYROTROPIN , *THYROID diseases , *DOGS , *AUTOANTIBODIES - Abstract
Background Objective Animals Methods Results Conclusions and Clinical Relevance Knowledge about primary hypoadrenocorticism coexisting with immune‐mediated thyroiditis (Schmidt's syndrome) in dogs is limited.To evaluate thyroid function in dogs with naturally occurring hypoadrenocorticism before and during treatment.Sixty‐six client‐owned dogs.Measurement of canine thyroid stimulating hormone (cTSH), total thyroxine (T4), free thyroxine, and autoantibodies against thyroglobulin, T4, and total triiodothyronine.Thirty‐eight dogs were assessed before and 28 during treatment. Follow‐up data were available for 24/38 and 17/28 dogs, with median follow‐up duration of 3.8 years (range, <1.0‐8.8 years) and 4 years (range, 1.1 weeks to 10.5 years), respectively. Canine thyroid stimulating hormone was above the reference range at the time of diagnosis of hypoadrenocorticism in 10 of 38 dogs but decreased into the reference range in 7 for which follow‐up data was available. Hypothyroidism was confirmed in 5 dogs at a median age of 11 years (range, 7‐15 years). In 4 dogs, the condition was diagnosed after a median treatment duration of 5.75 years (range, 2.6‐10 years), while in 1 dog, the diagnosis was made concurrently. One dog had detectable thyroid autoantibodies.Hypothyroidism occurs as a rare concurrent condition in dogs with hypoadrenocorticism, potentially at any phase of treatment. Close monitoring of cTSH levels in these dogs could be beneficial, as early changes might indicate the onset of hypothyroidism. The low prevalence of detectable thyroid autoantibodies suggests that nonimmune mechanisms might contribute to thyroid dysfunction. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Predictive Factors for the Efficacy of Radioactive Iodine Treatment of Graves' Disease: An Experience From 613 Chinese Patients.
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Feng, Wenwen, Shi, He, Yang, Yanli, Liu, Jing, Chen, Shiying, Ren, Minghui, Li, Yajie, Liu, Wei, Cui, Dai, and Falhammar, Henrik
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STATISTICAL models , *RISK assessment , *IODINE radioisotopes , *PREDICTION models , *DISEASE duration , *THYROID gland function tests , *RECEIVER operating characteristic curves , *RESEARCH funding , *SEX distribution , *MULTIPLE regression analysis , *TREATMENT effectiveness , *RETROSPECTIVE studies , *AGE distribution , *EYE diseases , *MULTIVARIATE analysis , *DESCRIPTIVE statistics , *CONFIDENCE , *THYROID gland , *HYPERTHYROIDISM , *STATISTICS , *GRAVES' disease , *THYROTROPIN , *DATA analysis software , *PATIENTS' attitudes , *TIME , *HYPOTHYROIDISM - Abstract
Objective: The utilization of radioactive iodine‐131I (RAI) has long been established as a cost‐effective and conventional treatment for managing Graves' disease (GD). However, the accurate prediction of the clinical response to RAI treatment remains difficult. The successful resolution of GD through RAI therapy is typically characterized by the induction of hypothyroidism or euthyroidism. Thus, the principal aim of this study was to identify plausible predictors of RAI efficacy in the treatment of GD. Methods: The clinical data of 613 GD patients, who underwent RAI treatment for the first time, were retrospectively analyzed, including age, gender, duration of hyperthyroidism, presence or absence of ocular signs, thyroid volume, thyroid weight, thyroid function (FT3, FT4, and TSH), radioactive iodine uptake (RAIU) at 2 h/6 h/24 h (2‐h/6‐h/24‐h RAIU) prior to RAI treatment, the highest RAIU (RAIUmax), and administered activity of 131I and 131I activity per gram of thyroid tissue. Success of RAI treatment was defined as achieving hypothyroidism or euthyroidism for more than 1 year after the initial treatment. Univariate and multivariate logistics regression analyses were conducted to identify factors that influence the efficacy of RAI treatment for GD. And at last, based on the results of the multivariate logistic regression analysis, a nomogram model was established. Results: In this study, the success rate of RAI treatment for GD was 91.2% (559/613). Univariate analysis demonstrated that several factors, including age (p = 0.005), thyroid volume (p = 0.001), thyroid‐stimulating hormone (TSH, p = 0.042), ratio of RAIU at 6 h to 24 h (6‐h/24‐h RAIU, p = 0.048), total 131I activity (p = 0.026), and 131I activity per gram of thyroid tissue (p = 0.001), were significantly associated with treatment outcome. Multivariate logistic regression analysis indicated thyroid volume and 131I activity per gram of thyroid tissue as significant independent predictors of radioactive iodine therapy (RIT) efficacy. The area under the ROC curve of the established nomogram model was 0.769 (95% confidence interval [CI]: 0.692–0.846), indicating that the model has good discriminatory ability. Conclusion: Calculated‐dose RAI is effective in the treatment of GD. The smaller thyroid volume and the higher 131I activity per gram of thyroid tissue are predictors of RAI efficacy in the treatment of GD. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Relationship of serum iron and thyroid hormone in obesity and after laparoscopic sleeve gastrectomy.
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Wang, Xingchun, Fang, Yaling, Huang, Xiu, Du, Lei, Ren, Hui, Sheng, Chunjun, Yang, Peng, Huang, Yueye, and Qu, Shen
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THYROID gland physiology , *BARIATRIC surgery , *IRON , *IRON in the body , *GASTRECTOMY , *THYROXINE , *RESEARCH funding , *LAPAROSCOPIC surgery , *SEX distribution , *IRON overload , *DESCRIPTIVE statistics , *THYROID hormones , *TRIIODOTHYRONINE , *THYROTROPIN , *PATIENT aftercare , *REGRESSION analysis , *DISEASE complications - Abstract
Background: Iron is an essential element for thyroid function. However, no study focuses on the association between iron and thyroid in individuals with obesity. Our research aimed to investigate the iron status in relation to baseline thyroid hormone levels and after laparoscopic sleeve gastrectomy (LSG). Methods: A total of 216 subjects with obesity were enrolled and divided into low and high iron groups depending on the median value. The association between iron and thyroid hormone was analyzed and compared before and after LSG at the 6-month follow-up in patients who underwent LSG. Results: 1) In all, Total Triiodothyronine (TT3) was significantly higher in high iron than low iron group (P = 0.008). TT3 and thyroid stimulating hormone (TSH) were significantly higher in high iron than low iron group (1.92 ± 0.61 vs. 1.69 ± 0.28 nmol/l, P = 0.029; 2.93 ± 1.66 vs. 1.88 ± 1.03 mU/l, P = 0.002) in females while not in males (all P > 0.05). 2) Iron was significantly positively associated with free triiodothyronine (FT3), free thyroxine (FT4), TT3 and TSH (all P < 0.05). Adjusted for body mass index (BMI), total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), fasting insulin (FINS) and homeostatic model assessment of insulin resistance (HOMA-IR), FT3, FT4 and TSH were still significantly associated with iron (all P < 0.05). 3). Regression analysis showed that iron was significantly associated with FT4 (β = 0.338, P = 0.038). 3) LSG led to decreased FT3, FT3, TT3, total thyroxine (TT4) and TSH at 6 months follow-up (all P < 0.05). Changed FT4 was significantly associated with changed iron (r = 0.520, P = 0.009). Subjects with iron decreased had more significant decreased TT4 than subjects without iron decreased (P = 0.021). Conclusion: Serum iron overload is significantly associated with impaired thyroid function in subjects with obesity. LSG led to improved thyroid function which is associated with a change in iron. Trial Registration: NCT04548232 registration date is on October 9, 2022, registered in https://register.clinicaltrials.gov/. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Association between hypothyroidism and metabolic syndrome in Qinghai, China.
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Fan, Xiaoxia, Yao, Yongli, Chai, Shengjun, Wang, Beibei, Xie, Yanling, Jiang, Yanping, Lin, Lijun, Li, Yanan, Fan, Peiyun, Luo, Wei, Wang, Shuqiong, Song, Kang, Zhao, Lingling, and Cai, Chunmei
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THYROTROPIN ,THYROID diseases ,THYROID hormones ,METABOLIC syndrome ,DIAGNOSIS - Abstract
Objective: To investigate the epidemiological characteristics of hypothyroidism in Qinghai Province, analyze its related influencing factors, establish the normal reference range of thyroid function, and explore the relationship between thyroid hormone (THs), thyroid stimulating hormone (TSH) and metabolic syndrome (MS) in Qinghai population within the normal range, so as to provide some scientific basis for the prevention and treatment of hypothyroidism in Qinghai Province. Methods: A total of 2790 residents aged 18 and over from Qinghai were selected through stratified cluster random sampling. Data were collected via questionnaires, physical examinations, and laboratory tests. Results: 1. A total of 2628 eligible residents in Qinghai were included in this study, and the total prevalence of hypothyroidism was 30.25%, among which the prevalence of subclinical hypothyroidism was 29.22%, and the prevalence of clinical hypothyroidism was 1.03%. 2. The prevalence of hypothyroidism in women was significantly higher than that in men (36.69% vs 24.30%); smoking and drinking were risk factors for hypothyroidism. 3. In the excluded subjects, 1544 were abnormal thyroid ultrasound, abnormal thyroid function and/or positive thyroid autoantibodies, and the remaining 1084 were reference populations. According to the reference population data, the 95% reference ranges of TSH, FT4, FT3 were 0.43-5.51 mIU/L, 11.0-20.4 pmol/L, 3.63-5.73 pmol/L, respectively. 4. In the normal thyroid function population in Qinghai, MS and its related components were positively correlated with FT3 and FT4 levels, but not significantly correlated with TSH levels. Conclusion: 1. The prevalence of hypothyroidism in adults in Qinghai is relatively high, accounting for about one-thirtieth of the total population. Smoking and drinking have a certain impact on the incidence of hypothyroidism. 2. It provides a reference range for the diagnosis of thyroid diseases in Qinghai province, which is different from that of reagent suppliers, and has certain promotion significance in the western region. 3. MS and its related components are positively correlated with FT3 and FT4 levels, but not with TSH levels in people with normal thyroid function in Qinghai. Early thyroid function screening is of great significance for the prevention of MS. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Hyperthyroidism, hypothyroidism, thyroid stimulating hormone, and dementia risk: results from the NHANES 2011–2012 and Mendelian randomization analysis.
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Sheng, Xixi, Gao, Jixiang, Chen, Kunfei, Zhu, Xuzhen, and Wang, Yu
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ALZHEIMER'S disease risk factors ,DEMENTIA risk factors ,RISK assessment ,CROSS-sectional method ,CLUSTER analysis (Statistics) ,MULTIPLE regression analysis ,QUESTIONNAIRES ,LOGISTIC regression analysis ,STATISTICAL sampling ,SOCIOECONOMIC factors ,DESCRIPTIVE statistics ,ODDS ratio ,HYPERTHYROIDISM ,STATISTICS ,THYROTROPIN ,HEALTH outcome assessment ,DATA analysis software ,CONFIDENCE intervals ,HYPOTHYROIDISM ,COGNITION ,DISEASE complications - Abstract
Introduction: As the world ages, dementia places a heavy burden on society and the economy, but current methods of diagnosing dementia are still limited and there are no better therapies that target the causes of dementia. The purpose of this work is to explore the relationship between thyroid disease, thyroid stimulating hormone (TSH) concentrations, free tetraiodothyronine (FT4) concentrations and cognitive function. Methods: This study utilized cognitive function and thyroid data from the 2011–2012 National Health and Nutrition Examination Survey (NHANES) to assess the relationship between different groups of TSH and FT4 concentrations and cognitive function using weighted logistic regression and restricted cubic spline (RCS), and then used two-sample Mendelian Randomization (MR) to assess the causal relationship between hyperthyroidism, hypothyroidism, TSH and FT4 concentrations with dementia. Results: Our analysis of the 2011–2012 NHANES data showed that the individuals with low TSH concentrations had higher Alzheimer's Disease Word List Registry Consortium1 (CERAD1) and CERAD.delay.recall scores than individuals with high TSH concentrations, and individuals with low FT4 concentrations had higher CERAD3 and Animal Fluency Test scores than individuals with high FT4 concentrations. Our results also showed a non-linear relationship between serum TSH and FT4 concentrations and the Animal Fluency Test. The TSH concentrations within the range of 1.703 to 3.145 mIU/L exhibit a positive correlation with Animal Fluency Test, whereas concentrations outside this range are negatively correlated with Animal Fluency Test. The FT4 concentrations exhibited a positive correlation with Animal Fluency Test to the left of the FT4 concentrations inflection point (0.849 ng/L), whereas to the right of this inflection point, correlation was negative. MR analysis results further indicate that genetic predisposition to hyperthyroidism may be associated with a reduced risk of dementia and vascular dementia(VaD). Conversely, genetic predisposition to hypothyroidism appears to be linked with an increased risk of dementia and VaD. Additionally, genetic predisposition to elevated TSH concentrations may be correlated with a heightened risk of risk of Alzheimer's disease (AD). Conclusion: This study provides evidence of a nonlinear relationship between TSH and FT4 concentrations and cognitive function, with hyperthyroidism decreasing the risk of dementia and VaD, hypothyroidism increasing the risk of dementia and VaD, and elevated serum TSH concentrations increasing the risk of AD. Furthermore, prioritizing early detection, diagnosis, and treatment through the assessment of thyroid function in individuals at high risk for developing dementia is of paramount importance. This strategy has the potential to significantly contribute to the prevention and deceleration of dementia progression. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Sex Differences in Physiological Responses to a National Collegiate Athletic Association Division I Soccer Season.
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McFadden, Bridget A., Walker, Alan J., Cintineo, Harry P., Bozzini, Brittany N., Sanders, David J., Chandler, Alexa J., and Arent, Shawn M.
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EXERCISE physiology , *REPEATED measures design , *THYROXINE , *SOCCER , *SEX distribution , *OMEGA-3 fatty acids , *PHYSICAL training & conditioning , *GLOBAL Positioning System , *MULTIVARIATE analysis , *HYDROCORTISONE , *ENERGY metabolism , *HEART beat , *CREATINE kinase , *ANALYSIS of variance , *COLLEGE sports , *ATHLETIC ability , *THYROTROPIN , *EMPLOYEES' workload , *BIOMARKERS , *CONNECTIVE tissue growth factor , *VITAMIN D , *INTERLEUKINS - Abstract
Identifying physiological changes that occur in response to workload demands can help to elucidate athlete management and recovery strategies. The purpose of this study was to compare the physical and physiological demands between men and women throughout the course of a collegiate soccer season. Men (N 5 23) and women (N 5 26) soccer players participated in blood draws before preseason (T1) and every 4 weeks thereafter (T2-T4). Workload was determined at all practices and games via heart rate and global positioning satellite monitoring systems. Repeated measures multivariate analysis of variance and linear mixed models were used to assess workload and biomarker responses throughout the season (p, 0.05). Both teams experienced the highest workloads during the first 4 weeks of the season (p, 0.05), which was followed by several biomarker perturbations. Sex-by-Time interactions were observed for total cortisol, growth hormone, insulin-like growth factor-1, thyroxine, thyroid-stimulating hormone, vitamin D, and omega 3 fatty acid index (p, 0.05). Additional Sex effects were observed for free and total testosterone, estrogen, prolactin, sex-hormone binding globulin, creatine kinase, and iron levels (p, 0.05). Women soccer players experienced further Time effects for free cortisol, iron, ferritin, and percent transferrin saturation (p, 0.05). Male soccer players experienced additional Time effects for total testosterone, estrogen, creatine kinase, interleukin-6, triiodothyronine, and ferritin (p, 0.05). Despite similar patterns of change in workloads, differential fluctuations in physiological markers were observed between the sexes. Understanding sex differences in response to comparable workloads may enhance exercise prescriptions for better athlete management plans. Additional strategies to increase iron may be warranted in female athletes. [ABSTRACT FROM AUTHOR]
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- 2024
18. Age-Specific Reference Intervals for Thyroid-Stimulating Hormones and Free Thyroxine to Optimize Diagnosis of Thyroid Disease.
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Jansen, Heleen I., Dirks, Niek F., Hillebrand, Jacquelien J., ten Boekel, Edwin, Brinkman, Jacoline W., Buijs, Madelon M., Demir, Ayşe Y., Dijkstra, Ineke M., Endenburg, Silvia C., Engbers, Paula, Gootjes, Jeannette, Janssen, Marcel J.W., Kamphuis, Stephan, Kniest-de Jong, Wilhelmina H.A., Kruit, Adrian, Michielsen, Etienne, Wolthuis, Albert, van Trotsenburg, A.S. Paul, den Heijer, Martin, and Bruinstroop, Eveline
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OLDER people , *GENERAL practitioners , *AGE groups , *HOSPITAL utilization , *THYROTROPIN , *THYROID diseases - Abstract
Background: Thyroid-stimulating hormone (TSH) and subsequent free thyroxine (FT4) concentrations outside the reference interval (RI) are used to diagnose thyroid diseases. Most laboratories do not provide age-specific RIs for TSH and FT4 beyond childhood, although TSH concentrations vary with age. Therefore, we aimed to establish TSH and FT4 age-specific RIs throughout life and aimed to determine whether using these RIs would result in reclassification of thyroid disease diagnoses in adults. Methods: This multicenter retrospective cross-sectional study used big data to determine indirect RIs for TSH and FT4. These RIs were determined by TMC and refineR-analysis, respectively, using four different immunoassay platforms (Roche, Abbott, Siemens, and Beckman Coulter). Retrospective data (2008–2022) from 13 Dutch laboratories for general practitioners and local hospitals were used. RIs were evaluated per manufacturer. Age groups were established from 2 to 20 years by 2-year categories and decade categories between 20 and 100 years. Results: We included totally 7.6 million TSH and 2.2 million FT4 requests. TSH upper reference limits (URLs) and FT4 lower reference limits were higher in early childhood and decreased toward adulthood. In adulthood, TSH URLs increased from 60 years in men, and from 50 years in women, while FT4 URLs increased from 70 years onward. Using adult age-specific RIs resulted in a decrease in diagnoses of subclinical and overt hypothyroidism in women above 50 and men above 60 years in our Roche dataset. Conclusion: This study stressed the known importance of using age-specific RIs for TSH and FT4 in children. This study also showed the clinical relevance of using age-specific RIs for TSH in adulthood to reduce diagnoses of subclinical hypothyroidism in older persons. Therefore, implementation of adult TSH age-specific RIs should be strongly considered. Data are less uniform regarding FT4 age-specific RIs and more research should be performed before implementing these in clinical practice. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Epidemiological, Clinical, Laboratory, and Radiological Characteristics of Children and Adolescents Diagnosed with Hashimoto’s Thyroiditis: A Single-Center Experience.
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Kilci, Fatih and Sarıkaya, Emre
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AUTOIMMUNE thyroiditis , *RISK assessment , *THYROXINE , *WORK , *THYROID gland function tests , *T-test (Statistics) , *DATA analysis , *RECEIVER operating characteristic curves , *BODY mass index , *PUBERTY , *PARAMETERS (Statistics) , *KRUSKAL-Wallis Test , *BODY weight , *AUTOANTIBODIES , *ULTRASONIC imaging , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *CHI-squared test , *MANN Whitney U Test , *THYROID gland , *CLINICAL pathology , *MATHEMATICAL statistics , *STATURE , *MEDICAL records , *ACQUISITION of data , *ANALYSIS of variance , *STATISTICS , *HYPERTHYROIDISM , *NEEDLE biopsy , *DATA analysis software , *THYROTROPIN , *CONFIDENCE intervals , *HYPOTHYROIDISM , *EXPERIENTIAL learning , *MEDICAL referrals , *PATIENT aftercare , *NONPARAMETRIC statistics , *COMORBIDITY , *DISEASE risk factors , *SYMPTOMS , *ADOLESCENCE , *CHILDREN - Abstract
Objective: This study aimed to investigate the epidemiological, clinical, laboratory, and radiological characteristics of children diagnosed with Hashimoto’s thyroiditis and to present the experiences of a referral center. Materials and Methods: This study included 200 pediatric patients diagnosed with Hashimoto’s thyroiditis between January 2020 and May 2024 at a single center. The data were extracted and compiled from the participants’ medical records, including clinical information, physical examination findings, laboratory test results, and radiological imaging. Results: Mean age of the study population was 11.3 ± 3.2 years at diagnosis, with a female predominance. At the time of clinical presentation, 8.5% of the study participants were 6 years of age or younger. The majority of patients, comprising 39.5% of the cohort, exhibited euthyroid thyroid function. Additionally, 33.5% of the patients were classified as having subclinical hypothyroidism, 22% demonstrated overt hypothyroidism, and 5% presented with hyperthyroidism. Approximately one-third of the study participants were referred for further evaluation due to the identification of abnormal thyroid function test results during routine screening examinations. 48% of the patients had a documented family history of thyroid disease. At diagnosis, 39.5% were prepubertal. The rate of overt hypothyroidism was higher in prepubertal patients compared to pubertal patients (41.8% vs. 9.1%, P < .005). Mean gland volume SDS was 2.61 ± 3.69, and 45.5% had goiter. Thyroid nodular lesions were identified in 5.5% of the study participants. Fine-needle aspiration biopsy was performed on five patients, revealing benign findings in three cases and atypia of undetermined significance in the remaining two cases. Conclusion: Patints with subclinical hypothyroidism who have a baseline TSH level exceeding 8.5 mIU/L at initial presentation and do not receive treatment are likely to progress to overt hypothyroidism during subsequent follow-up. Prepubertal cases were more frequently observed compared to previous reports, and the course of hypothyroidism was more severe in prepubertal patients. These findings suggest a potential shift towards earlier onset of autoimmunity in children. Further studies are warranted to substantiate this observation. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Endocrine immune-related adverse events by immune checkpoint inhibitors and potential predictive markers: a prospective study from a single tertiary center.
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Barlas, Tugba, Sutcuoglu, Osman, Akdogan, Orhun, Toruner, Fusun Balos, Akturk, Mujde, Ozdemir, Nuriye, Yazici, Ozan, and Altinova, Alev Eroglu
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DRUG side effects , *IMMUNE checkpoint inhibitors , *THYROTROPIN , *THYROID diseases , *CHEMOKINES - Abstract
Immune checkpoint inhibitors (ICIs) can trigger immune-related adverse events (irAEs). The appearance pattern of irAEs, who is prone to them, and their mechanisms are still uncertain. In this study, we aimed to monitor patients initiated on ICIs for endocrinological aspects and to investigate the potential predictive markers in the development of endocrine-irAEs. The study prospectively included 43 patients with metastatic disease scheduled for anti-PD-1/ L1 therapy. Endocrinological follow-up was conducted at specified intervals as well as in response to any additional reported complaints. Serum concentrations of CXCL10, IL-1beta, and IL-17A were measured prior to ICI and during the endocrine-irAEs. A total of 39.5% of the patients experienced endocrine-irAEs, with a median onset time of 3 months. Among patients, 34.9% developed thyroid-related adverse events, and 4.6% experienced hypophysitis. Thyroid autoantibodies were associated with a higher incidence of thyroid-related irAEs (P = 0.004). In the irAE group, median pre-ICI CXCL10 and baseline thyroid stimulating hormone (TSH) levels were significantly higher, baseline total testosterone level in men was lower than in the non-irAE group (P < 0.05), whereas IL-1beta and IL-17A levels did not differ (P > 0.05). Serum CXCL10, IL-1beta, and IL-17A concentrations did not differ significantly pre-ICI and during adverse events (P > 0.05). Pre-ICI CXCL10 concentration was correlated positively with anti-TPO levels in patients with at least one thyroid autoantibody positivity (r = 0.706, P = 0.01) and negatively with baseline total testosterone level of men (r = 0.509, P = 0.002). Our results suggest that higher pre-ICI serum CXCL10 and TSH levels might have a predictive role in the development of endocrinopathies. Besides, baseline thyroid antibody measurements could be beneficial in predicting thyroid dysfunction. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Time-dependent characteristics of analytical measurands.
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Özçürümez, Mustafa K., Coşkun, Abdurrahman, Arzideh, Farhad, Streichert, Thomas, Quast, Christin, Canbay, Ali, Götze, Oliver, and Broecker-Preuss, Martina
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BLOOD collection , *CREATINE kinase , *BIOLOGICAL variation , *THYROTROPIN , *DIAGNOSTIC errors - Abstract
Biological variation is a relevant component of diagnostic uncertainty. In addition to within-subject and between-subject variation, preanalytical variation also includes components that contribute to biological variability. Among these, daily recurring, i.e., diurnal physiological variation is of particular importance, as it contains both a random and a non-random component if the exact time of blood collection is not known. We introduce four time-dependent characteristics (TDC) of diurnal variations for measurands to assess the relevance and extent of time dependence on the evaluation of laboratory results. TDC address (i) a threshold for considering diurnality, (ii) the expected relative changes per time unit, (iii) the permissible time interval between two blood collections at different daytimes within which the expected time dependence does not exceed a defined analytical uncertainty, and (iv) a rhythm-expanded reference change value. TDC and their importance will be exemplified by the measurands aspartate aminotransferase, creatine kinase, glucose, thyroid stimulating hormone, and total bilirubin. TDCs are calculated for four time slots that reflect known blood collection schedules, i.e., 07:00–09:00, 08:00–12:00, 06:00–18:00, and 00:00–24:00. The amplitude and the temporal location of the acrophase are major determinates impacting the diagnostic uncertainty and thus the medical interpretation, especially within the typical blood collection time from 07:00 to 09:00. We propose to check measurands for the existence of diurnal variations and, if applicable, to specify their time-dependent characteristics as outlined in our concept. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Human Amylin as a Novel Diagnostic Marker for Hypothyroidism in Iraqi Patients.
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Ibrahim, Duha Khalil and Farhan, Layla Othman
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THYROTROPIN ,PEPTIDE hormones ,AMYLIN ,IRAQIS ,HYPOTHYROIDISM - Abstract
Copyright of Baghdad Science Journal is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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23. Associations of gestational thyrotropin levels with disease progression among pregnant women with differentiated thyroid cancer: a retrospective cohort study.
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Xin Li, Peng Fu, Wu-Cai Xiao, Fang Mei, Fan Zhang, Shanghang Zhang, Jing Chen, Rui Shan, Bang-Kai Sun, Shi-Bing Song, Chun-Hui Yuan, and Zheng Liu
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LYMPHATIC metastasis ,CANCER diagnosis ,PREGNANCY outcomes ,PREGNANT women ,WATCHFUL waiting - Abstract
Purpose: Pregnant women with a diagnosis of differentiated thyroid cancer (DTC) were potentially high-risk but largely ignored study population. We aimed to explore whether gestational thyrotropin levels were associated with progression of DTC. Methods: We conducted a retrospective cohort study at Peking University Third Hospital in Beijing, China from January 2012 to December 2022. We included pregnant women with a pre-pregnancy DTC managed by active surveillance (under-surveillance DTC) or surgical treatment (after-surgery DTC). Dynamic changes of gestational thyrotropin levels across multiple time points were characterized by both statistical (average level, change instability, longitudinal trajectory) and clinical (thyroid dysfunction, thyrotropin suppression, and achievement of thyrotropin suppression target) indicators. Outcomes were clinician-validated progression of DTC, measured separately for patients under surveillance (tumor enlargement or lymph node metastasis) and those after surgery (≥ 3 mm growth in the size of existing metastatic foci, development of new lymph node metastases, ≥ 2 mm growth in the size of existing cancer foci in the contralateral thyroid, or biochemical progression). Results: Among 43 and 118 patients with under-surveillance and after-surgery DTC, we observed no evidence of associations between any of the quantitative or clinical indicators of gestational thyrotropin levels and progression-free survival, after a median of 2.63 (IQR: 0.90-4.73) and 4.22 (2.53-6.02) year follow-up, respectively (all P values > 0.05). Conclusions: Gestational thyrotropin levels appeared to play a minor role in the progression of under-surveillance or after-surgery DTC. Clinicians might focus on the risk of adverse pregnancy outcomes when optimizing thyrotropin levels for pregnant women with a diagnosis of DTC. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Defining Gestational Thyroid Dysfunction Through Modified Nonpregnancy Reference Intervals: An Individual Participant Meta-analysis.
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Osinga, Joris A J, Nelson, Scott M, Walsh, John P, Ashoor, Ghalia, Palomaki, Glenn E, López-Bermejo, Abel, Bassols, Judit, Aminorroaya, Ashraf, Broeren, Maarten A C, Chen, Liangmiao, Lu, Xuemian, Brown, Suzanne J, Veltri, Flora, Huang, Kun, Männistö, Tuija, Vafeiadi, Marina, Taylor, Peter N, Tao, Fang-Biao, Chatzi, Lida, and Kianpour, Maryam
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THYROID gland function tests ,THYROID diseases ,REFERENCE values ,THYROTROPIN ,HYPOTHYROIDISM ,PLACENTAL growth factor - Abstract
Background Establishing local trimester-specific reference intervals for gestational TSH and free T4 (FT4) is often not feasible, necessitating alternative strategies. We aimed to systematically quantify the diagnostic performance of standardized modifications of center-specific nonpregnancy reference intervals as compared to trimester-specific reference intervals. Methods We included prospective cohorts participating in the Consortium on Thyroid and Pregnancy. After relevant exclusions, reference intervals were calculated per cohort in thyroperoxidase antibody-negative women. Modifications to the nonpregnancy reference intervals included an absolute modification (per.1 mU/L TSH or 1 pmol/L free T4), relative modification (in steps of 5%) and fixed limits (upper TSH limit between 3.0 and 4.5 mU/L and lower FT4 limit 5-15 pmol/L). We compared (sub)clinical hypothyroidism prevalence, sensitivity, and positive predictive value (PPV) of these methodologies with population-based trimester-specific reference intervals. Results The final study population comprised 52 496 participants in 18 cohorts. Optimal modifications of standard reference intervals to diagnose gestational overt hypothyroidism were −5% for the upper limit of TSH and +5% for the lower limit of FT4 (sensitivity,.70, CI, 0.47-0.86; PPV, 0.64, CI, 0.54-0.74). For subclinical hypothyroidism, these were −20% for the upper limit of TSH and −15% for the lower limit of FT4 (sensitivity, 0.91; CI, 0.67-0.98; PPV, 0.71, CI, 0.58-0.80). Absolute and fixed modifications yielded similar results. CIs were wide, limiting generalizability. Conclusion We could not identify modifications of nonpregnancy TSH and FT4 reference intervals that would enable centers to adequately approximate trimester-specific reference intervals. Future efforts should be turned toward studying the meaningfulness of trimester-specific reference intervals and risk-based decision limits. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Obesity may impair response to ovarian stimulation. A retrospective observational study on oocyte quality.
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Iavarone, Irene, Mele, Daniela, Caprio, Francesca, Andreoli, Giada, Vastarella, Maria Giovanna, de Franciscis, Pasquale, and Ronsini, Carlo
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OVARIAN follicle ,OVARIAN reserve ,INDUCED ovulation ,OBESITY in women ,THYROTROPIN - Abstract
Background: Ovulatory dysfunction is more common in women with obesity. Body fat distribution is also crucial because anovulatory women have a greater waist circumference and more abdominal fat than ovulatory women of similar BMI. The primary aim of the present study is to determine whether there is a relationship between BMI and reproductive characteristics, including hormonal values, antral follicle count (AFC), endometrial assessment at transvaginal ultrasound evaluation (TVUS) during controlled ovarian stimulation (COS), and oocyte retrieval after Ovum Pick-Up (OPU). Methods: Data from a cohort of 183 patients were analyzed and divided into three groups based on weight status: normal weight, overweight, and obesity. Evaluated reproductive characteristics included: age, basal values of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17-beta-estradiol (E2), thyroid stimulating hormone (TSH), anti-müllerian hormone (AMH), antral-follicle-count (AFC), duration of COS, E2, and progesterone at the last monitoring, TVUS endometrial thickness at the last monitoring before OPU, FOI after OPU. Additionally, the number of meiosis II oocytes retrieved (MII), the total dose of FSH administered, the ratio between MII and total FSH administered, and OSI were registered. Results: AMH levels were significantly lower in obese patients compared to normal weight and overweight women (1.05 IQR 1.20, 1.58 IQR 2.16, 1.32 IQR 1.38, respectively, p-value = 0.032). When looking at the MII/FSH ratio, the normal weight group showed a median value of 3.3 with an IQR of 4.0, the overweight group showed a median value of 2.3 with an IQR of 1.9, and the obese group had a median value of 2.6 with an IQR of 2.8. Those data were statistically significant (p-value = 0.049). Conclusion: These results emphasize the importance of considering weight status in fertility assessment and treatment planning. [ABSTRACT FROM AUTHOR]
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- 2024
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26. TSH enhances neurite outgrowth.
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Mansoori, Maryam, Latif, Rauf, Morshed, Syed A., Zaidi, Mone, and Davies, Terry F.
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HORMONE receptors ,NEURONAL differentiation ,THYROTROPIN ,PROTEIN expression ,NEURODEGENERATION - Abstract
Extra-thyroidal effects of TSH have been reported in various tissues expressing the TSH receptor (TSHR) including several areas of the brain. However, the influence of TSH on neuronal phenotypes has not been examined. Using a wellcharacterized human neuroblastoma cell line (SH-SY5Y), we have examined TSH signaling effects on the phenotype of these cells after their neuronal differentiation. Following an 18-day differentiation protocol, we successfully redifferentiated the SH-SY5Y cells into ~100% neuronal cells as indicated by the development of extensive neurofilaments with SMI-31 expression. Furthermore, using absolute digital PCR, we quantified TSHR mRNA, and also TSHR protein expression, in the redifferentiated cells and found that the neuronal cells expressed high quantities of both TSHR message and protein at baseline. Exposure to TSH induced primary, secondary, and tertiary neurite outgrowths, which are essential for cell-cell communication. Quantitative analysis of neurites using ImageJ showed a dose-dependent increase in neurites. The addition of TSH up to 1 mU/ml resulted in a ~2.5-fold increase in primary, and ~1.5-fold in secondary and tertiary neurites. The lengths of the neurites remained unaffected with the dosage of TSH treatment. Furthermore, TSHR signaling in the differentiated cells resulted in enhanced generation of cAMP, pPI3K, pAKT, and pNFkB pathways and suppression of pMAPK suggesting an influence of these signals in driving neurite outgrowth. These data showed that the TSH/TSHR axis in neurons may contribute to enhanced neurite outgrowth. The potential pathophysiological effects of TSH on the induction of neurite outgrowth and its relationship to neurodegenerative diseases remain to be explored. [ABSTRACT FROM AUTHOR]
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- 2024
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27. The change in thyroid function categories with time in patients with subclinical hypothyroidism: a systematic review and meta-analysis.
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Zhang, Xueqi, Zhang, Guofeng, Wang, Songwen, Jin, Jing, Zhang, Shimiao, and Teng, Xiaochun
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HYPOTHYROIDISM diagnosis , *HYPOTHYROIDISM treatment , *THYROXINE , *RISK assessment , *MEDICAL information storage & retrieval systems , *REFERENCE values , *THYROID gland function tests , *RESEARCH funding , *AUTOANTIBODIES , *SEX distribution , *AGE distribution , *META-analysis , *DESCRIPTIVE statistics , *THYROID hormones , *SYSTEMATIC reviews , *MEDLINE , *ODDS ratio , *THYROID gland , *MEDICAL databases , *THYROTROPIN , *ONLINE information services , *CONFIDENCE intervals , *HYPOTHYROIDISM , *DISEASE progression - Abstract
Background: Subclinical hypothyroidism (SCH) is characterized by elevated levels of thyroid hormone (TSH) and normal levels of free thyroxine (FT4). The outcomes of SCH patients are crucial for determining treatment plans; therefore, our aim is to summarize the existing prospective studies to understand the changes in thyroid function over time in SCH patients and the factors influencing these changes, providing references for clinical diagnosis and treatment. Methods: We searched PubMed, Embase, Cochrane Library, and Web of Science for prospective follow-up studies on natural outcomes of SCH published until September 2024. Results are presented as the overall risk ratio (RR) and 95% confidence intervals (CI). Results: We reviewed 8 prospective follow-up studies involving 1,859 individuals and extracted data from them for a meta-analysis. We found that when TSH levels are ≥ 10 mU/L, patients with SCH are more likely to progress to overt hypothyroidism (OH) (RR11.38, 95%CI 4.98–26.03, P<0.001) and were less likely to return to normal TSH levels (RR 0.20, 95%CI 0.09–0.42, P<0.001) compared to patients with TSH between 4.5 and 9.9 mU/L. In addition, patients who test positive for thyroid peroxidase antibodies (TPOAb) are more likely to progress to OH (RR 2.53, 95% CI 1.86–3.44, P < 0.001) and less likely to return to euthyroidism (RR 0.68, 95% CI 0.60–0.76, P < 0.001) compared to TPOAb-negative patients. Conclusion: The results indicated that a large proportion of patients diagnosed with SCH will return to normal TSH levels or maintain SCH. Additionally, patients with TSH levels ≥ 10 mU/L or positive for TPOAb are more likely to experience progression and should be closely monitored. However, we did not find any gender differences in the natural outcome of SCH. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Exercise Attenuates Doxorubicin‐Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR‐30d‐5p/GALNT7.
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Wu, Haiyan, Zhou, Ruoyu, Kong, Hanxin, Yang, Jieqiong, Liu, Suijuan, Wei, Xiaolin, Li, Kunzhi, Zhang, Yunmei, and Fang, Weirong
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THYROID hormone receptors , *MYOCARDIAL injury , *THYROTROPIN , *CARDIOTOXICITY , *DOXORUBICIN - Abstract
Objective: Doxorubicin (DOX) is an extensively used chemotherapeutic agent that induces cardiotoxicity. Studies have reported that exercise (EXE) can alleviate DOX‐induced cardiotoxicity. Therefore, this study aimed to explore the mechanism by which EXE attenuates DOX‐induced myocardial injury. Methods: In this study, cell and animal models of DOX‐induced myocardial injury were constructed. The animal model was subjected to EXE intervention. Results: In this study, in vitro experiments revealed that miR‐30d‐5p negatively regulated polypeptide N‐acetylgalactosaminyltransferase 7 (GALNT7) and that GALNT7 negatively regulated the expression of thyroid stimulating hormone receptor (TSHR). miR‐30d‐5p downregulated the expression of GALNT7, promoted the expression of TSHR, and promoted macrophage M1 polarization, thus aggravating cardiomyocyte injury. In vivo experiments revealed that EXE intervention significantly downregulated miR‐30d‐5p and TSHR expression, upregulated GALNT7, reduced inflammation, and promoted M2 macrophage polarization, thereby alleviating DOX‐induced myocardial injury. In addition, overexpression of miR‐30d‐5p or knockdown of GALNT7 weakened the intervention effect of EXE, whereas overexpression of GALNT7 or knockdown of TSHR promoted the effect of EXE. Conclusion: EXE can modulate the miR‐30d‐5p/GALNT7 axis to inhibit the expression of TSHR, thereby regulating the polarization of macrophages to the M2 phenotype and ultimately alleviating DOX‐induced myocardial injury, which provides new targets and strategies for the clinical treatment of myocardial injury. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Serum Adropin Levels Are Elevated in Patients With Hyperthyroidism.
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Wang, Xin, Chang, Xiaona, Wang, Qiu, Ding, Xiaoyu, Wang, Jiaxuan, Cui, Ruixiang, Wang, Guang, Liu, Jia, and Grzmil, Pawel
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HYPERTHYROIDISM diagnosis , *PREDICTIVE tests , *CROSS-sectional method , *THYROXINE , *REFERENCE values , *HORMONES , *RESEARCH funding , *DESCRIPTIVE statistics , *THYROID hormones , *TRIIODOTHYRONINE , *THYROTROPIN , *RADIATION doses , *BIOMARKERS , *REGRESSION analysis - Abstract
Objective: Adropin is a unique hormone, which controls metabolism and energy homeostasis. Hyperthyroidism is a disease with a high metabolic rate that affects both glucose and lipid metabolism. We aimed to investigate the change of adropin levels and the association between adropin levels and clinical parameters in patients with hyperthyroidism. Methods: This cross‐sectional study comprised 90 newly diagnosed patients with hyperthyroidism and 90 age‐ and gender‐matched healthy controls. Circulating adropin levels and thyroid hormone levels were evaluated in each participant. Results: Compared with the healthy controls, the hyperthyroid patients had significantly higher levels of serum adropin (p < 0.001). In addition, adropin levels were positively correlated with free triiodothyronine (FT3) and free thyroxine (FT4), whereas they were negatively correlated with thyroid‐stimulating hormone (TSH). A multivariate linear regression analysis showed that serum adropin concentrations were independently correlated with FT3 and TSH after adjustment for age, gender, and other confounding factors (FT3: β = 0.231, p < 0.05; TSH: β = −0.301, p < 0.05). Conclusions: Patients with hyperthyroidism had elevated serum adropin levels. And the serum adropin concentrations were independently correlated with the FT3 and TSH levels. [ABSTRACT FROM AUTHOR]
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- 2024
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30. The association between circulating saturated fatty acids and thyroid function: results from the NHANES 2011-2012.
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Wei Zhao, Xinnan Peng, Yazhuo Liu, Shen Li, Xinyu Li, Zhengnan Gao, Cheng Han, and Zizhao Zhu
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HEALTH & Nutrition Examination Survey ,SATURATED fatty acids ,THYROTROPIN ,THYROID hormones ,IODIDE peroxidase - Abstract
Background: Excessive saturated fatty acids (SFAs) are known to be detrimental to human health. Although the majority of research and dietary guidelines have focused on the intake of SFAs, there has been limited attention to the relationship between circulating SFA levels and hormonal regulation, such as that of thyroid hormones. Methods: To explore potential associations, we conducted an investigation with 579 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. Subgroup analyses and multivariable linear regression models were used to estimate the relationships between eleven distinct SFA concentrations and various thyroid parameters. Results: For 579 adults, subgroup analysis of thyroid stimulating hormone (TSH) revealed significant differences in nine specific SFAs and the total SFA levels (all p < 0.05). Furthermore, multivariable linear regression analysis identified positive correlations between certain SFAs and various parameters, including TSH, total triiodothyronine (TT3), free triiodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), thyroglobulin (Tg), the ratio of FT3 to free thyroxine (FT4) (FT3/FT4), and the thyrotroph T4 resistance index (TT4RI). Conversely, negative correlations were observed between certain SFAs and total thyroxine (TT4), FT4, the ratio of FT3/TT3, and the thyroid feedback quantilebased index (TFQI) (all p < 0.05). Conclusion: These findings collectively suggest associations between SFAs and thyroid parameters, highlighting the need for future studies to elucidate the underlying mechanisms of these interactions. [ABSTRACT FROM AUTHOR]
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- 2024
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31. 甲状腺激素敏感性指标与乳腺癌风险的相关性研究.
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刘皓然, 方子豪, 廖定君, and 陈学彰
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TRIIODOTHYRONINE , *THYROXINE , *THYROTROPIN , *BREAST cancer , *THYROID cancer - Abstract
Objective To analyze whether there is a threshold effect between thyroid hormone sensitivity indexes and breast cancer, and to analyze the subgroup analysis and interaction test of age. Methods 2 892 adults from NHANES were collected between 2007 and 2012, including 83 breast cancer patients. Central thyroid hormone sensitivity indices were calculated, including Thyroid Feedback Quantile Index for T4(TFQIFT4) and T3(TFQIFT3), Thyroid Stimulating Hormone T4 Resistance Index(TT4RI), Thyroid Stimulating Hormone T3 Resistance Index(TT3RI), and TSH Index(TSHI), as well as peripheral thyroid hormone sensitivity index FT3/FT4. The association between breast cancer and the thyroid system was investigated using a multivariable logistic regression model. Smooth curve fitting and stratified analysis were used too, and subgroup analysis and interaction tests were performed based on age. Results Model3 showed that Thyroid Stimulating Hormone (TSH) (OR=1.33, 95%CI:1.08-1.63), TFQIFT4(OR=2.61, 95%CI:1.25-5.45), TFQIFT3(OR=3.15, 95%CI:1.18-8.44), TT4RI(OR=1.03, 95%CI:1.01-1.05), TT3RI(OR=1.10, 95%CI:1.03-1.18), and TSHI(OR=1.68, 95%CI:1.14-2.50) were significantly positively associated with the risk of breast cancer. A linear relationship with breast cancer was observed when TFQIFT3≥0.7, TSHI≥2.4, and TT4RI<50(P<0.05). TFQIFT4 showed a threshold effect(likelihood ratio test=0.040) when TFQIFT4<0.25. The relationship between TFQIFT4 and breast cancer was not significant(OR=1.07, 95%CI:0.36-3.15), but when TFQIFT4≥0.25, it was significantly associated with an increased risk of breast cancer(OR=12.79, 95%CI:2.50-65.40). Subgroup analysis further revealed that in women over 55 years old, increased central thyroid hormone sensitivity indices were associated with breast cancer risk(P<0.05). Conclusion Increased central thyroid hormone sensitivity indices are significantly associated with the risk of breast cancer, which may be a potential indicator for breast cancer detection in the future. [ABSTRACT FROM AUTHOR]
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- 2024
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32. An Update on Advances in Hypopituitarism: Etiology, Diagnosis, and Current Management.
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Iglesias, Pedro
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HORMONE therapy , *PITUITARY tumors , *GENETIC mutation , *ENDOCRINE diseases , *PITUITARY hormones , *HYPOPITUITARISM - Abstract
This article provides an updated review of hypopituitarism (HP), an endocrine disorder characterized by a deficiency of one or more pituitary hormones. The various etiologies are reviewed, including pituitary neuroendocrine tumors (PitNETs), hypothalamic lesions, genetic mutations, and acquired factors such as head trauma, medications, neoplasms, and infiltrative diseases. It is noted that PitNETs are responsible for approximately half of the cases in adults, whereas in children the causes are predominantly congenital. Diagnosis is based on clinical evaluation and hormonal testing, with identification of the specific hormonal deficiencies essential for effective treatment. Laboratory tests present challenges and limitations that must be understood and addressed. Hormone replacement therapy is the mainstay of treatment, significantly improving patients' quality of life. It is important to know the possible interactions between hormone replacement therapies in HP. Recent advances in understanding the pathophysiology of HP and the importance of a multidisciplinary approach to the management of associated complications are discussed. This article emphasizes the need for comprehensive evaluation and continuous follow-up to optimize outcomes in patients with HP and highlights the importance of ongoing research to improve diagnostic and treatment strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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33. New onset of Graves' disease after controlled ovarian stimulation: A case report and brief literature review.
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Vassallo, Alberto, Di Filippo, Luigi, Frara, Stefano, Bertoli, Massimo, Pagani, Mauro, and Presciuttini, Barbara
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INDUCED ovulation , *LITERATURE reviews , *RECEPTOR antibodies , *THYROTROPIN , *THYROID gland - Abstract
De novo onset of Graves' disease (GD) after controlled ovarian stimulation (OS) is exceptional. Only one case of progression to GD after OS in a patient with pre‐existing subclinical hyperthyroidism has been reported. We describe the case of a patient with neither previous thyroid disorders nor autoimmunity who developed GD after OS for primary infertility. A 40‐year‐old woman with primary infertility underwent four cycles of OS. Her thyroid function performed before the last cycle was unremarkable (thyroid stimulating hormone [TSH] 1.9 mU/L, fT4 1.3 ng/dL, fT3 2.4 pg/mL), and thyroid autoimmunity was negative (anti‐thyroperoxidase antibodies and anti‐thyroglobuline antibodies). Six weeks after the last cycle she developed overt thyrotoxicosis (TSH < 0.005 mU/L, fT4 4.79 ng/dL, fT3 15.6 pg/mL) with anti‐thyrotropin receptor antibodies (TRAb) positivity (9.2 IU/L). She was diagnosed with GD and anti‐thyroid therapy was instituted. After 1 year of treatment, thyroid function was still suboptimal (TSH 0.2 mU/L, fT4 1.04 ng/dL, fT3 2.2 pg/mL), and TRAb titer still elevated (8.75 IU/L). Despite her desire to achieve pregnancy, a further cycle of OS was postponed until complete remission of thyroid dysfunction and withdrawal of anti‐thyroid therapy. Although TSH assay after OS is not recommended in euthyroid women without autoimmunity, in the presence of hyperthyroid symptoms throughout OS it is advisable to evaluate thyroid function and TRAb. It is advisable to carefully evaluate the course of GD before proceeding with further courses of OS that could lead to its exacerbation or recurrence. In cases where a strong desire for pregnancy persists, thyroidectomy may be proposed. [ABSTRACT FROM AUTHOR]
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- 2024
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34. Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin.
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Kehinde, Samuel Abiodun, Fatokun, Tolulope Peter, Olajide, Abosede Temitope, Praveena, Sarva Mangala, Sokan-Adeaga, Adewale Allen, Adekunle, Adegbola Philip, Fouad, Dalia, and Papadakis, Marios
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POLLUTANTS , *THYROTROPIN , *CONSUMER goods , *OXIDANT status , *NARINGIN , *PLASTIC marine debris , *THYROID hormones - Abstract
The widespread presence of microplastics in the environment has raised significant concerns regarding their potential impact on human and animal health. Among various microplastic types, polyethylene microplastics (PE-MPs) are particularly prevalent due to the extensive use in packaging and consumer products. Exploring the uncharted therapeutic potentials of naringin, this study delves into its mitigating effects on disruptions in kallikrein-3 levels, steroidal-thyroidal hormone balance, and antioxidant defense triggered by PE-MPs exposure, paving the way for novel interventions in environmental toxin-induced endocrine and oxidative stress disorders. Male Wistar rats (n = 24) were randomly grouped into four: Control, PE-MPs (1.5 mg/kg), PE-MPs + NAR (1.5 mg/kg PE-MPs + 100 mg/kg NAR), and NAR (100 mg/kg). Hormonal and antioxidant parameters were assessed after 28 days of exposure. PE-MPs exposure caused a significant increase(p < 0.005) in the level of kallikrein-3 (KLK-3) while it significantly reduces the levels of testosterone (TST), luteinizing hormone, thyroid stimulating hormone (TSH) and Free-triiodothyronine (fT3) and Total cholesterol (TChol) concentration. PE-MPs exposure also disrupted significantly (p < 0.005) antioxidant profile by down-regulating the activities of glutathione-S-transferase, catalase (CAT), superoxide dismutase (SOD) and reducing levels of glutathione (GSH) and ascorbic acid (AA) while concentration of malondialdehyde (MDA) levels were increased relative to control. However, the mitigating potentials of naringin on disruptions in hormonal and antioxidant profiles caused by PE-MPs exposure were demonstrated, as NAR normalized KLK-3, steroid, and thyroid hormone levels, cholesterol concentration, and enhanced antioxidant defense. This suggests that NAR is a promising protective agent against endocrine and oxidative damage induced by environmental contaminants such as microplastics. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Adult reference intervals for serum thyroid‐stimulating hormone using Abbott Alinity i measuring system.
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Stefanska, Anna, Krintus, Magdalena, Siodmiak, Joanna, Wolska, Aleksandra, Szternel, Lukasz, Gackowska, Lidia, and Panteghini, Mauro
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LANGUAGE models , *THYROTROPIN , *LITERATURE reviews , *CARDIOVASCULAR diseases risk factors , *MANN Whitney U Test , *THYROID hormone regulation , *IMMUNOASSAY , *THYROTROPIN receptors , *THYROID gland function tests - Published
- 2024
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36. Biological rhythms in premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.
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Nexha, Adile, Caropreso, Luisa, de Azevedo Cardoso, Taiane, Suh, Jee Su, Tonon, André C., and Frey, Benicio N.
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PREMENSTRUAL syndrome , *SLEEP quality , *CIRCADIAN rhythms , *BIOLOGICAL rhythms , *THYROTROPIN - Abstract
Background: Women with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) typically experience a range of psychological and physiological symptoms that negatively affect their quality of life. Disruption in biological rhythms, including alterations of the sleep–wake cycle, have been implicated in PMS/PMDD, though literature is still growing to substantiate these findings. The objective of this study is to systematically review the available literature on biological rhythms disruption in PMS/PMDD. Methods: A literature search was conducted on four databases (Pubmed, Embase, Medline, and Web of Science) on December 3rd, 2021. This search yielded a total of 575 articles that assessed the relationship between biological rhythms and PMS/PMDD/premenstrual symptoms. Results: After the exclusion of irrelevant articles and hand-searching references, 25 articles were included in this systematic review. Some studies showed that women with PMS/PMDD present lower melatonin levels, elevated nighttime core body temperature, and worse subjective perception of sleep quality when compared to women without PMS/PMDD. Other biological rhythms parameters showed either no differences between groups (wrist actimetry) or conflicting results (objective sleep parameters, cortisol, prolactin, and thyroid stimulating hormone). Conclusion: Current research demonstrates that women with PMS/PMDD experience lower melatonin levels, higher body temperature, and worse subjective perception of sleep quality. This review outlines some possible mechanisms behind these findings and proposes recommendations for future research. This systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42020149921. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Analysis of bone mineral profile and TSH in early non-dialysis stages of chronic kidney disease - a retrospective cross-sectional study.
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Rajan, Immaculate Rithika, Elango, Karthick, Selvarajan, Sathya, Krishnamurthy, Sowmya, and Sathyamoorthy, Sridharan Kopula
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THYROTROPIN , *VITAMIN D , *GLOMERULAR filtration rate , *CHRONIC kidney failure , *RENAL osteodystrophy - Abstract
The objective of this study is to analyse the levels of Thyroid stimulating hormone (TSH) and the Bone Mineral Profile (Vitamin D, Parathyroid hormone (PTH), calcium, phosphorus, magnesium, and alkaline phosphatase [ALP]) levels in the early stages of chronic kidney disease (CKD) based on Glomerular filtration rate (GFR). A retrospective analysis was conducted involving 247 CKD patients admitted to the nephrology department at Sri Ramachandra Medical College Hospital from January to June 2022. The estimated GFR (eGFR) was calculated utilizing the CKDEPI formula provided by the National Kidney Foundation. All biomarkers were analysed using automated platforms. The baseline ages for the three groups were 52.5, 68, and 66.5 years respectively (p<0.001). The comparative analysis revealed statistically significant differences solely among Vitamin D, creatinine, PTH, and phosphorus across the three groups. Further correlation analysis demonstrated changes in bore significant correlations with only creatinine, vitamin D, and PTH. This study concludes that in the early stages of CKD, vitamin D followed by PTH appears to be the earliest biomarker for assessing CKD-Mineral and Bone Disorder (CKD-MBD) occurring prior to any alterations in calcium and phosphate levels. As such, early consideration of supplementation may prove beneficial in mitigating disease progression and preventing cardiovascular complications. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Gender-specific Association between Thyroid Stimulating Hormone and Haematological Indices in Hypothyroid Patients: A Cross-sectional Study.
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POLISETTY, LOHITHA and SINHA, SMRITI
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HYPOTHYROIDISM , *THYROTROPIN , *BLOOD cell count , *CROSS-sectional method , *ERYTHROCYTES - Abstract
Introduction: Hypothyroidism has long been known to cause metabolic deceleration, including its effects on haematopoietic tissue, leading to anaemia. Anaemia and hypothyroidism can co-exist and present challenges for each other, resulting in a decline in quality of life. Aim: To address the gender-specific association of Thyroid Stimulating Hormone (TSH) with various haematological indices among a cohort of hypothyroid patients. Materials and Methods: A cross-sectional observational study was conducted at a tertiary care teaching hospital in Hyderabad, Telangana, India, from October 2022 to February 2023, after obtaining ethical clearance from the institutional ethics committee. A total of 347 newly diagnosed, biochemically proven hypothyroid patients attending the hospital were included in the study. The patients were divided into subclinical and overt hypothyroid groups based on their TSH values and thyroxine levels. All patients underwent blood tests for a complete blood count, including all haematological indices such as erythrocyte count, Haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), and Red cell Distribution Width (RDW). Gender-based stratification of the study population was performed. Data were analysed using the Student's unpaired t-test, Chi-square test, and univariate linear regression with Statistical Package for the Social Sciences (SPSS) version 22.0. Results: The study highlighted a high prevalence of anaemia among overt hypothyroid patients 88 (54%) compared to subclinical hypothyroid patients 63 (34.24%). Moreover, the prevalence of anaemia was higher in females than in males. The most common type of anaemia encountered was microcytic anaemia, followed by normocytic anaemia. Linear regression analysis yielded a positive correlation between TSH and all haematological parameters, including RDW. This correlation was especially significant among females. Conclusion: TSH affected all the haematological parameters, including RDW, and the association was stronger in females as compared to males in both subclinical and overt hypothyroidism. [ABSTRACT FROM AUTHOR]
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- 2024
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39. TSH Stimulation before PET/CT as Our Frenemy in Detecting Thyroid Cancer Metastases—Final Results of a Retrospective Analysis.
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Kołodziej, Maciej, Saracyn, Marek, Lubas, Arkadiusz, Brodowska-Kania, Dorota, Mazurek, Andrzej, Dziuk, Mirosław, Durma, Adam Daniel, Niemczyk, Stanisław, and Kamiński, Grzegorz
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THYROID gland tumors , *RECEIVER operating characteristic curves , *RESEARCH funding , *POSITRON emission tomography computed tomography , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *METASTASIS , *MEDICAL records , *ACQUISITION of data , *THYROTROPIN - Abstract
Simple Summary: Non-iodine avid differentiated thyroid cancer (DTC) may be a diagnostic problem, especially in patients with an indeterminate response to treatment (i.e., with thyroglobulin (Tg) concentration in the range of 1–10 ng/mL). PET/CT with [18F]FDG may be a useful technique for visualizing non-iodine avid DTC lesions. Presented study assessed the usefulness of using exogenous stimulation with recombinant human TSH (rhTSH) before PET/CT with [18F]FDG in detecting non-iodine avid foci of DTC in patients with elevated sTg and negative 131I WBS and the usefulness of Tg concentration in predicting a positive result of [18F]FDG PET/CT in this type of patients and to determine the optimal Tg cut-off point for obtaining a positive [18F]FDG PET/CT result. In a retrospective analysis including 73 patients with DTC suspected of having non-iodine avid recurrence or metastases there was no effect of rhTSH stimulation on the sensitivity and specificity of PET/CT, but a positive impact on the number of lesions visible in the examination was observed. Moreover, rhTSH stimulation allowed for visualization of non-iodine avid lesions with lower Tg concentration. Introduction: Non-iodine avid metastases of differentiated thyroid cancer (DTC) can be found using PET/CT with a fluorine-18-labeled glucose analog ([18F]FDG). There are ongoing discussions on the appropriateness of using exogenous thyrotropin (TSH) stimulation before this examination. Material and Methods: In a retrospective study, 73 PET/CT scans with [18F]FDG performed after exogenous stimulation with recombinant human TSH (rhTSH) and without such stimulation were analyzed. All analyzed patients were suspected of having non-iodine-avid foci of DTC. Results: The stimulation with rhTSH before the PET/CT did not affect the percentage of positive results: 37.5% (18/48) with rhTSH and 40% (10/25) without rhTSH (p = 0.83). The analysis of the ROC curves established the cut-off thyroglobulin point for a positive PET/CT result separately for both subgroups. There was no statistically significant difference between obtaining a positive PET/CT result and the baseline thyroglobulin concentration (both stimulated and unstimulated). The exogenous stimulation of TSH prior to the PET/CT had no effect on the [18F]FDG uptake in the PET/CT lesions. Conclusions: PET/CT with [18F]FDG remains a useful method for the diagnosis of non-iodine-avid DTC lesions; in the presented group, a positive effect of rhTSH stimulation on the number of DTC foci visible in the PET/CT was found, but without affecting its effectiveness. [ABSTRACT FROM AUTHOR]
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- 2024
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40. Prognostic Implications of Maintaining the Target Thyroid-Stimulating Hormone Status Based on the 2015 American Thyroid Association Guidelines in Patients with Low-Risk Papillary Thyroid Carcinoma after Lobectomy: A 5-Year Landmark Analysis.
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Jeon, Ye Won, Suh, Young Jin, and Lim, Seung Taek
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RISK assessment , *MEDICAL protocols , *REFERENCE values , *THYROID gland tumors , *CANCER relapse , *RECEIVER operating characteristic curves , *SURGERY , *PATIENTS , *PAPILLARY carcinoma , *DESCRIPTIVE statistics , *CANCER patients , *KAPLAN-Meier estimator , *THYROTROPIN , *COMPARATIVE studies , *CONFIDENCE intervals , *SURVIVAL analysis (Biometry) , *THYROIDECTOMY , *PROPORTIONAL hazards models , *REGRESSION analysis , *DISEASE risk factors - Abstract
Simple Summary: Thyroid cancer is very common, with approximately 580,000 cases reported worldwide in 2020. Proper evaluation and management are necessary to ensure maximum patient care. It is important to consider the entire thyroid stimulating hormone (TSH) test results rather than the average or partial TSH test results to accurately evaluate the TSH status of patients with low-risk papillary thyroid carcinoma (PTC) after lobectomy. In patients with low-risk PTC after lobectomy, recurrence-free survival can be worse if the TSH status of patients, despite fulfilling the 2015 American Thyroid Association guideline recommendations, is maintained below a certain percentage among the total number of TSH tests during the postoperative follow-up period. Clinicians should make deliberate efforts to maintain the postoperative TSH status of patients with low-risk PTC who underwent lobectomy within an appropriate level during the postoperative follow-up period using thorough examinations. Background: The 2015 American Thyroid Association guidelines recommend the maintenance of serum thyroid stimulating hormone (TSH) levels ≤2 mIU/L in patients with low-risk papillary thyroid carcinoma (PTC) who underwent lobectomy; however, the evidence is insufficient. We investigated the association between maintaining the TSH status at ≤2 mIU/L and tumor recurrence in patients with low-risk PTC who underwent lobectomy through a 5-year landmark analysis. Methods: Between 2010 and 2016, 662 patients with low-risk PTC were included. The postoperative TSH status was determined using the 'TSH > 2 ratio', which was calculated using the TSH test results during the 5-year follow-up. The optimal cutoff value of 'TSH > 2 ratio' for tumor recurrence was determined using a receiver operating characteristic curve analysis. Recurrence-free survival (RFS) was compared between the groups using Kaplan–Meier and Cox proportional hazard regression analyses. Results: Patients with 'TSH > 2 ratio' > 0.1833 (n = 498) had a worse RFS outcome compared to patients with 'TSH > 2 ratio' ≤ 0.1833 (n = 164; p < 0.001). 'TSH > 2 ratio' > 0.1833 was a significant risk factor for tumor recurrence after the 5-year landmark (hazard ratio: 4.795, 95% confidence interval: 2.102–10.937, p < 0.001). Conclusions: Maintaining TSH levels ≤ 2 mIU/L below a certain percentage among the total TSH tests during the 5-year follow-up period has a negative impact on tumor recurrence. [ABSTRACT FROM AUTHOR]
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- 2024
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41. The Association Between Hypothyroidism and Cognitive Function Change in Women across the Menopause Transition: The Study of Women's Health Across the Nation.
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Ettleson, Matthew D., Karavolos, Kelly, Burnett-Bowie, Sherri-Ann M., Powell, Lynda H., and Janssen, Imke
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COGNITIVE processing speed , *OLDER patients , *THYROID gland function tests , *THYROID diseases , *THYROTROPIN , *CONGENITAL hypothyroidism - Abstract
Background: Patients treated for hypothyroidism with levothyroxine (LT4) monotherapy may present with persistent hypothyroidism symptoms, including cognitive symptoms, despite having a normal thyroid stimulating hormone (TSH) level. It remains unclear whether LT4 monotherapy is sufficient to normalize cognitive function outcomes over time. Methods: This is a multisite longitudinal study of a diverse group of women during midlife representing 5 ethnic/racial groups from 7 enrollment sites across the United States in the Study of Women's Health Across the Nation. Women were screened for a history of thyroid disease and the use of LT4. The study consisted of two primary groups: women with LT4-treated hypothyroidism and control women without thyroid disease. Each participant completed up to 9 cognitive assessments over the study period testing processing speed, working memory, and episodic memory (immediate and delayed recall). Multivariable generalized linear mixed models of scores for each cognitive assessment were developed to determine the association between LT4-treated hypothyroidism and cognitive function trajectories. Covariates included sociodemographic, clinical characteristics, and menopausal status (pre/early peri, late peri, and surgical/post). Sensitivity analyses were conducted to assess the impact of abnormal TSH levels and practice effects (i.e., improvements in scoring after repeated testing). Results: Of the 2033 women who were included in the study, 227 (11.2%) met criteria for LT4-treated hypothyroidism. At baseline, both processing speed and working memory scores were higher in LT4-treated women (mean processing speed scores: 56.5 vs 54.4; p value = 0.006; mean working memory scores: 6.8 vs 6.4; p value = 0.018). However, when considering the effect of LT4-treated hypothyroidism over time, there were no significant differences in the rate of cognitive decline (in any measure) between the hypothyroidism and control groups with or without covariate adjustment. The results were similar when considering LT4-treated women with abnormal TSH levels or after minimizing practice effects. Conclusions: We observed no difference in cognitive decline between women with LT4-treated hypothyroidism and women without thyroid disease. For similar aged patients with cognitive complaints, if thyroid function testing is normal, clinicians should consider causes other than inadequate thyroid hormone treatment to explain these symptoms. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Subclinical Hyperthyroidism Enhances Gonadotropin‐Lowering Effects of Metformin in Postmenopausal Women.
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Krysiak, Robert, Kowalcze, Karolina, and Okopień, Bogusław
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TYPE 2 diabetes , *INSULIN sensitivity , *THYROTROPIN , *BLOOD sugar , *THYROID hormones , *THYROTROPIN receptors - Abstract
Metformin treatment decreases elevated concentrations of anterior pituitary hormones. The aim of this prospective, cohort study was to investigate whether hyperthyroidism modulates the impact of metformin on gonadotroph secretory function. The study population included 48 postmenopausal women with untreated type 2 diabetes or prediabetes, 24 of whom had coexisting grade 1 subclinical hyperthyroidism. Both groups were matched for age, insulin sensitivity, and gonadotropin levels. Over the entire study period, all participants were treated with metformin (2.55–3 g daily). Plasma glucose, insulin, thyroid‐stimulating hormone (TSH), total and free thyroid hormones, follicle‐stimulating hormone (FSH), luteinizing hormone (LH), estradiol, prolactin, adrenocorticotropic hormone (ACTH), and insulin‐like growth factor‐1 (IGF‐1) were assayed at entry and 6 months later. At baseline, the study groups differed in levels of TSH and thyroid hormones but not in body mass index, blood pressure, glucose homeostasis markers (fasting glucose, homeostatic model assessment 1 of insulin resistance ratio [HOMA1‐IR], and glycated hemoglobin [HbA1c]), and the remaining hormones. There were no differences between both groups in the degree of reduction in plasma glucose and HbA1c in response to metformin treatment. Although metformin decreased HOMA1‐IR in both groups, this effect was stronger in women with hyperthyroidism than with normal thyroid function (−50 ± 20% vs −30 ± 15%). Similar relationships were observed for FSH (−43 ± 21% vs −21 ± 12%). Only in hyperthyroid women did the drug reduce LH concentration (by 35 ± 17%). Metformin did not affect circulating levels of TSH, total and free thyroxine, total and free triiodothyronine, estradiol, prolactin, ACTH, and IGF‐1. The obtained results indicate that hyperthyroidism enhances the gonadotropin‐lowering effects of metformin, as well as the fact that this agent has a neutral effect on the hypothalamic–pituitary–thyroid axis in case of its overactivity. [ABSTRACT FROM AUTHOR]
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- 2024
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43. Short‐Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic‐Psycho Relevance.
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Chen, Lin, Ren, Ningning, Yang, Qing, Tian, Xingsong, and Falhammar, Henrik
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MENTAL depression risk factors , *RISK assessment , *THYROID gland tumors , *ATTITUDES toward illness , *SCIENTIFIC observation , *QUESTIONNAIRES , *MULTIPLE regression analysis , *ANXIETY , *DESCRIPTIVE statistics , *SEVERITY of illness index , *SURGICAL complications , *LONGITUDINAL method , *QUALITY of life , *ANXIETY testing , *SELF-report inventories , *THYROTROPIN , *CANCER patient psychology , *CANCER fatigue , *SLEEP quality , *PSYCHOLOGICAL tests , *EDUCATIONAL attainment , *MENTAL depression , *DISEASE incidence - Abstract
Objective: To understand whether TSH suppressive therapy affect short‐term postoperative cancer‐related depression and anxiety among DTC patients. To evaluate short‐term postoperative psychological problems and its relationship with baseline parameters, fatigue, sleep quality, illness perception, and patients' quality of life. Study Design and Methods: This was a prospective, observational, single center study. This study involved 831 TC patients who consecutively admitted to the inpatient department of hospital between 1st June 2020 and 31th February 2021. Results: Mean scores of the self‐rated anxiety scale (SAS) (49.04 vs. 40.69) and self‐rated depression scale (SDS) (44.61 vs. 39.86), as well as the incidence of anxiety (41.5% vs. 22.1%) and depression (22.5% vs. 2.4%) significantly decreased 3 months after surgery. For personal and clinical characteristics, low educational background (SAS, β = 1.392; SDS, β = 1.622; and p < 0.05), without children (SAS, β = 4.068; SDS, β = 1.873, and p < 0.01), FNAC (SAS, β = −0.981; SDS, β = −2.583; and p < 0.05), and multifocal tumor (SAS, β = −1.287; SDS, β = −2.681; and p < 0.05) were the main effects for both short‐term postoperative anxiety and depression. Multiple linear regression analysis identified the serum TSH level as a significant variable associated with worse SAS (Beta = −0.695 and p = 0.043) and SDS (Beta = −3.133 and p < 0.001) scores 3 months after surgery. FT4 was independently associated with SAS scores (Beta = −0.202 and p < 0.001). Patients with middle ATA risk had a significantly higher level of SDS scores (p = 0.033). Conclusion: We confirmed that cancer‐related anxiety and depression among DTC patients significantly alleviated 3 months after surgery. TSH suppression therapy has profound effects on cancer‐related anxiety and depression, and the degree of anxiety and depression significantly deteriorated with the decrease of TSH level. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Interpretation of TSH results can be improved by reference values fluctuating in time.
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Delanghe, Joris R., Van Elslande, Jan, Godefroid, Maaike, Speeckaert, Marijn M., and Maenhout, Thomas M.
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THYROTROPIN , *BIOLOGICAL variation , *MATHEMATICAL functions , *REFERENCE values , *CIRCADIAN rhythms - Abstract
The secretion of thyroid stimulating hormone (thyrotropin, TSH), is characterized by a marked circadian rhythm. Plasma or serum TSH values are significantly lower in the afternoon and in the evening as compared to the early morning. As in clinical practice, blood sampling time shows an important variation, a reliable assessment of thyroid status is often not an easy task for the clinician. The biological variation of TSH plays a major role in the intra-individual variability of TSH results in serum or plasma. The observed intra-day variation largely exceeds the reported inter-vendor variation and the coefficient of variation of clinical TSH assays. Therefore, a mathematical solution was sought for correcting interpretation of TSH results for sampling time.We have developed a cosinor model which allows to compensate TSH decision values for the fluctuating serum or plasma TSH concentrations throughout the day.The following mathematical function could be derived: corrected TSH cutoff_value (mIU/L)=0.40 + 0.24*cos(((π/12) *T) + 6) in which T represents the time (hours). This mathematical function can be easily implemented into a laboratory’s informatics system and furthermore allows a better tailored diagnosis of (subclinical) hyperthyroidism, regardless the blood sampling time.Implementing the corrected cut-off values result in a marked reduction of apparent (false positive) hyperthyroidism diagnosis, in particular in the afternoon. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Patient-Reported Outcomes of Depression and Fibromyalgia Symptoms Do Not Predict Non-Inflammatory versus Inflammatory Diagnoses at Initial Rheumatology Consultation.
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Schäfer, Arne, Kovacs, Magdolna Szilvia, Nigg, Axel, and Feuchtenberger, Martin
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STATISTICAL power analysis ,T-test (Statistics) ,RECEIVER operating characteristic curves ,FIBROMYALGIA ,RHEUMATOID arthritis ,MUSCULOSKELETAL system diseases ,LOGISTIC regression analysis ,QUESTIONNAIRES ,RETROSPECTIVE studies ,BLOOD sedimentation ,CHI-squared test ,LONGITUDINAL method ,PAIN ,OSTEOARTHRITIS ,MEDICAL records ,ACQUISITION of data ,ELECTRONIC health records ,HEALTH outcome assessment ,THYROTROPIN ,DATA analysis software ,MENTAL depression ,C-reactive protein ,VITAMIN D ,SYMPTOMS - Abstract
Objective: The objective of this study was to assess the potential value of patient-reported outcomes (PROs) of depression, fibromyalgia symptoms, and pain in predicting non-inflammatory vs. inflammatory diagnoses in rheumatology patients. Methods: This retrospective, single-center study evaluated electronic health record (EHR) data from adults who were seen for their first rheumatology consultation and subsequently received a diagnosis of an inflammatory (e.g., rheumatoid arthritis or spondyloarthritis) or non-inflammatory (e.g., osteoarthritis or fibromyalgia) condition. The PROs evaluated included depressive symptoms (Patient Health Questionnaire-2 [PHQ-2]), fibromyalgia symptom severity (FM SS), and pain. Results: A total of 3669 patients were evaluated, including patients with (n = 984; 26.82%) and without (n = 2685; 73.18%) inflammatory rheumatologic disease, of whom 141 (3.8%) had fibromyalgia. The non-inflammatory subgroup reported higher FM SS scores, and the inflammatory subgroup had higher pain and inflammatory markers. Bivariate models based on PHQ-2 and FM SS had a very low specificity (0.3%) for predicting non-inflammatory conditions, resulting in the misclassification of >99% of inflammatory cases. Adding pain, inflammatory markers, and other relevant EHR variables increased specificity but still resulted in a high level of misclassification. Conclusions: The PROs evaluated in this study are not suitable for predicting non-inflammatory vs. inflammatory rheumatologic disease, even when combined with other EHR variables. [ABSTRACT FROM AUTHOR]
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- 2024
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46. One sip of water with LT-4 supplementation—a key to euthyroidism in Hashimoto's thyroiditis.
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Schnedl, Wolfgang J., Michaelis, Simon, Mangge, Harald, and Enko, Dietmar
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Purpose: Recommended pharmacotherapy for hypothyroidism in Hashimoto's thyroiditis (HT) is oral supplementation with levothyroxine (LT-4). However, serum thyrotropin (TSH) levels within normal range are not consistently achieved with LT-4 medication. Patients and methods: We report on 35 HT patients with LT-4 therapy in this retrospective evaluation. In general, we recommend that a maximum of two sips of water, which would then amount to < 50 mL, be ingested at the same time as LT-4. We report on follow up examinations measuring TSH and antibodies against thyroid peroxidase (TPOAb) after 6 months to five years. Results: After median time of 643 days (range 98-1825) we found in 35 HT patients a statistical significant reduction of serum TSH (p < 0.001) and TPOAb (p = 0.006). The patients median body weight was 71 kg (range 48–98) and a daily LT-4 dosage was used with median 69.1 µg (range 25–150). This results in a daily LT-4 dose of median 1.01 µg/kg bodyweight (range 0.3–2.3). Conclusions: The reduction of water ingestion to a maximum of two sips, which is <50 mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT. [ABSTRACT FROM AUTHOR]
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- 2024
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47. Low Serum Fibroblast Growth Factor 21 Level and Its Altered Regulation by Thyroid Hormones in Patients with Hashimoto's Thyroiditis on Levothyroxine Substitution.
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Berta, Eszter, Halmi, Sándor, Molnár, István, Hutkai, Dávid, Csiha, Sára, Bhattoa, Harjit Pal, Lőrincz, Hajnalka, Somodi, Sándor, Katkó, Mónika, Harangi, Mariann, Paragh, György, Nagy, Endre V., and Bodor, Miklós
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AUTOIMMUNE thyroiditis ,LDL cholesterol ,ENZYME-linked immunosorbent assay ,MULTIPLE regression analysis ,THYROTROPIN ,FIBROBLAST growth factors - Abstract
Background/Objectives: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. We aimed to investigate serum FGF21 level and its relation to thyroid hormones and metabolic parameters among patients with Hashimoto's thyroiditis (HT). Methods: Eighty patients with HT on levothyroxine treatment and eighty-two age- and BMI-matched adults without thyroid disease serving as controls were enrolled. Serum FGF21 concentrations were determined with an enzyme-linked immunosorbent assay. Results: Median serum FGF21 level was significantly lower in HT patients compared with controls (74.2 (33.4–148.3) pg/mL vs. 131.9 (44.8–236.3) pg/mL; p = 0.03). We found a positive correlation between FGF21 and age, triglyceride, total cholesterol, and low-density lipoprotein cholesterol in both groups, while thyroid stimulating hormone and C-reactive protein showed a positive correlation, and thyroxine had an inverse correlation with FGF21 only in control subjects. According to multiple regression analyses, thyroid status is the main predictor of FGF21 in healthy controls, while it is not a significant predictor of FGF21 among HT patients on levothyroxine supplementation therapy. Conclusions: Our results indicate that the physiological role of thyroid function in the regulation of FGF21 synthesis is impaired in HT patients, which may contribute to the metabolic alterations characteristic of HT patients. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Glycated CD59 is a potential biomarker for gestational diabetes mellitus.
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Wanying Wang, Chong Xu, Xiaofan Lu, Wei Cao, Tengzi Zuo, Ying Zhang, Huiling Zou, and Yu Sun
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DIASTOLIC blood pressure ,ENZYME-linked immunosorbent assay ,RECEIVER operating characteristic curves ,GLUCOSE tolerance tests ,THYROTROPIN - Abstract
Objective: To explore the diagnostic value of glycated CD59 (gCD59) in gestational diabetes mellitus (GDM). Methods: A total of 707 pregnant women who underwent the first visit in the obstetric outpatient clinic of the Affliated Suqian Hospital of Xuzhou Medical University from January 2022 to July 2023 were included, and were grouped according to the International Association of the Diabetes and Pregnancy Study Groups(IADPSG) diagnostic criteria, and finally 113 cases in the GDM group and 559 cases in the normal glucose tolerance (NGT) group were included, and the concentration of gCD59 was determined by enzyme-linked immunosorbent assay (ELISA). The baseline data characteristics of the two groups were compared, the risk factors for GDM were explored by multivariate binary logistic analysis, and the diagnostic value of gCD59 in predicting GDM was explored by receiver operating characteristic (ROC) curve analysis. Results: The level of gCD59 in the GDM group was significantly higher than that in the NGT group (1.49 SPU vs 0.87 SPU). Multivariate regression analysis showed that gCD59, diastolic blood pressure (DBP) and thyroid stimulating hormone (TSH) were independent risk factors for GDM.The area under the curve (AUC) of gCD59 for the diagnosis of GDM was 0.681 (95% CI: 0.583-0.717), with a sensitivity of 71.7% and a specificity of 58.3%. In combination with fasting glucose, gCD59 effectively diagnosed GDM with higher AUC of 0.871 (95% CI: 0.708-1.000). Conclusion: gCD59 is an independent risk factor for GDM and a good biomarker for the diagnosis of GDM. [ABSTRACT FROM AUTHOR]
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- 2024
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49. ASSOCIATION OF SERUM CALCIUM AND ALBUMIN IN PATIENTS WITH HYPOTHYROIDISM.
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Maidala, Muhammad, Khan, Saba, Chowdhry, Shubhra, Srivastava, Rohit Kumar, Alam, Roshan, and Khan, Mohammad Mustufa
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ALBUMINS ,SERUM albumin ,THYROID hormone regulation ,BLOOD coagulation disorders ,THYROID gland function tests ,THYROTROPIN ,PEARSON correlation (Statistics) - Abstract
Thyroid hormones play a key role in the calcium homeostasis. Abnormal calcium levels in patients with hypothyroidism may lead to disease complications such as bone deformity, arthritis, blood clotting disorders, and nervous system dysfunctions. Several studies reported that serum calcium levels altered in patients with hypothyroidism, but results were inconsistent. It was aimed to determine the levels of serum calcium and serum albumin in patients with hypothyroidism. In this case-control study, a total of 60 subjects (30 hypothyroid patients and 30 age-matched healthy controls) were enrolled, aged between 18-60 years. Serum calcium and serum albumin were estimated along with thyroid function tests in each study subject. A student unpaired t-test was performed to compare the mean of variables. Pearson correlation analysis was performed among cases. A p-value < 0.05 was considered statistically significant. The mean of serum calcium, serum albumin, triiodothyronine (T3) and thyroxine (T4) were found significantly low in cases as compared to controls (p<0.001). However, the mean of thyroid stimulating hormone (TSH) was found significantly high in cases as compared to controls (p<0.001). A significant negative correlation was found between serum albumin and TSH among cases (r= -0.516, p<0.01). Serum calcium has shown a negative correlation with T3, T4 and TSH, but not significant. In conclusion, results showed that the mean of serum calcium, serum albumin, T3 and T4 were found significantly low in cases compared to controls. A significant negative correlation was found between serum albumin and TSH among cases. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Asociación entre resistencia a la insulina e hipotiroidismo subclínico en pacientes mexicanos que viven con obesidad.
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Balderas-Sánchez, Ramiro A. and Islas-Santiago, Yessica
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RISK assessment ,CROSS-sectional method ,STATISTICAL correlation ,ADIPOSE tissues ,OUTPATIENT medical care ,INSULIN resistance ,BLOOD sugar ,RESEARCH ,THYROTROPIN ,CARBOHYDRATE metabolism ,HYPOTHYROIDISM ,OBESITY ,DISEASE risk factors - Abstract
Copyright of Revista Mexicana de Endocrinología, Metabolismo y Nutrición is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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