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ABSTRACT Background Purpose Methods Results Conclusions Trial Registration Hypertension (HT) is a global health problem. Although there are effective treatment protocols, patients have difficulty in adapting to regular use of drugs, diet, and lifestyle changes. Mobile apps can be a potential alternative for managing HT and improving self‐care behavior.This study aimed to determine the effect of mobile application follow‐up on treatment compliance and self‐care management in patients with HT.This randomized controlled trial was conducted in November 2021 and March 2022 with 40 experimental and 40 control group patients with HT. Research data were collected using a patient information form, “Hill‐Bone Hypertension Treatment Compliance Scale (HBHTTCS),” “Hypertension Self‐Care Profile‐Motivation Scale (HTSPMS),” a mobile application program (daily blood pressure, pulse, medication, diet, exercise tracking) uploaded to the mobile phones of the patients, and individual motivational messages.The mean total score of the HBHTTCS at Week 6 was 14.57 ± 1.89 and the mean total score of the HTSPMS was 78.15 ± 2.05. There was a statistically significant difference in mean total HTSPMS (p = 0.000) and HBHTTCS (p = 0.000) scores and mean scores on medical (p = 0.002) and nutrition (p = 0.002) subscales of HBHTTCS between the first interview (1st‐week follow‐up) and the last interview (6th‐week follow‐up) of patients in the intervention group.This study showed that mobile application follow‐up increased motivation levels and treatment compliance in patients with HT and resulted in better self‐care. These positive findings indicate importance of integrating mobile applications in the disease management of HT patients.ClinicalTrials.gov ID: NCT05334446, https://clinicaltrials.gov/ct2/show/NCT05334446. [ABSTRACT FROM AUTHOR]

Objective To explore the influence of family member participatory nursing intervention mode on the disease control and self-management ability of patients with chronic arrhythmia. Methods A total of 126 patients with chronic arrhythmia were included in the study, and were divided into control group and observation group in the random drawing method, with 63 cases in each group, both given intervention for 3 months. The control group implemented routine nursing intervention mode, while the observation group adopted family member participatory nursing intervention mode on this basis. The scores of Mishel uncertainty in illness scale-family member form (MUIS-FM), self-management ability scale (SMAS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS), change of heart rate, treatment compliance, and complication rate were compared between the two groups before intervention, and 1 month and 3 months after intervention. Results After 1 month and 3 months of intervention, the scores of MUIS-FM, SAS and SDS in the observation group were all lower than those in the control group, while the score of SMAS was higher than that in the control group (all P < 0. 05). After 1 month of intervention, the minimum heart rate of the observation group was higher than that of the control group (P<0. 05); after 3 months of intervention, the resting heart rate and the minimum heart rate of the observation group were both higher than those of the control group (all P<0. 05). There was no statistically significant difference in the mean heart rate within 24 hours between the observation group and the control group after 1 month and 3 months of intervention (all P> 0. 05). The treatment compliance rate of the observation group was higher than that of the control group (96. 83% vs. 85. 71%, P<0. 05). There was no statistically significant difference in complication rate between the observation group and the control group (1. 59% vs. 9. 52%, P>0. 05). Conclusion Family member participatory nursing intervention mode could improve patients' emotional state, treatment compliance and self-management ability, and alleviate family members' uncertainty in illness, which helps patients with disease control. [ABSTRACT FROM AUTHOR]

Objectives: A 6‐week course of tetracycline eye ointment is an alternative to single ‐dose oral azithromycin in annual mass drug administration for trachoma control. Compliance with the recommended tetracycline eye ointment regimen has not been well characterised when administered as part of a trachoma control program. Methods: A routine mass drug administration for trachoma was carried out in 40 communities in the Amhara region of Ethiopia. Two tubes of tetracycline eye ointment, to be administered twice daily for 6 weeks, was offered to all children under 6 months of age, to pregnant women who declined to take azithromycin, and to all individuals with a macrolide allergy. Seven weeks following the mass drug administration, a treatment compliance survey was performed for all community members documented to have received tetracycline eye ointment during the mass drug administration. Results: Of the 491 individuals documented as having received tetracycline eye ointment from the treatment records, 367 completed the survey, of which 214 recalled being offered tetracycline eye ointment. A total of 105 (49%) respondents reported taking ≥1 daily dose of tetracycline eye ointment on most days of the week for at least the first week. Only 20 (9%) respondents reported taking at least 1 tetracycline eye ointment dose per week for 6 weeks. The most common reasons for low compliance included 'saving it for a future infection' and 'stopped because I (or my child) seemed healthy'. The odds of low compliance were greater for those who reported not having adequate counselling (e.g., odds ratio [OR] 5.3, 95% CI 2.5–28.9 when low compliance was defined as not taking a tetracycline eye ointment dose for most days of at least the first week). Conclusions: Compliance with tetracycline eye ointment was low when administered by a trachoma program during a routine mass drug administration, especially for those reporting inadequate counselling. Further research with a larger sample size and varied settings is warranted to better understand and improve compliance. [ABSTRACT FROM AUTHOR]

Aims/Background To implement a co-management mode among community-level diabetes patients and analyze its impact on diagnosis and treatment compliance and diabetic retinopathy of the patients. Methods A total of 80 patients who underwent diabetic retinopathy examination in Lanxi People's Hospital from January 2021 to March 2022 were retrospectively selected as the study objects. The clinical data of the patients were analyzed, including 40 patients who adopted the conventional diabetes management mode from January 2021 to August 2021 as the control group. From September 2021 to March 2022, 40 patients in the county medical service community diabetes management team model were adopted as the management group. The two groups of patients were compared in terms of diabetic retinopathy indictors, biochemical examination indicators, self-management ability, and nursing management satisfaction. Results Number of patients complying with treatment protocols in the management group was higher than that in the control group (p < 0.05). The blood spot area, macular thickness, hemangioma volume, and visual-field grayscale value in the management group at the last follow-up were all lower than those in the control group (p < 0.05). The levels of diastolic blood pressure (DBP), systolic blood pressure (SBP), fasting blood glucose (FBG), hemoglobin A1C (HbA1c), total cholesterol (TC), and triglyceride (TG) in the management group at the last follow-up were all lower than those in the control group (p < 0.05). The scores of disease cognition ability, self-management ability, and nursing management satisfaction in the management group were all higher than those in the control group (p < 0.05). Conclusion By changing management concept and implementing the whole-process management and treatment mode for diabetic patients within the scope of the county medical service community, the diagnosis and treatment compliance of the patients can be improved, and the effective control of blood glucose, blood pressure, and blood lipid levels can be achieved, thereby improving the self-management ability and nursing management satisfaction of the patients and providing a new nursing mode for chronic disease management. [ABSTRACT FROM AUTHOR]

Objective: Shortening the length of hospital stay (LOS) has become a major challenge for psychiatric hospitals in reducing unnecessary costs and improving the patient healthcare experience. We investigated the key factors associated with a long psychiatric hospitalization. Method: This was a retrospective study of 8,870 full-time psychiatric hospital stays (6,216 patients) in the Paris Psychiatry Hospital Group, with a discharge in 2022. We used machine learning tools and univariate and multivariate methods to explore the impact of demographic, pathway-related, and clinical variables on the LOS. Results: LOS >30 days was associated with age >55 years {odds ratio [OR] =2 [95% confidence interval 1.7--2.3]}, admission from outside the sectorization zone [OR=1.2 (1.1--1.3)], admission via a psychiatric emergency unit [OR, 1.2 (1.1-- 1.4)], and some clinical severity markers, such as psychotic disorder diagnosis [OR, 1.5 (1.3--1.7)], mandatory care [request of a third party, OR, 2.5 (2.1--2.9); case of imminent danger, OR, 2.3 (1.9--2.7)], the presence of seclusion and mechanical restraint measures (highlighting the positive effect of restraint duration), the somatic comorbidity for female sex [OR, 1.4 (1.2--1.7)], and treatment resistance [OR, 1.4 (1.2--1.6)]. Conversely, LOS ≤30 days was associated with being in a relationship [OR, 0.6 (0.5--0.8)], admission during a travel-related psychiatric episode [OR, 0.5 (0.3--0.6)], and personality and behavior disorders [OR, 0.7 (0.6--0.9)]. We found no significant association for features such as sex and a lack of treatment compliance. Conclusion: To our knowledge, this is the first recent study to investigate and highlight the impact of factors related to various illness severity markers, medication adherence, and patient journeys on the length of psychiatric hospital stay. A better understanding of long-stay risk factors might be helpful for optimizing the allocation of medical resources and anticipating tailored therapeutic programs. [ABSTRACT FROM AUTHOR]

Context: The annual incidence cases report depicts India as having the highest tuberculosis (TB) burden globally. Following a programmatic change, the daily fixed-dose combination (FDC) anti-TB treatment regimens were introduced by the Indian government’s National Tuberculosis Elimination Program (NTEP). Aims: The aim of the study was to assess the treatment outcomes among drug-sensitive pulmonary TB patients receiving daily FDC drugs and the associated factors influencing the treatment outcomes. Settings and Design: A prospective study was conducted among 300 drug-sensitive pulmonary TB cases in the Bruhat Bengaluru Mahanagara Palike (BBMP) area. Materials and Methods: The TB units and designated microscopic centers (DMCs) were selected by multistage random sampling. Data were collected through a pre-tested and semi-structured questionnaire. Patients were followed up until treatment completion. Statistical Analysis Used: Data were compiled and analyzed using IBM Statistical Package for Social Sciences (SPSS) statistics version 20.0. Descriptive statistics and the Chi-square test were used for interpretation. A P-value less than 0.05 was considered statistically significant. Results: Around 86.33% of patients were cured, 4% had completed treatment, and 1% had treatment failure. Older age, human immunodeficiency virus (HIV) reactive status, alcohol intake, tobacco use, and migrants were associated with poor outcomes. Conclusions: The daily FDC regimen had better outcomes than intermittent regimens. Smokers, alcoholics, migrants, and patients with co-morbidity need to be given priority in management as they are prone to poorer outcomes.

Objective: To investigate the therapeutic utility of psychological nursing interventions for prostatic hyperplasia clients while they are receiving therapy. Methods: Clinical data of 110 patients with prostate group hyperplasia who underwent treatment in our hospital were collected and analysed retrospectively, and the selected period was from October 2021 to October 2023. The 110 cases of prostate group hyperplasia patients were divided into a research group and a control group according to the different methods of care, and each group had 55 cases each. The research group received psychological nursing intervention based on the conventional nursing care given to the control group. The total treatment compliance rate and contentment with nursing were contrasted between the research and control groups, and changes in the Self Rating Anxiety Scale (SAS) score, Self Rating Depression Scale (SDS) score, Health Survey Short Form score, and sleep problems were observed between the research group and the control group. Results: The research group's overall compliance rate was 94.55% (52/53), a substantial increase over the control group's rate, 69.09% (38/55), P < 0.01. Following nursing, the research group's SAS and SDS scores were considerably more reduced than those of the control group, and both groups' scores were substantially lower than they were prior to nursing (P < 0.05). Conclusion: This retrospective study found that psychological nursing intervention applied to patients with prostatic hyperplasia can effectively improve the patient's compliance with treatment, effectively reduce the occurrence of negative emotions, improve the patient's quality of life, and improve sleep problems. In addition, psychological nursing intervention can effectively alleviate the tension between nurses and patients, and is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of nursing interventions based on Roy's Adaptation Model (RAM) in patients with Bipolar Disorder (BD). Methods Clinical data from 200 BD patients treated in our hospital from June 2021 to June 2023 were selected. Using a random number table method, patients were divided into a control group (receiving conventional nursing interventions) and an observation group (receiving RAM-based nursing interventions), with 100 patients in each group. Nursing was provided for 12 weeks. The effectiveness of nursing care as well as scores from the Bech-Rafaelsen Mania Scale (BRMS), Hamilton Depression Scale (HAMD), Social Dysfunction Screening Scale (SDSS), and Short Form Health Survey (SF36), were compared between the two groups. Results After the nursing intervention, the observation group showed significantly lower scores on the BRMS, HAMD, and SDSS compared to the control group (P< 0.05). Additionally. scores for treatment compliance, SF-36.and nursing satisfaction in the observation group were significantly higher after the intervention than the control group (P<0.05). Conclusion Nursing interventions based on Roy's Adaptation Model can reduce the levels of mania and depression in BD patients, effectively enhance their treatment compliance and social function, and promote improvements in their quality of life, thereby increasing patient satisfaction. [ABSTRACT FROM AUTHOR]

ABSTRACT: Context: The annual incidence cases report depicts India as having the highest tuberculosis (TB) burden globally. Following a programmatic change, the daily fixed-dose combination (FDC) anti-TB treatment regimens were introduced by the Indian government's National Tuberculosis Elimination Program (NTEP). Aims: The aim of the study was to assess the treatment outcomes among drug-sensitive pulmonary TB patients receiving daily FDC drugs and the associated factors influencing the treatment outcomes. Settings and Design: A prospective study was conducted among 300 drug-sensitive pulmonary TB cases in the Bruhat Bengaluru Mahanagara Palike (BBMP) area. Materials and Methods: The TB units and designated microscopic centers (DMCs) were selected by multistage random sampling. Data were collected through a pre-tested and semi-structured questionnaire. Patients were followed up until treatment completion. Statistical Analysis Used: Data were compiled and analyzed using IBM Statistical Package for Social Sciences (SPSS) statistics version 20.0. Descriptive statistics and the Chi-square test were used for interpretation. A P -value less than 0.05 was considered statistically significant. Results: Around 86.33% of patients were cured, 4% had completed treatment, and 1% had treatment failure. Older age, human immunodeficiency virus (HIV) reactive status, alcohol intake, tobacco use, and migrants were associated with poor outcomes. Conclusions: The daily FDC regimen had better outcomes than intermittent regimens. Smokers, alcoholics, migrants, and patients with co-morbidity need to be given priority in management as they are prone to poorer outcomes. [ABSTRACT FROM AUTHOR]

Background: The comorbidity of acute coronary syndrome and diabetes affects patient prognoses. Therefore, it is important to manage these diseases simultaneously. Purpose: In this study, the effect of nursing counseling on treatment compliance was investigated in patients who had received surgical treatment for acute coronary syndrome and had been recently diagnosed with diabetes. Methods: A quasi-experimental design with pretest–posttest control group was used. The study sample consisted of 60 patients (intervention group = 30, control group = 30). The data were collected using a patient information form, the Patient Learning Needs Scale, and the Scale for Patient Compliance with Type 2 Diabetes Mellitus Treatment. This study was conducted in compliance with the Transparent Reporting of Evaluations with Nonrandomized Designs checklist. Results: The intervention group earned significantly higher posttest scores on the Patient Learning Needs total scale and subscales than the control group. Moreover, intervention group compliance with treatment was higher than that of the control group. Furthermore, although significant improvements were found in the average posttest body mass index, fasting blood glucose, HbA1c, total cholesterol, triglyceride, and low-density lipoprotein cholesterol values of the control group, the between-group differences in these values were not significant. Conclusions/Implications for Practice: It is important for nurses to provide counseling services that align with the learning needs of their patients. Also, nursing counseling units should be created and staffed by both specialist nurses and nurse trainers working in healthcare institutions. [ABSTRACT FROM AUTHOR]

Background: The study aimed to investigate the connection between self-care behaviors and treatment adherence among individuals with type 2 diabetes. Methods: This cross-sectional correlational study was conducted between January and May 2022 in a public hospital involving 191 patients diagnosed with type 2 diabetes. Data were collected using the patient information form, the diabetes self-care scale, and the assessment scale for treatment compliance in type 2 diabetes. Results: The mean self-care score was 84.57 ± 14.46 years, and the mean treatment compliance score was 79.50 ± 11.13 years, with a significant negative correlation between them (r = -0.315, p < 0.001). Factors positively influencing self-care were being female (p < 0.05), unemployed (p < 0.05), farmer or civil servant (p < 0.05), hospitalized in the past year (p < 0.01), and exercising regularly or occasionally (p < 0.001). Treatment compliance was significantly higher in those who did not exercise (p < 0.01). A positive correlation was found between age and treatment compliance (r = 0.152, p < 0.05) but not with BMI or diagnosis duration. Conclusions: The study revealed that patients exhibited moderate levels of self-care and treatment compliance. Moreover, as selfcare improved, treatment compliance tended to decrease. [ABSTRACT FROM AUTHOR]

BACKGROUND: The psychology of pain is an important field of study that focuses on understanding the psychological factors associated with pain and developing effective approaches to its management. Pain is a complex sensation that affects a person's physical and mental well-being, and psychological factors can have a significant impact on the perception, response and coping with pain. This research study examines the contribution of psychotherapy in managing chronic pain and improving quality of life and treatment adherence. PARTICIPANTS AND PROCEDURE: The sample consisted of 87 participants who completed the McGill Pain Assessment Questionnaire, SF-36 Quality of Life questionnaire, and the Morisky Medication Adherence Scale (MMAS-8) questionnaire. Two groups were created: one group received psychotherapy to manage pain and illness, while the other group either did not receive psychotherapy or had no contact with this therapeutic method. RESULTS: The results showed that patients who received psychotherapy had higher scores in the dimensions of mental health, vitality, general health, physical pain, physical functioning, and social functioning compared to patients who did not receive psychotherapy. Statistical analysis confirmed significant differences between the two groups. Additionally, psychotherapy was associated with higher treatment adherence, as indicated by the mean scores of patients receiving psychotherapy compared to those who did not. CONCLUSIONS: This suggests that psychotherapy can contribute to increased treatment adherence. The results clearly show that patients who received psychotherapy have significantly higher levels of mental health, vitality, general health and functioning compared to patients who did not receive psychotherapy. [ABSTRACT FROM AUTHOR]

Background and Objective: Asthma control in pregnant women remains of utmost importance; suboptimal control can have adverse repercussions on both fetal and maternal health. The objective was to identify the factors that affect asthma control in pregnant Pakistani women presenting to a tertiary care hospital. Methods: This descriptive, cross-sectional research was conducted at KRL General Hospital between 1st November 2022 to 30th April 2023. Non-probability technique was used to sample one hundred and forty-five pregnant women with confirmed bronchial asthma irrespective of their trimester presented. Data regarding demographics and factors affecting asthma control was collected. Results: The mean age was 30.39 ± 4.33 years, with two-thirds (65%) being multiparous. Approximately 48% of participants were non-compliant with treatment, and less than 40% achieved adequate asthma control. A chi-squared test applied showed that multiparity (p = 0.003), treatment compliance (p < 0.001), BMI (p < 0.001), and proper inhaler technique (p < 0.001) were statistically significant factors affecting asthma control in pregnant women while, the level of education and household income did not exhibit a significant association. Multiple regression analysis qualified higher BMI, multiparity, treatment compliance, and inhaler technique as significant predictors of asthma control amongst pregnant women. Conclusion: Ensuring asthma control during pregnancy is important. This study identified BMI, multiparity, inhaler technique, and treatment compliance as factors that affect asthma control in pregnant women. Addressing these factors through regular antenatal check-ups can significantly mitigate risks and promote the optimal health of both maternal and fetal lives. [ABSTRACT FROM AUTHOR]

Background: Group education has demonstrated benefits among people with diabetes, including reduced A1C and improved self-monitoring practices. Despite this, attendance rates are low for a variety of reasons, including lack of understanding of potential benefits among patients. Objectives: The pharmacist-led diabetes self-management education program at a community hospital has low attendance. This project assesses characteristics associated with attendance and compares outcomes among attendees and non-attendees. Methods: Retrospective data was collected between July 2022 and December 2023. Variables included: age, sex, class attendance, pre- and ≥ 90-day post-class A1C, pre- and post-class BMI, attending pharmacist-led clinic prior to scheduled class, social determinants of health screening survey responses, and diagnosis of depression or anxiety. Results: 103 patients were identified. 53 % attended at least one class out of a series of four. Attendance at the pharmacist-led diabetes clinic (70 % among attendees versus 30 % among non-attendees, p

Feline behavioral problems can be treated successfully by good advice from cat-behavior advisors, but guardians often do not comply with their advice. An experimental survey under 703 cat guardians was used to investigate what advisors can do to increase their clients' compliance with environmental enrichment advice. By systematically varying the credibility of the advisor and the severity of their advice, the hypothesis was confirmed that highly credible advisors elicit more positive attitudes and compliance intentions than less credible advisors. Also as expected, mild advice resulted in stronger compliance intentions than severe advice because guardians believed they were better able to incorporate the required actions. Finally, guardians who more strongly thought of themselves as cat guardians were more likely to adopt the advice because they believed that other cat guardians would do the same. The investigation of factors that can increase cat guardians' compliance with advisors' recommendations for the treatment of behavioral problems is crucial because the wellbeing of domestic cats lies in the hands of their guardians. Several practical recommendations for cat-behavior advisors are offered. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

ObjectiveShortening the length of hospital stay (LOS) has become a major challenge for psychiatric hospitals in reducing unnecessary costs and improving the patient healthcare experience. We investigated the key factors associated with a long psychiatric hospitalization.MethodThis was a retrospective study of 8,870 full-time psychiatric hospital stays (6,216 patients) in the Paris Psychiatry Hospital Group, with a discharge in 2022. We used machine learning tools and univariate and multivariate methods to explore the impact of demographic, pathway-related, and clinical variables on the LOS.ResultsLOS >30 days was associated with age >55 years {odds ratio [OR] =2 [95% confidence interval 1.7–2.3]}, admission from outside the sectorization zone [OR=1.2 (1.1–1.3)], admission via a psychiatric emergency unit [OR, 1.2 (1.1–1.4)], and some clinical severity markers, such as psychotic disorder diagnosis [OR, 1.5 (1.3–1.7)], mandatory care [request of a third party, OR, 2.5 (2.1–2.9); case of imminent danger, OR, 2.3 (1.9–2.7)], the presence of seclusion and mechanical restraint measures (highlighting the positive effect of restraint duration), the somatic comorbidity for female sex [OR, 1.4 (1.2–1.7)], and treatment resistance [OR, 1.4 (1.2–1.6)]. Conversely, LOS ≤30 days was associated with being in a relationship [OR, 0.6 (0.5–0.8)], admission during a travel-related psychiatric episode [OR, 0.5 (0.3–0.6)], and personality and behavior disorders [OR, 0.7 (0.6–0.9)]. We found no significant association for features such as sex and a lack of treatment compliance.ConclusionTo our knowledge, this is the first recent study to investigate and highlight the impact of factors related to various illness severity markers, medication adherence, and patient journeys on the length of psychiatric hospital stay. A better understanding of long-stay risk factors might be helpful for optimizing the allocation of medical resources and anticipating tailored therapeutic programs.

Background: Tuberculosis (TB) remains a significant global health challenge, causing considerable morbidity and mortality worldwide. Despite advancements in healthcare, TB continues to prevail, particularly in resource-limited settings. Understanding latent tuberculosis infection (LTBI) is critical for TB control strategies. Objective: This review aimed to assess LTBI epidemiology together with diagnostic and treatment challenges in Nigeria. Methods: Search of relevant articles on Latent tuberculosis in Nigeria compared to other countries published between 2008 and 2023 were undertaken mainly using Google scholar and PubMed. Related articles from websites of World Health Organization and Federal Ministry of Health, Nigeria were also retrieved and reviewed. Results: LTBI represents a substantial reservoir for TB, with one-quarter of the world's population harboring the infection. The epidemiology of LTBI in Nigeria mirrors the global pattern, with a high prevalence observed among vulnerable populations. Diagnosis of LTBI relies on indirect methods, including tuberculin skin tests (TST) and interferon-gamma release assays (IGRAs). Challenges in treating LTBI persist, including poor screening tools, low treatment compliance, and adverse drug reactions. Addressing these issues requires a comprehensive approach, including improved screening, patient education, and healthcare infrastructure strengthening, to enhance LTBI management and contribute to TB control efforts globally and in Nigeria. Conclusion: Screening and treatment of LTBI remains a crucial preventive intervention for TB eradication. Innovative dedicated policies with augmented research and strategies would be necessary to establish a successful LTBI program in Nigeria.

Dragana Bugarski-Kirola,1,2 Brandon Abbs,2 Ramzey Odetalla,2 I-Yuan Liu,2 Mona Darwish,2 Daryl DeKarske3 1Acadia Pharmaceuticals GmbH, Basel, Switzerland; 2Acadia Pharmaceuticals Inc, Princeton, NJ, USA; 3Acadia Pharmaceuticals Inc, San Diego, CA, USACorrespondence: Dragana Bugarski-Kirola, Acadia Pharmaceuticals GmbH, Barfüẞerplatz 3, Basel, Switzerland, 4051, Tel +41798658317, Email dbugarski-kirola@acadia-pharm.comBackground: In patients with schizophrenia, study design to optimize adherence and objective measurement of adherence is critical for interpreting results. Two randomized, double-blind studies evaluating adjunctive pimavanserin in patients with schizophrenia who received stable antipsychotic treatment included measures to encourage and assess treatment adherence.Objective: This post hoc analysis evaluated adherence levels achieved in the Phase III ENHANCE study (NCT02970292) and the Phase II ADVANCE study (NCT02970305).Methods: Blood levels of participants receiving adjunctive treatment with pimavanserin or placebo added to their ongoing antipsychotic medication were tested and evaluated regularly throughout both studies. For both the background antipsychotic and pimavanserin, treatment adherence was defined as a blood sample test result above the lower limit of quantification.Results: Overall, 392 of 633 screened patients and 403 of 608 screened patients were in the safety populations in ENHANCE and ADVANCE, respectively. In ENHANCE, at weeks 1, 3, and 6/early termination (ET), the adherence rates remained ≥ 95.1% for the background antipsychotic in both pimavanserin and placebo treatment groups and ≥ 96.8% for pimavanserin. In ADVANCE, high adherence rates (≥ 90.6%) with the background antipsychotic (for both treatment groups) and pimavanserin (≥ 95.0%) were observed at weeks 2, 8, 14, and 26/ET.Conclusion: Rigorous screening was performed to exclude patients not adherent to their background antipsychotic before enrollment and to pimavanserin during study visits by using regular blood sampling. Mandatory caregiver participation further supported adherence to study treatment and procedures. These efforts may have contributed to the high levels of adherence to both background antipsychotic and pimavanserin reported in ENHANCE and ADVANCE.Keywords: adjunctive therapy, treatment compliance, pharmacokinetic drug levels, blood sampling, negative symptoms, caregiver participation

Simple Summary: Oclacitinib is a tablet-based therapy given for itching that is caused by allergic or atopic dermatitis in dogs. The objective of this study was to understand pet owners' perceptions of the conventional film-coated form of oclacitinib and the chewable form of oclacitinib in terms of convenience and value. Firstly, an interview phase with pet owners and veterinarians was used to develop detailed written profiles of these treatment options. Then, pet owners were invited to participate in a survey about their experiences and preferences. Overall, 1590 pet owners provided survey responses. Most respondents (62%) reported having experienced challenges giving tablet-based therapies to their dog(s), and half of the respondents (52%) had experience giving flavoured or chewable tablets to their dog. Comparing oclacitinib and chewable oclacitinib (with or without associated costs), the majority of the respondents preferred the chewable formulation in all countries for both short-term and long-term itch (≥58%; all p < 0.05). Chewable and/or palatable treatment options may be welcomed by pet owners and may have potential positive impacts on convenience, compliance, outcomes, quality of life, and the human–animal bond. Oclacitinib is an oral therapy indicated for pruritus associated with allergic or atopic dermatitis in dogs. This study sought to assess pet owners' perceptions of the relative convenience and value of the conventional film-coated formulation and the chewable formulation. A quantitative discrete-choice experimental methodology was applied, comparing (conventional, film-coated) oclacitinib versus chewable oclacitinib using unbranded treatment profiles. Initially, a qualitative interview phase with pet owners and veterinarians was conducted to develop detailed treatment profiles. Subsequently, pet owners participated in a quantitative survey. Overall, 1590 pet owners provided survey responses. Most respondents (62%) reported having experienced challenges administering tablet-based therapies to their dog(s). Half of all respondents (52%) had experience administering flavoured or chewable tablets to their dog. Comparing oclacitinib and chewable oclacitinib (with or without associated costs), the majority of the respondents preferred the chewable formulation in all regions across short-term and long-term scenarios (≥58%; all p < 0.05). The current research is one of few survey-driven studies for treatment preferences in companion animal medicine. Veterinarians may offer chewable or palatable treatment options where available, with potential positive impacts on convenience, compliance, outcomes, quality of life, and the human–animal bond. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Guardians of domestic cats may seek advice from a veterinarian or professional cat behavior advisor to address problematic cat behaviors. This advice typically involves a degree of environmental enrichment, which guardians sometimes experience as an encroachment on their personal lives and living environment. This may explain why compliance with enrichment advice is often poor and problem behaviors persist. The aim of this study was to investigate how advice compliance can be increased by addressing guardians' barriers to action. Using the Theory of Planned Behavior as a theoretical foundation, we differentiated between motivational- and capacity-related perceived behavioral control (PBC) to better understand the root of guardians' implementation resistance. We argue that motivational PBC is a more malleable construct than capacity PBC and tested the hypothesis that motivational PBC can increase when guardians experience social pressure when other guardians hold positive beliefs about environmental enrichment (subjective norm). We conducted a survey of 221 cat guardians who were asked to imagine they had sought and received enrichment advice to address their cat's behavioral problems. The positive or negative beliefs and actions of other cat guardians with respect to environmental enrichment were varied experimentally as a means of influencing the subjective norm. Results confirmed the prediction that exposure to others' positive enrichment beliefs (versus negative enrichment beliefs) results in a more positive subjective norm with respect to enrichment, which subsequently increases motivational PBC and compliance intention. Although compliance intention was also predicted by capacity PBC, capacity PBC was not influenced by subjective norm, as expected. This study is the first to differentiate between motivational- and capacity-related PBC as barriers to action, which proved fruitful. Understanding the nature of clients' implementation resistance helps practitioners select the most appropriate technique to address barriers to action. We offer several practical recommendations to this end. [ABSTRACT FROM AUTHOR]

Purpose: Prior studies have found that court-referred individuals are more likely to complete relationship violence intervention programs (RVIP) than self-referred individuals. The current study provides a more nuanced analysis by examining whether RVIP clients referred through various legal and non-legal pathways (Probation, Deferred Prosecution, Civil Court, Court Case Pending, or No Court Involvement) have differential program attendance or post-program recidivism. Methods: Archival data on referral pathways and program attendance were examined for 879 men who presented for services at a community-based RVIP, and post-program recidivism was examined for a subset of cases (n = 392). Results: Individuals with any type of court order were 1.9 times more likely than those with no court involvement to complete the intervention program. Individuals with court cases pending were somewhat less likely than court-referred cases to complete the intake process, but significantly more likely than those with no court involvement to complete the program. Criminal recidivism during the two-years after scheduled program completion did not differ significantly by referral pathway. The data also revealed social disparities in referral pathways. Black individuals and those with less than high school education were more likely to be on probation, whereas white individuals and those with post-secondary education were more likely to have no court involvement. Conclusions: The findings support the use of legal referral pathways that can limit the negative impacts of carceral system involvement while highlighting the need for better strategies to engage and retain RVIP clients who have no court involvement. [ABSTRACT FROM AUTHOR]

A persistent and influential barrier to effective cognitive-behavioral therapy (CBT) for patients with hoarding disorder (HD) is treatment retention and compliance. Recent research has suggested that HD patients have abnormal brain activity identified by functional magnetic resonance (fMRI) in regions often engaged for executive functioning (e.g., right superior frontal gyrus, anterior insula, and anterior cingulate), which raises questions about whether these abnormalities could relate to patients' ability to attend, understand, and engage in HD treatment. We examined data from 74 HD-diagnosed adults who completed fMRI-measured brain activity during a discarding task designed to elicit symptom-related brain dysfunction, exploring which regions' activity might predict treatment compliance variables, including treatment engagement (within-session compliance), homework completion (between-session compliance), and treatment attendance. Brain activity that was significantly related to within- and between-session compliance was found largely in insula, parietal, and premotor areas. No brain regions were associated with treatment attendance. The results add to findings from prior research that have found prefrontal, cingulate, and insula activity abnormalities in HD by suggesting that some aspects of HD brain dysfunction might play a role in preventing the engagement needed for therapeutic benefit. • No prior studies have examined fMRI predictors of treatment compliance. • We explored whether neural activation predicted treatment compliance in CBT for hoarding disorder. • Compliance was examined in three ways: within session, homework completion, and attendance. • Brain activity related to compliance was found largely in insula, parietal, and premotor areas. [ABSTRACT FROM AUTHOR]

Purpose: Lack of adequate knowledge about the disease is one of the key factors that misguide cancer patients and patients' caregivers in choosing a better management plan. The purpose of the study was to assess the patients' and caregivers' knowledge about the disease status and estimated treatment cost. Understanding of disease may improve adherence to treatment plans and quality of care. Methods: It was a cross-sectional study where 120 cancer patients were selected based on convenience sampling and the availability of record files and relevant data. The site, stage and prognosis of disease recorded from patients and caregivers were compared with the record of outpatient department and inpatient files with the help of the Fisher's exact test. The patients' knowledge about their financial estimates was also recorded. Three patients were selected for in-depth interviews based on purposive sampling to further support the findings. Results: Among 120 analysed patients, 60.83% were female. Around two-thirds of male patients (69.2%) and male caregivers (62.2%) knew about the site but only one-third of female patients (30.8%) and female caregivers (37.8%) knew the same. The primary responsibility for managing financial issues was caregivers in 89.16%. Only 7.5% knew the estimated cost. Nepali as the primary language and better education level is correlated with knowledge of disease status, among both patients and caregivers but was statistically significant only in knowing prognosis among native Nepali speaker caregivers (p < 0.001), and better-educated patients (p < 0.001). As per the in-depth interview, all three patients knew the site of their disease, but only the patient with breast cancer was aware of the stage of the disease. None of the patients were aware of their disease prognosis, treatment plan or the estimated cost of their treatment. Conclusion: The level of understanding is low for most patients and their immediate caregivers, particularly among those who are female, not literate and whose primary language is not Nepali. Appropriate strategy should be adopted to enhance basic understanding among patients and caregivers in our setting. [ABSTRACT FROM AUTHOR]

Treating chronic illness requires ongoing patient-provider cooperation, but individual differences in patients' negative perceptions of care can undermine this cooperation. Research suggests people high on borderline personality disorder (BPD) features may react negatively to and comply less with mental health and medical treatment. This might be particularly problematic in chronic pain treatment, where BPD features are over-represented and the dysregulation typifying BPD likely undermines consistent care. In a sample of 147 chronic pain patients, we investigated whether higher levels of BPD features – both in general and by specific facets – predicted worse perceptions of treatment and lower patient-reported compliance with treatment recommendations. Participants higher (vs. lower) on borderline features viewed treatment more negatively but did not report complying less with recommendations. We found evidence that this may reflect the unstable relationships facet of BPD. Our results indicate that, consistent with other treatment settings, BPD features may undermine care for chronic pain. Furthermore, our results highlight the importance of collaborative provider-patient relationships and patient agreement with the treatment of chronic pain, particularly among individuals higher on BPD features. [ABSTRACT FROM AUTHOR]

Purpose: Do cell phone text reminders impact the rate of compliance with pneumatic compression device (PCD) therapy among women with breast cancer-related lymphedema (BCRL)? Methods: A prospective, randomized, 2-group feasibility study conducted at 2 centers. Participants were adult females (≥18 years old) with unilateral BCRL who had the capability of receiving reminder text messages. All participants underwent PCD therapy. Participants were randomized 1:1 to control (no text messages) or test group (received text message reminders if the PCD had not been used for 2 consecutive days). The rate of compliance between treatment groups was the main outcome measure. Secondary outcome measures were changes in arm girth, quality of life (QOL), and symptom severity. Results: Twenty-nine participants were enrolled and randomized, 25 were available for follow-up at 60 days (14 test, 11 control). Overall, 52.2% (12/23) of all participants were completely compliant, an additional 43.5% (10/23) were partially compliant, and 1 patient (4.3%) was noncompliant. The test and control groups did not differ in device compliance. In the pooled population, weight, BMI, and arm girth were improved. Overall disease-specific QOL and symptom severity were improved. Regression analysis showed benefits were greater among participants with higher rates of compliance. Conclusions: Automated text reminders did not improve compliance in patients with BCRL as compliance rates were already high in this patient population. Improvements in weight, BMI, arm girth, disease-specific quality of life, and symptom severity measures were observed regardless of the treatment assignment. Full compliance resulted in greater functional and QOL benefits. Trial registration: The study was registered at (NCT04432727) on June 16, 2020. [ABSTRACT FROM AUTHOR]

Copyright of Mersin Üniversitesi sağlık Bilimleri Dergisi is the property of Mersin University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background Individuals with chronic diseases are less often presented to hospitals due to the restrictions enforced during the pandemic period and the fear of contracting the disease. The purpose of the present study was to investigate the effects of the anxiety level associated with novel coronavirus on daily life, treatment compliance, and metabolic conditions in elderly diabetes mellitus (DM) patients. Methods This study included 263 patients diagnosed with type 2 DM aged >65 years. The researchers collected the study data through the face-to-face interview method. The Patient Information Form, Coronavirus Anxiety Scale (CAS), Morisky Medication Adherence Scale, Insomnia Severity Index, and the Depression Anxiety Stress Scales (DASS-21) were used for data collection. Results The mean CAS score was 4.25±3.76. Mean CAS scores were higher in the participants who reported a decrease in the frequency of shopping, grocery/market visits, public transport use, hospital visits, and attending routine checks, during the pandemic (p<0.05). Furthermore, a significant positive correlation was found between the mean CAS score and the DASS-21 score (p<0.05). There was a significant negative correlation between the mean CAS score and the treatment compliance score (p<0.05). Conclusion The pandemic and coronavirus anxiety have had an adverse effect on daily life, treatment compliance, and metabolic conditions in elderly DM patients. [ABSTRACT FROM AUTHOR]

Abstract Background Nephropathic Cystinosis (NC), a rare disease characterised by intra-lysosomal accumulation of cystine, results in progressive kidney failure (KF). Compliance to lifelong oral cysteamine, the only therapy, is often compromised. The relationship between compliance and costs of NC has not been previously formally assessed. The present study evaluates the impact of compliance on lifetime (direct) costs of treating KF in NC patients in the United Kingdom. Methods A three-state (KF-free, post-KF, death) partitioned survival model was developed for hypothetical ‘Good Compliance’ (GC) and ‘Poor Compliance’ (PC) cohorts. Survival in the KF-free state was determined by a published regression function of composite compliance score (CCS). The CCS is a summation of annual compliance scores (ACS) over treatment duration prior to KF. ACSs are indexed on annual (average) leukocyte cystine levels (LCL). The Poor Compliance cohort was defined to reflect NC patients in a previous study with a mean LCL of 2.35 nmols nmol half-cystine/mg protein over the study period – and an estimated mean ACS of 1.64 over a 13.4 year treatment duration. The Good Compliance cohort was assumed to have an ACS of 2.25 for 21 years. Major KF costs were evaluated – i.e., dialysis, kidney transplants, and subsequent monitoring. Results The mean CCS was 47 for the GC and 22 for the PC cohort respectively, corresponding to estimated lifetime KF costs of £92,370 and £117,830 respectively – i.e., a cost saving of £25,460/patient, or £1,005/patient for every 1-unit improvement in CCS. Conclusion This analysis indicates that lifetime costs of KF in NC can be reduced through improved treatment compliance with oral cysteamine.

Objective To investigate the effect of narrative nursing on improving treatment compliance in patients with coronary heart disease (CHD). Methods Totally 53 hospitalized patients with CHD were divided into the control group(n=25) and the study group(n=28). All patients received routine nursing interventions during comprehensive treatment of CHD, and patients in the study group received narrative nursing intervention. A self-made questionnaire was used to measure patient compliance with CHD treatment and satisfaction with nursing service during hospitalization. Results The total rates of compliance with CHD treatment and satisfaction with nursing service in the study group were higher than those in the control group (P＜0. 05). Conclusion Narrative nursing is potentially effective to improve patient compliance with CHD treatment and satisfaction with nursing service, having a positive effect on mental well-being and recovery of patients. (目的 探讨叙事护理提高冠心病住院患者治疗依从性的效果。方法 选取2019年10月—2023年4月医院收治的53例冠心病患者为研究对象, 分为对照组(n=25)和研究组(n=28)。患者住院期间给予冠心病常规治疗方案, 对照组实施常规护理, 研究组在对照组基础上增加叙事护理干预。采用自制量表评估患者住院期间依从性和对护理服务的满意度。结果 研究组患者治疗依从性评价和满意度评价均优于对照组, 差异有统计学意义(P＜0. 05)。结论 叙事护理能提高冠心病住院患者依从性和满意度, 对促进患者康复和心理健康具有积极意义。)

Background The psychology of pain is an important field of study that focuses on understanding the psychological factors associated with pain and developing effective approaches to its management. Pain is a complex sensation that affects a person’s phys-ical and mental well-being, and psychological factors can have a significant impact on the perception, response and coping with pain. This research study examines the contribution of psychotherapy in managing chronic pain and improving quality of life and treatment adherence. Participants and procedure The sample consisted of 87 participants who completed the McGill Pain Assessment Questionnaire, SF-36 Quality of Life questionnaire, and the Morisky Medication Adherence Scale (MMAS-8) questionnaire. Two groups were created: one group received psychotherapy to manage pain and illness, while the other group either did not receive psychotherapy or had no contact with this therapeutic method. Results The results showed that patients who received psychotherapy had higher scores in the dimensions of mental health, vitali-ty, general health, physical pain, physical functioning, and social functioning compared to patients who did not receive psy-chotherapy. Statistical analysis confirmed significant differences between the two groups. Additionally, psychotherapy was associated with higher treatment adherence, as indicated by the mean scores of patients receiving psychotherapy compared to those who did not. Conclusions This suggests that psychotherapy can contribute to increased treatment adherence. The results clearly show that patients who received psychotherapy have significantly higher levels of mental health, vitality, general health and functioning com-pared to patients who did not receive psychotherapy.

Yvonne Commodore-Mensah,1,2,&ast; Sabianca Delva,3,&ast; Oluwabunmi Ogungbe,1,2,&ast; Lauren A Smulcer,4 Sally Rives,1 Cheryl R Dennison Himmelfarb,1,5,6 Miyong T Kim,7 Lee Bone,1,2,5 David Levine,1,2,5 Martha N Hill1,2,5 1Johns Hopkins School of Nursing, Baltimore, MD, USA; 2Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 3William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA; 4Elara Caring, Fort Polk North, LA, USA; 5Department of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; 6Department of Health, Behavior and Society, Johns Hopkins Bloombery School of Public Health, Baltimore, MD, USA; 7School of Nursing, University of Texas at Austin, Austin, TX, USA&ast;These authors contributed equally to this workCorrespondence: Yvonne Commodore-Mensah, Johns Hopkins School of Nursing, 525 N. Wolfe Street, Room N530U, Baltimore, MD, 21205, USA, Tel +1 4106141519, Email ycommod1@jhmi.eduBackground: Poor medication adherence hampers hypertension control and increases the risk of adverse health outcomes. Medication adherence can be measured with direct and indirect methods. The Hill-Bone Compliance to High Blood Pressure Therapy (HBCHBPT) Scale, one of the most popular adherence measures, indirectly assesses adherence to hypertension therapy in three behavioral domains: appointment keeping, diet and medication adherence.Aim: To synthesize evidence on the use of the HBCHBPT Scale, including psychometric properties, utility in diverse patient populations, and directions for future clinical use and research.Methods: We searched electronic databases, specifically CINAHL, PubMed, PsychInfo, Embase, and Web of Science. We included original studies that used the HBCHBPT Scale or its subscales to measure a health outcome, or methodological studies involving translations and validations of the scale. We extracted and synthesized data following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.Results: Fifty studies were included in this review, 44 on hypertension, two on diabetes, and others on other chronic conditions. The scale was successfully translated into numerous languages and used in descriptive and intervention studies. The scale demonstrated sound psychometric properties (Cronbach’s α coefficient 0.75) and sensitivity to capture intervention effects when used to evaluate the effectiveness of high blood pressure adherence interventions. The medication-taking subscale of HBCHBPT performs best and is widely used in diverse contexts to assess medication adherence for chronic conditions.Conclusion: The HBCHBPT Scale has high versatility globally and has been used in various settings by various healthcare worker cadres and researchers. The scale has several strengths, including high adherence phenotyping capabilities, contributing to the paradigm shift toward personalized health care.Keywords: medication adherence, treatment adherence, treatment compliance, hypertension, high blood pressure, Hill Bone Medication Adherence Scale, Hill-Bone Compliance to Blood Pressure Therapy Scale

Xiaoxiao Lu,1 Bruno Emond,2 Laura Morrison,2 Frederic Kinkead,2 Patrick Lefebvre,2 Marie-Hélène Lafeuille,2 Wasiulla Khan,1 Linda H Wu,1 Zaina P Qureshi,1 Ryan Jacobs3 1Real World Value and Evidence, Oncology, Janssen Scientific Affairs, LLC, Horsham, PA, USA; 2Health Economics and Outcomes Research, Analysis Group, Inc, Montréal, Québec, Canada; 3Hematology and Medical Oncology, Atrium Health Levine Cancer Institute, Charlotte, NC, USACorrespondence: Bruno Emond, Analysis Group, Inc, 1190 avenue des Canadiens-de-Montréal, Tour Deloitte, Suite 1500, Montréal, Quebec, H3B 0G7, Canada, Tel +1-514-394-4455, Fax +1-514-394-4461, Email Bruno.Emond@analysisgroup.comPurpose: Increased dosing frequency adversely affects treatment adherence and outcomes in chronic diseases; however, such data related to treatment adherence is lacking in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). This study compared adherence between patients treated with ibrutinib (once-daily) versus acalabrutinib (twice-daily) as first-line (1L) therapy for CLL/SLL.Patients and Methods: Specialty pharmacy electronic medical records were used to identify adults with CLL/SLL initiating 1L ibrutinib or acalabrutinib between 01/01/2018 and 11/30/2020. Adherence was measured by the proportion of days covered (PDC) and medication possession ratio (MPR) and was compared between cohorts using odds ratios (ORs) obtained from logistic regression models adjusted for baseline characteristics.Results: Between 01/01/2018 and 11/30/2020, 1374 and 140 patients initiated ibrutinib and acalabrutinib, respectively. Based on PDC/MPR ≥ 80%, patients treated with once-daily ibrutinib were more likely to be adherent than those treated with twice-daily acalabrutinib (OR ranges: PDC: 1.04– 1.76; MPR: 1.03– 1.58). At 6 months, patients on ibrutinib had a 58– 76% higher likelihood of staying adherent compared to patients on acalabrutinib (PDC: 75.9% for ibrutinib vs 63.6% for acalabrutinib, OR: 1.76, P= 0.008; MPR: 76.8% vs 66.9%, OR: 1.58, P= 0.036) with a similar trend noted for the entire line of treatment (LOT) (PDC: 53.0% vs 41.4%, OR: 1.53, P= 0.021; MPR: 58.7% vs 47.1%, OR: 1.50, P= 0.027).Conclusion: In this real-world analysis, CLL/SLL patients initiating 1L once-daily ibrutinib had > 50% higher treatment adherence than those initiating twice-daily acalabrutinib during their LOT. Given the importance of sustained adherence for disease control in CLL/SLL, dosing frequency may be an important consideration for patients and physicians.Graphical Abstract: Keywords: CLL/SLL, Bruton’s tyrosine kinase inhibitor, treatment compliance, proportion of days covered, medication possession ratio

Abstract Background Cervical cancer is one of the most common cancers and a major cause of morbidity among women globally. Chemoradiation therapy is the preferred standard treatment for women with stage IB to IVA. However, the benefits of this treatment can only be achieved if patients adhere to the treatment guidelines. In this study, the proportion of compliance or adherence to chemo-radiation treatment among cervical cancer patients at Uganda Cancer Institute (UCI) was determined. Methods This was a cross-sectional study that reviewed data retrospectively for 196 cervical cancer patients who were prescribed to chemo-radiation therapy at UCI between November 2020 to May 2021, having been diagnosed with disease stage IB to IVA. Patient data and information on treatment uptake was obtained by review of the patient’s medical records. Treatment compliance was determined by calculating the number of participants who completed the prescribed treatment (definitive pelvic concurrent chemoradiation to 50 Gy external beam radiotherapy with weekly concurrent cisplatin followed by intracavitary brachytherapy 24 Gy in 3 fractions at 8 Gy once a week over 3 weeks). Associations between patient factors and treatment adherence were determined using logistic regression analysis. In all statistical tests, a P- value of

Introduction: The success of pulmonary TB treatment remains low due to patients' lack of compliance with the treatment regimen. This study aims to determine factors related to treatment compliance among TB patients at the Internal Medicine Outpatient Clinic of the Raja Ampat Regional General Hospital. Methods: An observational research design with a cross-sectional study approach was employed, involving 125 tuberculosis patients receiving treatment at the Internal Medicine Outpatient Clinic of the Raja Ampat Regional General Hospital, selected through total sampling technique. Data collection utilized a structured questionnaire. Data were analyzed using univariate, bivariate (Chi-Square test), and multivariate (Binary Logistic Regression) analyses. Results: The majority of treatment-compliant TB patients among the 125 respondents were 74 (59.2%) in the compliant category. There was a significant relationship between age, education, knowledge, attitude, perception, motivation, and staff support with the level of treatment compliance. Good knowledge (AOR: 2.18; CI: 1.05-1.56; p 0.003) and high staff support (AOR: 1.27; CI: 1.11-1.68; p 0.006) increased TB patient treatment compliance. Conclusion: TB patient treatment compliance is still below the established standards. Knowledge and staff support enhance better treatment compliance, emphasizing the importance of education and improving service access, such as health worker visits to TB patients' homes.

Depression is a common emotional state in humans, which is sometimes triggered by stressful events and certain physical and/or mental conditions that may occur and may increase the body's vulnerability to various types of depressive disorders, causing sometimes organic changes difficult to quantify and to treat. Depressive conditions are major clinical problems that occur throughout life and often require a specialized treatment, but the use of the antidepressant compounds is often endangered by the risk of formidable side effects, requiring to stop the treatment or to use medicine doses that cannot determine the desired therapeutic results. These are reasons for the impressive expansion of the research on the depression types, with emphasize on etiological and etiopathogenetical studies, allowing the discovery of compounds with good therapeutic potential and an appropriate pharmacological profile to reduce the side effects. Diabetes (diabetes mellitus) is a major public health problem, with increasing costs and frequency in recent years. Late diagnosis, inadequate treatment, lack of ongoing monitoring or ignorance of the disease can have serious consequences for the health of that individual, his family and his community. The mental state of a patient with diabetes is different from one moment to the next and varies with the stage of the disease and the appearance of various complications. The stress of chronic illness, the pressure to have a lifestyle and a diet according to medical recommendations, sadness, anger and even denial of the disease, are feelings experienced by patients with diabetes at least once in their lives. [ABSTRACT FROM AUTHOR]

Copyright of Romanian Journal of Family Medicine / Revista Română de Medicina Familiei is the property of Media DOM Express and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Nephropathic Cystinosis (NC), a rare disease characterised by intra-lysosomal accumulation of cystine, results in progressive kidney failure (KF). Compliance to lifelong oral cysteamine, the only therapy, is often compromised. The relationship between compliance and costs of NC has not been previously formally assessed. The present study evaluates the impact of compliance on lifetime (direct) costs of treating KF in NC patients in the United Kingdom. Methods: A three-state (KF-free, post-KF, death) partitioned survival model was developed for hypothetical 'Good Compliance' (GC) and 'Poor Compliance' (PC) cohorts. Survival in the KF-free state was determined by a published regression function of composite compliance score (CCS). The CCS is a summation of annual compliance scores (ACS) over treatment duration prior to KF. ACSs are indexed on annual (average) leukocyte cystine levels (LCL). The Poor Compliance cohort was defined to reflect NC patients in a previous study with a mean LCL of 2.35 nmols nmol half-cystine/mg protein over the study period – and an estimated mean ACS of 1.64 over a 13.4 year treatment duration. The Good Compliance cohort was assumed to have an ACS of 2.25 for 21 years. Major KF costs were evaluated – i.e., dialysis, kidney transplants, and subsequent monitoring. Results: The mean CCS was 47 for the GC and 22 for the PC cohort respectively, corresponding to estimated lifetime KF costs of £92,370 and £117,830 respectively – i.e., a cost saving of £25,460/patient, or £1,005/patient for every 1-unit improvement in CCS. Conclusion: This analysis indicates that lifetime costs of KF in NC can be reduced through improved treatment compliance with oral cysteamine. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. Melanoma is a serious type of skin cancer with a high burden in New Zealand. MelNet Quality Statements (2021) guide the timeliness of investigations and management for melanoma patients, who might experience long delays waiting for treatment. Aim. To assess compliance of melanoma diagnosis and treatment timeliness with the MelNet Quality Statements at Waikato Hospital and in primary care for melanoma and melanoma in situ (MIS). Methods. This is a retrospective clinical audit of patients referred via the Suspected Skin Cancer (SSC) teledermatology pathway between June 2020 and June 2022, and histologically confirmed as having melanoma or MIS. Time intervals between elements of service were analysed. Results. For 43 melanomas and 105 MIS, compliance with MelNet Quality Statements across all melanoma services was poor, except for teledermatology response rates (100% compliance). From referral to first cancer treatment (Statement 2.1.1), compliance was 50% in general practice and 7.7% in Waikato Hospital. From teledermatologist response to biopsy (Statement 2.1.3), compliance was 65.2% in general practice and 7.7% in hospital plastics department. Histopathological reporting delays were also identified. Discussion. Long delays for melanoma care in hospital likely reflect system failures (such as inadequate funding and human resources) and the increasing burden of skin cancer. In contrast, primary care provided quicker diagnostic biopsies and surgical treatments for melanoma. [ABSTRACT FROM AUTHOR]

Neurometabolic disorders such as tyrosinemia type 1 (TYRSN1) may interfere with brain metabolism and show symptoms of attention-deficit hyperactivity disorder (ADHD) in patients treated with the enzyme inhibitor nitisinone [2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, NTBC]. It has been reported that ADHD treatment improves treatment compliance, which is imperative for the long-term prognosis of patients with TYRSN1. In this study, we report the case of a male patient who was diagnosed with TYRSN1 at 3 months of age and was subsequently treated with NTBC, restricted protein intake, and amino acids supplementation. At 7 years of age, he was referred for neuropsychiatric assessment, diagnosed with ADHD, and treated withmethylphenidate. The effects of the treatment were monitored via parental interviews, questionnaires covering ADHD symptoms, and a continuous performance test. A reduction in ADHD symptoms, particularly inattentiveness, was observed across all measures. The early identification of ADHD and the treatment of neurometabolic disorders, such as TYRSN1, may be important from a lifetime perspective as this may improve the prognosis of the medical condition as well. [ABSTRACT FROM AUTHOR]

Background: Cervical cancer is one of the most common cancers and a major cause of morbidity among women globally. Chemoradiation therapy is the preferred standard treatment for women with stage IB to IVA. However, the benefits of this treatment can only be achieved if patients adhere to the treatment guidelines. In this study, the proportion of compliance or adherence to chemo-radiation treatment among cervical cancer patients at Uganda Cancer Institute (UCI) was determined. Methods: This was a cross-sectional study that reviewed data retrospectively for 196 cervical cancer patients who were prescribed to chemo-radiation therapy at UCI between November 2020 to May 2021, having been diagnosed with disease stage IB to IVA. Patient data and information on treatment uptake was obtained by review of the patient's medical records. Treatment compliance was determined by calculating the number of participants who completed the prescribed treatment (definitive pelvic concurrent chemoradiation to 50 Gy external beam radiotherapy with weekly concurrent cisplatin followed by intracavitary brachytherapy 24 Gy in 3 fractions at 8 Gy once a week over 3 weeks). Associations between patient factors and treatment adherence were determined using logistic regression analysis. In all statistical tests, a P- value of < 0.05 was considered as significant. Results: The proportion of patients who were administered with external beam radiation (EBRT), chemotherapy and brachytherapy were 82.6%, 52.04% and 66.2% respectively. However, only 23 of 196 patients (11.7%) were found to have adhered to the treatment plan by completion of all definitive pelvic concurrent chemoradiation to 50 Gy external beam radiotherapy (5 weeks) with weekly concurrent cisplatin (5 cycles) followed by intracavitary brachytherapy 24 Gy in 3 fractions at 8 Gy once a week over 3 weeks (3 sessions). There were no significant associations between patient factors and treatment adherence after multivariable analysis. Conclusions: Treatment compliance was found in only 12% of the cohort participants. No association of patient factors with treatment compliance was found. Additional studies on treatment adherence with larger sample sizes are needed to confirm the associations. [ABSTRACT FROM AUTHOR]

Objective To explore the application of workshop education model based on Omaha system in the perioperative nursing of patients undergoing endoscopic lumbar discectomy for lumbar disc herniation, and evaluate its effect on compliance behavior of patients. Methods A convenience sample of 120 patients who underwent with endoscopic lumbar discectomy for lumbar disc herniation were included and divided into the control group. Based on the routine orthopedic care bundles, the control group received routine health education during hospitalization, and the observation group received workshop education mode based on Omaha system. The patient compliance, rehabilitation outcome and satisfaction was evaluated by compliance behavior and LDG-Knowledge questionnaire, Japanese Orthopaedic Association (JOA) scale and self-made satisfaction questionnaire, respectively. Results There was 1 case of death and 3 cases lost to follow-up, and clinical data of 57 cases in the control group and 59 cased in the observation group were analyzed. Scores of compliance behavior and LDG-Knowledge questionnaire in the observation group were higher than those in the control group at discharge form hospital, 1 month and 3 months after discharge from hospital respectively (P

Background: Interruptions in radiation treatment are known to have a deleterious effect on oncologic outcomes,specifically, an increase in tumor recurrence and decrease in cancer cure rate. Objectives: Our primary aim was to determine the factors influencing radiotherapy interruptions and provide solutions to decrease these dropouts. Materials and Methods: This was a retrospective observational study conducted between May 2009 and July 2010 at Mahatma Gandhi Cancer Hospital and Research Institute, a tertiary cancer center in Vishakhapatnam, Andhra Pradesh, India, on patients with histopathologically proven cancer, who were receiving radiation, either as definitive concurrent chemoradiation or in the adjuvant or palliative setting. Before the start and during treatment, patients were counseled by radiation oncologists, radiation coordinators, and radiation therapy technologists. During radiotherapy, an interruption of more than five consecutive days was considered a treatment interruption. Following a treatment interruption, patients were called on the telephone, counseling was done, and the cause of the treatment interruption was recorded and attempts were made to resolve the problem. Results: We enrolled 1200 patients in the study. There were more male (n = 724 [60.4%]) than female (n = 476 [39.6%]) patients. The cohort included 379 patients (31.6%) with carcinoma of the head-and-neck and 301 patients (25.1%) with gynecological malignancies. There were 100 (8.3%) treatment interruptions recorded during the study period. The common causes of radiation interruption were radiation-induced toxicity (n = 20 [20%]), patient death (n = 15 [15%]), financial (n = 15 [15%]), and social (n = 12 [12%]) issues. After counseling over the telephone, treatment could be restarted in 25 (25%) of the 100 patients who had interrupted and stopped radiotherapy. Conclusion: Treatment interruption is relatively common in our patients receiving radiotherapy. To prevent such dropouts and increase compliance to treatment, adequate and frequent counseling before and during radiation treatment is needed.

Background: Treatment compliance improves mental health and facilitates the resolution of the underlying illness. An accurate assessment of treatment compliance is necessary for effective and efficient treatment planning and for ensuring that changes in health outcomes can be attributed to the recommended regimen. Aim: This study aimed to develop a treatment compliance assessment scale for clients with mental illnesses and to evaluate its psychometric properties. Methodology: The initial questionnaire was developed through the Delphi expert consultation, pilot study, and semistructured interview. The instrument was applied to 130 clients attending the outpatient services of a tertiary care hospital in North India. Results: A seven-item clinician-rated questionnaire was formed in which exploratory factor analyses yielded two factors, including medication compliance and attitude toward current treatment. The instrument was found to have a good internal consistency (Chronbach's alpha was 0.932), split-half reliability (Guttman's split-half coefficient − 0.838), and test–retest reliability (0.882). The concurrent validity of demonstrated a significant correlation with the 12-item Medication Adherence Rating Scale at P ≤ 0.01. Conclusion: The clinician-rated treatment compliance assessment scale was found to be a valid instrument for assessing treatment compliance among patients with mental illnesses with adequate psychometric properties.

In this article, we want to present the reader with an interesting clinical case from authors’ practice, which, in our opinion, clearly demonstrates the efficacy and safety of using Gliatilin (choline alfoscerate) as a part of combination therapy in a 19-year-old man with so-called «long COVID syndrome», manifesting itself predominantly as mix of symptoms of asthenia, depression, anxiety, sleep and cognitive difficulties. This patient, for his ideological reasons and beliefs, refused taking antidepressants, anxiolytics, as well as any other psychotropic drugs. At the same time, the patient asked for help in choosing «a treatment, which will consist of only natural ingredients».