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This article examines the regulation of labor in the context of artificial intelligence (AI) in Eastern and Southern Africa, with a focus on South Africa and Kenya. It identifies two main concerns: the regulation of labor for African workers engaged in low-end AI work and the sharing of information in authoritarian states and its impact on organized labor and civil society. The article also discusses the lack of regulation for low-end AI work, such as data janitorial work, and the potential biases and negative effects of AI on women in sectors like fintech. It provides country-specific examples, including the use of AI in South Africa's healthcare and transportation systems, as well as the limited attention given to AI by established unions. The article concludes by emphasizing the importance of responsible AI practices and addressing regulatory concerns while harnessing the economic potential of AI. In South Africa, the call center industry is at risk of job loss due to AI, and the lack of AI policy and regulation exacerbates this issue. In Kenya, the development of a strong Fintech sector based on AI technologies has led to financial inclusion but also raises concerns about data privacy and protection. The article also highlights the emergence of union-like organizations in Kenya to represent workers in the digital platform economy. Overall, AI regulation in Africa is incomplete, and progress towards informal regulation has been uneven. [Extracted from the article]

This research studies the impact of articles appearing in the top four journals for consumer research— JCR , JMR , JM , and JCP— by examining factors that influence scholarly, public, and practical impact. This conceptually distinguishes between "incongruent novelty" (novelty arising from incongruity between an article and other existing articles) and "recombinant novelty" (novelty based on drawing from more disparate references). Incongruent novelty is decomposed into two components: (1) topic incongruity—incongruity between an article's topic and other existing topics at the time and (2) article incongruity—incongruity between an article and other existing articles on the same primary topic. By integrating topic modeling and word embedding to measure these constructs, we demonstrate varying impacts of types of novelty on three types of impact. Overall, our findings illustrate that topic and article incongruity have effects above and beyond recombinant novelty. For both scholarly and public impact, our results suggest that moderately high topic incongruity has the largest influence, suggesting that researchers should address novel topics. Additionally, scholarly citations are positively affected by lower and higher (vs. moderate) levels of article incongruity, suggesting that researchers either engage in programmatic research or add a new approach to the existing research on a topic. [ABSTRACT FROM AUTHOR]

Only a minority of Americans adequately engage in activities experts recommend to curb preventable diseases, such as the consumption of healthful foods and regular physical exercise. This poses a challenge for policy makers and social marketers alike, given the substantial impact descriptive norms have on behaviors in the health domain. The authors propose a new way to address this challenge by identifying what they call the "uptrend effect." This effect encourages descriptively nonnormative, healthy behaviors through uptrend messaging that makes salient actual increased engagement in those behaviors over time without referencing an objective descriptive norm. Across seven experimental studies, including studies conducted in the field and measuring real behaviors, this research demonstrates that uptrend messaging leads recipients to infer greater descriptive normativity for the target behavior, which subsequently improves engagement. The authors identify theoretically and practically relevant boundary conditions, showing that the uptrend effect is attenuated when the growth in a behavior is driven by a dissimilar group or when the message explicitly states a descriptive norm. They also demonstrate that uptrend messaging outperforms other norm-based approaches. The theory and findings of this research inform scholars, policy makers, and marketers by providing actionable and easy-to-implement techniques to encourage behaviors that improve consumer quality of life. [ABSTRACT FROM AUTHOR]

BACKGROUND: Primary thumb carpometacarpal (CMC) osteoarthritis is one of the most common conditions encountered by hand surgeons. Of the vast number of operations that have been proposed, none have demonstrated results significantly superior to trapeziectomy alone. AIM: The purpose of our study was to determine why surgeons opt for their technique in treating CMC arthritis. METHODS: A cross-sectional survey of active members of the American Society for Surgery of the Hand was conducted to evaluate the reasons behind their preferred technique in the treatment of isolated thumb CMC arthritis. Surgeons were contacted by e-mail once and provided with a link to a de-identified survey consisting of 5 treatment questions and 5 demographic questions. RESULTS: Of 950 responses were received. 40.5% of surgeons preferred trapeziectomy + ligament reconstruction tendon interposition (LRTI), followed by trapeziectomy + suspensionplasty (28.2%), suture button suspension (5.9 %), trapeziectomy alone (4.6%), prosthetic arthroplasty (3.2%), arthrodesis (1.1%), and other (6.6%). Proponents of trapeziectomy + LRTI cited familiarity (73.2%), exposure during fellowship (48.8%) and less proximal migration (60%) to be the main reasons affecting their decision. Surgeons who preferred trapeziectomy + suspensionplasty most reported simplicity (74.9%), fewer complications (45.3%), less proximal migration (43.8%), and avoidance of autogenous tissue harvest (42.7%). Advocates of suture button suspension cited avoidance of autogenous tissue harvest (80.4%), shorter immobilization (76.8%), and quicker recovery (73.2%) with their technique. Advocates of trapeziectomy alone cited simplicity (97.7%), fewer complications (86.4%), and avoidance of autogenous tissue harvest (59.1%). In their comments, 45% of surgeons choosing trapeziectomy alone cited evidence as an additional rationale. Advocates of prosthetic arthroplasty cited improved pinch strength (83.3%) and improved range of motion (63.3%), while those preferring arthrodesis cited better pinch strength (90%) and frequently in their comments, durability. Of the surgeons who preferred a technique other than LRTI, 41.8% reported they had tried LRTI in the past, citing complexity of the procedure, flexor carpi radialis harvest, and longer operative time as reasons for moving on. CONCLUSION: Our study provides an update on current treatment trends and offers new insight into the reasons behind surgeons decision making in the management of thumb carpometacarpal osteoarthritis. Despite strong Level 1 evidence supporting the use of trapeziectomy alone, our findings demonstrate that most surgeons continue to supplement trapeziectomy with other techniques such as LRTI or suspensionplasty. Several factors including familiarity, personal experience (Level 4 evidence), and comfort may be more influential than Level 1 evidence in determining the techniques in a surgeons armamentarium. Further prospective studies are needed to determine the optimal technique for surgical management of Eaton stages II-IV CMC arthritis and how these studies will affect surgeons choice.

BACKGROUND: With the growing opioid epidemic across the US, in-hospital utilization of opioids has garnered increasing attention. Using a national cohort, this study sought to characterize trends, outcomes, and factors associated with in-hospital opioid overdose (OD) following major elective operations. METHODS: We identified all adult (≥18 years) hospitalizations entailing select elective procedures in the 2016-2020 National Inpatient Sample. Patients who experienced in-hospital opioid overdose were characterized as OD (others: Non-OD). The primary outcome of interest was in-hospital OD. Multivariable logistic and linear regression models were developed to evaluate the association between in-hospital OD and mortality, length of stay (LOS), hospitalization costs, and non-home discharge. RESULTS: Of an estimated 11,096,064 hospitalizations meeting study criteria, 5375 (0.05 %) experienced a perioperative OD. Compared to others, OD were older (66 [57-73] vs 64 [54-72] years, p

INTRODUCTION: Coronavirus disease 2019 (COVID-19) can lead to cardiovascular complications. We aimed to understand the trends in admission for COVID-19 and the incidence of various cardiovascular events. MATERIAL AND METHODS: The 2020 and 2021 National Inpatient Sample (NIS) was studied for cases of COVID-19 between April 2020 and December 2021 in the United States. Linear-by-linear association helped us understand the trends of various events. RESULTS: The number of cases of COVID-19 was highest in January 2021 (261,469 patients). The incidence of acute pulmonary embolism rose from 2.08% in April 2020 to 4.82% in November 2021, while deep vein thrombosis cases rose from 1.74% in April 2020 to 2.63% in December 2021. The incidence of cardiac arrest varied, with a maximum of 3.00% in August 2021. Similarly, acute ischemic stroke cases experienced their highest incidence in January 2021 (0.91%). The incidence of myocarditis was highest in April and May 2020 (0.42% each). Peak takotsubo cases were seen between October and December 2021. The highest overall all-cause mortality among COVID-19 cases was seen in April 2020 (16.74%). CONCLUSIONS: Throughout the 21 months of our analysis, various trends in COVID-19 cases and incidence of cardiac events were noticed. This could relate to the different variants of COVID-19, their direct and indirect impact on coagulation pathways and the myocardial tissues, and the protective roles of the vaccines.

Aims Materials and Methods Results Conclusions Type 2 diabetes (T2D) and its complications disproportionally affect American Indian and Alaska Native (AI/AN) peoples. Prescribing decisions for anti‐diabetic medications are complicated and require balancing medication benefits, costs and side effects. Little is known about trends in anti‐diabetic medication use as well as acute diabetes complications among AI/AN adults. Here, we examined patterns and trends in anti‐diabetic medication use and rates of hospital admissions or emergency department (ED) visits due to severe hypoglycaemia and hyperglycaemia among AI/AN adults with T2D.We conducted a retrospective analysis of Indian Health Service (IHS) Improving Health Care Delivery Data Project. A total of 39 183 AI/AN adults aged ≥18 years with T2D who used IHS or Tribal health services during any of the fiscal years (FYs) 2009–2013 were included. Utilization rates of each class of anti‐diabetic medications and rates of severe hypoglycaemia and severe hyperglycaemia in emergency room and/or inpatient discharge diagnoses were calculated for each year. Longitudinal statistical models were fitted to examine time trends of anti‐diabetic medication use and complications.During 2009–2013, use of metformin (56.0%–60.5%), insulin (31.4%–35.9%) and dipeptidyl peptidase‐4 inhibitors (1.4%–9.0%) increased, whereas the use of sulfonylureas (40.3%–32.9%) and thiazolidinediones (TZDs, 31.6%–8.8%) decreased significantly. Trends in severe hypoglycaemia (1.6%–0.8%) and severe hyperglycaemia (2.0%–1.6%) declined gradually.There were significant changes in the utilization of different anti‐diabetic medication classes during 2009–2013 among AI/AN adults with T2D. Concurrently, there were significant reductions in severe hypoglycaemia and severe hyperglycaemia. [ABSTRACT FROM AUTHOR]

Aim: To summarize and analyze the research trends and frontiers in maintenance therapy for ovarian cancer over the past 20 years. Methods: Relevant articles were identified in Web of Science, and analyzed using CiteSpace and Excel. Results: 1204 articles from 61 countries led by the USA and England were included. 6821 authors, 2345 institutions and 292 journals have participated in the publication of papers, but the collaboration between them was not very close. The annual publication volume has increased significantly since 2015. Drug combination therapy, genetic testing, management of adverse reaction and prognostic factors are research trends and frontiers of this field. Conclusion: This is the first bibliometric research in this field, which can provide some references for researchers. Article highlights This is the first bibliometric research about maintenance therapy for ovarian cancer. A total of 1204 articles were collected in this study from January 2000 to September 2022, with 728 articles and 476 reviews. Since 2015, the number of articles has rapidly increased, and will continue to grow, indicating that maintenance therapy for ovarian cancer is receiving increasing attention from scholars. The top two most cited publications focused on Niraparib and Olaparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. The USA and England were the top two ranked countries with the most publications. However, less cooperation was observed among institutions from these countries. The USA and Univ Texas MD Anderson Canc Ctr were the most impact country and institution, respectively. Chemotherapy drugs alone, PARP inhibitors alone, or antiangiogenesis drugs alone were used for 1st-line, 2rd-line, or late-line maintenance therapy are the research foundation. Drug combination maintenance therapy based on effective monotherapy, as well as genetic testing, management of adverse reaction and prognostic factors are research trends and frontiers of maintenance therapy for ovarian cancer. [ABSTRACT FROM AUTHOR]

Objective: To investigate indications and surgical procedures of keratoplasty in a tertiary comprehensive hospital in northern part of China over a 20-year period. Methods: All patients undergoing keratoplasty between January 1, 2002 to December 31, 2021 in a tertiary comprehensive hospital in northern part of China were retrospectively reviewed. The annual proportion of keratoplasty indications and surgical procedures was recorded and analyzed. Results: A total of 8266 keratoplasty procedures were included. Leading indications were keratoleukoma (n = 2108, 25.50%), followed by regraft (n = 1453 ,17.58%), corneal endothelial dysfunction (n = 1085, 13.13%), and keratoconus (n = 922,11.15%). A decreasing trend was observed for keratoleukoma (P < 0.01) and an increasing trend for corneal endothelial dysfunction (P < 0.01), regraft (P = 0.012), corneal limbal dermoids (P < 0.01) and congenital corneal opacity (P < 0.01). From 2002 to 2021, the proportion of penetrating keratoplasty (PK) had decreased from 73.95% (2002 to 2006) to 53.49% (2017 to 2021). On contrary, anterior lamellar keratoplasty (ALK) (459–705, 26.05-31.96%, P = 0.034) and endothelial keratoplasty (EK) (0-321, 0.00-14.55%, P < 0.01) became more prevalent from 2002 to 2021. For cases with corneal endothelial dysfunction, EK became the preferred technique (74.72%) in the recent 5 years. Conclusion: Over the past 20 years, keratoleukoma and regraft have been the leading indications for keratoplasty. A noticeable shift in surgical preference from PK to DSAEK and ALK is evident, with key indications for keratoplasty including keratoleukoma, regraft, limbal dermoids, endothelial dysfunction, and keratoconus, respectively. [ABSTRACT FROM AUTHOR]

Background: Amid the national opioid epidemic, it is important to assess trends in opioid prescriptions. Long-acting opioids (LAOs) are of particular interest as they are among the most intensely misused prescription opioids. Moreover, understanding geographic trends in opioid prescriptions may help identify state-level variations, illustrating state-specific disparities.Objectives: The study aims to determine geographic trends in overall and LAO prescriptions under Medicaid and Medicare Part D from 2013 to 2021.Methods: We used data from the Centers for Medicare & Medicaid Services on opioid prescriptions from 2013 to 2021. The opioid prescribing proportion was calculated as the number of opioid claims divided by the total number of overall drug claims. The LAO prescribing proportion was calculated as number of LAO claims divided by total opioid claims.Results: Despite a general decrease nationwide, Medicaid opioid prescribing proportions increased in Iowa, Montana, and Virginia. There was an increasing trend in the national-level Medicaid LAO prescribing proportion from 2017 to 2021, with a 14.1% point increase (p for the annual percent change [APC]<0.05). For Medicare Part D, the overall prescribing proportions fell by 1.7% points from 2013 to 2021, while the LAO prescribing proportion fell by 3% points from 2016 to 2021 (p for APC < .05).Conclusions: The increasing trends in national-level Medicaid LAO prescribing and Medicaid opioid prescribing in Iowa, Montana, and Virginia are concerning, and have implications for clinical opioid prescribing. The decreasing trends in Medicare Part D may reflect ongoing efforts in opioid prescription management. [ABSTRACT FROM AUTHOR]

Based on the observations and the phase 6 of Coupled Model Intercomparison Project (CMIP6) multimodel simulations, we conducted a detection and attribution analysis for the observed changes in intensity and frequency indices of extreme precipitation during 1961–2014 over the whole of China and within distinct climate regions across the country. A space–time analysis is simultaneously applied in detection so that spatial structure on the signals is considered. Results show that the CMIP6 models can simulate the observed general increases of extreme precipitation indices during the historical period except for the drying trends from southwestern to northeastern China. The anthropogenic (ANT) signal is detectable and attributable to the observed increase of extreme precipitation over China, with human-induced greenhouse gas (GHG) increases being the dominant contributor. Additionally, we also detected the ANT and GHG signals in China's temperate continental, subtropical–tropical monsoon, and plateau mountain climate zones, demonstrating the role of human activity in historical extreme precipitation changes on much smaller spatial scales. Significance Statement: The observed intensification of extreme precipitation globally has been attributed to human influences. Here, we demonstrate that anthropogenic forcing has discernably intensified extreme precipitation over the period 1961–2014, over China and in three of its four climate zones, with human-induced greenhouse gas increases being the dominant contributor. Our results strengthen the body of evidence that greenhouse gas increases are intensifying extreme precipitation by quantifying their role in observed changes at smaller regional scales than previously reported. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to use visual mapping and bibliometric analysis to summarize valuable information on the tumor microenvironment (TME)-related research on hepatocellular carcinoma (HCC) in the past 20 years and to identify the research hotspots and trends in this field. Methods: We screened all of the relevant literature on the TME of HCC in the Web of Science database from 2003 to 2023 and analysed the research hotspots and trends in this field via VOSviewer and CiteSpace. Results: A total of 2,157 English studies were collected. According to the prediction, the number of papers that were published in the past three years will be approximately 1,394, accounting for 64.63%. China published the most papers (n=1,525) and had the highest total number of citations (n=32,253). Frontiers In Immunology published the most articles on the TME of HCC (n=75), whereas, Hepatology was the journal with the highest total number of citations (n=4,104) and average number of citations (n=91). The four clusters containing keywords such as "cancer-associated fibroblasts", "hepatic stellate cells", "immune cells", "immunotherapy", "combination therapy", "landscape", "immune infiltration", and "heterogeneity" are currently hot research topics in this field. The keywords "cell death", "ferroptosis", "biomarkers", and "prognostic features" have emerged relatively recently, and these research directions are becoming increasingly popular. Conclusions: We identified four key areas of focus in the study of the TME in HCC: the main components and roles in the TME, immunotherapy, combination therapy, and the microenvironmental landscape. Moreover, the result of our study indicate that effect of ferroptosis on the TME in HCC may become a future research trend. [ABSTRACT FROM AUTHOR]

Background: CDK7 has been demonstrated to play a crucial role in the initiation and progression of malignancy. Therefore, targeting CDK7, which regulates the transcription process, has emerged as a new promising approach for treating cancer. Research on CDK7 inhibitors has significantly increased over the past 2 decades, with almost 600 related papers in the Web of Science Core Collection database. To effectively identify future research hotspots and potential future directions, it is crucial to systematically review and visually present the research on this topic from a comprehensive viewpoint, ensuring scientific reliability. Methods: This study performed bibliometric analysis via CiteSpace and VOSviewer scientometrics analysis software to examine data on the publication of articles on CDK7 inhibitors over the past 2 decades; the data included country of publication, author names, institution names, scientific categories, cited journals, and keywords related to the field of CDK7 inhibitors. Results: This bibliometric analysis included 426 publications from 41 different nations, referencing a total of 15,892 sources. Research associated with CDK7 inhibitors has rapidly expanded since 2016, and the US and China are the two countries with the highest publication output among the countries and institutes that produce literature on CDK7 inhibitors. Furthermore, the US is the country that most frequently engages in international cooperation. The evolution of keywords identifying antitumor strategies related to CDK7-mediated cellular transcription processes has been the research focus in recent years. Conclusion: In this study, we identified research efforts and their evolving patterns and predicted advances in the CDK7 inhibitor field. The knowledge structure of CDK7 inhibitors encompasses pharmacological mechanisms, therapeutic targets, and cancer treatment strategies. The primary objectives of contemporary research are to discover the processes underlying cancer progression, identify specific signaling pathways, and develop effective clinical medicines. [ABSTRACT FROM AUTHOR]

The study examines the spatiotemporal and statistical characteristics of the daily ultraviolet index (UVI) over the Johor state of Malaysia. The datasets utilized in this study are the Ozone Monitoring Instrument (OMI)/Aura satellite's daily UVI observations between October 2004 and March 2023. The innovative trend analysis (ITA) method is employed to identify the statistical trend of daily UVI. Basic statistics of daily, monthly, and seasonal UVI are also carried out to better characterize UVI in the study area. The daily UVI data collected for the analysis exhibit wide variability, with more than 80% of the daily UVI data falling above UVI 8, indicating the severity of UV radiation (UVR) reaching the study area. The monthly and seasonal UVI also display highly varying characteristics, as observed in the daily data. The pixel-based analysis of ITA results indicates a significant increasing and decreasing trend of daily UVI in the region, with values varying between − 9.42 × 10−6 and 3.79 × 10−5. However, for the study area as a whole, UVI shows a significant increasing trend of 4.50 × 10−5. The influence of parameters such as cloud optical thickness (COT), solar zenith angle (SZA), and O3 column on the strength of UVR reaching the study area is also investigated. Based on the results, the study area is characterized by low thickness, broken clouds, and sometimes cloudless conditions. Overall, the results show that UVI in the study area is increasing, and therefore, proper health guidelines and direct UVR exposure regulations need to be implemented to reduce serious health risks associated with UVR exposure. [ABSTRACT FROM AUTHOR]

Introduction: Anal fissure (AF) poses a common challenge in clinical practice, prompting various treatment approaches. This multicenter study, conducted by the Italian Society of Colorectal Surgery, aimed to assess treatment trends in AF over a 10 year period. Methods: A survey of proctologists and retrospective analysis of patient records were conducted to evaluate treatment modalities and outcomes across six different clinical scenarios based on AF presentation (acute/chronic) stratified by sphincter function (normal/hypertonic/hypotonic). Results: Analysis of data from 17 principal investigators and 22,016 patients revealed significant variability in treatment approaches, influenced by factors such as symptom duration, anal tone, and surgeon preference. Conservative treatments were commonly utilized, while surgical interventions were reserved for refractory cases. Specifically, pharmaceutical treatment was administered to 66–75% of patients in cases of acute AF and 63–67% for chronic AF, while 10–15% underwent anal dilation, and < 2% received botulinum toxin injection. Among medical treatments, nifedipine with lidocaine and glycerin film-forming ointments were the most utilized. The most performed surgical techniques were fissurectomy and anoplasty, except for patients with chronic AF and hypertonic sphincter where sphincterotomy prevailed. Trends in treatment utilization varied depending on the clinical scenario, with notable shifts observed over time. Conclusions: This study provides insights into the evolving landscape of AF management, highlighting the need for further research to elucidate optimal treatment strategies and improve patient outcomes. [ABSTRACT FROM AUTHOR]

We study the air temperature with 10 years of hourly measured in 12 automatic weather stations, located in the State of Bahia (Brazil), considering mainly its auto‐ and cross‐correlation. We found that, in general, there is a positive linear trend, indicating warming in this variable for all stations. Also, we observe that the probability distribution function clearly exhibits a bimodal distribution, meaning that there are two main seasonal cycles (the largest relating to winter, the other to summer). In order to have a more robust statistical analysis, detrended fluctuation analysis (DFA) method was applied in these time‐series to analyzing data where traditional methods might struggle due to nonstationary. In this case, DFA was useful in identifying long‐range autocorrelations in these time‐series (with persistent and antipersistent behavior) with specific seasonal time‐scales (1 day and 1 year). However, if we quantify the cross‐correlations between the air temperature in Salvador and the other stations, by ρDCCA, we found that detrended cross‐correlation analysis cross‐correlation coefficient is always positive with two peaks, the first is located at n = 24 (1 day) and the second at n = 8766 (1 year). In this sense, ρDCCA coefficient provides insights how air temperature in Salvador is correlated with air temperature in other weather stations over different time‐scales, helping to understand their long‐term interactions. These results, for example, allow us to identify temporal scales that may be useful to better understand trends in the air temperature and that can help us further answer global warming questions. [ABSTRACT FROM AUTHOR]

Polycythemia vera (PV) is a myeloproliferative tumor with low incidence and complex symptoms, affecting patients' quality of life and shortening their life span. Since the beginning of the 21st century, there has been an update but a need for uniform consensus regarding diagnosing and treating PV. With the continued interest of researchers in this field, a bibliometric study of PV is necessary. This paper aims to analyze articles on PV through bibliometric software to provide collaborative information and new ideas for researchers in this field. We collected PV-related publications in the Web of Science Core Collection database from 2000 to 2023. The included literature was analyzed using Citespace (6.2.R2), VOSviewer (1.6.19), and Bibliometrix. The study included country/region, institution, authors, journals, keywords, and references, and a visual knowledge network diagram was constructed. Microsoft Excel 2013 was also used for statistical analysis. A total of 1,093 articles were eventually included. The number of PV-related publications has steadily increased from 2000 to the present, with great potential for future growth. The US and US institutions have contributed more to this field, with the US ranking first in the number of publications, total citations, and centrality. Alessandro M. Vannucchi is the most published author. Tefferi, Ayalew is the most cited author. And BLOOD has the most publications, topping the list of the eleven high-productivity core source journals. The most cited article was "Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders" (Baxter, EJ, 2005). By examining the keywords, we found that the diagnosis and typing of true erythrocytosis, the use of ruxolitinib, and the tyrosine kinase JAK2 are the research hotspots in the field; genetic and molecular research in the field of true erythrocytosis is a cutting-edge topic in the field; and risk factors for true erythrocytosis is a cutting-edge hotspot issue in the field. The fruitful research in this century has laid the foundation for developing the field of PV. The information in this article will provide researchers with current hotspots and future potential in the discipline, helping the field achieve more extraordinary breakthroughs. Currently, research should focus on increasing global multicenter collaborative research in diagnosis and treatment to develop scientifically recognized diagnostic and treatment protocols and new clinical drug research. Our proposed model of global innovation collaboration will provide strong support for future research. [ABSTRACT FROM AUTHOR]

Purpose: Our recent analysis reported decreasing trends in intake of free sugar in children and adolescents in Germany. Here we set out to update this analysis with current dietary intake (until 2023) because of the strong public health nutrition interest in sugar intake. Methods: In total, 4,218 dietary records kept between 2010 and 2023 by 751 participants (46.0% females, 3–18 years) from the German Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) cohort were examined. Age and time trends in free sugar intake (%E/d) were analysed using polynomial mixed-effects regression models. Results: Median intake data indicate a decline in the intake of free sugar between 2010/2011 (16.7%E) and 2022/2023 (11.7%E). Trend analyses confirmed, that intake of free sugars decreased continuously between 2017 and 2023 (Linear trend: β = -0.4126, p < 0.0001). In addition, free sugar intake changed significantly with age (Linear trend: β = 1.2922, p < 0.0001; quadratic trend: β = -0.08613, p = 0.0094; cubic trend: β = 0.001442, p = 0.1725), i.e. the intake of free sugars increases continuously up to early adolescence (9/10 years) and decreases again thereafter. Conclusion: The intake of free sugar among children and adolescents continued to decline, but still exceeded the WHO recommendations in 2023. Further measures to reduce free sugar intake would therefore be desirable, as well as continuous monitoring of sugar intake levels among this age groups. [ABSTRACT FROM AUTHOR]

Elevation‐dependent warming (EDW) has been a topic of intense debate due to limited observed data in global highland areas. This study aims to fill this gap by utilizing CRU and ERA5 datasets from 1981 to 2021 to explore the trends of climate change and its elevation dependency. The anomalies of temperature indicators (Tmean, Tmax, and Tmin) in both ERA5 and CRU showed significant warming trends over global highlands. Moreover, the response of temperature indicators to elevation across global highlands is not spatially uniform. The linear regression model based on the elevation showed significant warming signals for the temperature indicators at various elevations over the global highlands. On a regional scale, Tmean and Tmax predominantly showed linear EDW over EU highlands, while Tmean in Asian highlands exhibited EDW signals at 4–5 km. Tmin showed EDW at 2.5–5.5 km with ERA5 and 3–5 km with CRU. In the Andes, EDW was prominent at 2.5–4 km. Overall, EDW signals are evident in all studied regions but vary across them. While assessing the driving factors, the results of this study indicate that total column water vapour (TCWV), snow depth (SD), snow albedo, and normalized difference vegetation index (NDVI) correlated positively with the temperature indicators. These findings emphasize the significance of elevation‐specific interactions between environmental factors and temperature in forecasting temperature changes in mountainous areas. Additionally, temperature exhibited coherence with teleconnection indices from the Atlantic and Pacific Oceans. Asian and European (EU) highlands exhibited interzonal coherence with the Pacific and Atlantic Oceans, while North American (NA) highlands showed coherence, followed by South American (SA) highlands. These findings provide a comprehensive understanding of EDW and its implications for highland regions globally, including the potential for more severe depletion of snow/ice resources in a warmer future. [ABSTRACT FROM AUTHOR]

Introduction: Gastric cancer (GC) remains a significant global public health problem, despite the decreasing trends in GC mortality rates in the last 5 decades. Our study aimed to examine the pattern of GC mortality in Montenegro between 1990 and 2018 and to contribute to the future by designing a national long-term strategy for the control and prevention of GC. Methods: Gastric cancer mortality data in Montenegro from 1990 to 2018 were collected. Mortality rates were age-standardized to the World Standard Population for estimating both the overall and gender-specific trends. The joinpoint regression model was used to assess GC mortality and identified significant changes in the linear time trend. Linear and Poisson regressions were also applied for additional trend analyses. Results: Joinpoint regression reveals a statistically significant decrease in the age-standardized rate for the overall level, on average by 1.4% per year (AAPC [95% IP] = −1.4 [−2.4 to −0.4]; p = 0.007), which was due to a decrease in the age-standardized rate in men with an average annual change of −1.8% (AAPC [95% IP] = −1.8 [−2.9 to −0.6]; p = 0.003), while in women the rates were stable (p = 0.565). The results for age groups indicate that a decline was registered at the overall level, and among men, as a consequence of the trend of decreasing age-specific rates for the age group 55–64 on average annually by 2% among men (AAPC [95% IP] = −2 [−3.8 to −0.1]; p = 0.035), and for the overall level (AAPC [95% IP] = −2 [−3.7 to −0.3]; p = 0.026). Conclusion: Our findings indicate a noteworthy decline in age-standardized overall GC mortality rates among men in Montenegro, while rates for women have remained constant. National strategies to further reduce mortality rates for GC are necessary. [ABSTRACT FROM AUTHOR]

Background and aims: Alcohol consumption has decreased in England in recent decades, while alcohol‐specific death rates have remained relatively stable. Age–period–cohort (APC) models offer the potential for understanding these paradoxical trends. This study aimed to use an APC model approach to measure long‐term trends in alcohol abstention and consumption in England from 2001 to 2019. Design, setting and participants: The study used grouped and proxy‐variable APC models of repeat cross‐sectional survey data, set in England (2001–19). Participants were residents in England aged 13 years or over who took part in the Health Survey for England. Measurements: Outcome variables were alcohol abstention and consumption in units. We created nine age groups (13–15, 16–17, 18–24, 25–34, until 65–74 and 75+, reference 45–54 years), four periods (2001–04, 2005–09, 2010–14 to 2015–19, reference 2005–09) and 18 5‐year birth cohorts (1915–19 to 2000–04, reference 1960–64). We proxied age effects (systolic and diastolic blood pressure), period effects (alcohol affordability, internet usage and household alcohol expenditure) and birth cohort effects (prevalence of smoking and prevalence of overweight). Findings The odds of abstaining were considerably larger at young ages, 13–15 years [odds ratio (OR) = 5.38; 95% confidence interval (CI) = 4.50–6.43], were lowest during the first period, 2001–04 (OR = 0.83; 95% CI = 0.79–0.86) and had a U‐shaped pattern by birth cohort. For units of alcohol, the incidence rate ratio (IRR) increased until age 18–24 years (IRR = 1.41, 95% CI = 1.34–1.48) and decreased afterwards, were highest during the first period, 2001–04 (IRR = 1.07; 95% CI = 1.05–1.08) and showed an inverted J‐shape by birth cohort. Our proxy variable approach revealed that using blood pressure measures, alcohol affordability and prevalence of overweight as proxies resulted in APC effects that differed from our base‐case model. However, internet usage, household expenditure on alcohol and smoking prevalence resulted in APC effects similar to our base‐case model. Conclusions: The discrepancy between decreasing alcohol consumption and increasing alcohol‐related deaths observed in England from 2001 to 2019 may, in part, be explained by the halt in abstention trends since 2010 and a slight consumption decline since 2001. [ABSTRACT FROM AUTHOR]

Predicting landslide displacement is crucial for the prevention and mitigation of landslide disasters. This study proposes a method based on a stacking ensemble learning strategy to predict landslide displacement, incorporating distinct yet effective individual models: the Voight model, the GM(1,1) grey model, and the backpropagation neural network (BPNN). These models are respectively emblematic of empirical, statistical, and nonlinear approaches to modeling. The stacking ensemble learning method marries creep theory, grey system theory, and nonlinear theory to accurately capture the statistical trends and step-like behavior characteristic of landslide displacement. A key feature of this approach is the tailored use of non-cross-validation, partial cross-validation, and 5-fold cross-validation for the Voight, GM(1,1), and BPNN models, respectively. This ensures that the conditions for model applicability are satisfied while fully leveraging their strengths, allowing the ensemble method to enhance prediction performance. The method is demonstrated through its application to the Xintan landslide in Zigui County, Hubei, China. Comparative analysis of the Voight, GM(1,1), BPNN, and the proposed stacking ensemble learning model reveals that the ensemble model achieves superior accuracy, underscoring its effectiveness in predicting landslide displacement. This promising method can effectively capture the landslide evolution process and be promoted to predict displacement in other landslide scenarios. [ABSTRACT FROM AUTHOR]

• Improvement in detection and anticipation of placental complications may be effective in addressing the increasing trend of PPH • Increasing C-sections trends and other interventions may also need to be addressed while quality improvement projects will have a role to play. • Further staff education to upskill to reduce the incidence of unintentional cutting during caesarean section and episiotomies. To analyse temporal trends for primary Postpartum Haemorrhage (PPH), Major Obstetric Haemorrhage (MOH) between 2005 and 2021 and to examine the causes and factors contributing to the risk of PPH during 2017–2021. International ICD-10-AM diagnostic codes from hospital discharge records were used to identify cases of PPH. Temporal trends in PPH and MOH incidence were illustrated graphically. Poisson regression was used to assess the time trends and to examine factors associated with the risk of PPH during 2017–2021. A total of 1,003,799 childbirth hospitalisations were recorded; 5.6% included a diagnosis of primary PPH. Risk increased almost fourfold from 2.5% in 2005 to 9.6% in 2021. The ICD-10 AM code for other immediate primary PPH was recorded for 85% of PPH cases in 2017–2021 whereas a diagnosis of uterine inertia/atony was associated with just 3.6% of the cases. Respectively, trauma-related, tissue-related and thrombin-related causes were associated with one third, 4.2% and 0.5% of cases. A wide range of factors relating to the woman including comorbidities, mode of delivery, labour-related interventions and associated traumas increased risk of PPH but placental complications, especially morbidly adherent placenta, were strong risk factors. Improvement in detection and anticipation of placental complications may be effective in addressing the increasing trend of PPH, however, the trends of increasing C-sections and other interventions may also need to be addressed while staff education and quality improvement projects will have a role to play. [ABSTRACT FROM AUTHOR]

Creating innovative methodologies and interventions in chemistry education is essential to promote positive student transformation outcomes. Although chemistry educators are key in utilizing its potential in the classroom, very little is known about its efficacy in teaching and learning. This study aims to determine the current research trends in chemistry education. It examines the effect of chemistry education research findings included in the meta-analysis on using varied teaching methodologies on student transformation outcomes. A systematic review and meta-analysis of a pool of studies related to chemistry instruction in the Philippines and through on site or online browsing were conducted. Results show that the country's pedagogical trend in chemistry education centers mainly on cooperative and inquiry-based learning, which aligns with and supports the framework and goals of 21st-century teaching. Results suggested that chemistry teachers can consider employing one of the various pedagogies and methods that effectively improve students' cognitive and affective outcomes. Heterogeneity test warrants that significant differences exist between the grouped features. The effect size data are directly influenced by the significance of the test derived from each study. Studies with significant results tend to have a larger effect size and significantly affect the study variables. [ABSTRACT FROM AUTHOR]

The incidence of human illness due to Salmonella Infantis reported to Foodborne Diseases Active Surveillance Network and the prevalence of Infantis on chicken carcasses reported by the United States Department of Agriculture Food Safety and Inspection Service have increased significantly in the past decade. However, the trends do not appear coincident, as would be expected if the increased prevalence in chicken led to the increase in the incidence of human illness. Salmonella Infantis incidence and prevalence trends are analyzed using penalized B‐spline methods for generalized additive regression models. The association between the two time series is analyzed using time‐lagged rank‐order cross‐correlation. Geographic variations in reported incidence and trends are also explored. The increase in human incidence of Salmonella Infantis began circa 2011. The increase in chicken carcass prevalence began circa 2015. A 4‐year lag on chicken carcass prevalence maximizes the rank‐order cross‐correlation with the incidence of illness. While chicken consumption undoubtedly contributes to the incidence of human illness due to Salmonella Infantis, the initial increase in reported illness was likely due to one or more other transmission pathways. Other potential transmission pathways include non‐chicken foodborne, waterborne, person‐to‐person, animal contact, and environmental. [ABSTRACT FROM AUTHOR]

The continuous challenges to which family firms are subjected have led research in this field to focus on various aspects, thus generating a large and heterogeneous body of literature. This paper describes the evolution, status, and trends in family business literature over the decade 2012–2022 and also identifies gaps that may require further investigation. In that regard, new opportunities for additional analyses are also determined. To this end, a bibliometric study has been carried out based on a collection of articles from the Business Source Premier, Web of Science, and Scopus databases, yielding a total of 4064 articles. We analyze the main indicators of activity in family business research over the aforementioned period. The most productive authors and institutions, leading journals, and main research topics of these publications are reflected in this analysis. Likewise, the relationships between the most frequent co-authorships within the field are mapped, as well as the connections between co-words in published articles. In addition, the 10 most influential works published during those 10 years and changes in trends related to the most popular topics, in contrast to previous years, are also highlighted. Plain English Summary: Trends in the field of family business research have changed over the last decade, with "entrepreneurship and innovation" becoming the most researched topic. Our work updates knowledge on how family business studies have evolved and highlights the current lack of micro-research on this subject. Thus, by recognizing the importance of micro-level variables and underexplored areas, this paper paves the way for further scholarly inquiry in this discipline. As they conduct their own investigations and contribute to the growing body of knowledge in this area, researchers and scholars in this field will benefit from the insights provided in this article. [ABSTRACT FROM AUTHOR]

Background: Overall inferior vena cava filter (IVCF) utilization has decreased in the United States since the 2010 US Food and Drug Administration (FDA) safety communication. The FDA renewed this safety warning in 2014 with additional mandates on reporting IVCF-related adverse events. We evaluated the impact of the FDA recommendations on IVCF placements for different indications from 2010 to 2019 and further assessed utilization trends by region and hospital teaching status. Methods: Inferior vena cava filter placements between 2010 and 2019 were identified in the Nationwide Inpatient Sample database using the associated International Classification of Diseases, Ninth Revision, Clinical Modification, and Tenth Revision codes. Inferior vena cava filter placements were categorized by indication for venous thromboembolism (VTE) "treatment" in patients with VTE diagnosis and contraindication to anticoagulation and "prophylaxis" in patients without VTE. Generalized linear regression was used to analyze utilization trends. Results: A total of 823 717 IVCFs were placed over the study period, of which 644 663 (78.3%) were for VTE treatment and 179 054 (21.7%) were for prophylaxis indications. The median age for both categories of patients was 68 years. The total number of IVCFs placed for all indications decreased from 129 616 in 2010 to 58 465 in 2019, with an aggregate decline rate of −8.4%. The decline rate was higher between 2014 and 2019 than between 2010 and 2014 (−11.6% vs −7.2%). From 2010 to 2019, IVCF placement for VTE treatment and prophylaxis trended downward at rates of −7.9% and −10.2%, respectively. Urban nonteaching hospitals saw the highest decline for both VTE treatment (−17.2%) and prophylactic indications (−18.0%). Hospitals located in the Northeast region had the highest decline rates for VTE treatment (−10.3%) and prophylactic indications (−12.5%). Conclusion: The higher decline rate in IVCF placements between 2014 and 2019 compared with 2010 and 2014 suggests an additional impact of the renewed 2014 FDA safety indications on national IVCF utilization. Variations in IVCF use for VTE treatment and prophylactic indications existed across hospital teaching types, locations, and regions. Clinical Impact: Inferior vena cava filters (IVCF) are associated with medical complications. The 2010 and 2014 FDA safety warnings appeared to have synergistically contributed to a significant decline in IVCF utilization rates from 2010 – 2019 in the US. IVC filter placements in patients without venous thromboembolism (VTE) declined at a higher rate than VTE. However, IVCF utilization varied across hospitals and geographical locations, likely due to the absence of universally accepted clinical guidelines on IVCF indications and use. Harmonization of IVCF placement guidelines is needed to standardize clinical practice, thereby reducing the observed regional and hospital variations and potential IVC filter overutilization. [ABSTRACT FROM AUTHOR]

Background: It is generally perceived that minimally invasive nephroureterectomy (MINU), especially in the form of robotic-assisted laparoscopy, is gaining an increasing role in many institutions. Objective: The aim of our study was to investigate contemporary trends in the adoption of MINU in the United States compared with open nephroureterectomy (ONU). Methods: Patients who underwent ONU or MINU between 2011 and 2021 were retrospectively analyzed using PearlDiver Mariner, an all-payer insurance claims database. International Classification of Diseases diagnosis and procedure codes were used to identify the type of surgical procedure, patients' characteristics, social determinants of health (SDOH), and perioperative complications. The primary objective assessed different trends and costs in NU adoption, while secondary objectives analyzed factors influencing the postoperative complications, including SDOH. Outcomes were compared using multivariable regression models. Results: Overall, 15,240 patients underwent ONU (n = 7675) and MINU (n = 7565). Utilization of ONU declined over the study period, whereas that of MINU increased from 29 to 72% (p = 0.01). The 60-day postoperative complication rate was 23% for ONU and 19% for MINU (p < 0.001). At multivariable analysis, ONU showed a significantly higher risk of postoperative complications (odds ratio 1.33, 95% CI 1.20–1.48). Approximately 5% and 9% of patients reported at least one SDOH at baseline for both ONU and MINU (p < 0.001). Conclusions: Contemporary trend analysis of a large national dataset confirms that there has been a significant shift towards MINU, which is gradually replacing ONU. A minimally invasive approach is associated with lower risk of complications. SDOH are non-clinical factors that currently do not have an impact on the outcomes of nephroureterectomy. [ABSTRACT FROM AUTHOR]

Racial and ethnic disparities persist in cancer survival rates across the United States, despite overall improvements. This comprehensive analysis examines trends in 5-year relative survival rates from 2002–2006 to 2015–2019 for major cancer types, elucidating differences among racial/ethnic groups to guide equitable healthcare strategies. Data from the SEER Program spanning 2000–2020 were analyzed, focusing on breast, colorectal, prostate, lung, pancreatic cancers, non-Hodgkin lymphoma, acute leukemia, and multiple myeloma. Age-standardized relative survival rates were calculated to assess racial (White, Black, American Indian/Alaska Native, Asian/Pacific Islander) and ethnic (Hispanic, Non-Hispanic) disparities, utilizing period analysis for recent estimates and excluding cases identified solely through autopsy or death certificates. While significant survival improvements were observed for most cancers, notable disparities persisted. Non-Hispanic Blacks exhibited the largest gain in breast cancer survival, with an increase of 5.2% points (from 77.6 to 82.8%); however, the survival rate remained lower than that of Non-Hispanic Whites (92.1%). Colorectal cancer survival declined overall (64.7–64.1%), marked by a 6.2% point drop for Non-Hispanic American Indian/Alaska Natives (66.3–60.1%). Prostate cancer survival declined across all races, with Non-Hispanic American Indian/Alaska Natives showing a decrease of 7.7% points (from 96.9 to 89.2%). Lung cancer, acute leukemia, and multiple myeloma showed notable increases across groups. Substantial racial/ethnic disparities in cancer survival underscore the notable need for tailored strategies ensuring equitable access to advanced treatments, particularly addressing significant trends in colorectal and pancreatic cancers among specific minority groups. Careful interpretation of statistical significance is warranted given the large dataset. [ABSTRACT FROM AUTHOR]

Background: Limited data exists on trends in prevalence of adverse childhood experiences (ACE) at the national level and sociodemographic correlates of having ACEs. This study examined trends in ACE prevalence and sociodemographic correlates in US adults over 14 years using nationally representative data. Methods: Data on 447,162 adults from the Behavioral Risk Factor Surveillance System (BRFSS) across four timepoints (2009–2010; 2011–2012; 2019–2020; 2021–2022) was analyzed and weighted for population estimates. The primary outcome was ACEs with 3 groups used (0 vs. 1 + ACEs; <4 vs. 4 + ACEs; 0 vs. 1 vs. 2 vs. 3 vs. 4 + ACEs). Sociodemographic factors included age, sex, race/ethnicity, employment, education, marital status, income and insurance status. Prevalence trends were examined by estimating prevalence of ACE groupings (0/1+; <4/4+; 0,1,2,3,4+) across the four timepoints and trend analysis was performed to determine if the differences over time were statistically significant. Unadjusted and adjusted prevalence ratios were estimated using log-binomial regression models with ACE groupings as the outcome and timepoints as the primary independent variable with sociodemographic factors as covariates. Results: Across the four time points, prevalence of ACEs was higher across groupings of ACEs by time. For ACEs 1+, prevalence was 62.2% (2009–2010); 62.2% (2011–2012); 64.5% (2019–2020); and 67.2% (2021–2022). For ACEs 4+, prevalence was 17.4% (2009–2010); 18.1% (2011–2012); 20.4% (2019–2020); and 22.6% (2021–2022). Prevalence of ACE 1 + was higher for older adults, Non-Hispanic Black adults, Non-Hispanic Other adults, and those with higher education. Prevalence of 4 + ACEs was higher for females, and lower for those with higher education and those with higher annual incomes. Conclusion: This study shows an increased prevalence of having ACEs over a 14-year period and identified independent sociodemographic correlates of having ACEs in a nationally representative study. Targeted interventions are needed to reduce burden of ACEs using population-based approaches. [ABSTRACT FROM AUTHOR]

This study aims to evaluate the impact of the in-situ ocean observations on seasonal forecasts. A series of seasonal reforecasts have been conducted for the period 1993-2015, in which different sets of ocean observations were withdrawn in the production of the ocean initial conditions, while maintaining a strong constrain in sea surface temperature (SST). By comparing the different reforecast sets, it is possible to assess the impact on the forecast of ocean and atmospheric variables. Results show that the in-situ observations have profound and significant impacts on the mean state of forecast ocean and atmospheric variables, which can be classified into different categories: i) impact due to local air-sea interaction, as direct consequence of changes in the mixed layer in the ocean initial conditions, and visible in the early stages of the forecasts; ii) changes due to different ocean dynamical balances, most visible in the Equatorial Pacific in forecasts initialized in May, which amplify and evolve with forecast lead time; iii) changes to the atmospheric circulation resulting from changes in large scale SST gradients; these are non-local, mediated by the atmospheric bridge, and they are obvious from the visible impact of the removing in-situ observations on the Atlantic basin only in the global atmospheric circulation; iv) changes in the atmospheric tropical deep convection associated with the structure of the warm pools. The ocean observations have also a significant impact on the representation of the trends of the ocean initial conditions, which affect the trends in the seasonal forecasts of ocean and atmospheric variables. The impact of the ocean observing system in the Atlantic and extratropics appears dominated by Argo, but this is not the case in the Tropical Pacific, where the other ocean observing systems play a role in constraining the ocean state. [ABSTRACT FROM AUTHOR]

Objective: We summarize the global, regional, and national burden of inflammatory bowel disease (IBD) in children and adolescents from 1990 to 2019. Methods: Based on the Global Burden of Disease Study 2019, the data of IBD in children and adolescents were analyzed by sex, age, year, and location. Joinpoint analysis was applied to assess the temporal trend of the disease burden. Results: From 1990 to 2019, the incidence of IBD in children and adolescents increased by 22.8%, from 20,897.42 to 25,658.55 cases, especially in high SDI region. During the same period, the DALY numbers decreased by 53.5%, from 243,081.06 to 113,119.86, with all SDI regions experiencing a clear drop in DALYs except high SDI regions. In 2019, early-onset IBD incidence and DALY numbers were reported at 2,053.52 (95% UI: 1,575.62 to 2,677.49) and 73,797.46 (95% UI: 43,655.86 to 105,998.63), respectively. Conclusion: Early-onset IBD in children and adolescents remains a significant global health concern. The disease burden has not improved in developed countries over the past 30 years, highlighting the need for targeted interventions. [ABSTRACT FROM AUTHOR]

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting a significant portion of the population, with prevalence rates of 25% in children and 7-10% in adults. AD not only poses physical challenges but also profoundly impacts patients' mental well-being and quality of life. The stability of gut microbiota is crucial for overall health and can influence AD progression by modulating immune function, skin barrier integrity, and neuroendocrine signaling, which may be an effective target for the prevention and treatment of AD. Thus, exploring the interactions between AD and gut microbiota, particularly in infants, can provide insights into potential preventive and therapeutic strategies. This study aimed to explore the correlation between AD and gut microbiota while providing an overview of current research trends and emerging areas of interest in this field. Methods: A comprehensive search was conducted on the Web of Science Core Collection (WOSCC) for relevant publications from January 1, 2014, to December 31, 2023. English-language articles and reviews were included. Two investigators independently screened the publications, and visual analysis was performed using CiteSpace, VOSviewer, Scimago Graphica, and Microsoft Excel software. Results: A total of 804 articles were included, showing a significant increase in publications over the past decade. The United States, Wageningen University, and University Ulsan (represented by Hong SJ) had the highest number of published papers. Nutrients was the journal with the most publications, while the Journal of Allergy and Clinical Immunology had the highest number of citations and centrality among co-cited journals. Keyword visualization analysis identified "atopic dermatitis" and "gut microbiota" as central themes. Notably, there has been a notable shift in research focus over the years, with early studies concentrating on "Fecal microbiota," "caesarean section," and "first 6 months," while recent studies have highlighted the roles of "cells," "dysbiosis," and "prebiotics." This shift indicates growing interest in the underlying mechanisms and potential therapeutic interventions related to the intestinal microecology in AD treatment. Conclusion: The field of AD and gut microbiota research has evolved significantly, with an increasing focus on understanding the intricate interactions between gut microbiota and AD pathogenesis. Recent years have witnessed increased interest in understanding the relationship between AD and gut microbiota, with researchers conducting extensive studies exploring various aspects of this connection. This review analyzes research trends over the past decade, highlighting trends and hotspots in the study of AD, particularly in infants, and the role of microbiota. This review serves as a valuable reference for future investigations, aiming to provide deeper insights into this burgeoning field and suggests directions for future research. [ABSTRACT FROM AUTHOR]

Introduction: The Democratic Republic of Congo (DRC) does not have national prevalence data for arterial hypertension (HTN) or diabetes (type I and II combined) to aid evidence-based decision-making, despite the assumption of epidemiological transition in low- and middle-income countries. The aim of this study was to estimate a proxy of prevalence for HTN and diabetes. Methodology: This study used routine monthly reported data pertaining to HTN and diabetes from the District Health Information Software 2 (DHIS2), spanning 2019–2023. Data underwent quality assessment and adjustments using standardization before analysis. Equity analyses were carried out at the national and sub-national levels. Epidemiological curves and maps were produced to analyze trends in the prevalence of HTN and diabetes among adults aged 18 and over. Permission to use the data was obtained from the regulatory authority. Results: Over five years, incidence of HTN increased from 13.23% (CI 95%: 13.22–13.24) to 15.23% (CI 95%: 15.22–15.24) (+15.1% relative increase), and diabetes rose from 2.73% (CI 95%: 2.72–2.74) to 3.345% (CI 95%: 3.34–3.35) (+16.3% relative increase), with provincial variations observed. Conclusions: In the DRC, hypertension and diabetes are advancing rapidly. Primary and preventative healthcare services and public health interventions must prioritize these diseases. [ABSTRACT FROM AUTHOR]

Objectives: To investigate temporal trends and overall complication rates among open partial nephrectomy (OPN) and minimally invasive partial nephrectomy (MIPN), including the impact of social determinants of health (SDOH) on postoperative outcomes. Methods: Patients who underwent OPN or MIPN between 2011 and 2021 were retrospectively analyzed by using PearlDiver-Mariner, an all-payer insurance claims database. The International Classification of Diseases diagnosis and procedure codes were used to identify the type of surgical operation, patient's characteristics (age, sex, region, insurance plan), postoperative complications and SDOH, categorized in education, healthcare, environmental, social, and economic domains. Outcomes were compared using multivariable regression models. Results: Overall, 65,325 patients underwent OPN (n = 23,377) or MIPN (n = 41,948). OPN adoption declined over the study period, whereas that of MIPN increased from 24% to 34% (p = 0.001). The 60-day postoperative complication rate was 15% for the open and 9% for the minimally invasive approach. Approximately 16% and 11% of patients reported at least one SDOH at baseline for OPN and MIPN, respectively. SDOH were associated with higher odds of postoperative complications (OPN = OR: 1.11, 95% CI: 1.01–1.25; MIPN = OR: 1.31, 95% CI: 1.18–1.46). The open approach showed a significantly higher risk of postoperative complications (OR: 1.62, 95% CI: 1.54–1.70) compared to the minimally invasive one. Conclusions: Our findings confirm that MIPN is gradually replacing OPN, which carries a higher risk of complications. SDOH are significant predictors of postoperative complications following PN, regardless of the approach. [ABSTRACT FROM AUTHOR]

Extreme rainfall events (EREs) caused by convection are a major prediction challenge and can lead to deadly flash flooding. This study investigates EREs from 2003 to 2023 over the central and eastern United States using high‐resolution (4‐km) Stage IV precipitation analyses. EREs were defined where 12‐hr accumulations exceeded the 10‐year average recurrence interval thresholds. Summertime (June–August) EREs exhibited pronounced interannual variability, but with statistically significant increasing trends in annual frequency, particularly among those caused by mesoscale convective systems. Significant relationships were also found between summertime convective EREs over the central United States and enhanced poleward moisture transport, consistent with a westward expansion of the climatological North Atlantic Subtropical High. This relationship may aid in medium‐ and long‐range forecasting. However, the spatial scale of EREs often included localized or narrow bands of extreme accumulations, revealing significant challenges in the accurate representation of EREs in weather and climate models. Plain Language Summary: Extreme rainfall events often result from slow‐moving thunderstorms that drop heavy rain over the same area for several hours, which can cause deadly flash flooding. This study defines an extreme rainfall event where the 12‐hr accumulation would only exceed that amount once every 10 years on average, with a focus on the summer months over the central and eastern United States from 2003 to 2023. Our results show a significant increasing trend in the number of extreme events, especially those caused by larger, longer‐duration storms. Our use of a high‐resolution rainfall data set also revealed that extreme rainfall often occurs due to nighttime thunderstorms producing heavy rainfall over highly localized areas or narrow (20–40 km wide) swaths. These characteristics present a challenge for global weather and climate models. The frequency of these summertime extreme events also significantly varied from year to year. Summers with more extreme events were associated with a greater northward transport of moist air around the western edge of an area of high pressure that extends westward from the Atlantic Ocean. The relationship between this flow pattern and extreme rainfall suggests a possible path for improving forecasts of extreme rainfall. Key Points: High‐resolution rainfall data reveal an increasing trend in extreme summertime rainfall, especially from mesoscale convective systemsMore events occurred during summers with greater southerly moisture transport driven by differences in the North Atlantic Subtropical HighThe relatively small scale of extreme convective rainfall presents a challenge for representing these events in weather and climate models [ABSTRACT FROM AUTHOR]

Observed precipitation changes in the Southeast United States (SEUS) are spatially heterogeneous. Most of the inland SEUS and eastern Gulf Coast become drier, and the East Coast north of Charleston, South Carolina, and southern Florida become wetter from the old 30-yr period of 1961–90 to the recent period of 1991–2020. The observed climate change is examined from the perspective of daily weather types (WTs). A k-means clustering analysis has been conducted using daily 850-hPa circulation for 1948–2021. The obtained 10 WTs peak in different seasons, respectively. The frequencies and precipitation intensity of the WTs have been analyzed. A winter WT characterized by a western Appalachian trough (WAT) and a summer WT featuring North Atlantic subtropical high (NASH) have a rising trend of annual frequency from 1948 to 2021. An Appalachian high in the autumn has a decreasing frequency but becomes drier and stronger. Some precipitation intensity change and small location shift have also been observed. The drying up on the eastern Gulf Coast and the inland area of the SEUS is mainly caused by the weakened southwesterly low-level jet (LLJ) on the western flank of the NASH that reduces rain in the spring, the less frequent but stronger and drier Appalachian high in the summer and autumn, and the weaker and more western located Plains trough (PT) in the winter, spring, and autumn. The precipitation increase in the East Coast and southern Florida is majorly due to more frequent, stronger, and rainier troughs along the western Appalachian as well as the East Coast. [ABSTRACT FROM AUTHOR]

Physical fitness is considered an important indicator of health in adolescents. Despite the recognized benefits of regular physical activity, recent studies indicate a decline in physical fitness among adolescents, including agility, a key component of fitness often overlooked in research. This study aimed to investigate trends in agility among urban Catalan adolescents over two decades. A total of 1439 students, aged 13–15 years, participated in the 8 × 10 m shuttle run test between 2002 and 2022. The results revealed a significant decline in agility performance across both boys (F(3,839) = 392, p < 0.001, ηp2 = 0.584) and girls (F(3,593) = 414, p < 0.001, ηp2 = 0.677) over time, with notable differences observed between consecutive five-year periods. The findings underscore the urgency of addressing declining physical fitness among adolescents and advocate for enhanced physical education programs and community-based interventions to promote regular physical activity. Recognizing the importance of agility and other aspects of physical fitness in adolescent health, policymakers, educators, and healthcare professionals are urged to collaborate on initiatives to mitigate the risk of future health issues. Further research is recommended to explore the multifaceted influences on adolescent physical fitness and develop targeted interventions to improve overall health outcomes in this population. [ABSTRACT FROM AUTHOR]

Aims Method Results Conclusion Anal cancer, despite its rarity, is a matter of serious concern in the United States, with an uptrend in recent years and marked racial disparities in mortality rates. The aim of this work was to investigate anal cancer mortality trends and sex race disparities in the United States from 1999 to 2020.This is a retrospective study using data from the CDC WONDER database (1999–2020). We investigated deaths attributed to anal cancer, identified by the ICD‐10 code C21.1, and excluded individuals aged 14 years and under. The Mann–Kendall trend test was used to investigate temporal trends and a t‐test was used to compare continuous variables.Both male and female age‐adjusted mortality attributed to anal cancer increased significantly during the study period across all subgroups, including race (Black and White), US Census region (Northeast, Midwest, South and West) and age (15–64 and ≥65 years) (p < 0.001 for all comparisons). For each subgroup, women demonstrated significantly higher rates of mortality than men, except in the Black population, where Black men had higher rates than Black women (0.40 vs. 0.29, p < 0.001). Additionally, Black men had significantly higher mean mortality rates than White men (0.40 vs. 0.27, p < 0.001). The highest rates of anal cancer mortality were among geriatric individuals, especially women aged ≥65 years, at 1.18 per 100 000.The rise in anal cancer mortality and racial and sex disparities present a significant challenge for healthcare providers and policy makers. Further studies are required to devise evidence‐based strategies to effectively tackle this challenge. [ABSTRACT FROM AUTHOR]

Trend detection in environmental data subjected to natural fluctuations can prove difficult. With river temperature, the difficulty also lies in the typically limited lengths of the time series. In this work, three different river temperature data sources (continuous and spot instream measurements, and satellite thermal images) were combined to build 30- to 44-year-long time series at 116 locations, distributed throughout most of the Quebec Province territory. Mann-Kendall tests and a non-linear model were used to detect and quantify trends. Uncertainty and biases due to the different data sources and uneven samplings were evaluated and included in the assessment of the trends’ quantification and reliability. Overall, most trends detected in the temperature of Quebec rivers are positive, with higher warming occurring in summer. Annual maxima are found to have increased by 0.023°C/year (median value) between 1979 and 2022, and this maximum appears to occur 2.6 days (median value) later. [ABSTRACT FROM AUTHOR]

AbstractRuth Brunyate Wiemer, MA, OTR was instrumental in implementing the changes mandated by the adoption of the 1965 Bylaws which effectively separated the national occupational therapy association into a business league (American Occupational Therapy Association) and a charitable research focused organization (American Occupational Therapy Foundation). Wiemer may not be as well- known as her friend and colleague Wilma L. West, yet they shared similar attributes; West is known as the “thinker”, Wiemer was the “doer”. The paper’s focus is on Wiemer’s life, work, and her important contributions to the profession of occupational therapy. [ABSTRACT FROM AUTHOR]

AbstractAimMethodsResultsConclusionsGuillain-Barré syndrome (GBS) is an autoimmune neurological disorder, with an estimated 6.4% increase in cases worldwide from 1990 to 2019. We aim to identify the GBS-related mortality trends in the US stratified by age, sex, race, and region.We used data from the CDC-WONDER database to calculate crude (CMR) and age-adjusted mortality rates (AAMRs) per 1,000,000 people. We examined the temporal trends through annual percent change (APC) and the average annual percent change (AAPC) in rates using Joinpoint regression.From 1999 to 2020, a total of 10,097 GBS-related deaths occurred in the US. The AAMR decreased till 2014 (APC: −1.91) but increased back to initial levels by 2020 (APC: 3.77). AAMR was higher in males (1.7) than females (1.1), decreasing till 2015 for females and 2014 for males, but increasing thereafter only for females. Non-Hispanic (NH) American Indians or Alaska Natives displayed the highest AAMR (1.8) while NH Asians or Pacific Islanders displayed the lowest (0.6). AAMRs also varied by region (West: 1.5; South: 1.5; Midwest: 1.4; Northeast: 1.1). Rural regions exhibited a higher AAMR (1.7) than urban regions (1.3). Most deaths occurred in medical facilities (60.99%). The adults aged ≥85 years exhibited an alarmingly high CMR (14.0).While the mortality rates for GBS initially declined till 2014, they climbed back up afterwards. Highest mortality was exhibited by males and NH American Indians or Alaska Natives, residents of rural regions, and adults ≥85 years. Equitable efforts are needed to reduce the burden on high-risk populations. [ABSTRACT FROM AUTHOR]

Introduction Methods Results Conclusions Bipolar disorder (BD) hospitalization rates in children and adolescents vary greatly across place and over time. There are no population‐based studies on youth BD hospitalizations in Spain.We identified all patients aged 10–19 hospitalized due to BD in Spain between 2000 and 2021, examined their demographic and clinical characteristics, and assessed temporal trends in hospitalizations – overall and stratified by age and presence of additional psychiatric comorbidity. We used Joinpoint regressions to identify inflection points and quantify whole‐period and annual percentage changes (APCs) in trends.Of 4770 BD hospitalizations in 10–19‐year‐olds between 2000 and 2021 (average annual rate: 4.8 per 100,000), over half indicated an additional psychiatric comorbidity, most frequently substance abuse (62.2%), mostly due to cannabis (72.4%). During the study period, admissions increased twofold with an inflection point: Rates increased annually only between 2000 and 2008, for APCs 34.0% (95% confidence interval: 20.0%, 71.1%) among 10–14‐year‐olds, 10.3% (6.4%, 14.3%) among 15–19‐year‐olds, and 15.5% (11.5%, 22.7%) among patients with additional psychiatric comorbidity. Between 2009 and 2021, rates decreased moderately among 10–14‐year‐olds – APC: −8.3% (−14.1%, −4.4%) and slightly among 15–19‐year‐olds without additional psychiatric comorbidity – APC: −2.6(−5.7, −1.0), remaining largely stable among 15–19‐year‐olds overall.Recent trends in hospitalization due to BD in 10–19‐year‐olds in Spain indicate salient increases in the early 2000s – especially among (i) patients aged 10–14 (decreasing moderately after 2009 among 10–14‐year‐olds and plateauing among 15–19‐year‐olds) and (ii) patients with additional psychiatric comorbidity (i.e., cannabis use disorder). These findings suggest links with recent changes in clinical practices for children and recent trends in substance use among Spanish youth. [ABSTRACT FROM AUTHOR]