1. Picrasidine S Induces cGAS‐Mediated Cellular Immune Response as a Novel Vaccine Adjuvant.
- Author
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Ding, Xiaofan, Sun, Mengxue, Guo, Fusheng, Qian, Xinmin, Yuan, Haoyu, Lou, Wenjiao, Wang, Qixuan, Lei, Xiaoguang, and Zeng, Wenwen
- Subjects
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VACCINE effectiveness , *IMMUNE response , *INTERFERON receptors , *TYPE I interferons , *VIRAL vaccines , *CANCER vaccines , *SMALL molecules - Abstract
New adjuvants that trigger cellular immune responses are urgently needed for the effective development of cancer and virus vaccines. Motivated by recent discoveries that show activation of type I interferon (IFN‐I) signaling boosts T cell immunity, this study proposes that targeting this pathway can be a strategic approach to identify novel vaccine adjuvants. Consequently, a comprehensive chemical screening of 6,800 small molecules is performed, which results in the discovery of the natural compound picrasidine S (PS) as an IFN‐I inducer. Further analysis reveals that PS acts as a powerful adjuvant, significantly enhancing both humoral and cellular immune responses. At the molecular level, PS initiates the activation of the cGAS‐IFN‐I pathway, leading to an enhanced T cell response. PS vaccination notably increases the population of CD8+ central memory (TCM)‐like cells and boosts the CD8+ T cell‐mediated anti‐tumor immune response. Thus, this study identifies PS as a promising candidate for developing vaccine adjuvants in cancer prevention. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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