1. Peculiar Histopathologic Feature of an Erythematous/Morbilliform Eruption in a COVID-19-Positive Patient
- Author
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Emanuela Bonoldi, Marco Merli, Franco Rongioletti, Dieter Metze, Valentina Caputo, Caputo, V., Metze, D., Bonoldi, E., Merli, M., and Rongioletti, F.
- Subjects
Adult ,Keratinocytes ,medicine.medical_specialty ,Pathology ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Dermatology ,Pathology and Forensic Medicine ,vacuolated keratinocytes ,medicine ,Humans ,medicine.diagnostic_test ,biology ,business.industry ,SARS-CoV-2 ,COVID-19 ,General Medicine ,Exanthema ,Morbilliform ,exanthematous eruptions ,Morbilliform rash ,Skin biopsy ,immunohistochemistry ,biology.protein ,anti-SARS-CoV-2 Spike S1 antibodies ,Immunohistochemistry ,Histopathology ,Female ,Antibody ,business - Abstract
One of the most common patterns of presentations that have been described in COVID-19 patients includes the erythematous/papular/morbilliform eruptions. However, actually, the diffuse exanthems containing macules and papules were not specific to COVID-19, and even histopathology does not show any specific signs that could help to differentiate COVID-19 skin lesions from non-COVID-19 causes such as drugs or other viral infections. We present the case of a COVID-19-positive woman with a morbilliform rash, whose skin biopsy showed the presence of some peculiar cytopathic epidermal changes that could represent a possible distinctive histopathological feature related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection The presence of viral particles in the keratinocytes with additional positivity of endothelial cells and eccrine glands by immunohistochemistry using an anti-SARS-CoV-2 Spike S1 antibodies supports a causal relation of the lesions with SARS-CoV-2 infection.
- Published
- 2021