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1. Infectious disease events in people with HIV receiving kidney transplantation: Analysis of the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study

Author

Kusejko, Katharina, Kouyos, Roger D., Bernasconi, Enos, Boggian, Katia, Braun, Dominique L., Calmy, Alexandra, Cavassini, Matthias, van Delden, Christian, Furrer, Hansjakob, Garzoni, Christian, Hirsch, Hans H., Hirzel, Cedric, Manuel, Oriol, Schmid, Patrick, Khanna, Nina, Haidar, Fadi, Bonani, Marco, Golshayan, Dela, Dickenmann, Michael, Sidler, Daniel, Schnyder, Aurelia, Mueller, Nicolas J., Günthard, Huldrych F., and Schreiber, Peter W.

Published
2024
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3. Surgical site infections after kidney transplantation are independently associated with graft loss

Author

Amico, Patrizia, Aubert, John-David, Banz, Vanessa, Beckmann, Sonja, Beldi, Guido, Berger, Christoph, Berishvili, Ekaterine, Berzigotti, Annalisa, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Catana, Emmanuelle, Cairoli, Anne, Chalandon, Yves, De Geest, Sabina, De Rougemont, Olivier, De Seigneux, Sophie, Dickenmann, Michael, Dreifuss, Joëlle Lynn, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Golshayan, Déla, Goossens, Nicolas, Haidar, Fadi, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hirt, Patricia, Hoessly, Linard, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laesser, Bettina, Lamoth, Frédéric, Lehmann, Roger, Leichtle, Alexander, Manuel, Oriol, Marti, Hans-Peter, Martinelli, Michele, McLin, Valérie, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Mueller, Nicolas J., Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Oldani, Graziano, Pascual, Manuel, Passweg, Jakob, Pazeller, Rosemarie, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schachtner, Thomas, Schaub, Stefan, Scherrer, Alexandra, Schnyder, Aurelia, Schuurmans, Macé, Schwab, Simon, Sengstag, Thierry, Simonetta, Federico, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Stürzinger, Ueli, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhelm, Markus, Yerly, Patrick, Schreiber, Peter W., Hoessly, Linard D., Boggian, Katia, Neofytos, Dionysios, van Delden, Christian, Egli, Adrian, Hirzel, Cédric, Schmied, Bruno, Guerke, Lorenz, Matter, Maurice, de Rougemont, Olivier, Bonani, Marco, Sidler, Daniel, and Kuster, Stefan P.

Published
2024
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4. Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

Author

Sollier, Julie, Basler, Marek, Broz, Petr, Dittrich, Petra S., Drescher, Knut, Egli, Adrian, Harms, Alexander, Hierlemann, Andreas, Hiller, Sebastian, King, Carolyn G., McKinney, John D., Moran-Gilad, Jacob, Neher, Richard A., Page, Malcolm G. P., Panke, Sven, Persat, Alexandre, Picotti, Paola, Rentsch, Katharina M., Rivera-Fuentes, Pablo, Sauer, Uwe, Stolz, Daiana, Tschudin-Sutter, Sarah, van Delden, Christian, van Nimwegen, Erik, Veening, Jan-Willem, Zampieri, Mattia, Zinkernagel, Annelies S., Khanna, Nina, Bumann, Dirk, Jenal, Urs, and Dehio, Christoph

Published
2024
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6. Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland

Author

Amico, Patrizia, Bachofner, Adrian, Banz, Vanessa, Beckmann, Sonja, Beldi, Guido, Berger, Christoph, Berishvili, Ekaterine, Berzigotti, Annalisa, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Cairoli, Anne, Catana, Emmanuelle, Chalandon, Yves, De Geest, Sabina, De Seigneux, Sophie, Dickenmann, Michael, Dreifuss, Joëlle Lynn, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Frossard, Jaromil, Garzoni, Christian, Golshayan, Déla, Goossens, Nicolas, Haidar, Fadi, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans, Hirt, Patricia, Hoessly, Linard, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Kremer, Andreas, Krueger, Thorsten, Kuhn, Christian, Laesser, Bettina, Lamoth, Frédéric, Lehmann, Roger, Leichtle, Alexander, Manuel, Oriol, Marti, Hans-Peter, Martinelli, Michele, McLin, Valérie, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Müller, Nicolas, Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Oldani, Graziano, Pascual, Manuel, Passweg, Jakob, Pazeller, Rosemarie, Posfay-Barbe, Klara, Reineke, David, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rössler, Rothlin, Silvia, Ruschitzka, Frank, Schachtner, Thomas, Schaub, Stefan, Scherrer, Alexandra, Schneidawind, Dominik, Schnyder, Aurelia, Schuurmans, Macé, Schwab, Simon, Sengstag, Thierry, Simonetta, Federico, Steiger, Jürg, Stirniman, Guido, Stürzinger, Ueli, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhlem, Markus, Yerly, Patrick, Bocchi, Federica, Müller, Selina, Binet, Isabelle, Golshayan, Dela, Müller, Thomas, Sidler, Daniel, and Storni, Federico

Published
2024
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7. Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Author

Amico, Patrizia, Aubert, John-David, Banz, Vanessa, Beckmann, Sonia, Beldi, Guido, Berger, Christoph, Berishvili, Ekaterine, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Catana, Emmanuelle, Chalandon, Yves, De Geest, Sabina, De Seigneux Michael Dickenmann, Sophie, Dreifuss, Joëlle Lynn, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Gaudet, Christophe, Golshayan, Déla, Goossens, Nicolas, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hirt, Patricia, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laager, Mirjam, Laesser, Bettina, Lamoth, Frédéric, Lehmann, Roger, Leichtle, Alexander, Manuel, Oriol, Marti, Hans-Peter, Martinelli, Michele, McLin, Valérie, Mellac, Katell, Mercay, Aurelia, Mettler, Karin, Mueller, Nicolas J., Müller, Antonia, Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Oldani, Graziano, Pascual, Manuel, Passweg, Jakob, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schachtner, Thomas, Schanz, Urs, Schaub, Stefan, Schwab, Simon, Schnyder, Aurelia, Schuurmans, Macé, Sengstag, Thierry, Simonetta, Federico, Steiger, Jürg, Stirniman, Guido, Stürzinger, Ueli, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhlem, Markus, Yerly, Patrick, Halfon, Matthieu, Taffé, Patrick, Bucher, Christian, Haidar, Fadi, Huynh-do, Uyen, Mani, Laila-Yasmin, Wehmeier, Caroline, Fakhouri, Fadi, and Golshayan, Dela

Published
2024
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10. Bloodstream infections in allogeneic haematopoietic cell recipients from the Swiss Transplant Cohort Study: trends of causative pathogens and resistance rates

Author

Sava, Mihaela, Bättig, Veronika, Gerull, Sabine, Passweg, Jakob R., Khanna, Nina, Garzoni, Christian, Gerber, Bernhard, Mueller, Nicolas J., Schanz, Urs, Berger, Christoph, Chalandon, Yves, van Delden, Christian, Neofytos, Dionysios, Stampf, Susanne, Franzeck, Fabian C., and Weisser, Maja

Published
2023
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11. Efficacy of ceftazidime-avibactam in solid organ transplant recipients with bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae

Author

Paul, Mical, Carratala, Jordi, Oriol, Isabel, Rodríguez-Álvarez, Regino José, Cordero, Elisa, Lepe, José Antonio, de Lucas, Esperanza Merino, Muñoz, Patricia, Fortún, Jesús, Coussement, Julien, Dewispelaere, Laurent, Eriksson, Britt Marie, van Delden, Christian, Manuel, Oriol, Clemente, Wanessa T., Strabelli, Tania Mara Varejão, Pilmis, Benoit, Roilides, Emmanuel, Ranganathan N, Iyer, Grossi, Paolo A., Soldani, Fabio, Rizzi, Marco, Tan, Ban Hock, Lowman, Warren, Gunseren, Filiz, Arslan, Hande, Tufan, Zeliha Koçak, Kazak, Esra, David, Miruna D., Steinke, Seema Mehta, Ostrander, Darin, Avery, Robin, Lease, Erika D., Pérez-Nadales, Elena, Fernández-Ruiz, Mario, Natera, Alejandra M., Gutiérrez-Gutiérrez, Belén, Mularoni, Alessandra, Russelli, Giovanna, Pierrotti, Ligia Camera, Pinheiro Freire, Maristela, Falcone, Marco, Tiseo, Giusy, Tumbarello, Mario, Raffaelli, Francesca, Abdala, Edson, Bodro, Marta, Gervasi, Elena, Fariñas, María Carmen, Seminari, Elena M., Castón, Juan José, Marín-Sanz, Juan Antonio, Gálvez-Soto, Víctor, Rana, Meenakshi M., Loeches, Belén, Martín-Dávila, Pilar, Pascual, Álvaro, Rodríguez-Baño, Jesús, Aguado, José María, Martínez-Martínez, Luis, and Torre-Cisneros, Julián

Published
2023
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14. The MELD upgrade exception: a successful strategy to optimize access to liver transplantation for patients with high waiting list mortality

Author

Amico, Patrizia, Axel, Andres, Aubert, John-David, Banz, Vanessa, Sonja, Beckmann, Beldi, Guido, Benden, Christian, Berger, Christoph, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Carrel, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Dreifuss, Joëlle L., Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola G., Gaudet, Christophe, Giostra, Emiliano, Golshayan, Déla, Hadaya, Karine, Halter, Jörg, Hauri, Dimitri, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans, Hirt, Patricia, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laesser, Bettina, Lang, Brian, Lehmann, Roger, Leichtle, Alexander, Lovis, Christian, Manuel, Oriol, Marti, Hans-Peter, Martin, Pierre Y., Martinelli, Michele, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Meylan, Pascal, Mueller, Nicolas, Müller, Antonia, Müller, Thomas, Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Pascual, Manuel, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Schuurmans, Macé, Simonetta, Federico, Staufer, Katharina, Stampf, Susanne, Steiger, Jürg, Stirniman, Guido, Stürzinger, Ueli, Toso, Christian, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhlem, Markus, Yerly, Patrick, Dirchwolf, Melisa, Becchetti, Chiara, Gschwend, Sarah G., Dutkowski, Philipp, Beyeler, Franziska, Schropp, Jonas, and Dufour, Jean-François

Published
2022
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20. Burden, epidemiology, and outcomes of microbiologically confirmed respiratory viral infections in solid organ transplant recipients: a nationwide, multi-season prospective cohort study

Author

Mombelli, Matteo, Lang, Brian M., Neofytos, Dionysios, Aubert, John-David, Benden, Christian, Berger, Christoph, Boggian, Katia, Egli, Adrian, Soccal, Paola M., Kaiser, Laurent, Hirzel, Cédric, Pascual, Manuel, Koller, Michael, Mueller, Nicolas J., van Delden, Christian, Hirsch, Hans H., and Manuel, Oriol

Published
2021
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21. Immunogenicity of High-Dose Versus MF59-Adjuvanted Versus Standard Influenza Vaccine in Solid Organ Transplant Recipients: The Swiss/Spanish Trial in Solid Organ Transplantation on Prevention of Influenza (STOP-FLU Trial)

Author

Swiss National Science Foundation, Sánchez-Céspedes, Javier [0000-0003-2707-1979], Mombelli, Matteo, Neofytos, Dionysios, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M., Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F., Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J., Egli, Adrian, Cordero, Van Delden, Christian, Manuel, Oriol, Swiss National Science Foundation, Sánchez-Céspedes, Javier [0000-0003-2707-1979], Mombelli, Matteo, Neofytos, Dionysios, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M., Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F., Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J., Egli, Adrian, Cordero, Van Delden, Christian, and Manuel, Oriol

Abstract

[Background] The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so new vaccination strategies are needed in this population., [Methods] Adult SOT recipients from 9 transplant clinics in Switzerland and Spain were enrolled if they were >3 months after transplantation. Patients were randomized (1:1:1) to a MF59-adjuvanted or a high-dose vaccine (intervention), or a standard vaccine (control), with stratification by organ and time from transplant. The primary outcome was vaccine response rate, defined as a ≥4-fold increase of hemagglutination-inhibition titers to at least 1 vaccine strain at 28 days postvaccination. Secondary outcomes included polymerase chain reaction–confirmed influenza and vaccine reactogenicity., [Results] A total of 619 patients were randomized, 616 received the assigned vaccines, and 598 had serum available for analysis of the primary endpoint (standard, n = 198; MF59-adjuvanted, n = 205; high-dose, n = 195 patients). Vaccine response rates were 42% (84/198) in the standard vaccine group, 60% (122/205) in the MF59-adjuvanted vaccine group, and 66% (129/195) in the high-dose vaccine group (difference in intervention vaccines vs standard vaccine, 0.20; 97.5% confidence interval [CI], .12–1); P < .001; difference in high-dose vs standard vaccine, 0.24 [95% CI, .16–1]; P < .001; difference in MF59-adjuvanted vs standard vaccine, 0.17 [97.5% CI, .08–1]; P < .001). Influenza occurred in 6% of the standard, 5% in the MF59-adjuvanted, and 7% in the high-dose vaccine groups. Vaccine-related adverse events occurred more frequently in the intervention vaccine groups, but most of the events were mild., [Conclusions] In SOT recipients, use of an MF59-adjuvanted or a high-dose influenza vaccine was safe and resulted in a higher vaccine response rate.

Published
2024

22. Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation?

Author

Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Hirsch, Hans H; https://orcid.org/0000-0003-0883-0423, Meylan, Pascal, Boggian, Katia, Hirzel, Cédric; https://orcid.org/0000-0002-7870-912X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Sidler, Daniel; https://orcid.org/0000-0002-2435-5936, Schnyder, Aurelia, Schaub, Stefan; https://orcid.org/0000-0002-9170-1341, Golshayan, Déla, Haidar, Fadi, Bonani, Marco, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schreiber, Peter W; https://orcid.org/0000-0001-8123-2601, Swiss Transplant Cohort Study, et al, Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Hirsch, Hans H; https://orcid.org/0000-0003-0883-0423, Meylan, Pascal, Boggian, Katia, Hirzel, Cédric; https://orcid.org/0000-0002-7870-912X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Sidler, Daniel; https://orcid.org/0000-0002-2435-5936, Schnyder, Aurelia, Schaub, Stefan; https://orcid.org/0000-0002-9170-1341, Golshayan, Déla, Haidar, Fadi, Bonani, Marco, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schreiber, Peter W; https://orcid.org/0000-0001-8123-2601, Swiss Transplant Cohort Study, and et al

Abstract

Background Infectious diseases (IDs) are highly relevant after solid organ transplantation in terms of morbidity and mortality, being among the most common causes of death. Patients undergoing kidney retransplantation (re-K-Tx) have been already receiving immunosuppressive therapy over a prolonged period, potentially facilitating subsequent infections. Comparing ID events after re-K-Tx and first kidney transplantation (f-K-Tx) can delineate patterns and risks of ID events associated with prolonged immunosuppression. Methods We included adult patients with records on f-K-Tx and re-K-Tx in the Swiss Transplant Cohort Study. We analyzed ID events after f-K-Tx and re-K-Tx within the same patients and compared infection rates, causative pathogens, and infection sites. Recurrent time-to-event analyses were performed for comparison of infection rates. Results A total of 59 patients with a median age of 47 years (range, 18–73) were included. Overall, 312 ID events in 52 patients occurred. In multivariable recurrent event modeling, the rate of ID events was significantly lower after re-K-Tx (hazard ratio, 0.70; P = .02). More bacterial (68.9% vs 60.4%) and fungal (4.0% vs 1.1%) infections were observed after f-K-Tx but fewer viral infections (27.0% vs 38.5%) as compared with re-K-Tx (P = .11). After f-K-Tx, urinary and gastrointestinal tract infections were more frequent; after re-K-Tx, respiratory tract and surgical site infections were more frequent (P < .001). Conclusions ID events were less frequent after re-K-Tx. Affected sites differed significantly after f-K-Tx vs re-K-Tx.

Published
2024

23. Epidemiology, outcomes and risk factors for recurrence of Clostridioides difficile infections following allogeneic hematopoietic cell transplantation: a longitudinal retrospective multicenter study

Author

Ragozzino, Silvio; https://orcid.org/0000-0002-8100-2096, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Passweg, Jakob; https://orcid.org/0000-0001-7092-3351, Müller, Antonia, Medinger, Michael; https://orcid.org/0000-0003-0427-7747, Van Delden, Christian, Masouridi-Levrat, Stavroula; https://orcid.org/0000-0001-7502-5454, Chalandon, Yves; https://orcid.org/0000-0001-9341-8104, Tschudin-Sutter, Sarah, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Swiss Transplant Cohort Study, Ragozzino, Silvio; https://orcid.org/0000-0002-8100-2096, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Passweg, Jakob; https://orcid.org/0000-0001-7092-3351, Müller, Antonia, Medinger, Michael; https://orcid.org/0000-0003-0427-7747, Van Delden, Christian, Masouridi-Levrat, Stavroula; https://orcid.org/0000-0001-7502-5454, Chalandon, Yves; https://orcid.org/0000-0001-9341-8104, Tschudin-Sutter, Sarah, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, and Swiss Transplant Cohort Study

Published
2024

24. Immunogenicity of High-Dose vs. MF59-adjuvanted vs. Standard Influenza Vaccine in Solid Organ Transplant Recipients: The STOP-FLU trial

Author

Mombelli, Matteo, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M, Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F, Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Cordero, Elisa, van Delden, Christian, et al, Mombelli, Matteo, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M, Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F, Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Cordero, Elisa, van Delden, Christian, and et al

Abstract

BACKGROUND The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so that new vaccination strategies are needed in this population. METHODS Adult SOT recipients from nine transplant clinics in Switzerland and Spain were enrolled if they were >3 months after transplantation. High, with stratification by organ and time from transplant. The primary outcome was vaccine response rate, defined as a ≥4-fold increase of hemagglutination-inhibition titers to at least one vaccine strain at 28 days post-vaccination. Secondary outcomes included PCR-confirmed influenza and vaccine reactogenicity. RESULTS 619 patients were randomized, 616 received the assigned vaccines, and 598 had serum available for analysis of the primary endpoint (standard, n=198; MF59-adjuvanted, n=205; high-dose, n=195 patients). Vaccine response rates were 42% (84/198) in the standard vaccine group, 60% (122/205) in the MF59-adjuvanted vaccine group, and 66% (129/195) in the high-dose vaccine group (difference in intervention vaccines vs. standard vaccine, 0.20 [97.5% CI 0.12-1]; p<0.001; difference in high-dose vs. standard vaccine, 0.24 [95% CI 0.16-1]; p<0.001; difference in MF59-adjuvanted vs. standard vaccine, 0.17 [97.5% CI 0.08-1]; p<0.001). Influenza occurred in 6% the standard, 5% in the MF59-adjuvanted, and 7% in the high-dose vaccine groups. Vaccine-related adverse events occurred more frequently in the intervention vaccine groups, but most of the events were mild. CONCLUSIONS In SOT recipients, use of an MF59-adjuvanted or a high-dose influenza vaccine was safe and resulted in a higher vaccine response rate. TRIAL REGISTRATION Clinicaltrials.gov NCT03699839.

Published
2024

28. Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients

Author

Quteineh, Lina, Wójtowicz, Agnieszka, Bochud, Pierre-Yves, Crettol, Severine, Vandenberghe, Frederik, Venetz, Jean-Pierre, Manuel, Oriol, Golshayan, Dela, Lehmann, Roger, Mueller, Nicolas J., Binet, Isabelle, van Delden, Christian, Steiger, Jürg, Mohacsi, Paul, Dufour, Jean-Francois, Soccal, Paola M., Kutalik, Zoltan, Marques-Vidal, Pedro, Vollenweider, Peter, Recher, Mike, Hess, Christoph, Pascual, Manuel, and Eap, Chin B.

Published
2019
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29. Hepatitis E virus infection epidemiology in allogeneic hematopoietic cell transplant recipients

Author

Courjon, Johan, primary, Portillo, Vera, additional, Yerly, Sabine, additional, Vetter, Pauline, additional, Schibler, Manuel, additional, Mappoura, Maria, additional, Morin, Sarah, additional, Giannotti, Federica, additional, Mamez, Anne-Claire, additional, van Delden, Christian, additional, Kaiser, Laurent, additional, Chalandon, Yves, additional, Masouridi-Levrat, Stavroula, additional, and Neofytos, Dionysios, additional

Published
2023
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34. Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study

Author

European Study Group for Nocardia in Solid Organ Transplantation, Lebeaux, David, Freund, Romain, van Delden, Christian, Guillot, Hélène, Marbus, Sierk D., Matignon, Marie, Van Wijngaerden, Eric, Douvry, Benoit, De Greef, Julien, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Jacobs, Frédérique, Lortholary, Olivier, and Coussement, Julien

Published
2017

36. Revisiting Cytomegalovirus Serology in Allogeneic Hematopoietic Cell Transplant Recipients

Author

Portillo, Vera, primary, Masouridi-Levrat, Stavroula, additional, Royston, Léna, additional, Yerly, Sabine, additional, Schibler, Manuel, additional, Mappoura, Maria, additional, Morin, Sarah, additional, Giannotti, Federica, additional, Mamez, Anne-Claire, additional, van Delden, Christian, additional, Chalandon, Yves, additional, and Neofytos, Dionysios, additional

Published
2023
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38. Training in infectious diseases across Europe in 2021 – a survey on training delivery, content and assessment

Author

Ahl, Jonas, Ambrozaitis, Arvydas, Azap, Alpay, Beović, Bojana, Castelli, Francesco, Cisneros, José Miguel, Constantinou, Costas, Van Delden, Christian, De Barra, Eoghan, De Munter, Paul, Džupová, Olga, Fätkenheuer, Gerd, Flisiak, Robert, Florescu, Simin Aysel, Fsadni, Claudia, Holmberg, Ville, Jensen-Fangel, Søren, Koehler, Philipp, Kristjánsson, Már, Lind, Andreas, Michos, Athanasios, Miller, Alastair, Muller, Zsofia, Oliveira, Joaquim, Paul, Mical, Sal, Ertan, Santini, Marija, Sargsyants, Narina, Soják, L'ubomir, Soodla, Pilleriin, Staub, Therese, Thalhammer, Florian, Verbon, Annelies, Verdon, Renaud, Wegrzyn, Zbigniew, Brockhoff, Ronja A., Hicks, Scott R., Salmanton-García, Jon, Dušek, Davorka, Stahl, Jean-Paul, Beeching, Nick J., and Cornely, Oliver A.

Published
2021
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40. Toxoplasmosis in Transplant Recipients, Europe, 2010-2014

Author

Robert-Gangneux, Florence, Meroni, Valeria, Dupont, Damien, Botterel, Frangoise, Garcia, Jose M. Aguado, Brenier- Pinchart, Marie-Pierre, Accoceberry, Isabelle, Akan, Hamdi, Abbate, Isabella, Boggian, Katia, Bruschi, Fabrizio, Carratala, Jordi, David, Miruna, Drgona, Lubos, Djurkovic-Djakovic, Olgica, Farinas, Maria Carmen, Genco, Francesca, Gkrania-Klotsas, Effrossyni, Groll, Andreas H., Guy, Edward, Hirzel, Cedric, Khanna, Nina, Kurt, Ozgur, Junie, Lia Monica, Lazzarotto, Tiziana, Len, Oscar, Mueller, Nicolas J., Munoz, Patricia, Pana, Zoi Dorothea, Roilides, Emmanuel, Stajner, Tijana, van Delden, Christian, Villena, Isabelle, Pelloux, Herve, and Manuel, Oriol

Subjects
Toxoplasmosis -- Health aspects, Hematopoietic stem cell transplantation -- Health aspects, Stem cells -- Health aspects, Organ transplantation -- Health aspects, Liver -- Health aspects, Health
Abstract

Toxoplasmosis is a zoonosis that infects humans and other warm-blooded animals worldwide; prevalence and clinical severity vary by geographic area (1). After primary infection, the parasite persists lifelong within dormant [...]

Published
2018
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41. LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions

Author

Yu, Kang, Davidson, Chelsea L., Wojtowicz, Agnieszka, Lisboa, Luiz, Wang, Ting, Airo, Adriana M., Villard, Jean, Buratto, Jeremie, Sandalova, Tatyana, Achour, Adnane, Humar, Atul, Boggian, Katia, Cusini, Alexia, van Delden, Christian, Egli, Adrian, Manuel, Oriol, Mueller, Nicolas, Bochud, Pierre-Yves, and Burshtyn, Deborah N.

Subjects
Killer cells -- Genetic aspects -- Health aspects, Genetic polymorphisms -- Health aspects, Organ transplantation -- Complications and side effects, Immune response -- Genetic aspects, HLA antigens -- Physiological aspects -- Health aspects, Cytomegalovirus infections -- Risk factors -- Development and progression, Health care industry
Abstract

UL18 is a human CMV (HCMV) MHC class I (MHCI) homolog that efficiently inhibits leukocyte immunoglobulin-like receptor subfamily B member 1 [(LILRB1).sup.+] NK cells. We found an association of LILRB1 polymorphisms in the regulatory regions and ligand-binding domains with control of HCMV in transplant patients. Naturally occurring LILRB1 variants expressed in model NK cells showed functional differences with UL18 and classical MHCI, but not with HLA-G. The altered functional recognition was recapitulated in binding assays with the binding domains of LILRB1. Each of 4 nonsynonymous substitutions in the first 2 LILRB1 immunoglobulin domains contributed to binding with UL18, classical MHCI, and HLA-G. One of the polymorphisms controlled addition of an N-linked glycan, and that mutation of the glycosylation site altered binding to all ligands tested, including enhancing binding to UL18. Together, these findings indicate that specific LILRB1 alleles that allow for superior immune evasion by HCMV are restricted by mutations that limit LILRB1 expression selectively on NK cells. The polymorphisms also maintained an appropriate interaction with HLA-G, fitting with a principal role of LILRB1 in fetal tolerance., Introduction NK cells play a critical role during the early stages of human CMV (HCMV) infection, and the presence of HCMV alters the NK compartment (1, 2). The alterations include [...]

Published
2018
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43. Efficacy of ceftazidime-avibactam in solid organ transplant recipients with bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae

Author

Pérez-Nadales, Elena, primary, Fernández-Ruiz, Mario, additional, Natera, Alejandra M., additional, Gutiérrez-Gutiérrez, Belén, additional, Mularoni, Alessandra, additional, Russelli, Giovanna, additional, Camera Pierrotti, Ligia, additional, Pinheiro Freire, Maristela, additional, Falcone, Marco, additional, Tiseo, Giusy, additional, Tumbarello, Mario, additional, Raffaelli, Francesca, additional, Abdala, Edson, additional, Bodro, Marta, additional, Gervasi, Elena, additional, Fariñas, María Carmen, additional, Seminari, Elena M., additional, Castón, Juan José, additional, Marín-Sanz, Juan Antonio, additional, Gálvez-Soto, Víctor, additional, Rana, Meenakshi M., additional, Loeches, Belén, additional, Martín-Dávila, Pilar, additional, Pascual, Álvaro, additional, Rodríguez-Baño, Jesús, additional, Aguado, José María, additional, Martínez-Martínez, Luis, additional, Torre-Cisneros, Julián, additional, Paul, Mical, additional, Carratala, Jordi, additional, Oriol, Isabel, additional, Rodríguez-Álvarez, Regino José, additional, Cordero, Elisa, additional, Lepe, José Antonio, additional, de Lucas, Esperanza Merino, additional, Muñoz, Patricia, additional, Fortún, Jesús, additional, Coussement, Julien, additional, Dewispelaere, Laurent, additional, Eriksson, Britt Marie, additional, van Delden, Christian, additional, Manuel, Oriol, additional, Clemente, Wanessa T., additional, Strabelli, Tania Mara Varejão, additional, Pilmis, Benoit, additional, Roilides, Emmanuel, additional, Ranganathan N, Iyer, additional, Grossi, Paolo A., additional, Soldani, Fabio, additional, Rizzi, Marco, additional, Tan, Ban Hock, additional, Lowman, Warren, additional, Gunseren, Filiz, additional, Arslan, Hande, additional, Tufan, Zeliha Koçak, additional, Kazak, Esra, additional, David, Miruna D., additional, Steinke, Seema Mehta, additional, Ostrander, Darin, additional, Avery, Robin, additional, and Lease, Erika D., additional

Published
2023
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44. Bacteremia During the First Year After Solid Organ Transplantation: An Epidemiological Update

Author

Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Stampf, Susanne, Hoessly, Linard D, D'Asaro, Matilde, Tang, Gael Nguyen, Boggian, Katia, Hirzel, Cedric, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Manuel, Oriol, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Van Delden, Christian, Swiss Transplant Cohort Study, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Stampf, Susanne, Hoessly, Linard D, D'Asaro, Matilde, Tang, Gael Nguyen, Boggian, Katia, Hirzel, Cedric, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Manuel, Oriol, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Van Delden, Christian, and Swiss Transplant Cohort Study

Abstract

BACKGROUND: There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr). METHODS: Using the Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospective nested multicenter cohort study to describe the epidemiology of bacteremia in SOTr during the first year post-transplant. RESULTS: Of 4383 patients, 415 (9.5%) with 557 cases of bacteremia due to 627 pathogens were identified. One-year incidence was 9.5%, 12.8%, 11.4%, 9.8%, 8.3%, and 5.9% for all, heart, liver, lung, kidney, and kidney-pancreas SOTr, respectively (P = .003). Incidence decreased during the study period (hazard ratio, 0.66; P < .001). One-year incidence due to gram-negative bacilli (GNB), gram-positive cocci (GPC), and gram-positive bacilli (GPB) was 5.62%, 2.81%, and 0.23%, respectively. Seven (of 28, 25%) Staphylococcus aureus isolates were methicillin-resistant, 2/67 (3%) enterococci were vancomycin-resistant, and 32/250 (12.8%) GNB produced extended-spectrum beta-lactamases. Risk factors for bacteremia within 1 year post-transplant included age, diabetes, cardiopulmonary diseases, surgical/medical post-transplant complications, rejection, and fungal infections. Predictors for bacteremia during the first 30 days post-transplant included surgical post-transplant complications, rejection, deceased donor, and liver and lung transplantation. Transplantation in 2014-2019, CMV donor-negative/recipient-negative serology, and cotrimoxazole Pneumocystis prophylaxis were protective against bacteremia. Thirty-day mortality in SOTr with bacteremia was 3% and did not differ by SOT type. CONCLUSIONS: Almost 1/10 SOTr may develop bacteremia during the first year post-transplant associated with low mortality. Lower bacteremia rates have been observed since 2014 and in patients receiving cotrimoxazole prophylaxis. Variabilities in incidence, timing, and pathogen of bacteremia across different SOT types may be used to tailo

Published
2023

45. Vaccine-Preventable Infections Among Solid Organ Transplant Recipients in Switzerland

Author

Walti, Laura N, Mugglin, Catrina, Mombelli, Matteo, Manuel, Oriol, Hirsch, Hans H, Khanna, Nina, Mueller, Nicolas J, Berger, Christoph, Boggian, Katia, Garzoni, Christian, Neofytos, Dionysios, van Delden, Christian, Mäusezahl, Mirjam, Hirzel, Cédric, Swiss Transplant Cohort Study, Walti, Laura N, Mugglin, Catrina, Mombelli, Matteo, Manuel, Oriol, Hirsch, Hans H, Khanna, Nina, Mueller, Nicolas J, Berger, Christoph, Boggian, Katia, Garzoni, Christian, Neofytos, Dionysios, van Delden, Christian, Mäusezahl, Mirjam, Hirzel, Cédric, and Swiss Transplant Cohort Study

Abstract

IMPORTANCE Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden of vaccine-preventable infections (VPIs) among SOT recipients remains unclear. OBJECTIVES To assess the incidence rate of VPIs among SOT recipients and to evaluate whether SOT recipients are at increased risk for specific VPIs compared with the general population. DESIGN, SETTING, AND PARTICIPANTS This nationwide cohort study used data from the Swiss Transplant Cohort Study on VPIs in individuals who underwent SOT from May 2008 to June 2019 (follow-up until December 2019) and data from the Swiss Federal Office of Public Health on notifiable VPIs in the general population in the same period. Data were analyzed from January 2021 to June 2022. EXPOSURES Solid organ transplant. MAIN OUTCOMES AND MEASURES The main outcomes were the incidence rate of the following VPIs in SOT recipients: hepatitis A and B, diphtheria, Haemophilus influenzae infection, influenza, measles, mumps, pertussis, pneumococcal disease, poliomyelitis, meningococcal disease, rubella, tetanus, tick-borne encephalitis, and varicella zoster virus infection. Age-adjusted standardized incidence ratios were used to assess whether VPIs occurred more frequently in SOT recipients compared with the general population. For SOT recipients, factors associated with occurrence of VPIs were explored and the associated morbidity and mortality assessed. RESULTS Of 4967 SOT recipients enrolled (median age, 54 years [IQR, 42-62 years]; 3191 [64.2%] male), 593 (11.9%) experienced at least 1 VPI. The overall VPI incidence rate was higher in the population that underwent SOT (30.57 per 1000 person-years [PY]; 95% CI, 28.24-33.10 per 1000 PY) compared with the general population (0.71 per 1000 PY). The standardized age-adjusted incidence ratio for notifiable VPIs in SOT recipients was higher compared with the general population (27.84; 9

Published
2023

46. Donor-derived fulminant herpes simplex virus hepatitis after liver transplantation: Two cases and review of literature

Author

Reinhold, Ilana; https://orcid.org/0000-0002-6222-0418, Teasca, Laurent, Rodriguez, Elena Requejo, Berney, Thierry; https://orcid.org/0000-0002-4230-9378, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Hilty, Matthias; https://orcid.org/0000-0002-2765-881X, Andermatt, Rea; https://orcid.org/0000-0001-8694-1271, Saro, Francesca, Dutkowski, Philipp, Müllhaupt, Beat; https://orcid.org/0000-0002-9020-8192, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Swiss Transplant Cohort Study (STCS), Reinhold, Ilana; https://orcid.org/0000-0002-6222-0418, Teasca, Laurent, Rodriguez, Elena Requejo, Berney, Thierry; https://orcid.org/0000-0002-4230-9378, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Hilty, Matthias; https://orcid.org/0000-0002-2765-881X, Andermatt, Rea; https://orcid.org/0000-0001-8694-1271, Saro, Francesca, Dutkowski, Philipp, Müllhaupt, Beat; https://orcid.org/0000-0002-9020-8192, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, and Swiss Transplant Cohort Study (STCS)

Abstract

BACKGROUND Fulminant herpetic hepatitis due to herpes simplex virus (HSV), serotype 1 or 2, is a rare but often fatal complication after solid organ transplantation (SOT). HSV hepatitis in SOT recipients can occur either due to primary infection acquired post transplantation, viral reactivation in a seropositive patient, or as donor-derived infection. Cases of fatal hepatitis have been reported in the liver as well as in other SOT recipients. The fatal outcome is mostly due to delayed diagnosis and treatment, which is explained by the lack of clinical specificity of HSV hepatitis. METHODS We report two cases of fatal donor-derived HSV hepatitis in liver-transplanted recipients. We reviewed all published cases of donor-derived HSV infections after SOT with an evaluation of the presence of prophylaxis and outcome. RESULTS In both liver recipients, the retrospective determination of HSV serostatus was negative, and both cases occurred in the absence of cytomegalovirus or HSV prophylaxis. A review of the literature showed a significant series of cases of severe hepatitis, mostly fatal, as well as the absence of specific preventive therapy guidelines in cases of HSV serology mismatch. CONCLUSIONS The occurrence of two fatal donor-derived hepatitis made the Swiss Transplant Infectious Diseases working group modify its national recommendations regarding pretransplant serostatus determination and HSV prophylaxis after liver transplantation. Further studies are needed to assess this approach.

Published
2023

47. Bloodstream infections in allogeneic haematopoietic cell recipients from the Swiss Transplant Cohort Study: trends of causative pathogens and resistance rates

Author

Sava, Mihaela; https://orcid.org/0000-0001-5763-9073, Bättig, Veronika; https://orcid.org/0000-0002-7418-977X, Gerull, Sabine; https://orcid.org/0000-0002-6612-4220, Passweg, Jakob R; https://orcid.org/0000-0001-7092-3351, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Gerber, Bernhard; https://orcid.org/0000-0003-1708-8558, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schanz, Urs, Berger, Christoph; https://orcid.org/0000-0002-1730-8824, Chalandon, Yves; https://orcid.org/0000-0001-9341-8104, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Stampf, Susanne; https://orcid.org/0000-0003-3399-5078, Franzeck, Fabian C; https://orcid.org/0000-0001-7510-0231, Weisser, Maja; https://orcid.org/0000-0002-0134-1929, Sava, Mihaela; https://orcid.org/0000-0001-5763-9073, Bättig, Veronika; https://orcid.org/0000-0002-7418-977X, Gerull, Sabine; https://orcid.org/0000-0002-6612-4220, Passweg, Jakob R; https://orcid.org/0000-0001-7092-3351, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Gerber, Bernhard; https://orcid.org/0000-0003-1708-8558, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schanz, Urs, Berger, Christoph; https://orcid.org/0000-0002-1730-8824, Chalandon, Yves; https://orcid.org/0000-0001-9341-8104, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Stampf, Susanne; https://orcid.org/0000-0003-3399-5078, Franzeck, Fabian C; https://orcid.org/0000-0001-7510-0231, and Weisser, Maja; https://orcid.org/0000-0002-0134-1929

Published
2023

48. Nocardia Infection in Solid Organ Transplant Recipients: A Multicenter European Case-control Study

Author

European Study Group for Nocardia in Solid Organ Transplantation, Coussement, Julien, Lebeaux, David, van Delden, Christian, Guillot, Hẻlẻne, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Van Wijngaerden, Eric, Douvry, Benoit, Van Laecke, Steven, Vuotto, Fanny, Tricot, Leϊla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cẻdric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Lortholary, Olivier, and Jacobs, Frédérique

Published
2016

49. Bacteremia During the First Year After Solid Organ Transplantation: An Epidemiological Update

Author

Neofytos, Dionysios, Stampf, Susanne, Hoessly, Linard D, D'Asaro, Matilde, Tang, Gael Nguyen, Boggian, Katia, Hirzel, Cedric, Khanna, Nina, Manuel, Oriol, Mueller, Nicolas J, and Van Delden, Christian

Subjects
610 Medicine & health
Abstract

BACKGROUND There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr). METHODS Using the Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospective nested multicenter cohort study to describe the epidemiology of bacteremia in SOTr during the first year post-transplant. RESULTS Of 4383 patients, 415 (9.5%) with 557 cases of bacteremia due to 627 pathogens were identified. One-year incidence was 9.5%, 12.8%, 11.4%, 9.8%, 8.3%, and 5.9% for all, heart, liver, lung, kidney, and kidney-pancreas SOTr, respectively (P = .003). Incidence decreased during the study period (hazard ratio, 0.66; P < .001). One-year incidence due to gram-negative bacilli (GNB), gram-positive cocci (GPC), and gram-positive bacilli (GPB) was 5.62%, 2.81%, and 0.23%, respectively. Seven (of 28, 25%) Staphylococcus aureus isolates were methicillin-resistant, 2/67 (3%) enterococci were vancomycin-resistant, and 32/250 (12.8%) GNB produced extended-spectrum beta-lactamases. Risk factors for bacteremia within 1 year post-transplant included age, diabetes, cardiopulmonary diseases, surgical/medical post-transplant complications, rejection, and fungal infections. Predictors for bacteremia during the first 30 days post-transplant included surgical post-transplant complications, rejection, deceased donor, and liver and lung transplantation. Transplantation in 2014-2019, CMV donor-negative/recipient-negative serology, and cotrimoxazole Pneumocystis prophylaxis were protective against bacteremia. Thirty-day mortality in SOTr with bacteremia was 3% and did not differ by SOT type. CONCLUSIONS Almost 1/10 SOTr may develop bacteremia during the first year post-transplant associated with low mortality. Lower bacteremia rates have been observed since 2014 and in patients receiving cotrimoxazole prophylaxis. Variabilities in incidence, timing, and pathogen of bacteremia across different SOT types may be used to tailor prophylactic and clinical approaches.

Published
2023
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