Search

Your search keyword '"van Dijk-Lokkart, Elisabeth M"' showing total 39 results
Start Over Author "van Dijk-Lokkart, Elisabeth M"
39 results on '"van Dijk-Lokkart, Elisabeth M"'

1. Child outcomes after prenatal exposure to platinum and taxane-based chemotherapy: an unplanned interim analysis of the international network on cancer, infertility, and pregnancy study

Author

Van Assche, Indra A., Van Calsteren, Kristel, Huis in ’t Veld, Evangeline A., van Gerwen, Mathilde, Heylen, Laura, LeJeune, Charlotte L., Cardonick, Elyce, Halaska, Michael J., Fruscio, Robert, Fumagalli, Monica, van Dijk-Lokkart, Elisabeth M., Lemiere, Jurgen, van Grotel, Martine, Lagae, Lieven, van den Heuvel-Eibrink, Marry M., and Amant, Frédéric

Published
2024
Full Text
View/download PDF

5. The top 10 research priorities for inflammatory bowel disease in children and young adults: results of a James Lind Alliance Priority Setting Partnership

Author

Jagt, Jasmijn Z, primary, van Rheenen, Patrick F, additional, Thoma, Sophia M A, additional, Gower, Jonathan, additional, Reimering-Hartgerink, Pamela B, additional, van der Wielen, Heidi J H L, additional, van Steenbergen, Esther J, additional, Goutbeek, Anne-Marije, additional, van Dijk-Lokkart, Elisabeth M, additional, Vlietstra, Stijn, additional, Reinders, Dana, additional, den Otter, Yanniek, additional, Schoonderwoert, Isabella, additional, Schoonderwoert, Bas, additional, Schoonderwoert, Hannie, additional, van der Weide, Germa, additional, van Harten, Simone, additional, Mouthaan, Kees, additional, Benninga, Marc A, additional, de Boer, Nanne K H, additional, van der Horst, Daniëlle, additional, Scherpenzeel, Menne, additional, and de Meij, Tim G J, additional

Published
2023
Full Text
View/download PDF

6. Cognitive and Behavioral Development of 9-Year-Old Children After Maternal Cancer During Pregnancy: A Prospective Multicenter Cohort Study

Author

Van Assche, Indra A., primary, Huis in 't Veld, Evangeline A., additional, Van Calsteren, Kristel, additional, van Gerwen, Mathilde, additional, Blommaert, Jeroen, additional, Cardonick, Elyce, additional, Halaska, Michael J., additional, Fruscio, Robert, additional, Fumagalli, Monica, additional, Lemiere, Jurgen, additional, van Dijk-Lokkart, Elisabeth M., additional, Fontana, Camilla, additional, van Tinteren, Harm, additional, De Ridder, Jessie, additional, van Grotel, Martine, additional, van den Heuvel-Eibrink, Marry M., additional, Lagae, Lieven, additional, and Amant, Frédéric, additional

Published
2023
Full Text
View/download PDF

11. Association of Chemotherapy Timing in Pregnancy With Congenital Malformation

Author

van Gerwen, Mathilde, primary, Maggen, Charlotte, additional, Cardonick, Elyce, additional, Verwaaijen, Emma J., additional, van den Heuvel-Eibrink, Marry, additional, Shmakov, Roman G., additional, Boere, Ingrid, additional, Gziri, Mina M., additional, Ottevanger, Petronella B., additional, Lok, Christianne A. R., additional, Halaska, Michael, additional, Shao, Long Ting, additional, Struys, Ilana, additional, van Dijk-Lokkart, Elisabeth M., additional, Van Calsteren, Kristel, additional, Fruscio, Robert, additional, Zola, Paolo, additional, Scarfone, Giovanna, additional, and Amant, Frédéric, additional

Published
2021
Full Text
View/download PDF

13. Association of Chemotherapy Timing in Pregnancy With Congenital Malformation.

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service d'obstétrique, van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma J, van den Heuvel-Eibrink, Marry, Shmakov, Roman G, Boere, Ingrid, Gziri, Mina M, Ottevanger, Petronella B, Lok, Christianne A R, Halaska, Michael, Shao, Long Ting, Struys, Ilana, van Dijk-Lokkart, Elisabeth M, Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, Amant, Frédéric, International Network on Cancer, Infertility and Pregnancy, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service d'obstétrique, van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma J, van den Heuvel-Eibrink, Marry, Shmakov, Roman G, Boere, Ingrid, Gziri, Mina M, Ottevanger, Petronella B, Lok, Christianne A R, Halaska, Michael, Shao, Long Ting, Struys, Ilana, van Dijk-Lokkart, Elisabeth M, Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, Amant, Frédéric, and International Network on Cancer, Infertility and Pregnancy

Abstract

Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer. This multicenter cohort study evaluated all pregnant women who received chemotherapy between 1977 and 2019 registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database. Data were analyzed from February 15 to June 2, 2020. Cancer treatment with chemotherapy during pregnancy. Analysis was focused on major and minor structural malformations in offspring, defined by EUROCAT, detected during pregnancy or at birth. A total of 755 women in the INCIP database who underwent cancer treatment with chemotherapy during pregnancy were included in analysis. The median (range) age at cancer diagnosis was 33 (14-48) years. Among offspring, the major congenital malformation rate was 3.6% (95% CI, 2.4%-5.2%), and the minor congenital malformation rate was 1.9% (95% CI, 1.0%-3.1%). Chemotherapy exposure prior to 12 weeks gestational age was associated with a high rate of major congenital malformations, at 21.7% (95% CI, 7.5%-43.7%; odds ratio, 9.24 [95% CI, 3.13-27.30]). When chemotherapy was initiated after gestational age 12 weeks, the frequency of major congenital malformations was 3.0% (95% CI, 1.9%-4.6%), which was similar to the expected rates in the general population. Minor malformations were comparable when exposure occurred before or after gestational age 12 weeks (4.3% [95% CI, 0.1%-21.9%] vs 1.8% [95% CI, 1.0-3.0]; odds ratio, 3.13 [95% CI, 0.39-25.28]). Of 29 women who received chemotherapy prior to 12 weeks gestation, 17 (58.6%) were not aware of pregnancy, and 6 (20.7%) experienced a miscarriage (3 women [10.3%]) or decided to terminate their pregnancy (3 women [10.3%]). This cohort study fo

Published
2021

14. Association of Chemotherapy Timing in Pregnancy With Congenital Malformation.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma J, van den Heuvel-Eibrink, Marry, Shmakov, Roman G, Boere, Ingrid, Mhallem Gziri, Mina, Ottevanger, Petronella B, Lok, Christianne A R, Halaska, Michael, Shao, Long Ting, Struys, Ilana, van Dijk-Lokkart, Elisabeth M, Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, Amant, Frédéric, International Network on Cancer, Infertility and Pregnancy, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'obstétrique, van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma J, van den Heuvel-Eibrink, Marry, Shmakov, Roman G, Boere, Ingrid, Mhallem Gziri, Mina, Ottevanger, Petronella B, Lok, Christianne A R, Halaska, Michael, Shao, Long Ting, Struys, Ilana, van Dijk-Lokkart, Elisabeth M, Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, Amant, Frédéric, and International Network on Cancer, Infertility and Pregnancy

Abstract

IMPORTANCE: chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. however, the precise gestational age at which chemotherapy can be initiated safely remains unclear. OBJECTIVE: To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer. DESIGN, SETTING, AND PARTICIPANTS: This multicenter cohort study evaluated all pregnant women who received chemotherapy between 1977 and 2019 registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database. Data were analyzed from February 15 to June 2, 2020. EXPOSURES: Cancer treatment with chemotherapy during pregnancy. MAIN OUTCOMES AND MEASURES: Analysis was focused on major and minor structural malformations in offspring, defined by EUROCAT, detected during pregnancy or at birth. RESULTS: A total of 755 women in the INCIP database who underwent cancer treatment with chemotherapy during pregnancy were included in analysis. The median (range) age at cancer diagnosis was 33 (14-48) years. Among offspring, the major congenital malformation rate was 3.6% (95% CI, 2.4%-5.2%), and the minor congenital malformation rate was 1.9% (95% CI, 1.0%-3.1%). Chemotherapy exposure prior to 12 weeks gestational age was associated with a high rate of major congenital malformations, at 21.7% (95% CI, 7.5%-43.7%; odds ratio, 9.24 [95% CI, 3.13-27.30]). When chemotherapy was initiated after gestational age 12 weeks, the frequency of major congenital malformations was 3.0% (95% CI, 1.9%-4.6%), which was similar to the expected rates in the general population. Minor malformations were comparable when exposure occurred before or after gestational age 12 weeks (4.3% [95% CI, 0.1%-21.9%] vs 1.8% [95% CI, 1.0-3.0]; odds ratio, 3.13 [95% CI, 0.39-25.28]). Of 29 women who received chemotherapy prior to 12 weeks gestation, 17 (58.6%) were not aware of pregnancy, and 6 (20.7%) experienced a mis

Published
2021

15. Association of Chemotherapy Timing in Pregnancy with Congenital Malformation

Author

Van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma, Van Den Heuvel-Eibrink, Marry, Shmakov, Roman G., Boere, Ingrid, Gziri, Mina M., Ottevanger, Petronella B., Lok, Christianne A.R., Halaska, Michael, Shao, Long Ting, Struys, Ilana, Van Dijk-Lokkart, Elisabeth M., Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, Amant, Frédéric, Van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma, Van Den Heuvel-Eibrink, Marry, Shmakov, Roman G., Boere, Ingrid, Gziri, Mina M., Ottevanger, Petronella B., Lok, Christianne A.R., Halaska, Michael, Shao, Long Ting, Struys, Ilana, Van Dijk-Lokkart, Elisabeth M., Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, and Amant, Frédéric

Abstract

Importance: Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. Objective: To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer. Design, Setting, and Participants: This multicenter cohort study evaluated all pregnant women who received chemotherapy between 1977 and 2019 registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database. Data were analyzed from February 15 to June 2, 2020. Exposures: Cancer treatment with chemotherapy during pregnancy. Main Outcomes and Measures: Analysis was focused on major and minor structural malformations in offspring, defined by EUROCAT, detected during pregnancy or at birth. Results: A total of 755 women in the INCIP database who underwent cancer treatment with chemotherapy during pregnancy were included in analysis. The median (range) age at cancer diagnosis was 33 (14-48) years. Among offspring, the major congenital malformation rate was 3.6% (95% CI, 2.4%-5.2%), and the minor congenital malformation rate was 1.9% (95% CI, 1.0%-3.1%). Chemotherapy exposure prior to 12 weeks gestational age was associated with a high rate of major congenital malformations, at 21.7% (95% CI, 7.5%-43.7%; odds ratio, 9.24 [95% CI, 3.13-27.30]). When chemotherapy was initiated after gestational age 12 weeks, the frequency of major congenital malformations was 3.0% (95% CI, 1.9%-4.6%), which was similar to the expected rates in the general population. Minor malformations were comparable when exposure occurred before or after gestational age 12 weeks (4.3% [95% CI, 0.1%-21.9%] vs 1.8% [95% CI, 1.0-3.0]; odds ratio, 3.13 [95% CI, 0.39-25.28]). Of 29 women who received chemotherapy prior to 12 weeks gestation, 17 (58.6%) were not aware of pregnancy, and 6 (20.7%) experienced a

Published
2021

16. Association of Chemotherapy Timing in Pregnancy With Congenital Malformation

Author

van Gerwen, M, Maggen, C, Cardonick, E, Verwaaijen, E, van den Heuvel-Eibrink, M, Shmakov, R, Boere, I, Gziri, M, Ottevanger, P, Lok, C, Halaska, M, Shao, L, Struys, I, van Dijk-Lokkart, E, Van Calsteren, K, Fruscio, R, Zola, P, Scarfone, G, Amant, F, van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma J, van den Heuvel-Eibrink, Marry, Shmakov, Roman G, Boere, Ingrid, Gziri, Mina M, Ottevanger, Petronella B, Lok, Christianne A R, Halaska, Michael, Shao, Long Ting, Struys, Ilana, van Dijk-Lokkart, Elisabeth M, Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, Amant, Frédéric, van Gerwen, M, Maggen, C, Cardonick, E, Verwaaijen, E, van den Heuvel-Eibrink, M, Shmakov, R, Boere, I, Gziri, M, Ottevanger, P, Lok, C, Halaska, M, Shao, L, Struys, I, van Dijk-Lokkart, E, Van Calsteren, K, Fruscio, R, Zola, P, Scarfone, G, Amant, F, van Gerwen, Mathilde, Maggen, Charlotte, Cardonick, Elyce, Verwaaijen, Emma J, van den Heuvel-Eibrink, Marry, Shmakov, Roman G, Boere, Ingrid, Gziri, Mina M, Ottevanger, Petronella B, Lok, Christianne A R, Halaska, Michael, Shao, Long Ting, Struys, Ilana, van Dijk-Lokkart, Elisabeth M, Van Calsteren, Kristel, Fruscio, Robert, Zola, Paolo, Scarfone, Giovanna, and Amant, Frédéric

Abstract

Importance: Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. Objective: To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer. Design, Setting, and Participants: This multicenter cohort study evaluated all pregnant women who received chemotherapy between 1977 and 2019 registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database. Data were analyzed from February 15 to June 2, 2020. Exposures: Cancer treatment with chemotherapy during pregnancy. Main Outcomes and Measures: Analysis was focused on major and minor structural malformations in offspring, defined by EUROCAT, detected during pregnancy or at birth. Results: A total of 755 women in the INCIP database who underwent cancer treatment with chemotherapy during pregnancy were included in analysis. The median (range) age at cancer diagnosis was 33 (14-48) years. Among offspring, the major congenital malformation rate was 3.6% (95% CI, 2.4%-5.2%), and the minor congenital malformation rate was 1.9% (95% CI, 1.0%-3.1%). Chemotherapy exposure prior to 12 weeks gestational age was associated with a high rate of major congenital malformations, at 21.7% (95% CI, 7.5%-43.7%; odds ratio, 9.24 [95% CI, 3.13-27.30]). When chemotherapy was initiated after gestational age 12 weeks, the frequency of major congenital malformations was 3.0% (95% CI, 1.9%-4.6%), which was similar to the expected rates in the general population. Minor malformations were comparable when exposure occurred before or after gestational age 12 weeks (4.3% [95% CI, 0.1%-21.9%] vs 1.8% [95% CI, 1.0-3.0]; odds ratio, 3.13 [95% CI, 0.39-25.28]). Of 29 women who received chemotherapy prior to 12 weeks gestation, 17 (58.6%) were not aware of pregnancy, and 6 (20.7%) experienced a mis

Published
2021

17. Long-term neurodevelopmental outcome after prenatal exposure to maternal hematological malignancies with or without cytotoxic treatment

Author

van Gerwen, M, Huis In 't Veld, E, van Grotel, M, van den Heuvel-Eibrink, M, Van Calsteren, K, Maggen, C, Drochytek, V, Scarfone, G, Fontana, C, Fruscio, R, Cardonick, E, van Dijk-Lokkart, E, Amant, F, van Gerwen, Mathilde, Huis In 't Veld, Evangeline, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, Van Calsteren, Kristel, Maggen, Charlotte, Drochytek, Vit, Scarfone, Giovanna, Fontana, Camilla, Fruscio, Robert, Cardonick, Elyce, van Dijk-Lokkart, Elisabeth M, Amant, Frédéric, van Gerwen, M, Huis In 't Veld, E, van Grotel, M, van den Heuvel-Eibrink, M, Van Calsteren, K, Maggen, C, Drochytek, V, Scarfone, G, Fontana, C, Fruscio, R, Cardonick, E, van Dijk-Lokkart, E, Amant, F, van Gerwen, Mathilde, Huis In 't Veld, Evangeline, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, Van Calsteren, Kristel, Maggen, Charlotte, Drochytek, Vit, Scarfone, Giovanna, Fontana, Camilla, Fruscio, Robert, Cardonick, Elyce, van Dijk-Lokkart, Elisabeth M, and Amant, Frédéric

Abstract

Data on the long-term neurodevelopmental outcomes of children exposed to hematological maternal cancer with or without treatment during pregnancy are lacking. A total of 57 children, of whom 33 males and 24 females, prenatally exposed to hematological malignancies and its treatment, were invited for neuropsychological and physical examinations at 18months, 36months, 6, 9, 12, 15 and 18years of age. Oncological, obstetrical, neonatal and follow-up data of these children were collected. Parents were asked to complete questionnaires on their child's general health, school performances, social situation, behavioral development, executive functioning, and if their child receives supportive care. Non-Hodgkin lymphoma was diagnosed in 35.1%, Hodgkin lymphoma in 28.1%, acute myeloid leukemia in 15.8%, chronic myeloid leukemia in 12.3%, and acute lymphoblastic leukemia in 8.8%. Cognitive development at a median age of 10.7years was within the normal range. In subgroup analyses of children in early childhood, the gestational age at birth was correlated with the cognitive outcome at a median age of 1.7years. Scores for language development, intelligence, attention, memory and behavior, as well as clinical neurological and general pediatric examinations were within normal ranges. In subgroup analyses, the need for supportive care in the child was associated with the loss of the mother. Prenatal exposure to hematological maternal malignancies with or without treatment did not affect the neurodevelopment of the child in the long term. Yet, caution is indicated and surveillance of the emotional development of the child is needed, especially when the mother is deceased to cancer.

Published
2021

18. Long-term neurodevelopmental outcome after prenatal exposure to maternal hematological malignancies with or without cytotoxic treatment

Author

van Gerwen, Mathilde, primary, Huis in ‘t Veld, Evangeline, additional, van Grotel, Martine, additional, van den Heuvel-Eibrink, Marry M., additional, Van Calsteren, Kristel, additional, Maggen, Charlotte, additional, Drochytek, Vit, additional, Scarfone, Giovanna, additional, Fontana, Camilla, additional, Fruscio, Robert, additional, Cardonick, Elyce, additional, van Dijk-Lokkart, Elisabeth M., additional, and Amant, Frédéric, additional

Published
2021
Full Text
View/download PDF

19. Executive functioning in 6 year old children exposed to chemotherapy in utero

Author

van Gerwen, Mathilde, primary, Vandenbroucke, Tineke, additional, Gorissen, An-sofie, additional, van Grotel, Martine, additional, van den Heuvel-Eibrink, Marry, additional, Verwaaijen, Emma, additional, van der Perk, Madeleine, additional, Van Calsteren, Kristel, additional, van Dijk-Lokkart, Elisabeth M., additional, and Amant, Frédéric, additional

Published
2020
Full Text
View/download PDF

20. Chemotherapy Exposure Till a Gestational Age of 12 Weeks Relates to a Higher Occurrence of Congenital Malformations: Results from the International Network on Cancer, Infertility and Pregnancy

Author

van Gerwen, Mathilde, primary, Maggen, Charlotte, additional, van den Heuvel-Eibrink, Marry, additional, Cardonick, Elyce, additional, van Grotel, Martine, additional, Verwaaijen, Emma, additional, Shmakov, Roman G., additional, Boere, Ingrid, additional, Van Calsteren, Kristel, additional, Ottevanger, Nelleke, additional, van Nieuwenhoven, Christianne A., additional, van Dijk-Lokkart, Elisabeth M., additional, Amant, Frédéric, additional, and Group, International Network on Cancer, In, additional

Published
2020
Full Text
View/download PDF

22. Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Author

Van Dijk‐Lokkart, Elisabeth M., primary, Steur, Lindsay M. H., additional, Braam, Katja I., additional, Veening, Margreet A., additional, Huisman, Jaap, additional, Takken, Tim, additional, Bierings, Marc, additional, Merks, Johannes H., additional, Van den Heuvel‐Eibrink, Marry M., additional, Kaspers, Gertjan J. L., additional, Van Dulmen‐den Broeder, Eline, additional, and Van Litsenburg, Raphaële R. L., additional

Published
2019
Full Text
View/download PDF

23. Longitudinal development of cancer-related fatigue and physical activity in childhood cancer patients

Author

Van Dijk-Lokkart, Elisabeth M, Steur, Lindsay M H, Braam, Katja I, Veening, Margreet A, Huisman, Jaap, Takken, Tim, Bierings, Marc, Merks, Johannes H, Van den Heuvel-Eibrink, Marry M, Kaspers, Gertjan J L, Van Dulmen-den Broeder, Eline, Van Litsenburg, Raphaële R L, Van Dijk-Lokkart, Elisabeth M, Steur, Lindsay M H, Braam, Katja I, Veening, Margreet A, Huisman, Jaap, Takken, Tim, Bierings, Marc, Merks, Johannes H, Van den Heuvel-Eibrink, Marry M, Kaspers, Gertjan J L, Van Dulmen-den Broeder, Eline, and Van Litsenburg, Raphaële R L

Published
2019

24. Longitudinal development of cancer-related fatigue and physical activity in childhood cancer patients

Author

Psychosociale zorg, Activity&Health sectie exercise, Child Health, SCT patientenzorg, Regenerative Medicine and Stem Cells, Speerpunt, Zorg en O&O, PMC Medisch specialisten, Van Dijk-Lokkart, Elisabeth M, Steur, Lindsay M H, Braam, Katja I, Veening, Margreet A, Huisman, Jaap, Takken, Tim, Bierings, Marc, Merks, Johannes H, Van den Heuvel-Eibrink, Marry M, Kaspers, Gertjan J L, Van Dulmen-den Broeder, Eline, Van Litsenburg, Raphaële R L, Psychosociale zorg, Activity&Health sectie exercise, Child Health, SCT patientenzorg, Regenerative Medicine and Stem Cells, Speerpunt, Zorg en O&O, PMC Medisch specialisten, Van Dijk-Lokkart, Elisabeth M, Steur, Lindsay M H, Braam, Katja I, Veening, Margreet A, Huisman, Jaap, Takken, Tim, Bierings, Marc, Merks, Johannes H, Van den Heuvel-Eibrink, Marry M, Kaspers, Gertjan J L, Van Dulmen-den Broeder, Eline, and Van Litsenburg, Raphaële R L

Published
2019

25. Effects of a combined physical and psychosocial training for children with cancer : a randomized controlled trial

Author

Braam, Katja I, van Dijk-Lokkart, Elisabeth M, Kaspers, Gertjan J L, Takken, Tim, Huisman, Jaap, Buffart, Laurien M, Bierings, Marc B, Merks, Johannes H M, van den Heuvel-Eibrink, Marry M, Veening, Margreet A, van Dulmen-den Broeder, Eline, Braam, Katja I, van Dijk-Lokkart, Elisabeth M, Kaspers, Gertjan J L, Takken, Tim, Huisman, Jaap, Buffart, Laurien M, Bierings, Marc B, Merks, Johannes H M, van den Heuvel-Eibrink, Marry M, Veening, Margreet A, and van Dulmen-den Broeder, Eline

Published
2018

26. Effects of a combined physical and psychosocial training for children with cancer: a randomized controlled trial

Author

PMC Medisch specialisten, Activity&Health sectie exercise, Child Health, Psychosociale zorg, Longziekten onderzoek 1, Braam, Katja I, van Dijk-Lokkart, Elisabeth M, Kaspers, Gertjan J L, Takken, Tim, Huisman, Jaap, Buffart, Laurien M, Bierings, Marc B, Merks, Johannes H M, van den Heuvel-Eibrink, Marry M, Veening, Margreet A, van Dulmen-den Broeder, Eline, PMC Medisch specialisten, Activity&Health sectie exercise, Child Health, Psychosociale zorg, Longziekten onderzoek 1, Braam, Katja I, van Dijk-Lokkart, Elisabeth M, Kaspers, Gertjan J L, Takken, Tim, Huisman, Jaap, Buffart, Laurien M, Bierings, Marc B, Merks, Johannes H M, van den Heuvel-Eibrink, Marry M, Veening, Margreet A, and van Dulmen-den Broeder, Eline

Published
2018

27. Effects of a combined physical and psychosocial intervention program for childhood cancer patients on quality of life and psychosocial functioning: results of the QLIM randomized clinical trial

Author

van Dijk-Lokkart, Elisabeth M., Braam, Katja I., van Dulmen-den Broeder, Eline, Kaspers, Gertjan J. L., Takken, Tim, Grootenhuis, Martha A., Streng, Isabelle C., Bierings, Marc, Merks, Johannes H., van den Heuvel-Eibrink, Marry M., Veening, Margreet A., Huisman, Jaap, CCA - Quality of Life, Pediatric surgery, Pediatrics, Child and Adolescent Psychiatry & Psychosocial Care, and Paediatric Oncology

Subjects
Psychiatry and Mental health, SDG 3 - Good Health and Well-being, Oncology, Research Support, Non-U.S. Gov't, Randomized Controlled Trial, Journal Article, Experimental and Cognitive Psychology
Abstract

Objective: Although survival rates in childhood cancer have improved, prevention and reduction of late effects remain important. This study evaluates the effects of a combined physical exercise and psychosocial intervention on health-related quality of life (HrQoL) and psychosocial functioning in childhood cancer patients. Methods: In this multicenter randomized controlled trial, cancer patients (aged 8–18 years) and their parents filled in questionnaires on HrQoL, depressive symptoms, behavioral problems, and self-esteem. Measurements were conducted at baseline, shortly after the 12-week intervention period and 12 months after baseline. Generalized estimating equations analyses were performed to assess short-term and long-term psychosocial effects. Results: Of the 174 eligible patients, 68 (39.1%) participated. The intervention group consisted of 30 participants at baseline [mean age 13.0 (SD 3.0) years; 53% male], 26 at short-term and 22 at long-term follow-up. The ‘care as usual’ control group consisted of 38 participants at baseline [mean age 12.6 (SD 3.1) years; 53% male], 33 at short-term and 31 at long-term follow-up. Overall, the intervention did not improve psychosocial functioning and HrQoL. According to parent-proxy reports, the intervention leads to a greater improvement on pain-related HrQoL on both the short (β = 13.4; 95% CI: 3.0; 23.8) and long term (β = 13.0; 95% CI: 1.6; 24.4) and to greater improvement on procedural anxiety immediately after the intervention (β = 12.6; 95% CI: 1.9; 23.3). Conclusion: A combined physical and psychosocial training for children with cancer did not have effects on HrQoL or psychosocial functioning, with exception of modest positive effects on parent-reported pain and procedural anxiety.

Published
2016
Full Text
View/download PDF

28. Effects of a combined physical and psychosocial intervention program for childhood cancer patients on quality of life and psychosocial functioning: results of the QLIM randomized clinical trial

Author

PMC Medisch specialisten, UMC Utrecht, Kinderbewegingszorg patientenzorg, Child Health, Haematologie, Regenerative Medicine and Stem Cells, Zorg en O&O, Psychosociale zorg, van Dijk-Lokkart, Elisabeth M., Braam, Katja I., van Dulmen-den Broeder, Eline, Kaspers, Gertjan J L, Takken, Tim, Grootenhuis, Martha A., Streng, Isabelle C., Bierings, Marc, Merks, Johannes H., van den Heuvel-Eibrink, Marry M., Veening, Margreet A., Huisman, Jaap, PMC Medisch specialisten, UMC Utrecht, Kinderbewegingszorg patientenzorg, Child Health, Haematologie, Regenerative Medicine and Stem Cells, Zorg en O&O, Psychosociale zorg, van Dijk-Lokkart, Elisabeth M., Braam, Katja I., van Dulmen-den Broeder, Eline, Kaspers, Gertjan J L, Takken, Tim, Grootenhuis, Martha A., Streng, Isabelle C., Bierings, Marc, Merks, Johannes H., van den Heuvel-Eibrink, Marry M., Veening, Margreet A., and Huisman, Jaap

Published
2016

29. Cardiorespiratory fitness and physical activity in children with cancer

Author

Braam, Katja I, van Dijk-Lokkart, Elisabeth M, Kaspers, Gertjan J L, Takken, Tim, Huisman, Jaap, Bierings, Marc B, Merks, Johannes H M, van de Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, Veening, Margreet A, Braam, Katja I, van Dijk-Lokkart, Elisabeth M, Kaspers, Gertjan J L, Takken, Tim, Huisman, Jaap, Bierings, Marc B, Merks, Johannes H M, van de Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, and Veening, Margreet A

Published
2015

30. Applicability and evaluation of a psychosocial intervention program for childhood cancer patients

Author

PMC Medisch specialisten, Kinderbewegingszorg patientenzorg, Child Health, Haematologie, Psychosociale zorg, van Dijk-Lokkart, Elisabeth M., Braam, Katja I., Kaspers, Gertjan J L, van Dulmen-den Broeder, Eline, Takken, Tim, Grootenhuis, Martha A., Streng, Isabelle C., Bierings, Marc, Merks, Johannes H., Eibrink, Marry, Veening, Margreet A., Huisman, Jaap, PMC Medisch specialisten, Kinderbewegingszorg patientenzorg, Child Health, Haematologie, Psychosociale zorg, van Dijk-Lokkart, Elisabeth M., Braam, Katja I., Kaspers, Gertjan J L, van Dulmen-den Broeder, Eline, Takken, Tim, Grootenhuis, Martha A., Streng, Isabelle C., Bierings, Marc, Merks, Johannes H., Eibrink, Marry, Veening, Margreet A., and Huisman, Jaap

Published
2015

31. Factors influencing childhood cancer patients to participate in a combined physical and psychosocial intervention program: Quality of Life in Motion

Author

Psychosociale zorg, Child Health, PMC Medisch specialisten, Kinderbewegingszorg patientenzorg, Haematologie, Van Dijk-Lokkart, Elisabeth M., Braam, Katja I., Huisman, Jaap, Kaspers, Gertjan Jl, Takken, Tim, Veening, Margreet A., Bierings, MB, Merks, Hans, Grootenhuis, Martha A., Eibrink, Marry, Streng, Isabelle C., Van Dulmen-Den Broeder, Eline, Psychosociale zorg, Child Health, PMC Medisch specialisten, Kinderbewegingszorg patientenzorg, Haematologie, Van Dijk-Lokkart, Elisabeth M., Braam, Katja I., Huisman, Jaap, Kaspers, Gertjan Jl, Takken, Tim, Veening, Margreet A., Bierings, MB, Merks, Hans, Grootenhuis, Martha A., Eibrink, Marry, Streng, Isabelle C., and Van Dulmen-Den Broeder, Eline

Published
2015

32. Cardiorespiratory fitness and physical activity in children with cancer

Author

Braam, Katja I., primary, van Dijk-Lokkart, Elisabeth M., additional, Kaspers, Gertjan J.L., additional, Takken, Tim, additional, Huisman, Jaap, additional, Bierings, Marc B., additional, Merks, Johannes H.M., additional, van de Heuvel-Eibrink, Marry M., additional, van Dulmen–den Broeder, Eline, additional, and Veening, Margreet A., additional

Published
2015
Full Text
View/download PDF

33. Effects of a combined physical and psychosocial intervention program for childhood cancer patients on quality of life and psychosocial functioning: results of the QLIM randomized clinical trial

Author

van Dijk‐Lokkart, Elisabeth M., primary, Braam, Katja I., additional, van Dulmen‐den Broeder, Eline, additional, Kaspers, Gertjan J. L., additional, Takken, Tim, additional, Grootenhuis, Martha A., additional, Streng, Isabelle C., additional, Bierings, Marc, additional, Merks, Johannes H., additional, van den Heuvel‐Eibrink, Marry M., additional, Veening, Margreet A., additional, and Huisman, Jaap, additional

Published
2015
Full Text
View/download PDF

35. Factors influencing childhood cancer patients to participate in a combined physical and psychosocial intervention program: Quality of Life in Motion

Author

van Dijk-Lokkart, Elisabeth M., primary, Braam, Katja I., additional, Huisman, Jaap, additional, Kaspers, Gertjan JL, additional, Takken, Tim, additional, Veening, Margreet A., additional, Bierings, Marc, additional, Merks, Johannes H., additional, Grootenhuis, Martha A., additional, van den Heuvel-Eibrink, Marry, additional, Streng, Isabelle C., additional, and van Dulmen-den Broeder, Eline, additional

Published
2014
Full Text
View/download PDF

37. Long-Term Maternal Mental Health after Spontaneous Preterm Birth.

Author

Janssen LE, Laarman ARC, van Dijk-Lokkart EM, Bröring-Starre T, Oudijk MA, de Groot CJM, and de Boer MA

Subjects
Humans, Female, Prospective Studies, Adult, Pregnancy, Mental Health, Middle Aged, Social Support, Premature Birth psychology, Anxiety epidemiology, Depression epidemiology
Abstract

Objective: The aim of this study is to investigate whether a history of spontaneous preterm birth (SPTB) is associated with maternal depressive and anxiety symptoms, or psychosocial distress in the fifth decade of life., Study Design: This is a secondary analysis of the PreCaris-study, a prospective observational study in which we included 350 women with a history of SPTB between 22 0/7 and 36 6/7 weeks of gestation and compared them to 115 women who had a term birth. Primary outcomes were the Depression and Anxiety scores measured using the Hospital Anxiety Depression Scale and Psychosocial distress assessed with the Distress Thermometer for Parents. Secondary outcomes were self-reported impact of the birth in daily life and psychosocial support after delivery., Results: After a median of 13 years after delivery, no significant differences were found in primary outcomes. Significantly more women with a history of SPTB reported that the birth still had impact in daily life; adjusted odds ratio: 2.46 (95% confidence interval: 1.35-4.48). A total of 57 (16.3%) women after SPTB reported to have needed professional psychosocial support after delivery but did not receive it. These women more often had a high Anxiety score ( p  = 0.030), psychosocial distress ( p  = 0.001), and influence of birth in daily life ( p  = 0.000)., Conclusion: There are no long-term effects on depressive and anxiety symptoms and psychosocial distress in women who experienced SPTB compared with women who had a full-term pregnancy. A significant part of the women who delivered preterm needed psychosocial support but did not receive it and were at higher risk of anxiety, psychosocial distress, and impact in daily life. We therefore recommend offering all women after SPTB psychosocial support after delivery., Key Points: · No long-term effects on depressive and anxiety symptoms and psychosocial distress after SPTB.. · A total of 16.3% of the cases needed professional psychosocial support after delivery but did not receive it.. · This subgroup was at higher risk of anxiety symptoms, psychosocial distress, and impact on daily life.., Competing Interests: None declared., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).)

Published
2024
Full Text
View/download PDF

38. [Formula: see text]Long-term neurodevelopmental outcome after prenatal exposure to maternal hematological malignancies with or without cytotoxic treatment.

Author

van Gerwen M, Huis In 't Veld E, van Grotel M, van den Heuvel-Eibrink MM, Van Calsteren K, Maggen C, Drochytek V, Scarfone G, Fontana C, Fruscio R, Cardonick E, van Dijk-Lokkart EM, and Amant F

Subjects
Child, Child Development, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Intelligence, Male, Mothers, Pregnancy, Antineoplastic Agents, Hematologic Neoplasms complications, Prenatal Exposure Delayed Effects
Abstract

Data on the long-term neurodevelopmental outcomes of children exposed to hematological maternal cancer with or without treatment during pregnancy are lacking. A total of 57 children, of whom 33 males and 24 females, prenatally exposed to hematological malignancies and its treatment, were invited for neuropsychological and physical examinations at 18 months, 36 months, 6, 9, 12, 15 and 18 years of age. Oncological, obstetrical, neonatal and follow-up data of these children were collected. Parents were asked to complete questionnaires on their child's general health, school performances, social situation, behavioral development, executive functioning, and if their child receives supportive care. Non-Hodgkin lymphoma was diagnosed in 35.1%, Hodgkin lymphoma in 28.1%, acute myeloid leukemia in 15.8%, chronic myeloid leukemia in 12.3%, and acute lymphoblastic leukemia in 8.8%. Cognitive development at a median age of 10.7 years was within the normal range. In subgroup analyses of children in early childhood, the gestational age at birth was correlated with the cognitive outcome at a median age of 1.7 years. Scores for language development, intelligence, attention, memory and behavior, as well as clinical neurological and general pediatric examinations were within normal ranges. In subgroup analyses, the need for supportive care in the child was associated with the loss of the mother. Prenatal exposure to hematological maternal malignancies with or without treatment did not affect the neurodevelopment of the child in the long term. Yet, caution is indicated and surveillance of the emotional development of the child is needed, especially when the mother is deceased to cancer.

Published
2021
Full Text
View/download PDF

39. Association of Chemotherapy Timing in Pregnancy With Congenital Malformation.

Author

van Gerwen M, Maggen C, Cardonick E, Verwaaijen EJ, van den Heuvel-Eibrink M, Shmakov RG, Boere I, Gziri MM, Ottevanger PB, Lok CAR, Halaska M, Shao LT, Struys I, van Dijk-Lokkart EM, Van Calsteren K, Fruscio R, Zola P, Scarfone G, and Amant F

Subjects
Adolescent, Adult, Cohort Studies, Female, Gestational Age, Humans, Middle Aged, Odds Ratio, Pregnancy, Pregnancy Trimester, First, Pregnant Women, Time Factors, Young Adult, Abnormalities, Drug-Induced etiology, Antineoplastic Agents adverse effects, Antineoplastic Agents therapeutic use, Drug Administration Schedule, Fetal Development drug effects, Neoplasms drug therapy
Abstract

Importance: Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear., Objective: To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer., Design, Setting, and Participants: This multicenter cohort study evaluated all pregnant women who received chemotherapy between 1977 and 2019 registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database. Data were analyzed from February 15 to June 2, 2020., Exposures: Cancer treatment with chemotherapy during pregnancy., Main Outcomes and Measures: Analysis was focused on major and minor structural malformations in offspring, defined by EUROCAT, detected during pregnancy or at birth., Results: A total of 755 women in the INCIP database who underwent cancer treatment with chemotherapy during pregnancy were included in analysis. The median (range) age at cancer diagnosis was 33 (14-48) years. Among offspring, the major congenital malformation rate was 3.6% (95% CI, 2.4%-5.2%), and the minor congenital malformation rate was 1.9% (95% CI, 1.0%-3.1%). Chemotherapy exposure prior to 12 weeks gestational age was associated with a high rate of major congenital malformations, at 21.7% (95% CI, 7.5%-43.7%; odds ratio, 9.24 [95% CI, 3.13-27.30]). When chemotherapy was initiated after gestational age 12 weeks, the frequency of major congenital malformations was 3.0% (95% CI, 1.9%-4.6%), which was similar to the expected rates in the general population. Minor malformations were comparable when exposure occurred before or after gestational age 12 weeks (4.3% [95% CI, 0.1%-21.9%] vs 1.8% [95% CI, 1.0-3.0]; odds ratio, 3.13 [95% CI, 0.39-25.28]). Of 29 women who received chemotherapy prior to 12 weeks gestation, 17 (58.6%) were not aware of pregnancy, and 6 (20.7%) experienced a miscarriage (3 women [10.3%]) or decided to terminate their pregnancy (3 women [10.3%])., Conclusions and Relevance: This cohort study found that chemotherapy was associated with an increased risk of major congenital malformations only in the first 12 weeks of pregnancy. The risk of congenital malformations when chemotherapy was administered during the first trimester and the high number of incidental pregnancies during cancer treatment in the INCIP registry underscore the importance of contraceptive advice and pregnancy testing at the start of chemotherapeutic treatment in young women with cancer.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results