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1. Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas

Author

de Haan, Lorraine M., de Groen, Ruben A. L., de Groot, Fleur A., Noordenbos, Troy, van Wezel, Tom, van Eijk, Ronald, Ruano, Dina, Diepstra, Arjan, Koens, Lianne, Nicolae-Cristea, Alina, Hartog, Wietske C. E. den, Terpstra, Valeska, Ahsmann, Els, Dekker, Tim J. A., Sijs-Szabo, Aniko, Veelken, Hendrik, Cleven, Arjen H. G., Jansen, Patty M., and Vermaat, Joost S. P.

Published
2024
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2. Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands: interlaboratory variation in the primary diagnostic and recurrent setting

Author

van Opijnen, Mark P., Broekman, Marike L. D., Cuppen, Edwin, Dubbink, Hendrikus J., ter Elst, Arja, van Eijk, Ronald, Mühlebner, Angelika, Jansen, Casper, van der Geize, Robert, Speel, Ernst-Jan M., Groenen, Patricia J. T. A., de Vos, Filip Y. F., Wesseling, Pieter, de Leng, Wendy W. J., and Maas, Sybren L. N.

Published
2024
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5. Genetic Alterations in Patients with NF2 -Related Schwannomatosis and Sporadic Vestibular Schwannomas.

Author

Douwes, Jules P. J., van Eijk, Ronald, Maas, Sybren L. N., Jansen, Jeroen C., Aten, Emmelien, and Hensen, Erik F.

Subjects
*DNA analysis, *AGE distribution, *DESCRIPTIVE statistics, *ACOUSTIC neuroma, *GENES, *GENETIC mutation, *GENETICS
Abstract

Simple Summary: Vestibular schwannomas are tumors that occur on the nerve responsible for hearing and balance, the vestibulocochlear nerve. These benign tumors may appear on one side (unilateral) or both sides (bilateral), with bilateral cases often linked to a condition called NF2-related schwannomatosis. This study explored the genetic causes of vestibular schwannomas in three groups: patients with NF2, younger patients with a unilateral tumor, and older patients with a unilateral tumor. By analyzing DNA from the tumors and blood, we aimed to understand the genetic mutations that drive tumor development and how the genetics differed between the three groups. In all patients, it was found that one gene, NF2, played a major role in the development of vestibular schwannomas. However, there were also differences found in the types of genetic mutations and mechanisms involved, offering new insights into how these tumors form and progress. Background: Unilateral (uVS) and bilateral vestibular schwannoma (bVS) are distinct disease types, yet share tumorigenic features. This study examined causative genetic alterations in three groups: patients with NF2-related schwannomatosis (NF2), young patients with uVS (≤30 years), and older patients with uVS (≥40 years). Methods: Lymphocyte and vestibular schwannoma DNA was genetically analyzed. Outcomes included gene involvement, pathogenicity classification, variant type, effect, and location, and loss of heterozygosity (LOH) of chromosome 22. Results: Among 93 patients, 17% had NF2, 39% were ≤30 years with uVS, and 44% were ≥40 years with uVS. In all patients with NF2 (100%), two or more hits were detected in the tumor DNA, whereas patients with uVS had a slightly lower detection rate (89–98%). NF2-related tumors had a higher frequency of nucleotide variants (76%), while LOH events were more common in uVS (64–69%). Variants were mostly identified in NF2, with nonsense variants over-represented in patients with NF2 (38%) and frameshift variants more prevalent in uVS (44–51%). Conclusions: Biallelic NF2 inactivation primarily drives vestibular schwannoma tumorigenesis. In patients with NF2, two pathogenic NF2 variants or one NF2 variant with LOH are common, whereas patients with uVS often exhibit one NF2 variant with LOH. Additionally, variant types differ between patient groups. [ABSTRACT FROM AUTHOR]

Published
2025
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7. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

Author

de Groen, Ruben A.L., van Eijk, Ronald, Böhringer, Stefan, van Wezel, Tom, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-de Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., van den Berg, Anke, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie José, Pals, Steven T., Veelken, Hendrik, Bovée, Judith V.M.G., Cleven, Arjen H.G., and Vermaat, Joost S.P.

Published
2021
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9. External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium

Author

Pathologie Pathologen staf, Cancer, van der Leest, Paul, Rozendal, Pim, Hinrichs, John, van Noesel, Carel J M, Zwaenepoel, Karen, Deiman, Birgit, Huijsmans, Cornelis J J, van Eijk, Ronald, Speel, Ernst Jan M, van Haastert, Rick J, Ligtenberg, Marjolijn J L, van Schaik, Ron H N, Jansen, Maurice P H M, Dubbink, Hendrikus J, de Leng, Wendy W, Leers, Mathie P G, Tamminga, Menno, van den Broek, Daan, van Kempen, Léon C, Schuuring, Ed, Pathologie Pathologen staf, Cancer, van der Leest, Paul, Rozendal, Pim, Hinrichs, John, van Noesel, Carel J M, Zwaenepoel, Karen, Deiman, Birgit, Huijsmans, Cornelis J J, van Eijk, Ronald, Speel, Ernst Jan M, van Haastert, Rick J, Ligtenberg, Marjolijn J L, van Schaik, Ron H N, Jansen, Maurice P H M, Dubbink, Hendrikus J, de Leng, Wendy W, Leers, Mathie P G, Tamminga, Menno, van den Broek, Daan, van Kempen, Léon C, and Schuuring, Ed

Published
2024

10. Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands:interlaboratory variation in the primary diagnostic and recurrent setting

Author

van Opijnen, Mark P., Broekman, Marike L.D., Cuppen, Edwin, Dubbink, Hendrikus J., ter Elst, Arja, van Eijk, Ronald, Mühlebner, Angelika, Jansen, Casper, van der Geize, Robert, Speel, Ernst Jan M., Groenen, Patricia J.T.A., de Vos, Filip Y.F., Wesseling, Pieter, de Leng, Wendy W.J., Maas, Sybren L.N., van Opijnen, Mark P., Broekman, Marike L.D., Cuppen, Edwin, Dubbink, Hendrikus J., ter Elst, Arja, van Eijk, Ronald, Mühlebner, Angelika, Jansen, Casper, van der Geize, Robert, Speel, Ernst Jan M., Groenen, Patricia J.T.A., de Vos, Filip Y.F., Wesseling, Pieter, de Leng, Wendy W.J., and Maas, Sybren L.N.

Abstract

Purpose: Next generation sequencing (NGS) is an important tool used in clinical practice to obtain the required molecular information for accurate diagnostics of high-grade adult-type diffuse glioma (HGG). Since individual centers use either in-house produced or standardized panels, interlaboratory variation could play a role in the practice of HGG diagnosis and treatment. This study aimed to investigate the current practice in NGS application for both primary and recurrent HGG. Methods: This nationwide Dutch survey used the expertise of (neuro)pathologists and clinical scientists in molecular pathology (CSMPs) by sending online questionnaires on clinical and technical aspects. Primary outcome was an overview of panel composition in the different centers for diagnostic practice of HGG. Secondary outcomes included practice for recurrent HGG and future perspectives. Results: Out of twelve neuro-oncology centers, the survey was filled out by eleven (neuro)pathologists and seven CSMPs. The composition of the diagnostic NGS panels differed in each center with numbers of genes ranging from 12 to 523. Differences are more pronounced when tests are performed to find therapeutic targets in the case of recurrent disease: about half of the centers test for gene fusions (60%) and tumor mutational burden (40%). Conclusion: Current notable interlaboratory variations as illustrated in this study should be reduced in order to refine diagnostics and improve precision oncology. In-house developed tests, standardized panels and routine application of broad gene panels all have their own advantages and disadvantages. Future research would be of interest to study the clinical impact of variation in diagnostic approaches.

Published
2024

11. Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands: interlaboratory variation in the primary diagnostic and recurrent setting

Author

CMM Groep Van Mil, Pathologie Pathologen staf, Brain, Cancer, MS Medische Oncologie, Pathologie Groep Van Diest, van Opijnen, Mark P, Broekman, Marike L D, Cuppen, Edwin, Dubbink, Hendrikus J, Ter Elst, Arja, van Eijk, Ronald, Mühlebner, Angelika, Jansen, Casper, van der Geize, Robert, Speel, Ernst-Jan M, Groenen, Patricia J T A, de Vos, Filip Y F, Wesseling, Pieter, de Leng, Wendy W J, Maas, Sybren L N, CMM Groep Van Mil, Pathologie Pathologen staf, Brain, Cancer, MS Medische Oncologie, Pathologie Groep Van Diest, van Opijnen, Mark P, Broekman, Marike L D, Cuppen, Edwin, Dubbink, Hendrikus J, Ter Elst, Arja, van Eijk, Ronald, Mühlebner, Angelika, Jansen, Casper, van der Geize, Robert, Speel, Ernst-Jan M, Groenen, Patricia J T A, de Vos, Filip Y F, Wesseling, Pieter, de Leng, Wendy W J, and Maas, Sybren L N

Published
2024

12. External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium

Author

van der Leest, Paul, Rozendal, Pim, Hinrichs, John, van Noesel, Carel J.M., Zwaenepoel, Karen, Deiman, Birgit, Huijsmans, Cornelis J.J., van Eijk, Ronald, Speel, Ernst Jan M., van Haastert, Rick J., Ligtenberg, Marjolijn J.L., van Schaik, Ron H.N., Jansen, Maurice P.H.M., Dubbink, Hendrikus J., de Leng, Wendy W., Leers, Mathie P.G., Tamminga, Menno, van den Broek, Daan, van Kempen, Leon C., Schuuring, Ed, van der Leest, Paul, Rozendal, Pim, Hinrichs, John, van Noesel, Carel J.M., Zwaenepoel, Karen, Deiman, Birgit, Huijsmans, Cornelis J.J., van Eijk, Ronald, Speel, Ernst Jan M., van Haastert, Rick J., Ligtenberg, Marjolijn J.L., van Schaik, Ron H.N., Jansen, Maurice P.H.M., Dubbink, Hendrikus J., de Leng, Wendy W., Leers, Mathie P.G., Tamminga, Menno, van den Broek, Daan, van Kempen, Leon C., and Schuuring, Ed

Abstract

Background: Identification of tumor-derived variants in circulating tumor DNA (ctDNA) has potential as a sensitive and reliable surrogate for tumor tissue-based routine diagnostic testing. However, variations in pre(analytical) procedures affect the efficiency of ctDNA recovery. Here, an external quality assessment (EQA) was performed to determine the performance of ctDNA mutation detection work flows that are used in current diagnostic settings across laboratories within the Dutch COIN consortium (ctDNA on the road to implementation in The Netherlands). Methods: Aliquots of 3 high-volume diagnostic leukapheresis (DLA) plasma samples and 3 artificial reference plasma samples with predetermined mutations were distributed among 16 Dutch laboratories. Participating laboratories were requested to perform ctDNA analysis for BRAF exon 15, EGFR exon 18-21, and KRAS exon 2-3 using their regular circulating cell-free DNA (ccfDNA) analysis work flow. Laboratories were assessed based on adherence to the study protocol, overall detection rate, and overall genotyping performance. Results: A broad range of preanalytical conditions (e.g., plasma volume, elution volume, and extraction methods) and analytical methodologies (e.g., droplet digital PCR [ddPCR], small-panel PCR assays, and next-generation sequencing [NGS]) were used. Six laboratories (38%) had a performance score of >0.90; all other laboratories scored between 0.26 and 0.80. Although 13 laboratories (81%) reached a 100% overall detection rate, the therapeutically relevant EGFR p.(S752_I759del) (69%), EGFR p.(N771_H773dup) (50%), and KRAS p.(G12C) (48%) mutations were frequently not genotyped accurately. Conclusions: Divergent (pre)analytical protocols could lead to discrepant clinical outcomes when using the same plasma samples. Standardization of (pre)analytical work flows can facilitate the implementation of reproducible liquid biopsy testing in the clinical routine.

Published
2024

13. External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium

Author

van der Leest, Paul, primary, Rozendal, Pim, additional, Hinrichs, John, additional, van Noesel, Carel J M, additional, Zwaenepoel, Karen, additional, Deiman, Birgit, additional, Huijsmans, Cornelis J J, additional, van Eijk, Ronald, additional, Speel, Ernst Jan M, additional, van Haastert, Rick J, additional, Ligtenberg, Marjolijn J L, additional, van Schaik, Ron H N, additional, Jansen, Maurice P H M, additional, Dubbink, Hendrikus J, additional, de Leng, Wendy W, additional, Leers, Mathie P G, additional, Tamminga, Menno, additional, van den Broek, Daan, additional, van Kempen, Léon C, additional, and Schuuring, Ed, additional

Published
2024
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16. Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas

Author

de Haan, Lorraine M., primary, de Groen, Ruben A. L., additional, de Groot, Fleur A., additional, Noordenbos, Troy, additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ruano, Dina, additional, Diepstra, Arjan, additional, Koens, Lianne, additional, Nicolae-Cristea, Alina, additional, Hartog, Wietske C. E. den, additional, Terpstra, Valeska, additional, Ahsmann, Els, additional, Dekker, Tim J. A., additional, Sijs-Szabo, Aniko, additional, Veelken, Hendrik, additional, Cleven, Arjen H. G., additional, Jansen, Patty M., additional, and Vermaat, Joost S. P., additional

Published
2023
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17. Statin Use After Diagnosis of Colon Cancer and Patient Survival

Author

Voorneveld, Philip W., Reimers, Marlies S., Bastiaannet, Esther, Jacobs, Rutger J., van Eijk, Ronald, Zanders, Marjolein M.J., Herings, Ron M.C., van Herk-Sukel, Myrthe P.P., Kodach, Liudmila L., van Wezel, Tom, Kuppen, Peter J.K., Morreau, Hans, van de Velde, Cornelis J.H., Hardwick, James C.H., and Liefers, Gerrit Jan

Published
2017
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18. Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia

Author

Schubert, Stephanie A, Ruano, Dina, Elsayed, Fadwa A, Boot, Arnoud, Crobach, Stijn, Sarasqueta, Arantza Farina, Wolffenbuttel, Bruce, van der Klauw, Melanie M, Oosting, Jan, Tops, Carli M, van Eijk, Ronald, Vasen, Hans FA, Vossen, Rolf HAM, Nielsen, Maartje, Castellví-Bel, Sergi, Ruiz-Ponte, Clara, Tomlinson, Ian, Dunlop, Malcolm G, Vodicka, Pavel, Wijnen, Juul T, Hes, Frederik J, Morreau, Hans, de Miranda, Noel FCC, Sijmons, Rolf H, and van Wezel, Tom

Published
2017
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20. Supplementary Table 1 from Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort

Author

Middeldorp, Anneke, primary, Jagmohan-Changur, Shantie, primary, van Eijk, Ronald, primary, Tops, Carli, primary, Devilee, Peter, primary, Vasen, Hans F. A., primary, Hes, Frederik J., primary, Houlston, Richard, primary, Tomlinson, Ian, primary, Houwing-Duistermaat, Jeanine J., primary, Wijnen, Juul T., primary, Morreau, Hans, primary, and van Wezel, Tom, primary

Published
2023
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22. Supplementary Data from Cell Cycle/Apoptosis Molecule Expression Correlates with Imatinib Response in Patients with Advanced Gastrointestinal Stromal Tumors

Author

Romeo, Salvatore, primary, Debiec-Rychter, Maria, primary, Van Glabbeke, Martine, primary, Van Paassen, Heidi, primary, Comite, Paola, primary, Van Eijk, Ronald, primary, Oosting, Jan, primary, Verweij, Jaap, primary, Terrier, Philippe, primary, Schneider, Ulrike, primary, Sciot, Raf, primary, Blay, Jean Yves, primary, and Hogendoorn, Pancras C.W., primary

Published
2023
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23. Supplementary Table 1 from Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Author

Corver, Willem E., primary, Middeldorp, Anneke, primary, ter Haar, Natalja T., primary, Jordanova, Ekaterina S., primary, van Puijenbroek, Marjo, primary, van Eijk, Ronald, primary, Cornelisse, Cees J., primary, Fleuren, Gert Jan, primary, Morreau, Hans, primary, Oosting, Jan, primary, and van Wezel, Tom, primary

Published
2023
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24. Supplementary Figure 1 from Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Author

Corver, Willem E., primary, Middeldorp, Anneke, primary, ter Haar, Natalja T., primary, Jordanova, Ekaterina S., primary, van Puijenbroek, Marjo, primary, van Eijk, Ronald, primary, Cornelisse, Cees J., primary, Fleuren, Gert Jan, primary, Morreau, Hans, primary, Oosting, Jan, primary, and van Wezel, Tom, primary

Published
2023
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25. Data from Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Author

Corver, Willem E., primary, Middeldorp, Anneke, primary, ter Haar, Natalja T., primary, Jordanova, Ekaterina S., primary, van Puijenbroek, Marjo, primary, van Eijk, Ronald, primary, Cornelisse, Cees J., primary, Fleuren, Gert Jan, primary, Morreau, Hans, primary, Oosting, Jan, primary, and van Wezel, Tom, primary

Published
2023
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26. Supplementary Figure 2 from Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Author

Corver, Willem E., primary, Middeldorp, Anneke, primary, ter Haar, Natalja T., primary, Jordanova, Ekaterina S., primary, van Puijenbroek, Marjo, primary, van Eijk, Ronald, primary, Cornelisse, Cees J., primary, Fleuren, Gert Jan, primary, Morreau, Hans, primary, Oosting, Jan, primary, and van Wezel, Tom, primary

Published
2023
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27. Supplementary Figure and Table Legends from Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Author

Corver, Willem E., primary, Middeldorp, Anneke, primary, ter Haar, Natalja T., primary, Jordanova, Ekaterina S., primary, van Puijenbroek, Marjo, primary, van Eijk, Ronald, primary, Cornelisse, Cees J., primary, Fleuren, Gert Jan, primary, Morreau, Hans, primary, Oosting, Jan, primary, and van Wezel, Tom, primary

Published
2023
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28. Supplementary Figure 3 from Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Author

Corver, Willem E., primary, Middeldorp, Anneke, primary, ter Haar, Natalja T., primary, Jordanova, Ekaterina S., primary, van Puijenbroek, Marjo, primary, van Eijk, Ronald, primary, Cornelisse, Cees J., primary, Fleuren, Gert Jan, primary, Morreau, Hans, primary, Oosting, Jan, primary, and van Wezel, Tom, primary

Published
2023
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29. Supplementary Table 2 from Genome-wide Allelic State Analysis on Flow-Sorted Tumor Fractions Provides an Accurate Measure of Chromosomal Aberrations

Author

Corver, Willem E., primary, Middeldorp, Anneke, primary, ter Haar, Natalja T., primary, Jordanova, Ekaterina S., primary, van Puijenbroek, Marjo, primary, van Eijk, Ronald, primary, Cornelisse, Cees J., primary, Fleuren, Gert Jan, primary, Morreau, Hans, primary, Oosting, Jan, primary, and van Wezel, Tom, primary

Published
2023
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33. Molecular Diagnostics for TP53 Is Recommended in B-Cell Lymphomas

Author

De Haan, Lorraine M., primary, De Groen, Ruben A.L., additional, de Groot, Fleur, additional, Noordenbos, Troy, additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ruano, Dina, additional, Diepstra, Arjan, additional, Koens, Lianne, additional, Sijs-Szabo, Aniko, additional, Veelken, Hendrik, additional, Cleven, Arjen, additional, Jansen, Patty M., additional, and Vermaat, Joost S.P., additional

Published
2022
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34. Polyostotic DLBCL Is Characterized By a NF-Κb Pathway Affecting Molecular Profile and Superior Survival

Author

De Groen, Ruben A.L., primary, De Groot, Fleur A, additional, De Haan, Lorraine M., additional, van Wezel, Tom, additional, Noordenbos, Troy, additional, Boehringer, Stefan, additional, Van Eijk, Ronald, additional, Raghoo, Richard, additional, Ruano, Dina, additional, Sijs-Szabo, Aniko, additional, te Boome, Liane, additional, Terpstra, Valeska, additional, Levenga, Henriette, additional, Nicolae, Aline, additional, Posthuma, Ward, additional, Focke-Snieders, Isabelle, additional, Hardi, Lizan, additional, den Hartog, Wietske, additional, Böhmer, Lara H., additional, Van Den Berg, Anke, additional, Mutseaers, Pim, additional, Van Der Poel, Marjolein W.M., additional, Abdul Hamid, Myrurgia, additional, Woei-a-Jin, F.J. Sherida H., additional, Janssens, Ann, additional, Tousseyn, Thomas, additional, Bovée, Judith, additional, Veelken, Hendrik, additional, Pals, Steven T, additional, Diepstra, Arjan, additional, Nijland, Marcel, additional, Kersten, Marie José, additional, Jansen, Patty M., additional, Cleven, Arjen, additional, and Vermaat, Joost S.P., additional

Published
2022
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35. Genetic Stability of Driver Alterations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type and Their Relapses: A Rationale for the Use of Molecular-Based Methods for More Effective Disease Monitoring

Author

Schrader, Anne M. R., primary, de Groen, Ruben A. L., additional, Willemze, Rein, additional, Jansen, Patty M., additional, Quint, Koen D., additional, Cleven, Arjen H. G., additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ruano, Dina, additional, Veelken, J. H. (Hendrik), additional, Tensen, Cornelis P., additional, Neelis, Karen J., additional, Daniels, Laurien A., additional, Hauben, Esther, additional, Woei-A-Jin, F. J. S. H. (Sherida), additional, Busschots, A. M. (Annemie), additional, Vermeer, Maarten H., additional, and Vermaat, Joost S. P., additional

Published
2022
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41. Synchronous diffuse large B-cell lymphoma and mantle cell lymphoma: support for low-threshold biopsies and genetic testing

Author

de Groot, Fleur A., primary, de Haan, Lorraine M., additional, de Groen, Ruben A. L., additional, Heijmen, Linda, additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Bohmer, Lara, additional, Bot, Freek, additional, ten Berge, Rosita L., additional, Diepstra, Arjan, additional, Veelken, Hendrik, additional, Cleven, Arjen H. G., additional, Jansen, Patty M., additional, and Vermaat, Joost S. P., additional

Published
2021
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42. Clues for disease progression at time of diagnosis in patients with primary cutaneous follicle center lymphoma

Author

Schrader, Anne M.R., primary, de Groen, Ruben A.L., additional, Willemze, Rein, additional, Jansen, Patty M., additional, Quint, Koen D., additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ruano, Dina, additional, Diepstra, Arjan, additional, van den Berg, Anke, additional, Kakiailatu, Naomi, additional, Vermeer, Maarten H., additional, and Vermaat, Joost S.P., additional

Published
2021
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44. Whole-Exome Sequencing Studies of Parathyroid Carcinomas Reveal Novel PRUNE2 Mutations, Distinctive Mutational Spectra Related to APOBEC-Catalyzed DNA Mutagenesis and Mutational Enrichment in Kinases Associated With Cell Migration and Invasion

Author

Yu, Willie, McPherson, John R, Stevenson, Mark, van Eijk, Ronald, Heng, Hong Lee, Newey, Paul, Gan, Anna, Ruano, Dina, Huang, Dachuan, Poon, Song Ling, Ong, Choon Kiat, van Wezel, Tom, Cavaco, Branca, Rozen, Steven G, Tan, Patrick, Teh, Bin T, Thakker, Rajesh V, and Morreau, Hans

Published
2015

47. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

Author

de Groen, A. L., van Eijk, Ronald, Bohringer, Stefan, Wezel, Tom van, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-De Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., den Berg, Anke van, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie Jose, Pals, Steven T., Veelken, Hendrik, Bovee, Judith V.M.G., Cleven, Arjen H.G., Vermaat, Joost S.P., de Groen, A. L., van Eijk, Ronald, Bohringer, Stefan, Wezel, Tom van, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-De Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., den Berg, Anke van, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie Jose, Pals, Steven T., Veelken, Hendrik, Bovee, Judith V.M.G., Cleven, Arjen H.G., and Vermaat, Joost S.P.

Published
2021

48. Erratum: Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia

Author

Schubert, Stephanie A, Ruano, Dina, Elsayed, Fadwa A, Boot, Arnoud, Crobach, Stijn, Sarasqueta, Arantza Farina, Wolffenbuttel, Bruce, van der Klauw, Melanie M, Oosting, Jan, Tops, Carli M, van Eijk, Ronald, Vasen, Hans FA, Vossen, Rolf HAM, Nielsen, Maartje, Castellví-Bel, Sergi, Ruiz-Ponte, Clara, Tomlinson, Ian, Dunlop, Malcolm G, Vodicka, Pavel, Wijnen, Juul T, Hes, Frederik J, Morreau, Hans, de Miranda, Noel FCC, Sijmons, Rolf H, and van Wezel, Tom

Published
2018
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