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3. Electrocardiogram-based mortality prediction in patients with COVID-19 using machine learning

Author

van de Leur, R. R., Bleijendaal, H., Taha, K., Mast, T., Gho, J. M. I. H., Linschoten, M., van Rees, B., Henkens, M. T. H. M., Heymans, S., Sturkenboom, N., Tio, R. A., Offerhaus, J. A., Bor, W. L., Maarse, M., Haerkens-Arends, H. E., Kolk, M. Z. H., van der Lingen, A. C. J., Selder, J. J., Wierda, E. E., van Bergen, P. F. M. M., Winter, M. M., Zwinderman, A. H., Doevendans, P. A., van der Harst, P., Pinto, Y. M., Asselbergs, F. W., van Es, R., and Tjong, F. V. Y.

Published
2022
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5. Clinicopathological Factors as Predictors for Establishment of Patient Derived Head and Neck Squamous Cell Carcinoma Organoids

Author

MS Mondziekten/Kaakchirurgie, Pathologie Moleculair, MS Medische Oncologie, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, de Kort, W W B, Millen, R, Driehuis, E, Devriese, L A, van Es, R J J, Willems, S M, MS Mondziekten/Kaakchirurgie, Pathologie Moleculair, MS Medische Oncologie, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, de Kort, W W B, Millen, R, Driehuis, E, Devriese, L A, van Es, R J J, and Willems, S M

Published
2024

9. Ethiek in de ontwikkeling van Gedragscodes: Casus: de Gedragscode Arbeidsdeskundigen 2010 en de Gedragscode Arbeidsdeskundigen 2023.

Author

van Es, R.

Abstract

Copyright of Afwikkeling Personenschade is the property of Boom uitgevers Den Haag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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12. p-mTOR, p-ERK and PTEN Expression in Tumor Biopsies and Organoids as Predictive Biomarkers for Patients with HPV Negative Head and Neck Cancer

Author

Pathologie Research, MKA/BT Onderzoek, Pathologie Opleiding, Cancer, Onderzoek Beeld, Pathologie Moleculair, MS Medische Oncologie, MS Bijzondere Tandheelkunde, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, de Kort, W. W.B., de Ruiter, E. J., Haakma, W. E., Driehuis, E., Devriese, L. A., van Es, R. J.J., Willems, S. M., Pathologie Research, MKA/BT Onderzoek, Pathologie Opleiding, Cancer, Onderzoek Beeld, Pathologie Moleculair, MS Medische Oncologie, MS Bijzondere Tandheelkunde, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, de Kort, W. W.B., de Ruiter, E. J., Haakma, W. E., Driehuis, E., Devriese, L. A., van Es, R. J.J., and Willems, S. M.

Published
2023

22. Big Data and Artificial Intelligence: Opportunities and Threats in Electrophysiology

Author

van de Leur, R.R., Boonstra, M.J., Bagheri, A., Roudijk, R.W., Sammani, A., Taha, K., Doevendans, P.A.F.M., van der Harst, P., van Dam, P.M., Hassink, R.J., van Es, R., Asselbergs, F.W., Methodology and statistics for the behavioural and social sciences, and Leerstoel Heijden

Subjects
Big data, 030204 cardiovascular system & hematology, Field (computer science), Diagnostic modalities, 03 medical and health sciences, 0302 clinical medicine, big data, Physiology (medical), Medicine, Diseases of the circulatory (Cardiovascular) system, 030212 general & internal medicine, Artificial neural network, business.industry, ECG, Deep learning, Clinical performance, deep learning, artificial intelligence, neural networks, electrophysiology, cardiology, RC666-701, Clinical Arrhythmias, Narrative review, Artificial intelligence, Applications of artificial intelligence, Cardiology and Cardiovascular Medicine, business
Abstract

The combination of big data and artificial intelligence (AI) is having an increasing impact on the field of electrophysiology. Algorithms are created to improve the automated diagnosis of clinical ECGs or ambulatory rhythm devices. Furthermore, the use of AI during invasive electrophysiological studies or combining several diagnostic modalities into AI algorithms to aid diagnostics are being investigated. However, the clinical performance and applicability of created algorithms are yet unknown. In this narrative review, opportunities and threats of AI in the field of electrophysiology are described, mainly focusing on ECGs. Current opportunities are discussed with their potential clinical benefits as well as the challenges. Challenges in data acquisition, model performance, (external) validity, clinical implementation, algorithm interpretation as well as the ethical aspects of AI research are discussed. This article aims to guide clinicians in the evaluation of new AI applications for electrophysiology before their clinical implementation.

Published
2020

32. Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review

Author

Pathologie Groep Moelans, Pathologie Algemene Pat.zorg, Longziekten onderzoek 2, MS Medische Oncologie, Cancer, MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, de Kort, W. W.B., Spelier, S., Devriese, L. A., van Es, R. J.J., Willems, S. M., Pathologie Groep Moelans, Pathologie Algemene Pat.zorg, Longziekten onderzoek 2, MS Medische Oncologie, Cancer, MKA/BT Onderzoek, MS Hoofd-Hals Chirurgische Oncologie, Pathologie Pathologen staf, de Kort, W. W.B., Spelier, S., Devriese, L. A., van Es, R. J.J., and Willems, S. M.

Published
2021

37. Big data and artificial intelligence: Opportunities and threats in electrophysiology

Author

Methodology and statistics for the behavioural and social sciences, Leerstoel Heijden, van de Leur, R.R., Boonstra, M.J., Bagheri, A., Roudijk, R.W., Sammani, A., Taha, K., Doevendans, P.A.F.M., van der Harst, P., van Dam, P.M., Hassink, R.J., van Es, R., Asselbergs, F.W., Methodology and statistics for the behavioural and social sciences, Leerstoel Heijden, van de Leur, R.R., Boonstra, M.J., Bagheri, A., Roudijk, R.W., Sammani, A., Taha, K., Doevendans, P.A.F.M., van der Harst, P., van Dam, P.M., Hassink, R.J., van Es, R., and Asselbergs, F.W.

Published
2020

39. Low skeletal muscle mass is a strong predictive factor for surgical complications and a prognostic factor in oral cancer patients undergoing mandibular reconstruction with a free fibula flap

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Zorgeenheid MKA/BT Medisch, Other research (not in main researchprogram), Ansari, E, Chargi, N, van Gemert, J T M, van Es, R J J, Dieleman, F J, Rosenberg, A J W P, Van Cann, E M, de Bree, R, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Zorgeenheid MKA/BT Medisch, Other research (not in main researchprogram), Ansari, E, Chargi, N, van Gemert, J T M, van Es, R J J, Dieleman, F J, Rosenberg, A J W P, Van Cann, E M, and de Bree, R

Published
2020

40. Feasibility of CT quantification of intratumoural 166Ho-microspheres

Author

MS Bijzondere Tandheelkunde, Innovatie, Fysica Radiologie, Cancer, Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Zorgeenheid MKA/BT Medisch, Other research (not in main researchprogram), Brain, Researchgr. Nucleaire Geneeskunde, C Bakker, R, Bastiaannet, R, van Nimwegen, S A, D Barten-van Rijbroek, A, Van Es, R J J, Rosenberg, A J W P, de Jong, H W A M, Lam, M G E H, Nijsen, J F W, MS Bijzondere Tandheelkunde, Innovatie, Fysica Radiologie, Cancer, Divisie Beeld & Oncologie, MS Hoofd-Hals Chirurgische Oncologie, Zorgeenheid MKA/BT Medisch, Other research (not in main researchprogram), Brain, Researchgr. Nucleaire Geneeskunde, C Bakker, R, Bastiaannet, R, van Nimwegen, S A, D Barten-van Rijbroek, A, Van Es, R J J, Rosenberg, A J W P, de Jong, H W A M, Lam, M G E H, and Nijsen, J F W

Published
2020

41. Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study

Author

Team Onderzoek, Zorgeenheid Vaatchirurgie Medisch, Pathologie Pathologen staf, Circulatory Health, Brain, Regenerative Medicine and Stem Cells, Team Medisch, Groen, M H A, Slieker, F J B, Vink, A, de Borst, G J, Simons, M V, Ebbini, E S, Utrecht, University, Hazenberg, C E V B, van Es, R, Team Onderzoek, Zorgeenheid Vaatchirurgie Medisch, Pathologie Pathologen staf, Circulatory Health, Brain, Regenerative Medicine and Stem Cells, Team Medisch, Groen, M H A, Slieker, F J B, Vink, A, de Borst, G J, Simons, M V, Ebbini, E S, Utrecht, University, Hazenberg, C E V B, and van Es, R

Published
2020

45. Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts

Author

Sanchez-Duffhues, G., Mikkers, H., de Jong, D., Szuhai, K., de Vries, T. J., Freund, C., Bravenboer, N., van Es, R. J.J., Netelenbos, J. C., Goumans, M. J., Eekhoff, E. M.W., ten Dijke, P., Sanchez-Duffhues, G., Mikkers, H., de Jong, D., Szuhai, K., de Vries, T. J., Freund, C., Bravenboer, N., van Es, R. J.J., Netelenbos, J. C., Goumans, M. J., Eekhoff, E. M.W., and ten Dijke, P.

Published
2019

46. Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts

Author

Zorgeenheid MKA/BT Zorg, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Sanchez-Duffhues, G., Mikkers, H., de Jong, D., Szuhai, K., de Vries, T. J., Freund, C., Bravenboer, N., van Es, R. J.J., Netelenbos, J. C., Goumans, M. J., Eekhoff, E. M.W., ten Dijke, P., Zorgeenheid MKA/BT Zorg, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Sanchez-Duffhues, G., Mikkers, H., de Jong, D., Szuhai, K., de Vries, T. J., Freund, C., Bravenboer, N., van Es, R. J.J., Netelenbos, J. C., Goumans, M. J., Eekhoff, E. M.W., and ten Dijke, P.

Published
2019

50. Intratumoral injection of radioactive holmium ( (166) Ho) microspheres for treatment of oral squamous cell carcinoma in cats

Author

van Nimwegen, S A, Bakker, R C, Kirpensteijn, J, van Es, R J J, Koole, R, Lam, M G E H, Hesselink, J W, Nijsen, J F W, dCSCA AVR, dCSCA RMSC-1, and dCSCA RMSC-2

Subjects
head and neck, tongue, tumour, brachytherapy, translational model, holmium, feline, radionuclide
Abstract

BACKGROUND & AIMS: A "microbrachytherapy" was developed as treatment option for inoperable tumours by direct intratumoral injection of radioactive holmium-166 ( (166) Ho) microspheres (MS). (166) Ho emits β-radiation which potentially enables a high, ablative, radioactive-absorbed dose on the tumour tissue while sparing surrounding tissues. MATERIALS & METHODS: Safety and efficacy of (166) Ho microbrachytherapy were evaluated in a prospective cohort study of 13 cats with inoperable oral squamous cell carcinoma without evidence of distant metastasis. RESULTS: Local response rate was 55%, including complete response or partial response (downstaging) enabling subsequent marginal resection. Median survival time was 113 days overall, and 296 days for patients with local response. Side effects were minimal. Tumour volume was a significant predictor of response. DISCUSSION: Response rate may be further improved by optimizing the intratumoral spatial distribution of (166) Ho MS. CONCLUSION: (166) Ho microbrachytherapy has potential as a minimally invasive, single procedure radio-ablation treatment of unresectable tumours with minimal morbidity.

Published
2018

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